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<https://discovery.ucl.ac.uk/id/eprint/10047213> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10047213> <http://purl.org/dc/terms/title> "Systematic analysis of the gerontome reveals links between aging and age-related diseasesSystematic analysis of the gerontome reveals links between aging and age-related diseases"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10047213> <http://purl.org/ontology/bibo/abstract> "In model organisms, over 2,000 genes have been shown to modulate aging, the collection of which we call the ‘gerontome’.\r\nAlthough some individual aging-related genes have been the subject of intense scrutiny, their analysis as a whole has been\r\nlimited. In particular, the genetic interaction of aging and age-related pathologies remain a subject of debate. In this work, we\r\nperform a systematic analysis of the gerontome across species, including human aging-related genes. First, by classifying\r\naging-related genes as pro- or anti-longevity, we define distinct pathways and genes that modulate aging in different ways.\r\nOur subsequent comparison of aging-related genes with age-related disease genes reveals species-specific effects with strong\r\noverlaps between aging and age-related diseases in mice, yet surprisingly few overlaps in lower model organisms. We discover\r\nthat genetic links between aging and age-related diseases are due to a small fraction of aging-related genes which also\r\ntend to have a high network connectivity. Other insights from our systematic analysis include assessing how using datasets\r\nwith genes more or less studied than average may result in biases, showing that age-related disease genes have faster molecular\r\nevolution rates and predicting new aging-related drugs based on drug-gene interaction data. Overall, this is the largest\r\nsystems-level analysis of the genetics of aging to date and the first to discriminate anti- and pro-longevity genes, revealing\r\nnew insights on aging-related genes as a whole and their interactions with age-related diseases."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10047213> <http://purl.org/dc/terms/date> "2016-11-01" .
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<https://discovery.ucl.ac.uk/id/eprint/10047213> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10047213#authors> .
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<https://discovery.ucl.ac.uk/id/eprint/10047213> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10047213#authors> .
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<https://discovery.ucl.ac.uk/id/eprint/10047213> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f09676742d57bf0538f5e31006782379> .
<https://discovery.ucl.ac.uk/id/eprint/10047213> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10047213#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10047213#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-f09676742d57bf0538f5e31006782379> .
<https://discovery.ucl.ac.uk/id/eprint/10047213> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b81dcc7d9d60de40877ffa1afe240416> .
<https://discovery.ucl.ac.uk/id/eprint/10047213> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10047213#authors> .
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<https://discovery.ucl.ac.uk/id/eprint/10047213> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b5b978561278c57ec55b8b8e89e0617c> .
<https://discovery.ucl.ac.uk/id/eprint/10047213> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10047213#authors> .
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<https://discovery.ucl.ac.uk/id/eprint/10047213> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c67b1e3ecdc48ebcf30c48b1db0e150d> .
<https://discovery.ucl.ac.uk/id/eprint/10047213> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10047213#authors> .
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<https://discovery.ucl.ac.uk/id/person/ext-d4f5ed52da7d8254bc9a2b371b519cf8> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d4f5ed52da7d8254bc9a2b371b519cf8> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d4f5ed52da7d8254bc9a2b371b519cf8> <http://xmlns.com/foaf/0.1/familyName> "Fernandes"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d4f5ed52da7d8254bc9a2b371b519cf8> <http://xmlns.com/foaf/0.1/name> "M Fernandes"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f09676742d57bf0538f5e31006782379> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-f09676742d57bf0538f5e31006782379> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f09676742d57bf0538f5e31006782379> <http://xmlns.com/foaf/0.1/familyName> "Thornton"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f09676742d57bf0538f5e31006782379> <http://xmlns.com/foaf/0.1/name> "D Thornton"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b81dcc7d9d60de40877ffa1afe240416> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-b81dcc7d9d60de40877ffa1afe240416> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b81dcc7d9d60de40877ffa1afe240416> <http://xmlns.com/foaf/0.1/familyName> "Yang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b81dcc7d9d60de40877ffa1afe240416> <http://xmlns.com/foaf/0.1/name> "C Yang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b5b978561278c57ec55b8b8e89e0617c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-b5b978561278c57ec55b8b8e89e0617c> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b5b978561278c57ec55b8b8e89e0617c> <http://xmlns.com/foaf/0.1/familyName> "Freitas"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b5b978561278c57ec55b8b8e89e0617c> <http://xmlns.com/foaf/0.1/name> "A Freitas"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-56fd81b5fd3f14ac7f04ef9ccf8f0c43> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-56fd81b5fd3f14ac7f04ef9ccf8f0c43> <http://xmlns.com/foaf/0.1/givenName> "R"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-56fd81b5fd3f14ac7f04ef9ccf8f0c43> <http://xmlns.com/foaf/0.1/familyName> "Tacutu"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-56fd81b5fd3f14ac7f04ef9ccf8f0c43> <http://xmlns.com/foaf/0.1/name> "R Tacutu"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7c38ad7d32a8b2949f70fb0c557ad2df> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-7c38ad7d32a8b2949f70fb0c557ad2df> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7c38ad7d32a8b2949f70fb0c557ad2df> <http://xmlns.com/foaf/0.1/familyName> "Wan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7c38ad7d32a8b2949f70fb0c557ad2df> <http://xmlns.com/foaf/0.1/name> "C Wan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c67b1e3ecdc48ebcf30c48b1db0e150d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-c67b1e3ecdc48ebcf30c48b1db0e150d> <http://xmlns.com/foaf/0.1/givenName> "JP"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c67b1e3ecdc48ebcf30c48b1db0e150d> <http://xmlns.com/foaf/0.1/familyName> "de Magalhaes"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c67b1e3ecdc48ebcf30c48b1db0e150d> <http://xmlns.com/foaf/0.1/name> "JP de Magalhaes"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/person/ext-767d679ada55885aff070d809b2a8971> <http://xmlns.com/foaf/0.1/familyName> "Thoppil"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-767d679ada55885aff070d809b2a8971> <http://xmlns.com/foaf/0.1/name> "H Thoppil"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/person/ext-385f47765de17d2f2c93722ff8028e7b> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-385f47765de17d2f2c93722ff8028e7b> <http://xmlns.com/foaf/0.1/familyName> "Barardo"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-385f47765de17d2f2c93722ff8028e7b> <http://xmlns.com/foaf/0.1/name> "D Barardo"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-135d0677524795c10596e2def1da9f5a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-135d0677524795c10596e2def1da9f5a> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-135d0677524795c10596e2def1da9f5a> <http://xmlns.com/foaf/0.1/familyName> "Rajput"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-135d0677524795c10596e2def1da9f5a> <http://xmlns.com/foaf/0.1/name> "A Rajput"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0bd6c316d75b02a171a4fdcda14f8500> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-0bd6c316d75b02a171a4fdcda14f8500> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0bd6c316d75b02a171a4fdcda14f8500> <http://xmlns.com/foaf/0.1/familyName> "Wang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0bd6c316d75b02a171a4fdcda14f8500> <http://xmlns.com/foaf/0.1/name> "J Wang"^^<http://www.w3.org/2001/XMLSchema#string> .
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