eprintid: 10046122 rev_number: 20 eprint_status: archive userid: 608 dir: disk0/10/04/61/22 datestamp: 2018-04-06 14:05:44 lastmod: 2021-09-26 23:03:44 status_changed: 2018-04-06 14:05:44 type: article metadata_visibility: show creators_name: Nasirudeen, MB creators_name: Hailes, HC creators_name: Evans, JRG title: Preparation of 5-Hydroxymethylfurfural from Glucose and Fructose in Ionic Liquids by Reactive Vacuum Distillation Over a Solid Catalyst ispublished: pub divisions: UCL divisions: B04 divisions: C06 divisions: F56 keywords: 5-hydroxymethyl-furfural (5-HMF), catalysis, ionic liquids, cassava note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: BACKGROUND: The production of 5-hydroxymethylfurfural (5-HMF) from biomass provides an alternative pathway for many commercial chemicals and polymers particularly for countries with high insolation such as sub-Saharan Africa. OBJECTIVE: The goal is continuous or semi-continuous dehydration of glucose and fructose to 5-HMF over a reusable castalyst in a process which is commmercial viable. METHOD: We deploy a separable and resuable catalyst, a low volatility solvent and reactive vacuum distillation. Results: Using a sulfated zirconia (SZ) catalyst in 1-butyl-3-methylimidazolium chloride [BMIM]Cl ionic liquid as solvent, we are able to separate the product by reactive vacuum distillation and obtain yields for 5-HMF of 82% and 65% at a 5 g experimental scale using fructose and glucose as substrates in a 2 h reaction time at 180 oC. The ionic liquid and SZ exhibited high activity when recycled for five successive trials. CONCLUSION: The low volatility solvent and solid catalyst allow for reactive vacuum distillation taking the sequence of steps from biomass such as Cassava to 5-HMF closer to commercial viability. date: 2017 date_type: published publisher: BENTHAM SCIENCE PUBL LTD official_url: https://doi.org/10.2174/1570179414666161115155958 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green article_type_text: Article verified: verified_manual elements_id: 1298045 doi: 10.2174/1570179414666161115155958 lyricists_name: Evans, Julian lyricists_name: Hailes, Helen lyricists_id: JRGEV39 lyricists_id: HCHAI24 actors_name: Hailes, Helen actors_id: HCHAI24 actors_role: owner full_text_status: public publication: Current Organic Synthesis volume: 14 number: 4 pagerange: 596-603 pages: 8 issn: 1875-6271 citation: Nasirudeen, MB; Hailes, HC; Evans, JRG; (2017) Preparation of 5-Hydroxymethylfurfural from Glucose and Fructose in Ionic Liquids by Reactive Vacuum Distillation Over a Solid Catalyst. Current Organic Synthesis , 14 (4) pp. 596-603. 10.2174/1570179414666161115155958 <https://doi.org/10.2174/1570179414666161115155958>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10046122/1/Accepted%20Manuscript-435%205-12.pdf