eprintid: 10045883
rev_number: 35
eprint_status: archive
userid: 608
dir: disk0/10/04/58/83
datestamp: 2018-03-28 14:28:44
lastmod: 2021-10-03 23:56:07
status_changed: 2019-02-05 18:06:05
type: article
metadata_visibility: show
creators_name: Kim, M
creators_name: Maguire, EA
title: Hippocampus, Retrosplenial and Parahippocampal Cortices Encode Multicompartment 3D Space in a Hierarchical Manner.
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F83
divisions: C08
divisions: D09
note: © The Author(s) 2018. Published by Oxford University Press.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
abstract: Humans commonly operate within 3D environments such as multifloor buildings and yet there is a surprising dearth of studies that have examined how these spaces are represented in the brain. Here, we had participants learn the locations of paintings within a virtual multilevel gallery building and then used behavioral tests and fMRI repetition suppression analyses to investigate how this 3D multicompartment space was represented, and whether there was a bias in encoding vertical and horizontal information. We found faster response times for within-room egocentric spatial judgments and behavioral priming effects of visiting the same room, providing evidence for a compartmentalized representation of space. At the neural level, we observed a hierarchical encoding of 3D spatial information, with left anterior hippocampus representing local information within a room, while retrosplenial cortex, parahippocampal cortex, and posterior hippocampus represented room information within the wider building. Of note, both our behavioral and neural findings showed that vertical and horizontal location information was similarly encoded, suggesting an isotropic representation of 3D space even in the context of a multicompartment environment. These findings provide much-needed information about how the human brain supports spatial memory and navigation in buildings with numerous levels and rooms.
date: 2018-05-01
date_type: published
official_url: https://doi.org/10.1093/cercor/bhy054
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1544632
doi: 10.1093/cercor/bhy054
pii: 4938776
lyricists_name: Kim, Misun
lyricists_name: Maguire, Eleanor
lyricists_id: KIMAX63
lyricists_id: EMAGU26
actors_name: Waragoda Vitharana, Nimal
actors_id: NWARR44
actors_role: owner
full_text_status: public
publication: Cerebral Cortex
volume: 28
number: 5
pagerange: 1898-1909
event_location: United States
issn: 1460-2199
citation:        Kim, M;    Maguire, EA;      (2018)    Hippocampus, Retrosplenial and Parahippocampal Cortices Encode Multicompartment 3D Space in a Hierarchical Manner.                   Cerebral Cortex , 28  (5)   pp. 1898-1909.    10.1093/cercor/bhy054 <https://doi.org/10.1093/cercor%2Fbhy054>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10045883/7/Kim%20VoR%20bhy054.pdf