eprintid: 10045883 rev_number: 35 eprint_status: archive userid: 608 dir: disk0/10/04/58/83 datestamp: 2018-03-28 14:28:44 lastmod: 2021-10-03 23:56:07 status_changed: 2019-02-05 18:06:05 type: article metadata_visibility: show creators_name: Kim, M creators_name: Maguire, EA title: Hippocampus, Retrosplenial and Parahippocampal Cortices Encode Multicompartment 3D Space in a Hierarchical Manner. ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F83 divisions: C08 divisions: D09 note: © The Author(s) 2018. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. abstract: Humans commonly operate within 3D environments such as multifloor buildings and yet there is a surprising dearth of studies that have examined how these spaces are represented in the brain. Here, we had participants learn the locations of paintings within a virtual multilevel gallery building and then used behavioral tests and fMRI repetition suppression analyses to investigate how this 3D multicompartment space was represented, and whether there was a bias in encoding vertical and horizontal information. We found faster response times for within-room egocentric spatial judgments and behavioral priming effects of visiting the same room, providing evidence for a compartmentalized representation of space. At the neural level, we observed a hierarchical encoding of 3D spatial information, with left anterior hippocampus representing local information within a room, while retrosplenial cortex, parahippocampal cortex, and posterior hippocampus represented room information within the wider building. Of note, both our behavioral and neural findings showed that vertical and horizontal location information was similarly encoded, suggesting an isotropic representation of 3D space even in the context of a multicompartment environment. These findings provide much-needed information about how the human brain supports spatial memory and navigation in buildings with numerous levels and rooms. date: 2018-05-01 date_type: published official_url: https://doi.org/10.1093/cercor/bhy054 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_id: 1544632 doi: 10.1093/cercor/bhy054 pii: 4938776 lyricists_name: Kim, Misun lyricists_name: Maguire, Eleanor lyricists_id: KIMAX63 lyricists_id: EMAGU26 actors_name: Waragoda Vitharana, Nimal actors_id: NWARR44 actors_role: owner full_text_status: public publication: Cerebral Cortex volume: 28 number: 5 pagerange: 1898-1909 event_location: United States issn: 1460-2199 citation: Kim, M; Maguire, EA; (2018) Hippocampus, Retrosplenial and Parahippocampal Cortices Encode Multicompartment 3D Space in a Hierarchical Manner. Cerebral Cortex , 28 (5) pp. 1898-1909. 10.1093/cercor/bhy054 <https://doi.org/10.1093/cercor%2Fbhy054>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10045883/7/Kim%20VoR%20bhy054.pdf