eprintid: 10045093 rev_number: 23 eprint_status: archive userid: 608 dir: disk0/10/04/50/93 datestamp: 2018-03-13 12:01:06 lastmod: 2021-09-17 22:09:41 status_changed: 2018-03-13 12:01:06 type: article metadata_visibility: show creators_name: Hoeglinger, GU creators_name: Respondek, G creators_name: Stamelou, M creators_name: Kurz, C creators_name: Josephs, KA creators_name: Lang, AE creators_name: Mollenhauer, B creators_name: Mueller, U creators_name: Nilsson, C creators_name: Whitwell, JL creators_name: Arzberger, T creators_name: Englund, E creators_name: Gelpi, E creators_name: Giese, A creators_name: Irwin, DJ creators_name: Meissner, WG creators_name: Pantelyat, A creators_name: Rajput, A creators_name: van Swieten, JC creators_name: Troakes, C creators_name: Antonini, A creators_name: Bhatia, KP creators_name: Bordelon, Y creators_name: Compta, Y creators_name: Corvol, J-C creators_name: Colosimo, C creators_name: Dickson, DW creators_name: Dodel, R creators_name: Ferguson, L creators_name: Grossman, M creators_name: Kassubek, J creators_name: Krismer, F creators_name: Levin, J creators_name: Lorenzl, S creators_name: Morris, HR creators_name: Nestor, P creators_name: Oertel, WH creators_name: Poewe, W creators_name: Rabinovici, G creators_name: Rowe, JB creators_name: Schellenberg, GD creators_name: Seppi, K creators_name: van Eimeren, T creators_name: Wenning, GK creators_name: Boxer, AL creators_name: Golbe, LI creators_name: Litvan, I title: Clinical Diagnosis of Progressive Supranuclear Palsy: The Movement Disorder Society Criteria ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F84 divisions: F85 keywords: Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences & Neurology, progressive supranuclear palsy, evidence-based, consensus-based, clinical diagnostic criteria, RICHARDSON-OLSZEWSKI SYNDROME, NINDS NEUROPATHOLOGIC CRITERIA, CORTICOBASAL DEGENERATION, NONFLUENT APHASIA, NATURAL-HISTORY, PURE AKINESIA, FEATURES, ACCURACY, DEMENTIA, PSP note: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Background: PSP is a neuropathologically defined disease entity. Clinical diagnostic criteria, published in 1996 by the National Institute of Neurological Disorders and Stroke/Society for PSP, have excellent specificity, but their sensitivity is limited for variant PSP syndromes with presentations other than Richardson's syndrome. Objective: We aimed to provide an evidence- and consensus-based revision of the clinical diagnostic criteria for PSP. Methods: We searched the PubMed, Cochrane, Medline, and PSYCInfo databases for articles published in English since 1996, using postmortem diagnosis or highly specific clinical criteria as the diagnostic standard. Second, we generated retrospective standardized clinical data from patients with autopsy-confirmed PSP and control diseases. On this basis, diagnostic criteria were drafted, optimized in two modified Delphi evaluations, submitted to structured discussions with consensus procedures during a 2-day meeting, and refined in three further Delphi rounds. Results: Defined clinical, imaging, laboratory, and genetic findings serve as mandatory basic features, mandatory exclusion criteria, or context-dependent exclusion criteria. We identified four functional domains (ocular motor dysfunction, postural instability, akinesia, and cognitive dysfunction) as clinical predictors of PSP. Within each of these domains, we propose three clinical features that contribute different levels of diagnostic certainty. Specific combinations of these features define the diagnostic criteria, stratified by three degrees of diagnostic certainty (probable PSP, possible PSP, and suggestive of PSP). Clinical clues and imaging findings represent supportive features. Conclusions: Here, we present new criteria aimed to optimize early, sensitive, and specific clinical diagnosis of PSP on the basis of currently available evidence. date: 2017-05-03 date_type: published publisher: WILEY official_url: https://doi.org/10.1002/mds.26987 full_text_type: pub language: eng article_type_text: Article verified: verified_manual elements_id: 1292667 doi: 10.1002/mds.26987 lyricists_name: Bhatia, Kailash lyricists_name: Morris, Huw lyricists_name: Stamelou, Maria lyricists_id: KPBHA96 lyricists_id: HRMOR79 lyricists_id: MSTAM90 actors_name: Bhatia, Kailash actors_id: KPBHA96 actors_role: owner full_text_status: restricted publication: Movement Disorders volume: 32 number: 6 pagerange: 853-864 pages: 12 issn: 1531-8257 citation: Hoeglinger, GU; Respondek, G; Stamelou, M; Kurz, C; Josephs, KA; Lang, AE; Mollenhauer, B; ... Litvan, I; + view all <#> Hoeglinger, GU; Respondek, G; Stamelou, M; Kurz, C; Josephs, KA; Lang, AE; Mollenhauer, B; Mueller, U; Nilsson, C; Whitwell, JL; Arzberger, T; Englund, E; Gelpi, E; Giese, A; Irwin, DJ; Meissner, WG; Pantelyat, A; Rajput, A; van Swieten, JC; Troakes, C; Antonini, A; Bhatia, KP; Bordelon, Y; Compta, Y; Corvol, J-C; Colosimo, C; Dickson, DW; Dodel, R; Ferguson, L; Grossman, M; Kassubek, J; Krismer, F; Levin, J; Lorenzl, S; Morris, HR; Nestor, P; Oertel, WH; Poewe, W; Rabinovici, G; Rowe, JB; Schellenberg, GD; Seppi, K; van Eimeren, T; Wenning, GK; Boxer, AL; Golbe, LI; Litvan, I; - view fewer <#> (2017) Clinical Diagnosis of Progressive Supranuclear Palsy: The Movement Disorder Society Criteria. Movement Disorders , 32 (6) pp. 853-864. 10.1002/mds.26987 <https://doi.org/10.1002/mds.26987>. document_url: https://discovery.ucl.ac.uk/id/eprint/10045093/1/H-glinger_et_al-2017-Movement_Disorders.pdf