%0 Journal Article
%@ 2162-5514
%A Bhatia, KP
%A Stamelou, M
%D 2017
%F discovery:10045091
%J International Review of Neurobiology
%K Atypical parkinsonism, Autonomic, Cognition, Corticobasal degeneration, Multiple system atrophy, Nonmotor features, Progressive supranuclear palsy
%P 1285-1301
%T Chapter Forty-Six - Nonmotor Features in Atypical Parkinsonism
%U https://discovery.ucl.ac.uk/id/eprint/10045091/
%V 134
%X Atypical parkinsonism (AP) comprises mainly multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD), which are distinct pathological entities, presenting with a wide phenotypic spectrum. The classic syndromes are now called MSA-parkinsonism (MSA-P), MSA-cerebellar type (MSA-C), Richardson's syndrome, and corticobasal syndrome. Nonmotor features in AP have been recognized almost since the initial description of these disorders; however, research has been limited. Autonomic dysfunction is the most prominent nonmotor feature of MSA, but also gastrointestinal symptoms, sleep dysfunction, and pain, can be a feature. In PSP and CBD, the most prominent nonmotor symptoms comprise those deriving from the cognitive/neuropsychiatric domain. Apart from assisting the clinician in the differential diagnosis with Parkinson's disease, nonmotor features in AP have a big impact on quality of life and prognosis of AP and their treatment poses a major challenge for clinicians.
%Z This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.