@article{discovery10045091, month = {July}, pages = {1285--1301}, note = {This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.}, title = {Chapter Forty-Six - Nonmotor Features in Atypical Parkinsonism}, journal = {International Review of Neurobiology}, volume = {134}, year = {2017}, abstract = {Atypical parkinsonism (AP) comprises mainly multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD), which are distinct pathological entities, presenting with a wide phenotypic spectrum. The classic syndromes are now called MSA-parkinsonism (MSA-P), MSA-cerebellar type (MSA-C), Richardson's syndrome, and corticobasal syndrome. Nonmotor features in AP have been recognized almost since the initial description of these disorders; however, research has been limited. Autonomic dysfunction is the most prominent nonmotor feature of MSA, but also gastrointestinal symptoms, sleep dysfunction, and pain, can be a feature. In PSP and CBD, the most prominent nonmotor symptoms comprise those deriving from the cognitive/neuropsychiatric domain. Apart from assisting the clinician in the differential diagnosis with Parkinson's disease, nonmotor features in AP have a big impact on quality of life and prognosis of AP and their treatment poses a major challenge for clinicians.}, issn = {2162-5514}, url = {https://doi.org/10.1016/bs.irn.2017.06.001}, author = {Bhatia, KP and Stamelou, M}, keywords = {Atypical parkinsonism, Autonomic, Cognition, Corticobasal degeneration, Multiple system atrophy, Nonmotor features, Progressive supranuclear palsy} }