eprintid: 10045055 rev_number: 37 eprint_status: archive userid: 608 dir: disk0/10/04/50/55 datestamp: 2018-03-12 10:02:17 lastmod: 2021-12-13 01:35:32 status_changed: 2019-02-07 14:17:12 type: article metadata_visibility: show creators_name: Tsui, A creators_name: Kuh, D creators_name: Cardozo, L creators_name: Davis, D title: Vascular risk factors for male and female urgency urinary incontinence at age 68 years from a British birth cohort study ispublished: pub divisions: UCL divisions: B02 divisions: D14 divisions: GA3 divisions: G17 keywords: incontinence, adiposity, ageing, prevalence, urgency, urinary incontinence, vascular note: Copyright © 2018 The Authors. BJU International published by John Wiley & Sons Ltd on behalf of BJU International This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. abstract: OBJECTIVE: To investigate the prevalence of urgency urinary incontinence (UUI) at age 68 years and the contribution of vascular risk factors to male and female UUI pathogenesis in addition to the associations with raised body mass index (BMI). SUBJECTS AND METHODS: In all, 1 762 participants from the Medical Research Council (MRC) National Survey for Health and Development birth cohort who answered the International Consultation on Incontinence Questionnaire short form (ICIQ-SF), at age 68 years, were included. Logistic regression was used to estimate associations between UUI and earlier life vascular risk factors including: lipid status, diabetes, hypertension, BMI, previous stroke or transient ischaemic attack (TIA) diagnosis; adjusting for smoking status, physical activity, co-presentation of stress UI symptoms, educational attainment; and in women only, type of menopause, age at period cessation, and use of hormone replacement therapy (HRT). RESULTS: UUI was reported by 12% of men and 19% of women at age 68 years. Female sex, previous stroke or TIA diagnosis, increased BMI and hypertension (in men only) at age 60-64 years were independent risk factors for UUI. Female sex, increased BMI, and a previous diagnosis of stroke/TIA increased the relative risk of more severe UUI symptoms. Type and timing of menopause and HRT use did not alter the estimated associations between UUI and vascular risk factors in women. CONCLUSION: Multifactorial mechanisms lead to UUI and vascular risk factors may contribute to the pathogenesis of bladder overactivity in addition to higher BMI. Severe UUI appears to be a distinct presentation with more specific contributory mechanisms than milder UUI. date: 2018-07 date_type: published official_url: http://dx.doi.org/10.1111/bju.14137 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_id: 1541041 doi: 10.1111/bju.14137 lyricists_name: Davis, Daniel lyricists_name: Kuh, Diana lyricists_name: Tsui, Alex lyricists_id: DDAVI19 lyricists_id: DKUHX97 lyricists_id: ATSUI01 actors_name: Bracey, Alan actors_id: ABBRA90 actors_role: owner full_text_status: public publication: BJU International volume: 122 number: 1 pagerange: 118-125 event_location: England issn: 1464-410X citation: Tsui, A; Kuh, D; Cardozo, L; Davis, D; (2018) Vascular risk factors for male and female urgency urinary incontinence at age 68 years from a British birth cohort study. BJU International , 122 (1) pp. 118-125. 10.1111/bju.14137 <https://doi.org/10.1111/bju.14137>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10045055/7/Davis%20VoR%20Tsui_et_al-2018-BJU_International.pdf