eprintid: 10045055
rev_number: 37
eprint_status: archive
userid: 608
dir: disk0/10/04/50/55
datestamp: 2018-03-12 10:02:17
lastmod: 2021-12-13 01:35:32
status_changed: 2019-02-07 14:17:12
type: article
metadata_visibility: show
creators_name: Tsui, A
creators_name: Kuh, D
creators_name: Cardozo, L
creators_name: Davis, D
title: Vascular risk factors for male and female urgency urinary incontinence at age 68 years from a British birth cohort study
ispublished: pub
divisions: UCL
divisions: B02
divisions: D14
divisions: GA3
divisions: G17
keywords: incontinence, adiposity, ageing, prevalence, urgency, urinary incontinence, vascular
note: Copyright © 2018 The Authors. BJU International published by John Wiley & Sons Ltd on behalf of BJU International
This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
abstract: OBJECTIVE: To investigate the prevalence of urgency urinary incontinence (UUI) at age 68 years and the contribution of vascular risk factors to male and female UUI pathogenesis in addition to the associations with raised body mass index (BMI). SUBJECTS AND METHODS: In all, 1 762 participants from the Medical Research Council (MRC) National Survey for Health and Development birth cohort who answered the International Consultation on Incontinence Questionnaire short form (ICIQ-SF), at age 68 years, were included. Logistic regression was used to estimate associations between UUI and earlier life vascular risk factors including: lipid status, diabetes, hypertension, BMI, previous stroke or transient ischaemic attack (TIA) diagnosis; adjusting for smoking status, physical activity, co-presentation of stress UI symptoms, educational attainment; and in women only, type of menopause, age at period cessation, and use of hormone replacement therapy (HRT). RESULTS: UUI was reported by 12% of men and 19% of women at age 68 years. Female sex, previous stroke or TIA diagnosis, increased BMI and hypertension (in men only) at age 60-64 years were independent risk factors for UUI. Female sex, increased BMI, and a previous diagnosis of stroke/TIA increased the relative risk of more severe UUI symptoms. Type and timing of menopause and HRT use did not alter the estimated associations between UUI and vascular risk factors in women. CONCLUSION: Multifactorial mechanisms lead to UUI and vascular risk factors may contribute to the pathogenesis of bladder overactivity in addition to higher BMI. Severe UUI appears to be a distinct presentation with more specific contributory mechanisms than milder UUI.
date: 2018-07
date_type: published
official_url: http://dx.doi.org/10.1111/bju.14137
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1541041
doi: 10.1111/bju.14137
lyricists_name: Davis, Daniel
lyricists_name: Kuh, Diana
lyricists_name: Tsui, Alex
lyricists_id: DDAVI19
lyricists_id: DKUHX97
lyricists_id: ATSUI01
actors_name: Bracey, Alan
actors_id: ABBRA90
actors_role: owner
full_text_status: public
publication: BJU International
volume: 122
number: 1
pagerange: 118-125
event_location: England
issn: 1464-410X
citation:        Tsui, A;    Kuh, D;    Cardozo, L;    Davis, D;      (2018)    Vascular risk factors for male and female urgency urinary incontinence at age 68 years from a British birth cohort study.                   BJU International , 122  (1)   pp. 118-125.    10.1111/bju.14137 <https://doi.org/10.1111/bju.14137>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10045055/7/Davis%20VoR%20Tsui_et_al-2018-BJU_International.pdf