<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10045023> .
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<https://discovery.ucl.ac.uk/id/eprint/10045023> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10045023> <http://purl.org/dc/terms/title> "Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer's disease pathogenesis"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10045023> <http://purl.org/ontology/bibo/abstract> "Alzheimer’s disease (AD) is a leading cause of mortality among the\r\nelderly. We performed a whole-genome sequencing study of AD in\r\nthe Chinese population. In addition to the variants identified in or\r\naround the APOE locus (sentinel variant rs73052335, P = 1.44 ×\r\n10−14), two common variants, GCH1 (rs72713460, P = 4.36 × 10−5\r\n)\r\nand KCNJ15 (rs928771, P = 3.60 × 10−6\r\n), were identified and further\r\nverified for their possible risk effects for AD in three small non-Asian\r\nAD cohorts. Genotype–phenotype analysis showed that KCNJ15 variant\r\nrs928771 affects the onset age of AD, with earlier disease onset\r\nin minor allele carriers. In addition, altered expression level of the\r\nKCNJ15 transcript can be observed in the blood of AD subjects.\r\nMoreover, the risk variants of GCH1 and KCNJ15 are associated with\r\nchanges in their transcript levels in specific tissues, as well as\r\nchanges of plasma biomarkers levels in AD subjects. Importantly,\r\nnetwork analysis of hippocampus and blood transcriptome datasets\r\nsuggests that the risk variants in the APOE, GCH1, and KCNJ15 loci\r\nmight exert their functions through their regulatory effects on\r\nimmune-related pathways. Taking these data together, we identified\r\ncommon variants of GCH1 and KCNJ15 in the Chinese population\r\nthat contribute to AD risk. These variants may exert their\r\nfunctional effects through the immune system."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10045023> <http://purl.org/dc/terms/date> "2018-02-20" .
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<https://discovery.ucl.ac.uk/id/eprint/10045023> <http://purl.org/ontology/bibo/volume> "115" .
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<https://discovery.ucl.ac.uk/id/eprint/10045023> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10045023#authors> .
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<https://discovery.ucl.ac.uk/id/eprint/10045023> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10045023#authors> .
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<https://discovery.ucl.ac.uk/id/eprint/10045023> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10045023#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10045023#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-998185602b6a3933db90674ee0a62770> .
<https://discovery.ucl.ac.uk/id/eprint/10045023> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-51b28e57394a3376f392df823edecc68> .
<https://discovery.ucl.ac.uk/id/eprint/10045023> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10045023#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10045023#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-51b28e57394a3376f392df823edecc68> .
<https://discovery.ucl.ac.uk/id/eprint/10045023> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9e8dd76a103ce110c801cfcef9d0bb19> .
<https://discovery.ucl.ac.uk/id/eprint/10045023> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10045023#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10045023#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-9e8dd76a103ce110c801cfcef9d0bb19> .
<https://discovery.ucl.ac.uk/id/eprint/10045023> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-69936e8651e10746032e0e6b6457ea50> .
<https://discovery.ucl.ac.uk/id/eprint/10045023> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10045023#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10045023#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-69936e8651e10746032e0e6b6457ea50> .
<https://discovery.ucl.ac.uk/id/eprint/10045023> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-10305f46e3239f591780e03aa41e3d23> .
<https://discovery.ucl.ac.uk/id/eprint/10045023> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10045023#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10045023#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-10305f46e3239f591780e03aa41e3d23> .
<https://discovery.ucl.ac.uk/id/eprint/10045023> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2448e6afc583c13536a322c715a859f0> .
<https://discovery.ucl.ac.uk/id/eprint/10045023> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10045023#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10045023#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-2448e6afc583c13536a322c715a859f0> .
<https://discovery.ucl.ac.uk/id/eprint/10045023> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ff0ac9f4393d41f976064ebdb64b2b1e> .
<https://discovery.ucl.ac.uk/id/eprint/10045023> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10045023#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10045023#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-ff0ac9f4393d41f976064ebdb64b2b1e> .
<https://discovery.ucl.ac.uk/id/eprint/10045023> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e4e0620fb885bb2276138d9648efd105> .
<https://discovery.ucl.ac.uk/id/eprint/10045023> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10045023#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10045023#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-e4e0620fb885bb2276138d9648efd105> .
<https://discovery.ucl.ac.uk/id/eprint/10045023> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-802d1d28b292bf20f6308dc704a14c8b> .
<https://discovery.ucl.ac.uk/id/eprint/10045023> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10045023#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10045023#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-802d1d28b292bf20f6308dc704a14c8b> .
<https://discovery.ucl.ac.uk/id/person/ext-1455f8c343b004e50a65d28e814ca879> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1455f8c343b004e50a65d28e814ca879> <http://xmlns.com/foaf/0.1/givenName> "X"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1455f8c343b004e50a65d28e814ca879> <http://xmlns.com/foaf/0.1/familyName> "Zhou"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1455f8c343b004e50a65d28e814ca879> <http://xmlns.com/foaf/0.1/name> "X Zhou"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-69936e8651e10746032e0e6b6457ea50> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-69936e8651e10746032e0e6b6457ea50> <http://xmlns.com/foaf/0.1/givenName> "Y"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-69936e8651e10746032e0e6b6457ea50> <http://xmlns.com/foaf/0.1/familyName> "Chen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-69936e8651e10746032e0e6b6457ea50> <http://xmlns.com/foaf/0.1/name> "Y Chen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ff0ac9f4393d41f976064ebdb64b2b1e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-ff0ac9f4393d41f976064ebdb64b2b1e> <http://xmlns.com/foaf/0.1/givenName> "AKY"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ff0ac9f4393d41f976064ebdb64b2b1e> <http://xmlns.com/foaf/0.1/familyName> "Fu"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ff0ac9f4393d41f976064ebdb64b2b1e> <http://xmlns.com/foaf/0.1/name> "AKY Fu"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-51b28e57394a3376f392df823edecc68> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-51b28e57394a3376f392df823edecc68> <http://xmlns.com/foaf/0.1/givenName> "Q"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-51b28e57394a3376f392df823edecc68> <http://xmlns.com/foaf/0.1/familyName> "Zhao"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-51b28e57394a3376f392df823edecc68> <http://xmlns.com/foaf/0.1/name> "Q Zhao"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-10305f46e3239f591780e03aa41e3d23> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-10305f46e3239f591780e03aa41e3d23> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-10305f46e3239f591780e03aa41e3d23> <http://xmlns.com/foaf/0.1/familyName> "Hardy"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-10305f46e3239f591780e03aa41e3d23> <http://xmlns.com/foaf/0.1/name> "J Hardy"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e4e0620fb885bb2276138d9648efd105> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e4e0620fb885bb2276138d9648efd105> <http://xmlns.com/foaf/0.1/givenName> "Q"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e4e0620fb885bb2276138d9648efd105> <http://xmlns.com/foaf/0.1/familyName> "Guo"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e4e0620fb885bb2276138d9648efd105> <http://xmlns.com/foaf/0.1/name> "Q Guo"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-998185602b6a3933db90674ee0a62770> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-998185602b6a3933db90674ee0a62770> <http://xmlns.com/foaf/0.1/givenName> "KY"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-998185602b6a3933db90674ee0a62770> <http://xmlns.com/foaf/0.1/familyName> "Mok"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-998185602b6a3933db90674ee0a62770> <http://xmlns.com/foaf/0.1/name> "KY Mok"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-802d1d28b292bf20f6308dc704a14c8b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-802d1d28b292bf20f6308dc704a14c8b> <http://xmlns.com/foaf/0.1/givenName> "NY"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-802d1d28b292bf20f6308dc704a14c8b> <http://xmlns.com/foaf/0.1/familyName> "Ip"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-802d1d28b292bf20f6308dc704a14c8b> <http://xmlns.com/foaf/0.1/name> "NY Ip"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9e8dd76a103ce110c801cfcef9d0bb19> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-9e8dd76a103ce110c801cfcef9d0bb19> <http://xmlns.com/foaf/0.1/givenName> "K"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9e8dd76a103ce110c801cfcef9d0bb19> <http://xmlns.com/foaf/0.1/familyName> "Chen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9e8dd76a103ce110c801cfcef9d0bb19> <http://xmlns.com/foaf/0.1/name> "K Chen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2448e6afc583c13536a322c715a859f0> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-2448e6afc583c13536a322c715a859f0> <http://xmlns.com/foaf/0.1/givenName> "Y"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2448e6afc583c13536a322c715a859f0> <http://xmlns.com/foaf/0.1/familyName> "Li"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2448e6afc583c13536a322c715a859f0> <http://xmlns.com/foaf/0.1/name> "Y Li"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10045023> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> .
<https://discovery.ucl.ac.uk/id/eprint/10045023> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ArticleEPrint> .
<https://discovery.ucl.ac.uk/id/eprint/10045023> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/repository> .
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<https://discovery.ucl.ac.uk/id/document/632468> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/632468> <http://www.w3.org/2000/01/rdf-schema#label> "Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer's disease pathogenesis (Text)"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/eprint/10045023> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/632470> .
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