TY  - JOUR
PB  - CELL PRESS
A1  - Favuzzi, E
A1  - Marques-Smith, A
A1  - Deogracias, R
A1  - Winterflood, CM
A1  - Sanchez-Aguilera, A
A1  - Mantoan, L
A1  - Maeso, P
A1  - Fernandes, C
A1  - Ewers, H
A1  - Rico, B
JF  - Neuron
SP  - 639
VL  - 95
UR  - http://doi.org/10.1016/j.neuron.2017.06.028
ID  - discovery10044837
N2  - Activity-dependent neuronal plasticity is a fundamental mechanism through which the nervous system adapts to sensory experience. Several lines of evidence suggest that parvalbumin (PV+) interneurons are essential in this process, but the molecular mechanisms underlying the influence of experience on interneuron plasticity remain poorly understood. Perineuronal nets (PNNs) enwrapping PV+ cells are long-standing candidates for playing such a role, yet their precise contribution has remained elusive. We show that the PNN protein Brevican is a critical regulator of interneuron plasticity. We find that Brevican simultaneously controls cellular and synaptic forms of plasticity in PV+ cells by regulating the localization of potassium channels and AMPA receptors, respectively. By modulating Brevican levels, experience introduces precise molecular and cellular modifications in PV+ cells that are required for learning and memory. These findings uncover a molecular program through which a PNN protein facilitates appropriate behavioral responses to experience by dynamically gating PV+ interneuron function.
Y1  - 2017/08/02/
KW  - Parvalbumin interneurons
KW  -  inhibitory circuitries
KW  -  perineuronal netssynapse maturation
KW  -  AMPA receptors
KW  -  Kv channels
KW  -  learning and memory
KW  -  plasticity
KW  -  activity-dependent
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
EP  - 655
IS  - 3
AV  - public
SN  - 1097-4199
TI  - Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican
ER  -