TY - JOUR PB - CELL PRESS A1 - Favuzzi, E A1 - Marques-Smith, A A1 - Deogracias, R A1 - Winterflood, CM A1 - Sanchez-Aguilera, A A1 - Mantoan, L A1 - Maeso, P A1 - Fernandes, C A1 - Ewers, H A1 - Rico, B JF - Neuron SP - 639 VL - 95 UR - http://doi.org/10.1016/j.neuron.2017.06.028 ID - discovery10044837 N2 - Activity-dependent neuronal plasticity is a fundamental mechanism through which the nervous system adapts to sensory experience. Several lines of evidence suggest that parvalbumin (PV+) interneurons are essential in this process, but the molecular mechanisms underlying the influence of experience on interneuron plasticity remain poorly understood. Perineuronal nets (PNNs) enwrapping PV+ cells are long-standing candidates for playing such a role, yet their precise contribution has remained elusive. We show that the PNN protein Brevican is a critical regulator of interneuron plasticity. We find that Brevican simultaneously controls cellular and synaptic forms of plasticity in PV+ cells by regulating the localization of potassium channels and AMPA receptors, respectively. By modulating Brevican levels, experience introduces precise molecular and cellular modifications in PV+ cells that are required for learning and memory. These findings uncover a molecular program through which a PNN protein facilitates appropriate behavioral responses to experience by dynamically gating PV+ interneuron function. Y1 - 2017/08/02/ KW - Parvalbumin interneurons KW - inhibitory circuitries KW - perineuronal netssynapse maturation KW - AMPA receptors KW - Kv channels KW - learning and memory KW - plasticity KW - activity-dependent N1 - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions. EP - 655 IS - 3 AV - public SN - 1097-4199 TI - Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican ER -