%0 Journal Article
%@ 1097-4199
%A Favuzzi, E
%A Marques-Smith, A
%A Deogracias, R
%A Winterflood, CM
%A Sanchez-Aguilera, A
%A Mantoan, L
%A Maeso, P
%A Fernandes, C
%A Ewers, H
%A Rico, B
%D 2017
%F discovery:10044837
%I CELL PRESS
%J Neuron
%K Parvalbumin interneurons, inhibitory circuitries, perineuronal netssynapse maturation, AMPA receptors, Kv channels, learning and memory, plasticity, activity-dependent
%N 3
%P 639-655
%T Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican
%U https://discovery.ucl.ac.uk/id/eprint/10044837/
%V 95
%X Activity-dependent neuronal plasticity is a fundamental mechanism through which the nervous system adapts to sensory experience. Several lines of evidence suggest that parvalbumin (PV+) interneurons are essential in this process, but the molecular mechanisms underlying the influence of experience on interneuron plasticity remain poorly understood. Perineuronal nets (PNNs) enwrapping PV+ cells are long-standing candidates for playing such a role, yet their precise contribution has remained elusive. We show that the PNN protein Brevican is a critical regulator of interneuron plasticity. We find that Brevican simultaneously controls cellular and synaptic forms of plasticity in PV+ cells by regulating the localization of potassium channels and AMPA receptors, respectively. By modulating Brevican levels, experience introduces precise molecular and cellular modifications in PV+ cells that are required for learning and memory. These findings uncover a molecular program through which a PNN protein facilitates appropriate behavioral responses to experience by dynamically gating PV+ interneuron function.
%Z This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.