@article{discovery10044837,
           month = {August},
          volume = {95},
       publisher = {CELL PRESS},
           title = {Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican},
            year = {2017},
          number = {3},
         journal = {Neuron},
           pages = {639--655},
            note = {This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.},
        abstract = {Activity-dependent neuronal plasticity is a fundamental mechanism through which the nervous system adapts to sensory experience. Several lines of evidence suggest that parvalbumin (PV+) interneurons are essential in this process, but the molecular mechanisms underlying the influence of experience on interneuron plasticity remain poorly understood. Perineuronal nets (PNNs) enwrapping PV+ cells are long-standing candidates for playing such a role, yet their precise contribution has remained elusive. We show that the PNN protein Brevican is a critical regulator of interneuron plasticity. We find that Brevican simultaneously controls cellular and synaptic forms of plasticity in PV+ cells by regulating the localization of potassium channels and AMPA receptors, respectively. By modulating Brevican levels, experience introduces precise molecular and cellular modifications in PV+ cells that are required for learning and memory. These findings uncover a molecular program through which a PNN protein facilitates appropriate behavioral responses to experience by dynamically gating PV+ interneuron function.},
             url = {http://doi.org/10.1016/j.neuron.2017.06.028},
          author = {Favuzzi, E and Marques-Smith, A and Deogracias, R and Winterflood, CM and Sanchez-Aguilera, A and Mantoan, L and Maeso, P and Fernandes, C and Ewers, H and Rico, B},
        keywords = {Parvalbumin interneurons, inhibitory circuitries, perineuronal netssynapse maturation, AMPA receptors, Kv channels, learning and memory, plasticity, activity-dependent},
            issn = {1097-4199}
}