@article{discovery10044837, month = {August}, volume = {95}, publisher = {CELL PRESS}, title = {Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican}, year = {2017}, number = {3}, journal = {Neuron}, pages = {639--655}, note = {This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.}, abstract = {Activity-dependent neuronal plasticity is a fundamental mechanism through which the nervous system adapts to sensory experience. Several lines of evidence suggest that parvalbumin (PV+) interneurons are essential in this process, but the molecular mechanisms underlying the influence of experience on interneuron plasticity remain poorly understood. Perineuronal nets (PNNs) enwrapping PV+ cells are long-standing candidates for playing such a role, yet their precise contribution has remained elusive. We show that the PNN protein Brevican is a critical regulator of interneuron plasticity. We find that Brevican simultaneously controls cellular and synaptic forms of plasticity in PV+ cells by regulating the localization of potassium channels and AMPA receptors, respectively. By modulating Brevican levels, experience introduces precise molecular and cellular modifications in PV+ cells that are required for learning and memory. These findings uncover a molecular program through which a PNN protein facilitates appropriate behavioral responses to experience by dynamically gating PV+ interneuron function.}, url = {http://doi.org/10.1016/j.neuron.2017.06.028}, author = {Favuzzi, E and Marques-Smith, A and Deogracias, R and Winterflood, CM and Sanchez-Aguilera, A and Mantoan, L and Maeso, P and Fernandes, C and Ewers, H and Rico, B}, keywords = {Parvalbumin interneurons, inhibitory circuitries, perineuronal netssynapse maturation, AMPA receptors, Kv channels, learning and memory, plasticity, activity-dependent}, issn = {1097-4199} }