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<https://discovery.ucl.ac.uk/id/eprint/10044565> <http://purl.org/ontology/bibo/abstract> "Human pluripotent stem cells (hPSCs) possess great value for biomedical research. hPSCs can be scaled and differentiated to all cell types\r\nfound in the human body. The differentiation of hPSCs to human hepatocyte-like cells (HLCs) has been extensively studied, and efficient\r\ndifferentiation protocols have been established. The combination of extracellular matrix and biological stimuli, including growth factors, cytokines,\r\nand small molecules, have made it possible to generate HLCs that resemble primary human hepatocytes. However, the majority of procedures\r\nstill employ undefined components, giving rise to batch-to-batch variation. This serves as a significant barrier to the application of the technology.\r\nTo tackle this issue, we developed a defined system for hepatocyte differentiation using human recombinant laminins as extracellular matrices in\r\ncombination with a serum-free differentiation process. Highly efficient hepatocyte specification was achieved, with demonstrated improvements in\r\nboth HLC function and phenotype. Importantly, this system is easy to scale up using research and GMP-grade hPSC lines promising advances in\r\ncell-based modelling and therapies."^^<http://www.w3.org/2001/XMLSchema#string> .
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