<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10043939> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/dc/terms/title> "Downregulation of exosomal miR-204-5p and miR-632 as a biomarker for FTD: a GENFI study"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/ontology/bibo/abstract> "OBJECTIVE: To determine whether exosomal microRNAs (miRNAs) in cerebrospinal fluid (CSF) of patients with frontotemporal dementia (FTD) can serve as diagnostic biomarkers, we assessed miRNA expression in the Genetic Frontotemporal Dementia Initiative (GENFI) cohort and in sporadic FTD. METHODS: GENFI participants were either carriers of a pathogenic mutation in progranulin, chromosome 9 open reading frame 72 or microtubule-associated protein tau or were at risk of carrying a mutation because a first-degree relative was a known symptomatic mutation carrier. Exosomes were isolated from CSF of 23 presymptomatic and 15 symptomatic mutation carriers and 11 healthy non-mutation carriers. Expression of 752 miRNAs was measured using quantitative PCR (qPCR) arrays and validated by qPCR using individual primers. MiRNAs found differentially expressed in symptomatic compared with presymptomatic mutation carriers were further evaluated in a cohort of 17 patients with sporadic FTD, 13 patients with sporadic Alzheimer's disease (AD) and 10 healthy controls (HCs) of similar age. RESULTS: In the GENFI cohort, miR-204-5p and miR-632 were significantly decreased in symptomatic compared with presymptomatic mutation carriers. Decrease of miR-204-5p and miR-632 revealed receiver operator characteristics with an area of 0.89 (90% CI 0.79 to 0.98) and 0.81 (90% CI 0.68 to 0.93), respectively, and when combined an area of 0.93 (90% CI 0.87 to 0.99). In sporadic FTD, only miR-632 was significantly decreased compared with AD and HCs. Decrease of miR-632 revealed an area of 0.90 (90% CI 0.81 to 0.98). CONCLUSIONS: Exosomal miR-204-5p and miR-632 have potential as diagnostic biomarkers for genetic FTD and miR-632 also for sporadic FTD."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/dc/terms/date> "2018-08" . <https://discovery.ucl.ac.uk/id/document/838492> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/ontology/bibo/volume> "89" . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/ontology/bibo/issue> "8" . <https://discovery.ucl.ac.uk/id/publication/ext-1468330X> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-1468330X> <http://xmlns.com/foaf/0.1/name> "Journal of Neurology, Neurosurgery & Psychiatry"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-1468330X> . <https://discovery.ucl.ac.uk/id/publication/ext-1468330X> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:1468330X> . <https://discovery.ucl.ac.uk/id/publication/ext-1468330X> <http://purl.org/ontology/bibo/issn> "1468330X" . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-715e88c5ca9ec44973e3642506d6d4d9> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> . <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-715e88c5ca9ec44973e3642506d6d4d9> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7cb26a71a7c75da8edcfe71466c2c384> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> . <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-7cb26a71a7c75da8edcfe71466c2c384> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4892a2fe7587b7d24f9b30b705443eda> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> . <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-4892a2fe7587b7d24f9b30b705443eda> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2298c59fd2d7247d687b285ecfe346e4> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> . <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-2298c59fd2d7247d687b285ecfe346e4> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f8a409e3f5700ae116b92d5d7cfd8f66> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> . <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-f8a409e3f5700ae116b92d5d7cfd8f66> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-cf86211837b88f87447e58e05d533598> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> . <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-cf86211837b88f87447e58e05d533598> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7e6f596933b29dcad5f5c9f1344fe9e8> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> . <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-7e6f596933b29dcad5f5c9f1344fe9e8> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-642925327b8011c29178df337fedd6bf> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> . <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-642925327b8011c29178df337fedd6bf> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-18e46536ff4ceb77329ad3693eb81ac3> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> . <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-18e46536ff4ceb77329ad3693eb81ac3> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0f4fd31ffb9e17b7e491cc23ef9fad66> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> . <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-0f4fd31ffb9e17b7e491cc23ef9fad66> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1345207ae6bb413bf8b22910f382bc5b> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> . <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-1345207ae6bb413bf8b22910f382bc5b> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-22f44dc57c0ad9e7272f48430cd4549a> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> . <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-22f44dc57c0ad9e7272f48430cd4549a> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f2e7ef012f68034345dceee8a2f8ef66> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> . <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-f2e7ef012f68034345dceee8a2f8ef66> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0f5f840310448983c5f2955e4e3bfd3d> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> . <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-0f5f840310448983c5f2955e4e3bfd3d> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-42f49c4c7b9d513c7eaf12f934840162> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> . <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery.ucl.ac.uk/id/person/ext-42f49c4c7b9d513c7eaf12f934840162> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0e507fb3753cf50f12501c39ba8b2e2b> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> . <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_16> <https://discovery.ucl.ac.uk/id/person/ext-0e507fb3753cf50f12501c39ba8b2e2b> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9e4ec9fa925fcb4f9a52b754291a168c> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> . <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_17> <https://discovery.ucl.ac.uk/id/person/ext-9e4ec9fa925fcb4f9a52b754291a168c> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d7a59b9ab08cb7d98a3cc3f8c68f8e48> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> . <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_18> <https://discovery.ucl.ac.uk/id/person/ext-d7a59b9ab08cb7d98a3cc3f8c68f8e48> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0fa9818ac8d4d4fca5dff5c0d280959b> . <https://discovery.ucl.ac.uk/id/eprint/10043939> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> . <https://discovery.ucl.ac.uk/id/eprint/10043939#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_19> <https://discovery.ucl.ac.uk/id/person/ext-0fa9818ac8d4d4fca5dff5c0d280959b> . <https://discovery.ucl.ac.uk/id/person/ext-22f44dc57c0ad9e7272f48430cd4549a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-22f44dc57c0ad9e7272f48430cd4549a> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-22f44dc57c0ad9e7272f48430cd4549a> <http://xmlns.com/foaf/0.1/familyName> "Masellis"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-22f44dc57c0ad9e7272f48430cd4549a> <http://xmlns.com/foaf/0.1/name> "M Masellis"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0fa9818ac8d4d4fca5dff5c0d280959b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-0fa9818ac8d4d4fca5dff5c0d280959b> <http://xmlns.com/foaf/0.1/givenName> "."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0fa9818ac8d4d4fca5dff5c0d280959b> <http://xmlns.com/foaf/0.1/familyName> "Genetic FTD Initiative (GENFI)"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0fa9818ac8d4d4fca5dff5c0d280959b> <http://xmlns.com/foaf/0.1/name> ". Genetic FTD Initiative (GENFI)"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d7a59b9ab08cb7d98a3cc3f8c68f8e48> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-d7a59b9ab08cb7d98a3cc3f8c68f8e48> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d7a59b9ab08cb7d98a3cc3f8c68f8e48> <http://xmlns.com/foaf/0.1/familyName> "Robertson"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d7a59b9ab08cb7d98a3cc3f8c68f8e48> <http://xmlns.com/foaf/0.1/name> "J Robertson"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9e4ec9fa925fcb4f9a52b754291a168c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-9e4ec9fa925fcb4f9a52b754291a168c> <http://xmlns.com/foaf/0.1/givenName> "MC"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9e4ec9fa925fcb4f9a52b754291a168c> <http://xmlns.com/foaf/0.1/familyName> "Tartaglia"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9e4ec9fa925fcb4f9a52b754291a168c> <http://xmlns.com/foaf/0.1/name> "MC Tartaglia"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1345207ae6bb413bf8b22910f382bc5b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-1345207ae6bb413bf8b22910f382bc5b> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1345207ae6bb413bf8b22910f382bc5b> <http://xmlns.com/foaf/0.1/familyName> "Galimberti"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1345207ae6bb413bf8b22910f382bc5b> <http://xmlns.com/foaf/0.1/name> "D Galimberti"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-cf86211837b88f87447e58e05d533598> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-cf86211837b88f87447e58e05d533598> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-cf86211837b88f87447e58e05d533598> <http://xmlns.com/foaf/0.1/familyName> "Karydas"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-cf86211837b88f87447e58e05d533598> <http://xmlns.com/foaf/0.1/name> "A Karydas"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0e507fb3753cf50f12501c39ba8b2e2b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-0e507fb3753cf50f12501c39ba8b2e2b> <http://xmlns.com/foaf/0.1/givenName> "JD"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0e507fb3753cf50f12501c39ba8b2e2b> <http://xmlns.com/foaf/0.1/familyName> "Rohrer"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0e507fb3753cf50f12501c39ba8b2e2b> <http://xmlns.com/foaf/0.1/name> "JD Rohrer"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0f5f840310448983c5f2955e4e3bfd3d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-0f5f840310448983c5f2955e4e3bfd3d> <http://xmlns.com/foaf/0.1/givenName> "Z"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0f5f840310448983c5f2955e4e3bfd3d> <http://xmlns.com/foaf/0.1/familyName> "Zhang"^^<http://www.w3.org/2001/XMLSchema#string> . 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