eprintid: 10043650
rev_number: 53
eprint_status: archive
userid: 608
dir: disk0/10/04/36/50
datestamp: 2018-02-20 14:35:23
lastmod: 2021-12-02 23:06:28
status_changed: 2018-09-28 11:38:45
type: article
metadata_visibility: show
creators_name: Lemanska, A
creators_name: Dearnaley, DP
creators_name: Jena, R
creators_name: Sydes, MR
creators_name: Faithfull, S
title: Older Age, Early Symptoms and Physical Function are Associated with the Severity of Late Symptom Clusters for Men Undergoing Radiotherapy for Prostate Cancer
ispublished: pub
divisions: UCL
divisions: B02
divisions: D65
divisions: J38
keywords: Science & Technology, Life Sciences & Biomedicine, Oncology, Acute symptoms, late symptoms, PROs, prostate cancer, radiotherapy, survivorship, symptom clusters, QUALITY-OF-LIFE, DOSE CONFORMAL RADIOTHERAPY, RANDOMIZED CONTROLLED-TRIAL, ANDROGEN DEPRIVATION, RADIATION-THERAPY, HEALTH OUTCOMES, UNITED-KINGDOM, BREAST-CANCER, LUNG-CANCER, MANAGEMENT
note: © 2018 The Royal College of Radiologists. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/
licenses/by/4.0/)
abstract: AIMS:
To identify symptom clusters and predisposing factors associated with long-term symptoms and health-related quality of life after radiotherapy in men with prostate cancer.

MATERIALS AND METHODS:
Patient-reported outcomes (PROs) data from the Medical Research Council RT01 radiotherapy with neoadjuvant androgen deprivation therapy trial of 843 patients were used. PROs were collected over 5 years with the University of California, Los Angeles Prostate Cancer Index (UCLA-PCI) and the 36 item Short-Form Health Survey (SF-36). Symptom clusters were explored using hierarchical cluster analysis. The association of treatment dose, baseline patient characteristics and early symptom clusters with the change in severity of PROs over 3 years was investigated with multivariate linear mixed effects models.

RESULTS:
Seven symptom clusters of three or more symptoms were identified. The clusters were stable over time. The longitudinal profiles of symptom clusters showed the onset of acute symptoms during treatment for all symptom clusters and significant recovery by 6 months. Some clusters, such as physical health and sexual function, were adversely affected more than others by androgen deprivation therapy, and were less likely to return to pretreatment levels over time. Older age was significantly associated with decreased long-term physical function, physical health and sexual function (P < 0.001). Both baseline and acute symptom clusters were significant antecedents for impaired function and health-related quality of life at 3 years.

CONCLUSIONS:
Men with poorer physical function and health before or during treatment were more likely to report poorer PROs at year 3. Early assessment using PROs and lifestyle interventions should be used to identify those with higher needs and provide targeted rehabilitation and symptom management.
date: 2018-06
date_type: published
publisher: ELSEVIER SCIENCE LONDON
official_url: http://dx.doi.org/10.1016/j.clon.2018.01.016
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Article
verified: verified_manual
elements_id: 1535617
doi: 10.1016/j.clon.2018.01.016
lyricists_name: Sydes, Matthew
lyricists_id: MRSYD21
actors_name: Sydes, Matthew
actors_name: Dewerpe, Marie
actors_id: MRSYD21
actors_id: MDDEW97
actors_role: owner
actors_role: impersonator
full_text_status: public
publication: Clinical Oncology
volume: 30
number: 6
pagerange: 334-345
pages: 12
issn: 1433-2981
citation:        Lemanska, A;    Dearnaley, DP;    Jena, R;    Sydes, MR;    Faithfull, S;      (2018)    Older Age, Early Symptoms and Physical Function are Associated with the Severity of Late Symptom Clusters for Men Undergoing Radiotherapy for Prostate Cancer.                   Clinical Oncology , 30  (6)   pp. 334-345.    10.1016/j.clon.2018.01.016 <https://doi.org/10.1016/j.clon.2018.01.016>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10043650/7/Sydes_1-s2.0-S0936655518300475-main%20%281%29.pdf