eprintid: 10043569 rev_number: 39 eprint_status: archive userid: 608 dir: disk0/10/04/35/69 datestamp: 2018-02-16 12:32:54 lastmod: 2021-09-20 00:02:31 status_changed: 2019-01-24 11:11:42 type: article metadata_visibility: show creators_name: Marshall, CR creators_name: Hardy, CJD creators_name: Volkmer, A creators_name: Russell, LL creators_name: Bond, RL creators_name: Fletcher, PD creators_name: Clark, CN creators_name: Mummery, CJ creators_name: Schott, JM creators_name: Rossor, MN creators_name: Fox, NC creators_name: Crutch, SJ creators_name: Rohrer, JD creators_name: Warren, JD title: Primary progressive aphasia: a clinical approach ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D05 divisions: F71 divisions: D07 divisions: F86 keywords: Alzheimer’s disease, Frontotemporal dementia, Logopenic aphasia, Primary progressive aphasia, Semantic dementia note: © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. abstract: The primary progressive aphasias are a heterogeneous group of focal 'language-led' dementias that pose substantial challenges for diagnosis and management. Here we present a clinical approach to the progressive aphasias, based on our experience of these disorders and directed at non-specialists. We first outline a framework for assessing language, tailored to the common presentations of progressive aphasia. We then consider the defining features of the canonical progressive nonfluent, semantic and logopenic aphasic syndromes, including 'clinical pearls' that we have found diagnostically useful and neuroanatomical and other key associations of each syndrome. We review potential diagnostic pitfalls and problematic presentations not well captured by conventional classifications and propose a diagnostic 'roadmap'. After outlining principles of management, we conclude with a prospect for future progress in these diseases, emphasising generic information processing deficits and novel pathophysiological biomarkers. date: 2018-06 date_type: published official_url: http://doi.org/10.1007/s00415-018-8762-6 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_id: 1533874 doi: 10.1007/s00415-018-8762-6 pii: 10.1007/s00415-018-8762-6 lyricists_name: Bond, Rebecca lyricists_name: Crutch, Sebastian lyricists_name: Fox, Nicholas lyricists_name: Hardy, Christopher lyricists_name: Marshall, Charles lyricists_name: Rohrer, Jonathan lyricists_name: Rossor, Martin lyricists_name: Russell, Lucy lyricists_name: Schott, Jonathan lyricists_name: Volkmer, Anna lyricists_name: Warren, Jason lyricists_id: RLBON31 lyricists_id: SJCRU02 lyricists_id: NCIFO25 lyricists_id: HARDY72 lyricists_id: CRMAR37 lyricists_id: JDROH34 lyricists_id: MNROS52 lyricists_id: LLRUS40 lyricists_id: JMSCH12 lyricists_id: ALPVO49 lyricists_id: JDWAR75 actors_name: Waragoda Vitharana, Nimal actors_id: NWARR44 actors_role: owner full_text_status: public publication: Journal of Neurology volume: 265 number: 6 pagerange: 1474-1490 event_location: Germany issn: 1432-1459 citation: Marshall, CR; Hardy, CJD; Volkmer, A; Russell, LL; Bond, RL; Fletcher, PD; Clark, CN; ... Warren, JD; + view all <#> Marshall, CR; Hardy, CJD; Volkmer, A; Russell, LL; Bond, RL; Fletcher, PD; Clark, CN; Mummery, CJ; Schott, JM; Rossor, MN; Fox, NC; Crutch, SJ; Rohrer, JD; Warren, JD; - view fewer <#> (2018) Primary progressive aphasia: a clinical approach. Journal of Neurology , 265 (6) pp. 1474-1490. 10.1007/s00415-018-8762-6 <https://doi.org/10.1007/s00415-018-8762-6>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10043569/7/Bond%20VoR%20Marshall2018_Article_PrimaryProgressiveAphasiaAClin.pdf