TY  - JOUR
TI  - Primary progressive aphasia: a clinical approach
AV  - public
Y1  - 2018/06//
EP  - 1490
N2  - The primary progressive aphasias are a heterogeneous group of focal 'language-led' dementias that pose substantial challenges for diagnosis and management. Here we present a clinical approach to the progressive aphasias, based on our experience of these disorders and directed at non-specialists. We first outline a framework for assessing language, tailored to the common presentations of progressive aphasia. We then consider the defining features of the canonical progressive nonfluent, semantic and logopenic aphasic syndromes, including 'clinical pearls' that we have found diagnostically useful and neuroanatomical and other key associations of each syndrome. We review potential diagnostic pitfalls and problematic presentations not well captured by conventional classifications and propose a diagnostic 'roadmap'. After outlining principles of management, we conclude with a prospect for future progress in these diseases, emphasising generic information processing deficits and novel pathophysiological biomarkers.
ID  - discovery10043569
KW  - Alzheimer?s disease
KW  -  Frontotemporal dementia
KW  -  Logopenic aphasia
KW  -  Primary progressive aphasia
KW  -  Semantic dementia
SP  - 1474
VL  - 265
IS  - 6
N1  - © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
UR  - http://doi.org/10.1007/s00415-018-8762-6
SN  - 1432-1459
JF  - Journal of Neurology
A1  - Marshall, CR
A1  - Hardy, CJD
A1  - Volkmer, A
A1  - Russell, LL
A1  - Bond, RL
A1  - Fletcher, PD
A1  - Clark, CN
A1  - Mummery, CJ
A1  - Schott, JM
A1  - Rossor, MN
A1  - Fox, NC
A1  - Crutch, SJ
A1  - Rohrer, JD
A1  - Warren, JD
ER  -