@article{discovery10043569,
         journal = {Journal of Neurology},
           pages = {1474--1490},
            note = {{\copyright} The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.},
           title = {Primary progressive aphasia: a clinical approach},
          volume = {265},
            year = {2018},
          number = {6},
           month = {June},
        keywords = {Alzheimer's disease, Frontotemporal dementia, Logopenic aphasia, Primary progressive aphasia, Semantic dementia},
        abstract = {The primary progressive aphasias are a heterogeneous group of focal 'language-led' dementias that pose substantial challenges for diagnosis and management. Here we present a clinical approach to the progressive aphasias, based on our experience of these disorders and directed at non-specialists. We first outline a framework for assessing language, tailored to the common presentations of progressive aphasia. We then consider the defining features of the canonical progressive nonfluent, semantic and logopenic aphasic syndromes, including 'clinical pearls' that we have found diagnostically useful and neuroanatomical and other key associations of each syndrome. We review potential diagnostic pitfalls and problematic presentations not well captured by conventional classifications and propose a diagnostic 'roadmap'. After outlining principles of management, we conclude with a prospect for future progress in these diseases, emphasising generic information processing deficits and novel pathophysiological biomarkers.},
             url = {http://doi.org/10.1007/s00415-018-8762-6},
            issn = {1432-1459},
          author = {Marshall, CR and Hardy, CJD and Volkmer, A and Russell, LL and Bond, RL and Fletcher, PD and Clark, CN and Mummery, CJ and Schott, JM and Rossor, MN and Fox, NC and Crutch, SJ and Rohrer, JD and Warren, JD}
}