eprintid: 10042641 rev_number: 24 eprint_status: archive userid: 608 dir: disk0/10/04/26/41 datestamp: 2018-02-07 17:19:38 lastmod: 2021-09-19 22:17:53 status_changed: 2018-02-07 17:19:38 type: article metadata_visibility: show creators_name: Andersson, JLR creators_name: Graham, MS creators_name: Drobnjak, I creators_name: Zhang, H creators_name: Campbell, J title: Susceptibility-induced distortion that varies due to motion: Correction in diffusion MR without acquiring additional data. ispublished: pub divisions: UCL divisions: B04 divisions: C05 divisions: F48 keywords: Diffusion, Dynamic, Movement, Registration, Susceptibility note: © 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). abstract: Because of their low bandwidth in the phase-encode (PE) direction, the susceptibility-induced off-resonance field causes distortions in echo planar imaging (EPI) images. It is therefore crucial to correct for susceptibility-induced distortions when performing diffusion studies using EPI. The susceptibility-induced field is caused by the object (head) disrupting the field and it is typically assumed that it remains constant within a framework defined by the object, (i.e. it follows the object as it moves in the scanner). However, this is only approximately true. When a non-spherical object rotates around an axis other than that parallel with the magnetic flux (the z-axis) it changes the way it disrupts the field, leading to different distortions. Hence, if using a single field to correct for distortions there will be residual distortions in the volumes where the object orientation is substantially different to that when the field was measured. In this paper we present a post-processing method for estimating the field as it changes with motion during the course of an experiment. It only requires a single measured field and knowledge of the orientation of the subject when that field was acquired. The volume-to-volume changes of the field as a consequence of subject movement are estimated directly from the diffusion data without the need for any additional or special acquisitions. It uses a generative model that predicts how each volume would look predicated on field change and inverts that model to yield an estimate of the field changes. It has been validated on both simulations and experimental data. The results show that we are able to track the field with high accuracy and that we are able to correct the data for the adverse effects of the changing field. date: 2018-05-01 date_type: published official_url: https://doi.org/10.1016/j.neuroimage.2017.12.040 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_id: 1520819 doi: 10.1016/j.neuroimage.2017.12.040 pii: S1053-8119(17)31060-1 language_elements: eng lyricists_name: Drobnjak, Ivana lyricists_name: Graham, Mark lyricists_name: Zhang, Hui lyricists_id: IDROB84 lyricists_id: MGRAH02 lyricists_id: HZHAN50 actors_name: Bracey, Alan actors_id: ABBRA90 actors_role: owner full_text_status: public publication: Neuroimage volume: 171 pagerange: 277-295 event_location: United States issn: 1095-9572 citation: Andersson, JLR; Graham, MS; Drobnjak, I; Zhang, H; Campbell, J; (2018) Susceptibility-induced distortion that varies due to motion: Correction in diffusion MR without acquiring additional data. Neuroimage , 171 pp. 277-295. 10.1016/j.neuroimage.2017.12.040 <https://doi.org/10.1016/j.neuroimage.2017.12.040>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10042641/1/1-s2.0-S1053811917310601-main.pdf