<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10042361> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/dc/terms/title> "HIV-1 co-receptor tropism and liver fibrosis in HIV-infected patients"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/ontology/bibo/abstract> "BACKGROUND: In vitro, gp120 of both X4 and R5 HIV-1 strains activates human hepatic stellate cells, but if it can promote liver fibrosis in vivo is unknown. We aimed to evaluate if patients carrying X4 or R5 strains have a different liver fibrosis (LF) progression over time. METHODS: A total of 1,137 HIV-infected patients in ICONA cohort (21% females, 7% HCV co-infected) with an available determination of HIV-1 co-receptor tropism (CRT), a Fibrosis-4 Index for Liver Fibrosis (FIB-4) <3.25 and at least one-year follow-up were included. CRT was assessed by gp120 sequencing on plasma RNA and geno2pheno algorithm (10% false positive rate) or by Trofile. LF was assessed by means of FIB-4. LF progression was defined as an absolute score increase or a transition to higher fibrosis stratum and/or occurrence of liver-related clinical events. RESULTS: A total of 249 (22%) patients carried X4 strains, which were associated with older age, lower CD4 count, lower nadir CD4, and intravenous drug use. Overall, X4 and R5 patients had similar baseline FIB-4 scores and similar mean FIB-4 slope after a median follow-up of 35 months. There was no difference between X4 and R5 for time to LF progression (p = 0.925). Estimated risk of LF at 24 months (95% CI) after baseline in X4 and R5 was 10.6% (8.3-12.9) and 9.9% (5.9-14.0), respectively. Age, HCV co-infection, diabetes, HIV-duration, HIV-RNA>100.000 cp/mL, antiretroviral therapy exposure were associated with LF progression at multivariate analysis. CONCLUSIONS: A slight LF progression over time was observed in HIV-infected patients. No difference was demonstrated for X4 and R5 HIV-1 strains in accelerating LF evolution."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/dc/terms/date> "2018" . <https://discovery.ucl.ac.uk/id/document/607651> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/ontology/bibo/volume> "13" . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/ontology/bibo/issue> "1" . <https://discovery.ucl.ac.uk/id/publication/ext-19326203> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-19326203> <http://xmlns.com/foaf/0.1/name> "PLoS One"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-19326203> . <https://discovery.ucl.ac.uk/id/publication/ext-19326203> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:19326203> . <https://discovery.ucl.ac.uk/id/publication/ext-19326203> <http://purl.org/ontology/bibo/issn> "19326203" . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8fe9efe96cef1aafe9b3b94bc937377b> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10042361#authors> . <https://discovery.ucl.ac.uk/id/eprint/10042361#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-8fe9efe96cef1aafe9b3b94bc937377b> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8fefdc426d3010bc4adb4cbbfc75752e> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10042361#authors> . <https://discovery.ucl.ac.uk/id/eprint/10042361#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-8fefdc426d3010bc4adb4cbbfc75752e> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-37d297ff450c134bbf6ec1f1886541a6> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10042361#authors> . <https://discovery.ucl.ac.uk/id/eprint/10042361#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-37d297ff450c134bbf6ec1f1886541a6> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-abb3d4fc92fb0514ee8dd5e201ab662d> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10042361#authors> . <https://discovery.ucl.ac.uk/id/eprint/10042361#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-abb3d4fc92fb0514ee8dd5e201ab662d> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9862295aea5db9be16b156e7317ec460> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10042361#authors> . <https://discovery.ucl.ac.uk/id/eprint/10042361#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-9862295aea5db9be16b156e7317ec460> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-01bf323a0093638037fc1ec9df2651c0> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10042361#authors> . <https://discovery.ucl.ac.uk/id/eprint/10042361#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-01bf323a0093638037fc1ec9df2651c0> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-caa552c8b80bd9045f0155220083f53c> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10042361#authors> . <https://discovery.ucl.ac.uk/id/eprint/10042361#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-caa552c8b80bd9045f0155220083f53c> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-844767291d2bc1c628c4a300f2be79cc> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10042361#authors> . <https://discovery.ucl.ac.uk/id/eprint/10042361#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-844767291d2bc1c628c4a300f2be79cc> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-54a1626045b9f555f6e49b88bf27ba2b> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10042361#authors> . <https://discovery.ucl.ac.uk/id/eprint/10042361#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-54a1626045b9f555f6e49b88bf27ba2b> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c9d5c853560105bb0eb47d58b4b47a52> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10042361#authors> . <https://discovery.ucl.ac.uk/id/eprint/10042361#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-c9d5c853560105bb0eb47d58b4b47a52> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-35c90a90adf79875e0460417d3001a7e> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10042361#authors> . <https://discovery.ucl.ac.uk/id/eprint/10042361#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-35c90a90adf79875e0460417d3001a7e> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4287399977adac3887d2f9b527056a0b> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10042361#authors> . <https://discovery.ucl.ac.uk/id/eprint/10042361#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-4287399977adac3887d2f9b527056a0b> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-759522c63249ab77e164b090bbb68c42> . <https://discovery.ucl.ac.uk/id/eprint/10042361> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10042361#authors> . <https://discovery.ucl.ac.uk/id/eprint/10042361#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-759522c63249ab77e164b090bbb68c42> . <https://discovery.ucl.ac.uk/id/person/ext-35c90a90adf79875e0460417d3001a7e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-35c90a90adf79875e0460417d3001a7e> <http://xmlns.com/foaf/0.1/givenName> "L"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-35c90a90adf79875e0460417d3001a7e> <http://xmlns.com/foaf/0.1/familyName> "Monno"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-35c90a90adf79875e0460417d3001a7e> <http://xmlns.com/foaf/0.1/name> "L Monno"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-844767291d2bc1c628c4a300f2be79cc> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-844767291d2bc1c628c4a300f2be79cc> <http://xmlns.com/foaf/0.1/givenName> "G"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-844767291d2bc1c628c4a300f2be79cc> <http://xmlns.com/foaf/0.1/familyName> "Bruno"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-844767291d2bc1c628c4a300f2be79cc> <http://xmlns.com/foaf/0.1/name> "G Bruno"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-37d297ff450c134bbf6ec1f1886541a6> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-37d297ff450c134bbf6ec1f1886541a6> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-37d297ff450c134bbf6ec1f1886541a6> <http://xmlns.com/foaf/0.1/familyName> "Shanyinde"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-37d297ff450c134bbf6ec1f1886541a6> <http://xmlns.com/foaf/0.1/name> "M Shanyinde"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-01bf323a0093638037fc1ec9df2651c0> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-01bf323a0093638037fc1ec9df2651c0> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-01bf323a0093638037fc1ec9df2651c0> <http://xmlns.com/foaf/0.1/familyName> "Di Biagio"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-01bf323a0093638037fc1ec9df2651c0> <http://xmlns.com/foaf/0.1/name> "A Di Biagio"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-caa552c8b80bd9045f0155220083f53c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-caa552c8b80bd9045f0155220083f53c> <http://xmlns.com/foaf/0.1/givenName> "G"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-caa552c8b80bd9045f0155220083f53c> <http://xmlns.com/foaf/0.1/familyName> "Cassola"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-caa552c8b80bd9045f0155220083f53c> <http://xmlns.com/foaf/0.1/name> "G Cassola"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9862295aea5db9be16b156e7317ec460> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-9862295aea5db9be16b156e7317ec460> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9862295aea5db9be16b156e7317ec460> <http://xmlns.com/foaf/0.1/familyName> "Nozza"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9862295aea5db9be16b156e7317ec460> <http://xmlns.com/foaf/0.1/name> "S Nozza"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c9d5c853560105bb0eb47d58b4b47a52> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-c9d5c853560105bb0eb47d58b4b47a52> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c9d5c853560105bb0eb47d58b4b47a52> <http://xmlns.com/foaf/0.1/familyName> "Puoti"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c9d5c853560105bb0eb47d58b4b47a52> <http://xmlns.com/foaf/0.1/name> "M Puoti"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-abb3d4fc92fb0514ee8dd5e201ab662d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-abb3d4fc92fb0514ee8dd5e201ab662d> <http://xmlns.com/foaf/0.1/givenName> "F"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-abb3d4fc92fb0514ee8dd5e201ab662d> <http://xmlns.com/foaf/0.1/familyName> "Ceccherini Silberstein"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-abb3d4fc92fb0514ee8dd5e201ab662d> <http://xmlns.com/foaf/0.1/name> "F Ceccherini Silberstein"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4287399977adac3887d2f9b527056a0b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-4287399977adac3887d2f9b527056a0b> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4287399977adac3887d2f9b527056a0b> <http://xmlns.com/foaf/0.1/familyName> "d'Arminio Monforte"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4287399977adac3887d2f9b527056a0b> <http://xmlns.com/foaf/0.1/name> "A d'Arminio Monforte"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8fefdc426d3010bc4adb4cbbfc75752e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-8fefdc426d3010bc4adb4cbbfc75752e> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8fefdc426d3010bc4adb4cbbfc75752e> <http://xmlns.com/foaf/0.1/familyName> "Cozzi-Lepri"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8fefdc426d3010bc4adb4cbbfc75752e> <http://xmlns.com/foaf/0.1/name> "A Cozzi-Lepri"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-54a1626045b9f555f6e49b88bf27ba2b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-54a1626045b9f555f6e49b88bf27ba2b> 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