eprintid: 10042316
rev_number: 24
eprint_status: archive
userid: 608
dir: disk0/10/04/23/16
datestamp: 2018-02-05 17:37:09
lastmod: 2021-12-02 23:07:40
status_changed: 2018-02-05 17:37:09
type: article
metadata_visibility: show
creators_name: Aytac-Kipergil, E
creators_name: Demirkiran, A
creators_name: Uluc, N
creators_name: Yavas, S
creators_name: Kayikcioglu, T
creators_name: Salman, S
creators_name: Karamuk, SG
creators_name: Ilday, FO
creators_name: Unlu, MB
title: Development of a Fiber Laser with Independently Adjustable Properties for Optical Resolution Photoacoustic Microscopy
ispublished: pub
divisions: UCL
divisions: B04
divisions: C05
divisions: F42
keywords: Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, PHOTONIC CRYSTAL FIBER, STIMULATED RAMAN-SCATTERING, SUPERCONTINUUM GENERATION, DIODE EXCITATION, COHERENCE TOMOGRAPHY, COMPUTED-TOMOGRAPHY, BIOLOGICAL TISSUES, NANOSECOND, MICROVASCULATURE, BIOMEDICINE
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abstract: Photoacoustic imaging is based on the detection of generated acoustic waves through thermal expansion of tissue illuminated by short laser pulses. Fiber lasers as an excitation source for photoacoustic imaging have recently been preferred for their high repetition frequencies. Here, we report a unique fiber laser developed specifically for multiwavelength photoacoustic microscopy system. The laser is custom-made for maximum flexibility in adjustment of its parameters; pulse duration (5–10 ns), pulse energy (up to 10 μJ) and repetition frequency (up to 1 MHz) independently from each other and covers a broad spectral region from 450 to 1100 nm and also can emit wavelengths of 532, 355, and 266 nm. The laser system consists of a master oscillator power amplifier, seeding two stages; supercontinuum and harmonic generation units. The laser is outstanding since the oscillator, amplifier and supercontinuum generation parts are all-fiber integrated with custom-developed electronics and software. To demonstrate the feasibility of the system, the images of several elements of standardized resolution test chart are acquired at multiple wavelengths. The lateral resolution of optical resolution photoacoustic microscopy system is determined as 2.68 μm. The developed system may pave the way for spectroscopic photoacoustic microscopy applications via widely tunable fiber laser technologies.
date: 2016-12-08
date_type: published
publisher: NATURE PUBLISHING GROUP
official_url: https://doi.org/10.1038/srep38674
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Article
verified: verified_manual
elements_id: 1499629
doi: 10.1038/srep38674
lyricists_name: Aytac Kipergil, Esra
lyricists_id: EAYTA73
actors_name: Smith, Daniel
actors_id: DSMIT53
actors_role: owner
full_text_status: public
publication: Scientific Reports
volume: 6
article_number: 38674
pages: 10
issn: 2045-2322
citation:        Aytac-Kipergil, E;    Demirkiran, A;    Uluc, N;    Yavas, S;    Kayikcioglu, T;    Salman, S;    Karamuk, SG;         ... Unlu, MB; + view all <#>        Aytac-Kipergil, E;  Demirkiran, A;  Uluc, N;  Yavas, S;  Kayikcioglu, T;  Salman, S;  Karamuk, SG;  Ilday, FO;  Unlu, MB;   - view fewer <#>    (2016)    Development of a Fiber Laser with Independently Adjustable Properties for Optical Resolution Photoacoustic Microscopy.                   Scientific Reports , 6     , Article 38674.  10.1038/srep38674 <https://doi.org/10.1038/srep38674>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10042316/1/srep38674.pdf