TY  - JOUR
N1  - This work is licensed under a Creative Commons Attribution 4.0 International License. The images
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EP  - 10
AV  - public
Y1  - 2016/12/08/
VL  - 6
TI  - Development of a Fiber Laser with Independently Adjustable Properties for Optical Resolution Photoacoustic Microscopy
KW  - Science & Technology
KW  -  Multidisciplinary Sciences
KW  -  Science & Technology - Other Topics
KW  -  PHOTONIC CRYSTAL FIBER
KW  -  STIMULATED RAMAN-SCATTERING
KW  -  SUPERCONTINUUM GENERATION
KW  -  DIODE EXCITATION
KW  -  COHERENCE TOMOGRAPHY
KW  -  COMPUTED-TOMOGRAPHY
KW  -  BIOLOGICAL TISSUES
KW  -  NANOSECOND
KW  -  MICROVASCULATURE
KW  -  BIOMEDICINE
A1  - Aytac-Kipergil, E
A1  - Demirkiran, A
A1  - Uluc, N
A1  - Yavas, S
A1  - Kayikcioglu, T
A1  - Salman, S
A1  - Karamuk, SG
A1  - Ilday, FO
A1  - Unlu, MB
JF  - Scientific Reports
SN  - 2045-2322
PB  - NATURE PUBLISHING GROUP
UR  - https://doi.org/10.1038/srep38674
ID  - discovery10042316
N2  - Photoacoustic imaging is based on the detection of generated acoustic waves through thermal expansion of tissue illuminated by short laser pulses. Fiber lasers as an excitation source for photoacoustic imaging have recently been preferred for their high repetition frequencies. Here, we report a unique fiber laser developed specifically for multiwavelength photoacoustic microscopy system. The laser is custom-made for maximum flexibility in adjustment of its parameters; pulse duration (5?10?ns), pulse energy (up to 10??J) and repetition frequency (up to 1?MHz) independently from each other and covers a broad spectral region from 450 to 1100?nm and also can emit wavelengths of 532, 355, and 266?nm. The laser system consists of a master oscillator power amplifier, seeding two stages; supercontinuum and harmonic generation units. The laser is outstanding since the oscillator, amplifier and supercontinuum generation parts are all-fiber integrated with custom-developed electronics and software. To demonstrate the feasibility of the system, the images of several elements of standardized resolution test chart are acquired at multiple wavelengths. The lateral resolution of optical resolution photoacoustic microscopy system is determined as 2.68??m. The developed system may pave the way for spectroscopic photoacoustic microscopy applications via widely tunable fiber laser technologies.
ER  -