eprintid: 10039938
rev_number: 36
eprint_status: archive
userid: 608
dir: disk0/10/03/99/38
datestamp: 2017-12-14 10:44:49
lastmod: 2022-11-08 13:58:21
status_changed: 2018-07-17 11:11:20
type: article
metadata_visibility: show
creators_name: Spiers, HJ
creators_name: Olafsdottir, HF
creators_name: Lever, C
title: Hippocampal CA1 Activity Correlated with the Distance to the Goal and Navigation Performance
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D05
divisions: F67
divisions: C08
note: © 2017 The Authors. Hippocampus Published by Wiley Periodicals, Inc.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
abstract: Coding the distance to a future goal is an important function of a neural system supporting navigation. While some evidence indicates the hippocampus increases activity with proximity to the goal, others have found activity to decreases with proximity. To explore goal distance coding in the hippocampus we recorded from CA1 hippocampal place cells in rats as they navigated to learned goals in an event arena with a win-stay lose-shift rule. CA1 activity was positively correlated with the distance - decreasing with proximity to the goal. The stronger the correlation between distance to the goal and CA1 activity, the more successful navigation was in a given task session. Acceleration, but not speed, was also correlated with the distance to the goal. However, the relationship between CA1 activity and navigation performance was independent of variation in acceleration and variation in speed. These results help clarify the situations in which CA1 activity encodes navigationally relevant information and the extent to which it relates to behavior. This article is protected by copyright. All rights reserved.
date: 2018-09
date_type: published
official_url: http://dx.doi.org/10.1002/hipo.22813
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1511354
doi: 10.1002/hipo.22813
lyricists_name: Olafsdottir, Hauour
lyricists_name: Spiers, Hugo
lyricists_id: HFOLA90
lyricists_id: HJSPI38
actors_name: Smith, Daniel
actors_id: DSMIT53
actors_role: owner
full_text_status: public
publication: Hippocampus
volume: 28
number: 9
pagerange: 644-658
event_location: United States
issn: 1098-1063
citation:        Spiers, HJ;    Olafsdottir, HF;    Lever, C;      (2018)    Hippocampal CA1 Activity Correlated with the Distance to the Goal and Navigation Performance.                   Hippocampus , 28  (9)   pp. 644-658.    10.1002/hipo.22813 <https://doi.org/10.1002/hipo.22813>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10039938/1/Spiers_et_al-2017-Hippocampus.pdf