eprintid: 10039775 rev_number: 20 eprint_status: archive userid: 608 dir: disk0/10/03/97/75 datestamp: 2017-12-11 11:35:12 lastmod: 2021-09-20 00:14:08 status_changed: 2017-12-11 11:35:12 type: article metadata_visibility: show creators_name: Johnston, CJC creators_name: Smyth, DJ creators_name: Kodali, RB creators_name: White, MPJ creators_name: Harcus, Y creators_name: Filbey, KJ creators_name: Hewitson, JP creators_name: Hinck, CS creators_name: Ivens, A creators_name: Kemter, AM creators_name: Kildemoes, AO creators_name: Le Bihan, T creators_name: Soares, DC creators_name: Anderton, SM creators_name: Brenn, T creators_name: Wigmore, SJ creators_name: Woodcock, HV creators_name: Chambers, RC creators_name: Hinck, AP creators_name: McSorley, HJ creators_name: Maizels, RM title: A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells ispublished: pub divisions: UCL divisions: B02 divisions: C10 divisions: D17 divisions: K71 note: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. abstract: Helminth parasites defy immune exclusion through sophisticated evasion mechanisms, including activation of host immunosuppressive regulatory T (Treg) cells. The mouse parasite Heligmosomoides polygyrus can expand the host Treg population by secreting products that activate TGF-β signalling, but the identity of the active molecule is unknown. Here we identify an H. polygyrus TGF-β mimic (Hp-TGM) that replicates the biological and functional properties of TGF-β, including binding to mammalian TGF-β receptors and inducing mouse and human Foxp3+ Treg cells. Hp-TGM has no homology with mammalian TGF-β or other members of the TGF-β family, but is a member of the complement control protein superfamily. Thus, our data indicate that through convergent evolution, the parasite has acquired a protein with cytokine-like function that is able to exploit an endogenous pathway of immunoregulation in the host. date: 2017-11-23 date_type: published official_url: http://doi.org/10.1038/s41467-017-01886-6 oa_status: green full_text_type: pub pmcid: PMC5701006 language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_id: 1513359 doi: 10.1038/s41467-017-01886-6 pii: 10.1038/s41467-017-01886-6 lyricists_name: Chambers, Rachel lyricists_name: Woodcock, Hannah lyricists_id: RCCHA90 lyricists_id: WOODC51 actors_name: Stacey, Thomas actors_id: TSSTA20 actors_role: owner full_text_status: public publication: Nature Communications volume: 8 article_number: 1741 event_location: England issn: 2041-1723 citation: Johnston, CJC; Smyth, DJ; Kodali, RB; White, MPJ; Harcus, Y; Filbey, KJ; Hewitson, JP; ... Maizels, RM; + view all <#> Johnston, CJC; Smyth, DJ; Kodali, RB; White, MPJ; Harcus, Y; Filbey, KJ; Hewitson, JP; Hinck, CS; Ivens, A; Kemter, AM; Kildemoes, AO; Le Bihan, T; Soares, DC; Anderton, SM; Brenn, T; Wigmore, SJ; Woodcock, HV; Chambers, RC; Hinck, AP; McSorley, HJ; Maizels, RM; - view fewer <#> (2017) A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells. Nature Communications , 8 , Article 1741. 10.1038/s41467-017-01886-6 <https://doi.org/10.1038/s41467-017-01886-6>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10039775/1/A%20structurally%20distinct%20TGF-%CE%B2%20mimic%20from%20an%20intestinal%20helminth%20parasite%20potently%20induces%20regulatory%20T%20cells.pdf