<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10039775> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/dc/terms/title> "A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/ontology/bibo/abstract> "Helminth parasites defy immune exclusion through sophisticated evasion mechanisms, including activation of host immunosuppressive regulatory T (Treg) cells. The mouse parasite Heligmosomoides polygyrus can expand the host Treg population by secreting products that activate TGF-β signalling, but the identity of the active molecule is unknown. Here we identify an H. polygyrus TGF-β mimic (Hp-TGM) that replicates the biological and functional properties of TGF-β, including binding to mammalian TGF-β receptors and inducing mouse and human Foxp3+ Treg cells. Hp-TGM has no homology with mammalian TGF-β or other members of the TGF-β family, but is a member of the complement control protein superfamily. Thus, our data indicate that through convergent evolution, the parasite has acquired a protein with cytokine-like function that is able to exploit an endogenous pathway of immunoregulation in the host."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/dc/terms/date> "2017-11-23" . <https://discovery.ucl.ac.uk/id/document/581785> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/ontology/bibo/volume> "8" . <https://discovery.ucl.ac.uk/id/publication/ext-20411723> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-20411723> <http://xmlns.com/foaf/0.1/name> "Nature Communications"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-20411723> . <https://discovery.ucl.ac.uk/id/publication/ext-20411723> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:20411723> . <https://discovery.ucl.ac.uk/id/publication/ext-20411723> <http://purl.org/ontology/bibo/issn> "20411723" . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-71b29bb68561ddca941363987d63caa4> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> . <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-71b29bb68561ddca941363987d63caa4> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c0e2a7f65652d9e0ba5b9b67b200eb6b> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> . <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-c0e2a7f65652d9e0ba5b9b67b200eb6b> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2c18c160bcc0403659bbe7dc5543d817> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> . <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-2c18c160bcc0403659bbe7dc5543d817> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4ed39815c2519e6168eb4849eaefd511> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> . <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-4ed39815c2519e6168eb4849eaefd511> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a43856587d4bb922589606ed3cde8791> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> . <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-a43856587d4bb922589606ed3cde8791> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c300c48d0b30c0c19a22a20dff01777e> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> . <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-c300c48d0b30c0c19a22a20dff01777e> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-fa6e8f89a156de7c0daea371011900e6> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> . <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-fa6e8f89a156de7c0daea371011900e6> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8636c97cdf5cbfee0bbf02ae9724c29a> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> . <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-8636c97cdf5cbfee0bbf02ae9724c29a> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b6cbc6742cab983747620e9cc1cde106> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> . <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-b6cbc6742cab983747620e9cc1cde106> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-625f0d52ec93b94be143f890d85cbd31> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> . <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-625f0d52ec93b94be143f890d85cbd31> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-dfac4ad0ee2f8df36111846bb5e9ed83> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> . <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-dfac4ad0ee2f8df36111846bb5e9ed83> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c3fbf97ddbabfcd3d3c9bbcfa16004fd> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> . <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-c3fbf97ddbabfcd3d3c9bbcfa16004fd> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-be6a738c7f14a4459581e8e190e0e3cc> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> . <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-be6a738c7f14a4459581e8e190e0e3cc> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-dc9edc4796349bb7dd6fc52d83299d93> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> . <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-dc9edc4796349bb7dd6fc52d83299d93> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-22eace83ddc685575989ac28dc99ca6e> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> . <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery.ucl.ac.uk/id/person/ext-22eace83ddc685575989ac28dc99ca6e> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ccf7e8ea7d9004eac017f853c00f7670> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> . <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_16> <https://discovery.ucl.ac.uk/id/person/ext-ccf7e8ea7d9004eac017f853c00f7670> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-03c4adc2a6d5a3e20c426038c808aeb1> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> . <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_17> <https://discovery.ucl.ac.uk/id/person/ext-03c4adc2a6d5a3e20c426038c808aeb1> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-12264a2aae0136bc169c368a55b9dd79> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> . <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_18> <https://discovery.ucl.ac.uk/id/person/ext-12264a2aae0136bc169c368a55b9dd79> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f90384bea31fa7ceceb3a6c23bf86e66> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> . <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_19> <https://discovery.ucl.ac.uk/id/person/ext-f90384bea31fa7ceceb3a6c23bf86e66> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b2970161d4d6940d4e1a6b35b6d1cd12> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> . <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_20> <https://discovery.ucl.ac.uk/id/person/ext-b2970161d4d6940d4e1a6b35b6d1cd12> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6794551b5ad3db02f27398f6d6d98934> . <https://discovery.ucl.ac.uk/id/eprint/10039775> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> . <https://discovery.ucl.ac.uk/id/eprint/10039775#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_21> <https://discovery.ucl.ac.uk/id/person/ext-6794551b5ad3db02f27398f6d6d98934> . <https://discovery.ucl.ac.uk/id/person/ext-12264a2aae0136bc169c368a55b9dd79> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-12264a2aae0136bc169c368a55b9dd79> <http://xmlns.com/foaf/0.1/givenName> "RC"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-12264a2aae0136bc169c368a55b9dd79> <http://xmlns.com/foaf/0.1/familyName> "Chambers"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-12264a2aae0136bc169c368a55b9dd79> <http://xmlns.com/foaf/0.1/name> "RC Chambers"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ccf7e8ea7d9004eac017f853c00f7670> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-ccf7e8ea7d9004eac017f853c00f7670> <http://xmlns.com/foaf/0.1/givenName> "SJ"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ccf7e8ea7d9004eac017f853c00f7670> <http://xmlns.com/foaf/0.1/familyName> "Wigmore"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ccf7e8ea7d9004eac017f853c00f7670> <http://xmlns.com/foaf/0.1/name> "SJ Wigmore"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-b2970161d4d6940d4e1a6b35b6d1cd12> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-b2970161d4d6940d4e1a6b35b6d1cd12> <http://xmlns.com/foaf/0.1/givenName> "HJ"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-b2970161d4d6940d4e1a6b35b6d1cd12> <http://xmlns.com/foaf/0.1/familyName> "McSorley"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-b2970161d4d6940d4e1a6b35b6d1cd12> <http://xmlns.com/foaf/0.1/name> "HJ McSorley"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c0e2a7f65652d9e0ba5b9b67b200eb6b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-c0e2a7f65652d9e0ba5b9b67b200eb6b> <http://xmlns.com/foaf/0.1/givenName> "DJ"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c0e2a7f65652d9e0ba5b9b67b200eb6b> <http://xmlns.com/foaf/0.1/familyName> "Smyth"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c0e2a7f65652d9e0ba5b9b67b200eb6b> <http://xmlns.com/foaf/0.1/name> "DJ Smyth"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-2c18c160bcc0403659bbe7dc5543d817> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-2c18c160bcc0403659bbe7dc5543d817> <http://xmlns.com/foaf/0.1/givenName> "RB"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-2c18c160bcc0403659bbe7dc5543d817> <http://xmlns.com/foaf/0.1/familyName> "Kodali"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-2c18c160bcc0403659bbe7dc5543d817> <http://xmlns.com/foaf/0.1/name> "RB Kodali"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8636c97cdf5cbfee0bbf02ae9724c29a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-8636c97cdf5cbfee0bbf02ae9724c29a> <http://xmlns.com/foaf/0.1/givenName> "CS"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8636c97cdf5cbfee0bbf02ae9724c29a> <http://xmlns.com/foaf/0.1/familyName> "Hinck"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8636c97cdf5cbfee0bbf02ae9724c29a> <http://xmlns.com/foaf/0.1/name> "CS Hinck"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-dfac4ad0ee2f8df36111846bb5e9ed83> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-dfac4ad0ee2f8df36111846bb5e9ed83> <http://xmlns.com/foaf/0.1/givenName> "AO"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-dfac4ad0ee2f8df36111846bb5e9ed83> <http://xmlns.com/foaf/0.1/familyName> "Kildemoes"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-dfac4ad0ee2f8df36111846bb5e9ed83> <http://xmlns.com/foaf/0.1/name> "AO Kildemoes"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-b6cbc6742cab983747620e9cc1cde106> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-b6cbc6742cab983747620e9cc1cde106> 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