TY  - GEN
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
SP  - 2095
AV  - restricted
Y1  - 2018///
EP  - 2100
TI  - Modeling of spreading and drying of aqueous polymer coatings on pharmaceutical tablets during film coating
A1  - Christodoulou, C
A1  - Mazzei, L
A1  - García-Muñoz, S
A1  - Sorensen, E
T3  - Computer Aided Chemical Engineering
KW  - pharmaceutical
KW  -  film coating
KW  -  drying
KW  -  modeling
CY  - San Diego, CA, USA
PB  - Elsevier
UR  - https://doi.org/10.1016/B978-0-444-64241-7.50344-X
N2  - Pharmaceutical tablets are film coated for several reasons, the most common being the enhancement of taste and appearance, the protection of sensitive ingredients and the control of active ingredient release. In this work, we developed a mathematical model that simulates coating spray impact, film formation and drying on pharmaceutical tablet surfaces. To describe spray impingement and liquid film formation we developed a 1-D film-spreading model. To predict the drying of the liquid film, we used the ?mixture modeling? theory and the ?lubrication approximation? theory to simplify the equations describing the liquid-particle system. The current model allows predicting the thickness of an evaporating coating layer applied on a curved tablet. We performed variance-based sensitivity analysis to study the effect of spray parameters on coating spreading and initial liquid film thickness and to investigate the influence of tablet and film properties on drying.
ID  - discovery10039039
ER  -