?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Modeling+of+spreading+and+drying+of+aqueous+polymer+coatings+on+pharmaceutical+tablets+during+film+coating&rft.creator=Christodoulou%2C+C&rft.creator=Mazzei%2C+L&rft.creator=Garc%C3%ADa-Mu%C3%B1oz%2C+S&rft.creator=Sorensen%2C+E&rft.description=Pharmaceutical+tablets+are+film+coated+for+several+reasons%2C+the+most+common+being+the+enhancement+of+taste+and+appearance%2C+the+protection+of+sensitive+ingredients+and+the+control+of+active+ingredient+release.+In+this+work%2C+we+developed+a+mathematical+model+that+simulates+coating+spray+impact%2C+film+formation+and+drying+on+pharmaceutical+tablet+surfaces.+To+describe+spray+impingement+and+liquid+film+formation+we+developed+a+1-D+film-spreading+model.+To+predict+the+drying+of+the+liquid+film%2C+we+used+the+%E2%80%9Cmixture+modeling%E2%80%9D+theory+and+the+%E2%80%9Clubrication+approximation%E2%80%9D+theory+to+simplify+the+equations+describing+the+liquid-particle+system.+The+current+model+allows+predicting+the+thickness+of+an+evaporating+coating+layer+applied+on+a+curved+tablet.+We+performed+variance-based+sensitivity+analysis+to+study+the+effect+of+spray+parameters+on+coating+spreading+and+initial+liquid+film+thickness+and+to+investigate+the+influence+of+tablet+and+film+properties+on+drying.&rft.subject=pharmaceutical%2C+film+coating%2C+drying%2C+modeling&rft.publisher=Elsevier&rft.contributor=Eden%2C+MR&rft.contributor=Ierapetritou%2C+MG&rft.contributor=Towler%2C+GP&rft.date=2018&rft.type=Proceedings+paper&rft.publisher=13th+International+Symposium+on+Process+Systems+Engineering&rft.language=eng&rft.source=+++++In%3A+Eden%2C+MR+and+Ierapetritou%2C+MG+and+Towler%2C+GP%2C+(eds.)+Computer+Aided+Chemical+Engineering.++(pp.+pp.+2095-2100).++Elsevier%3A+San+Diego%2C+CA%2C+USA.+(2018)+++++&rft.identifier=https%3A%2F%2Fdiscovery.ucl.ac.uk%2Fid%2Feprint%2F10039039%2F