TY  - JOUR
SN  - 0264-1275
UR  - http://doi.org/10.1016/j.matdes.2017.09.052
ID  - discovery10024561
N2  - Core/shell microparticles for development of drug delivery systems were prepared using co-axial electrohydrodynamic atomization technique in order to develop fixed dose combined formulations incorporating paracetamol and indomethacin as model drugs. The developed drug delivery systems offered successful co-encapsulation of paracetamol and indomethacin with high drug encapsulation efficiencies of 54% and 69% for paracetamol and indomethacin, respectively. The developed formulations were further characterised with respect to their morphology, drug release profile and possible interactions. In comparison to the release rate of the free indomethacin, the developed formulation resulted in enhanced dissolution rate of indomethacin. This study demonstrates a versatile polymeric platform where multiple drug encapsulation and co-delivery is made possible by utilizing co-axial electrohydrodynamic atomization. The proposed system offered high processing yield of 60?70%, as a single-step platform for preparation of fixed dose formulations for oral drug delivery, particularly in geriatric therapy.
KW  - Electrohydrodynamic atomization; Drug delivery; Oral; Polypharmacy
KW  -  fixed dose combination
A1  - Shams, T
A1  - Parhizkar, M
A1  - Illangakoon, UE
A1  - Orlu, M
A1  - Edirisinghe, M
JF  - Materials & Design
EP  - 213
AV  - public
VL  - 136
Y1  - 2017/12/15/
SP  - 204
TI  - Core/shell microencapsulation of indomethacin/paracetamol by co-axial electrohydrodynamic atomization
N1  - © 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://
creativecommons.org/licenses/by/4.0/).
ER  -