eprintid: 10024534
rev_number: 23
eprint_status: archive
userid: 608
dir: disk0/10/02/45/34
datestamp: 2017-10-08 10:22:07
lastmod: 2021-09-26 22:32:10
status_changed: 2017-12-04 17:06:04
type: article
metadata_visibility: show
creators_name: Suppa, A
creators_name: Quartarone, A
creators_name: Siebner, H
creators_name: Chen, R
creators_name: Di Lazzaro, V
creators_name: Del Giudice, P
creators_name: Paulus, W
creators_name: Rothwell, JC
creators_name: Ziemann, U
creators_name: Classen, J
title: The associative brain at work: Evidence from paired associative stimulation studies in humans.
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F84
keywords: Paired associative stimulation, Plasticity, Primary motor cortex, STDP
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: The original protocol of Paired Associative Stimulation (PAS) in humans implies repetitive cortical and peripheral nerve stimuli, delivered at specific inter-stimulus intervals, able to elicit non-invasively long-term potentiation (LTP)- and long-term depression (LTD)-like plasticity in the human motor cortex. PAS has been designed to drive cortical LTP/LTD according to the Hebbian rule of associative plasticity. Over the last two decades, a growing number of researchers have increasingly used the PAS technique to assess cortical associative plasticity in healthy humans and in patients with movement disorders and other neuropsychiatric diseases. The present review covers the physiology, pharmacology, pathology and motor effects of PAS. Further sections of the review focus on new protocols of "modified PAS" and possible future application of PAS in neuromorphic circuits designed for brain-computer interface.
date: 2017-11
date_type: published
official_url: https://doi.org/10.1016/j.clinph.2017.08.003
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1426462
doi: 10.1016/j.clinph.2017.08.003
pii: S1388-2457(17)30920-3
language_elements: eng
lyricists_name: Rothwell, John
lyricists_id: JCROT52
full_text_status: public
publication: Clin Neurophysiol
volume: 128
number: 11
pagerange: 2140-2164
event_location: Netherlands
issn: 1872-8952
citation:        Suppa, A;    Quartarone, A;    Siebner, H;    Chen, R;    Di Lazzaro, V;    Del Giudice, P;    Paulus, W;             ... Classen, J; + view all <#>        Suppa, A;  Quartarone, A;  Siebner, H;  Chen, R;  Di Lazzaro, V;  Del Giudice, P;  Paulus, W;  Rothwell, JC;  Ziemann, U;  Classen, J;   - view fewer <#>    (2017)    The associative brain at work: Evidence from paired associative stimulation studies in humans.                   Clin Neurophysiol , 128  (11)   pp. 2140-2164.    10.1016/j.clinph.2017.08.003 <https://doi.org/10.1016/j.clinph.2017.08.003>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10024534/1/Rothwell_The%20Associative%20Brain%20at%20Work%204%202%202017a.pdf