TY  - JOUR
SP  - 2140
UR  - https://doi.org/10.1016/j.clinph.2017.08.003
KW  - Paired associative stimulation
KW  -  Plasticity
KW  -  Primary motor cortex
KW  -  STDP
TI  - The associative brain at work: Evidence from paired associative stimulation studies in humans.
ID  - discovery10024534
SN  - 1872-8952
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
EP  - 2164
JF  - Clin Neurophysiol
AV  - public
N2  - The original protocol of Paired Associative Stimulation (PAS) in humans implies repetitive cortical and peripheral nerve stimuli, delivered at specific inter-stimulus intervals, able to elicit non-invasively long-term potentiation (LTP)- and long-term depression (LTD)-like plasticity in the human motor cortex. PAS has been designed to drive cortical LTP/LTD according to the Hebbian rule of associative plasticity. Over the last two decades, a growing number of researchers have increasingly used the PAS technique to assess cortical associative plasticity in healthy humans and in patients with movement disorders and other neuropsychiatric diseases. The present review covers the physiology, pharmacology, pathology and motor effects of PAS. Further sections of the review focus on new protocols of "modified PAS" and possible future application of PAS in neuromorphic circuits designed for brain-computer interface.
VL  - 128
IS  - 11
A1  - Suppa, A
A1  - Quartarone, A
A1  - Siebner, H
A1  - Chen, R
A1  - Di Lazzaro, V
A1  - Del Giudice, P
A1  - Paulus, W
A1  - Rothwell, JC
A1  - Ziemann, U
A1  - Classen, J
Y1  - 2017/11//
ER  -