eprintid: 10023432
rev_number: 29
eprint_status: archive
userid: 608
dir: disk0/10/02/34/32
datestamp: 2017-10-08 02:29:30
lastmod: 2021-09-20 00:14:45
status_changed: 2017-11-03 14:29:55
type: article
metadata_visibility: show
creators_name: Olafsdottir, HF
creators_name: Barry, C
creators_name: Carpenter, F
title: Task Demands Predict a Dynamic Switch in the Content of Awake Hippocampal Replay
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: C08
divisions: D09
divisions: F96
keywords: Place cell; grid cell; entorhinal cortex; hippocampus; replay; planning; memory consolidation; navigation
note: © 2017 The Authors. Published by Elsevier Inc.
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
abstract: Reactivation of hippocampal place cell sequences during behavioral immobility and rest has been linked with both memory consolidation and navigational planning. Yet it remains to be investigated whether these functions are temporally segregated, occurring during different behavioral states. During a self-paced spatial task, awake hippocampal replay occurring either immediately before movement toward a reward location or just after arrival at a reward location preferentially involved cells consistent with the current trajectory. In contrast, during periods of extended immobility, no such biases were evident. Notably, the occurrence of task-focused reactivations predicted the accuracy of subsequent spatial decisions. Additionally, during immobility, but not periods preceding or succeeding movement, grid cells in deep layers of the entorhinal cortex replayed coherently with the hippocampus. Thus, hippocampal reactivations dynamically and abruptly switch between operational modes in response to task demands, plausibly moving from a state favoring navigational planning to one geared toward memory consolidation.
date: 2017-11-15
date_type: published
publisher: Elsevier
official_url: http://doi.org/10.1016/j.neuron.2017.09.035
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Article
verified: verified_manual
elements_id: 1425960
doi: 10.1016/j.neuron.2017.09.035
lyricists_name: Barry, Caswell
lyricists_name: Carpenter, Francis
lyricists_name: Olafsdottir, Hauour
lyricists_id: CJBAR36
lyricists_id: FCARP75
lyricists_id: HFOLA90
actors_name: Olafsdottir, Haudur
actors_name: Laslett, David
actors_id: HFOLA90
actors_id: DLASL34
actors_role: owner
actors_role: impersonator
full_text_status: public
publication: Neuron
volume: 96
number: 4
pagerange: 925-935
issn: 0896-6273
citation:        Olafsdottir, HF;    Barry, C;    Carpenter, F;      (2017)    Task Demands Predict a Dynamic Switch in the Content of Awake Hippocampal Replay.                   Neuron , 96  (4)   pp. 925-935.    10.1016/j.neuron.2017.09.035 <https://doi.org/10.1016/j.neuron.2017.09.035>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10023432/1/Olafsdottir_1-s2.0-S0896627317309042-main.pdf