eprintid: 10004444
rev_number: 31
eprint_status: archive
userid: 587
source: pure
dir: disk0/00/00/44/44
datestamp: 2010-05-13 10:15:58
lastmod: 2017-12-07 21:11:34
status_changed: 2010-05-13 10:15:58
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Yirmiya, Nurit
creators_name: Charman, Tony
creators_id: 
creators_id: t.charman@ioe.ac.uk
title: The prodrome of autism: early behavioral and biological signs, regression, peri- and post-natal development and genetics
ispublished: pub
divisions: B14
note: The definitive version is available at www3.interscience.wiley.com
abstract: Autism is one of the most heritable neurodevelopmental conditions and has an early onset, with symptoms being required to be present in the first 3 years of life in order to meet criteria for the ‘core’ disorder in the classification systems. As such, the focus on identifying a prodrome over the past 20 years has been on pre-clinical signs or indicators that will be present very early in life, certainly in infancy. A number of novel lines of investigation have been used to this end, including retrospective coding of home videos, prospective population screening and ‘high risk’ sibling studies; as well as the investigation of pre- and peri-natal, brain developmental and other biological factors. Whilst no single prodromal sign is expected to be present in all cases, a picture is emerging of indicative prodromal signs in infancy and initial studies are being undertaken to attempt to ameliorate the early presentation and even ‘prevent’ emergence of the full syndrome.
date: 2010-04
date_type: published
oa_status: green
language: eng
primo: open
primo_central: open_green
full_text_status: public
publication: Journal of Child Psychology and Psychiatry
volume: 51
number: 4
pagerange: 432-458
pages: 27
refereed: TRUE
issn: 0021-9630
citation:        Yirmiya, Nurit;    Charman, Tony;      (2010)    The prodrome of autism: early behavioral and biological signs, regression, peri- and post-natal development and genetics.                   Journal of Child Psychology and Psychiatry , 51  (4)   pp. 432-458.          Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10004444/1/Yimrmiya2010The432.pdf