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Jennifer H. Stuart, Rebecca P. Sumner, Yongxu Lu, Joseph S. Snowden, Geoffrey L. Smith
Vaccinia Virus Protein C6 Inhibits Type I IFN Signalling in the Nucleus and Binds to the Transactivation Domain of STAT2
www.plospathogens.org
www.plospathogens.org
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(19)Tj
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(25)Tj
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(].)Tj
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(C6)Tj
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(shown)Tj
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(be)Tj
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(a)Tj
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(dual)Tj
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(function)Tj
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(that)Tj
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(inhibits)Tj
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(type)Tj
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(I)Tj
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(IFN)Tj
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(signalling)Tj
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(well)Tj
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(as)Tj
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(I)Tj
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(production.)Tj
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(presented)Tj
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(show)Tj
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(that)Tj
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(the)Tj
1.4683 0 Td
(inhibition)Tj
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(of)Tj
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(IFN)Tj
/F11 1 Tf
()Tj
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(-induced)Tj
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(JAK/STAT)Tj
4.6204 0 Td
(signalling)Tj
4.0705 0 Td
(occurs)Tj
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(at)Tj
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(a)Tj
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(late)Tj
1.6214 0 Td
(stage)Tj
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(in)Tj
1.0318 0 Td
(the)Tj
1.4684 0 Td
(pathway,)Tj
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(downstream)Tj
5.193 0 Td
(of)Tj
-34.435 -1.3039 Td
(STAT)Tj
2.6021 0 Td
(phosphorylation,)Tj
7.0356 0 Td
(heterodimerisation,)Tj
8.09 0 Td
(and)Tj
1.7291 0 Td
(nuclear)Tj
3.1975 0 Td
(translocation)Tj
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(and)Tj
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(downstream)Tj
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(ISGF3)Tj
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(binding)Tj
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(to)Tj
1.0262 0 Td
(the)Tj
1.4683 0 Td
(ISRE,)Tj
2.4491 0 Td
(thus)Tj
1.9389 0 Td
(indicating)Tj
4.2633 0 Td
(an)Tj
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(inhibitory)Tj
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(of)Tj
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(C6)Tj
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(or)Tj
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(formation)Tj
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(the)Tj
1.4683 0 Td
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3.8495 0 Td
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(C6)Tj
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(associate)Tj
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(with)Tj
1.9956 0 Td
(the)Tj
1.4683 0 Td
(transcriptional)Tj
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(domain)Tj
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(\(TAD\))Tj
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(providing)Tj
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(a)Tj
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(plausible)Tj
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(mechanism)Tj
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(this)Tj
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(formation.)Tj
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(C6)Tj
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(the)Tj
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(transcriptional)Tj
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(induction)Tj
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(all)Tj
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()Tj
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(-dependent)Tj
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(the)Tj
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(our)Tj
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(this)Tj
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(C6)Tj
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(cytoplasmic-replicating)Tj
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(influence)Tj
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(nucleus)Tj
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(crucial)Tj
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(innate)Tj
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(signalling)Tj
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(path-)Tj
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(highlights)Tj
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(the)Tj
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(interactions.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 209.0267 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Results)Tj
/F0 1 Tf
0 -1.5023 Td
(C6)Tj
1.4834 0 Td
(inhibits)Tj
3.2835 0 Td
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(I)Tj
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(IFN)Tj
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(signalling)Tj
ET
Q
q
1 j
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BT
/F7 1 Tf
1 TL
-0.004 Tc
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4.6147 0 Td
(C6)Tj
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/F11 1 Tf
()Tj
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(IRF-3/7)Tj
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(26)Tj
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(determine)Tj
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(HEK293T)Tj
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(V5-)Tj
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(TAP-)Tj
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(S1)Tj
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