Alcohol Consumption and Incident Cataract Surgery in Two Large UK Cohorts

Purpose To examine the association of alcohol consumption and type of alcoholic beverage with incident cataract surgery in 2 large cohorts. Design Longitudinal, observational study. Participants We included 469 387 participants of UK Biobank with a mean age of 56 years and 23 162 participants of European Prospective Investigation of Cancer (EPIC)-Norfolk with a mean age of 59 years. Methods Self-reported alcohol consumption at baseline was ascertained by a touchscreen questionnaire in UK Biobank and a food-frequency questionnaire in EPIC-Norfolk. Cases were defined as participants undergoing cataract surgery in either eye as ascertained via data linkage to National Health Service procedure statistics. We excluded participants with cataract surgery up to 1 year after the baseline assessment visit or those with self-reported cataract at baseline. Cox proportional hazards models were used to examine the associations of alcohol consumption with incident cataract surgery, adjusted for age, sex, ethnicity, Townsend deprivation index, body mass index (BMI), smoking, and diabetes status. Main Outcome Measures Incident cataract surgery. Results There were 19 011 (mean cohort follow-up of 95 months) and 4573 (mean cohort follow-up of 193 months) incident cases of cataract surgery in UK Biobank and EPIC-Norfolk, respectively. Compared with nondrinkers, drinkers were less likely to undergo cataract surgery in UK Biobank (hazard ratio [HR], 0.89; 95% confidence interval [CI], 0.85–0.93) and EPIC-Norfolk (HR, 0.90; 95% CI, 0.84–0.97) after adjusting for covariables. Among alcohol consumers, greater alcohol consumption was associated with a reduced risk of undergoing cataract surgery in EPIC-Norfolk (P < 0.001), whereas a U-shaped association was observed in the UK Biobank. Compared with nondrinkers, subgroup analysis by type of alcohol beverage showed the strongest protective association with wine consumption; the risk of incident cataract surgery was 23% and 14% lower among those in the highest category of wine consumption in EPIC-Norfolk and UK Biobank, respectively. Conclusions Our findings suggest a lower risk of undergoing cataract surgery with low to moderate alcohol consumption. The association was particularly apparent with wine consumption. We cannot exclude the possibility of residual confounding, and further studies are required to determine whether this association is causal in nature.

cataract surgery, 11,13,14 and other studies have found no relationship. 15,16Evidence from prospective studies remains limited, and these have shown inconsistent findings. 8,9,15The Blue Mountains Eye Study (BMES) reported moderate alcohol consumption was associated with reduced likelihood of cataract surgery, 9 whereas increased risk of cataract surgery was reported among Swedish women with daily consumption of 1 alcoholic drinks. 8In contrast, the Nurses Health Study reported no association of cataract surgery with alcohol intake. 15n this large longitudinal observational study, we examined the association between alcohol consumption and the incidence of cataract surgery in 2 independent cohort studies, the UK Biobank and European Prospective Investigation of Cancer (EPIC)-Norfolk.We further examined the doseeresponse relationship between alcohol consumption and cataract surgery and examined associations with subtypes of alcoholic beverage.

EPIC-Norfolk
Study Population.The EPIC is a 10-country collaborative study that started in 1989. 17The EPIC-Norfolk, one of the UK centers, recruited 25 639 UK residents in East Anglia aged 40 to 79 years between 1993 and 1997. 18The study was approved by the Norwich Local Research Ethics Committee.Baseline examination comprised a clinic visit to obtain anthropometric measurements and completion of a detailed questionnaire to assess demographic, health, and lifestyle information.Choices for ethnicity included White, Black, Indian, Pakistan, Bangladesh, Chinese, and others.Townsend deprivation index was determined according to the participants' postcode at recruitment and the corresponding output area from the preceding national census.The index was calculated on the basis of the output area's employment status, home and car ownership, and household condition; the higher and more positive the index, the more deprived an area.Smoking status was defined as selfreported history of smoking cigarettes in the past or those who were currently smoking at baseline.Diabetes status was determined by self-report at baseline.Participants completed a questionnaire that evaluated their occupational and leisure physical activity.Physical activity at work was classified as 4 categories: sedentary, standing, physical work, and heavy manual work.Leisure activity assessed the time spent cycling, attending keep fit classes, swimming, or jogging in winter and summer. 19Height was measured using a stadiometer (Chasemores), and weight was measured using digital scales (Salter, Tonbridge).Body mass index (BMI) was calculated as weight (kilograms)/height (meters squared).
Assessment of Alcohol Consumption.In EPIC-Norfolk, baseline usual alcohol intake was ascertained by a validated food frequency questionnaire. 20,21The food frequency questionnaire measures a participant's usual food and drink intake during the previous year and contains a list of 130 items.Participants were asked to indicate their usual consumption, choosing from 9 frequency categories, which ranged from "never or less than once per month" to "6 or more times per day" (Table S1, available at www.aaojournal.org).One unit of alcohol is equivalent to 1 glass of wine; half a pint of beer, lager, or cider; or 1 single measure of spirits.Alcohol intake in grams was calculated using a custom-designed dietary assessment software program (Compositional Analyses from Frequency Estimates). 22e also categorized the intake of specific alcoholic beverages (wine, beer, and spirits) into tertiles based on the absolute alcohol intake from each beverage.

UK Biobank
Study Population.UK Biobank is a large community-based cohort of 502 504 UK residents registered with the National Health Service and aged 40 to 69 years at enrollment.Baseline examinations were carried out between 2006 and 2010 at 22 study assessment centers.The North West Multi-center Research Ethics Committee approved the study in accordance with the principles of the Declaration of Helsinki.The overall study protocol (http:// www.ukbiobank.ac.uk/resources/) and protocols for individual tests (http://biobank.ctsu.ox.ac.uk/crystal/docs.cgi)are available online.All participants provided informed consent.Participants answered a detailed questionnaire that covers a wide range of demographic, health, and lifestyle information. 23The choices for ethnicity included White (English/Irish or other White background), Asian or British Asian (Indian/Pakistani/ Bangladeshi or other Asian background), Black or Black British (Caribbean, African, or other Black background), Chinese, mixed (White and Black Caribbean or African, White, and Asian, or other mixed background), or other ethnic group (not defined).Townsend deprivation index was determined according to the participants' postcodes using the same method as detailed earlier for EPIC-Norfolk.Smoking status was determined by self-report.Diabetes status was defined by self-report of diabetes mellitus or use of diabetes medications.Physical activity was assessed using the short-form International Physical Activity Questionnaire, 24 which examined the frequency and duration of walking, moderate-intensity activity, and vigorous-intensity activity. 25eight was measured with the BV-418 MA body composition analyzer (Tanita).Height was measured using a Seca 202 height measure.
Assessment of Alcohol Consumption.Information on baseline alcohol consumption was obtained from a touchscreen selfadministered questionnaire in UK Biobank.Although the questionnaire has not been formally validated, multiple previous studies have demonstrated expected associations with alcohol. 26,27articipants were asked to indicate their usual consumption, choosing from 6 frequency categories, which were "never," "special occasions only," "1e3 times a month," "1e2 times a week," "3e4 times a week," and "daily or almost daily."Alcohol frequency was classified into 4 groups (1e3 times a month, 1e2 times a week, 3e4 times a week, and daily or almost daily) among drinkers (Table S1, available at www.aaojournal.org).We further assessed the consumption of different types of alcohol (red wine; white wine and champagne; beer and cider; spirits) among drinkers who reported alcohol consumption at least 1 to 2 times per week.Drinking frequency for each type of alcohol was categorized into 1 of 3 groups (1 to 2, 3 to 4, and 5 drinks per week).

Ascertainment of Incident Cataract Surgery in EPIC-Norfolk and UK Biobank
Incident cataract surgery was ascertained via linkage to hospital procedure records, namely, Hospital Episode Statistics for England, Scottish Morbidity Record for Scotland, and Patient Episode Database for Wales.It was defined as cataract surgery in either eye, and the date of event was defined as the date of first eye cataract surgery in participants undergoing bilateral sequential surgery.Participants were determined to have had cataract surgery if they had an OPCS Classification of Interventions and Procedures 4 code of C71.2 -"Phacoemulsification of lens" or C75.1 -"Insertion of prosthetic replacement for lens."We excluded participants with cataract surgery up to 1 year after the baseline assessment visit because this may indicate visually significant cataract having been present at baseline.Participants with self-reported cataract at baseline were also excluded from this study.The reliability of selfreported cataract has been evaluated in the Physicians' Health Study. 28Self-reported cataract was shown to be a good indicator of lens opacification compared with medical record data.

Definition of Covariables in EPIC-Norfolk and UK Biobank
Demographic characteristics in the analysis included age at baseline, sex, ethnicity (White or non-White), and Townsend deprivation index.Health and lifestyle factors included BMI, smoking status (never smoked vs. ever smoked), diabetes status (yes vs. no), and physical activity.Physical activity was categorized as low, moderate, and high in UK Biobank, 25 and EPIC-Norfolk participants were classified as inactive, moderately inactive, moderately active, or active. 29

Statistical Analysis
The baseline characteristics of EPIC-Norfolk and UK Biobank participants are presented as means (standard deviation [SD]) for continuous variables and numbers (percentage) for categorical variables.We conducted a survival analysis, and participants were censored at the following end points: date of first cataract surgery, date of death, or end of the data linkage (March 31, 2015, for EPIC-Norfolk and March 31, 2017, for UK Biobank), whichever came first.The data linkage to identify incident cataract surgery was done on a national level and would therefore even capture participants who had moved within the country.However, if participants had moved abroad, or if they have opted out of national statistics collection, then we would miss if they had cataract surgery.The numbers of such participants are likely to be low.Cox proportional hazards models were used to examine associations with incident cataract surgery.Given that nondrinkers may differ from current drinkers in aspects other than just alcohol consumption (e.g., people may decrease their alcohol consumption as they age or become ill), 30 we carried out a 2-step analysis.The first step was to compare the risk of incident cataract surgery in alcohol drinkers with that of nondrinkers.The second step was to examine for a dose response for the association between alcohol consumption and incident cataract surgery among drinkers only; we compared across quartiles of absolute alcohol intake in EPIC-Norfolk and across the frequency of alcohol consumption in UK Biobank.We further assessed the risk of incident cataract surgery with consumption of different types of alcoholic beverage.All associations were examined using univariable and multivariable models.Multivariable models were adjusted for age, sex, ethnicity, Townsend deprivation index, BMI, smoking, and diabetes status.In a sensitivity analysis, physical activity was also adjusted for in the multivariable models because of its association with alcohol intake 31 and cataract risk. 32Physical activity was not included in the primary analysis given the significant number of participants with missing data in UK Biobank.We additionally examined the association between alcohol intake and incident cataract surgery without excluding those with self-reported cataract.We constructed correlation and variance-covariance matrices for the continuous explanatory variables we examined (age, Townsend deprivation index, and BMI); there was no evidence for multicollinearity.Data analysis was performed using STATA software (version 16, StataCorp LP).

Results
Of the 25 639 EPIC-Norfolk participants, a total of 23 162 participants were included in this analysis after excluding 1229 with missing data and 1248 with baseline cataract or incident cataract surgery within 1 year (Fig 1).The mean follow-up time was 193 months (SD, 62 months), during which time 4573 participants underwent cataract surgery.Of the 502 504 UK Biobank participants, 469 387 participants were included after the exclusion of 22 568 participants with missing data and 10 549 participants with baseline cataract or incident cataract surgery within 1 year.The mean follow-up time was 95 months (SD, 15 months), during which time 19 011 participants underwent cataract surgery.In both cohorts, compared with participants who were included, those excluded were older, more likely women (only in EPIC-Norfolk) and non-White (only in UK Biobank), more likely to reside in a more deprived area, more likely to have a higher BMI, more likely to have ever smoked, more likely to have diabetes, and less likely to be drinkers (all P < 0.001) (Tables S2 and S3, available at www.aaojournal.org).The length of follow-up was considerably longer in the EPIC-Norfolk study than the UK Biobank.This does not alter the interpretation of the hazard ratio (HR) for either study; the HR reflects the ratio of the instantaneous risk at any point in time and therefore applies at any period of follow-up in either study.Notably, we confirmed that the proportional hazards assumption was met in both EPIC-Norfolk and UK Biobank.
Table 1 presents the baseline characteristics of both EPIC-Norfolk and UK Biobank participants included in the study.Compared with UK Biobank participants, EPIC-Norfolk participants were slightly older and more likely to be White, to live in a less-deprived area, to have a lower BMI, or to have ever smoked.The duration of follow-up was twice as long in EPIC-Norfolk compared with UK Biobank (193 months vs. 95 months).A greater proportion of participants were alcohol drinkers at baseline in UK Biobank compared with EPIC-Norfolk (92% vs. 81%).Among the drinkers in UK Biobank, 67%, 55%, 53%, and 37% consumed red wine, white wine/champagne, beer/cider, and spirits, respectively.Among the drinkers in EPIC-Norfolk, 85%, 57%, and 53% consumed wine, beer, and spirits, respectively.

Step 2: Examining for a DoseeResponse Association among Alcohol Drinkers Only
The doseeresponse associations between alcohol consumption and incident cataract surgery among alcohol drinkers only are shown in Table 2.In EPIC-Norfolk, the risk of incident cataract surgery was progressively lower with greater alcohol consumption (P < 0.001).In the multivariable adjusted analysis, participants in the third and highest quartiles of alcohol intake had 14% and 18% lower risk of incident cataract surgery, respectively, compared with those in the lowest quartile of alcohol intake.In UK Biobank, there was a U-shaped association between alcohol consumption and cataract surgery (Table 2).Compared with participants who drank 1 to 3 times or less per month, those who drank 1 to 2 times and 3 to 4 times per week had 7% and 6% lower risk of incident cataract surgery, respectively, whereas no significant association was observed among those with daily or almost daily alcohol consumption.Compared with participants who consumed alcohol 1 to 2 times per week or 3 to 4 times per week, those who drank daily or almost daily had 6% (95% CI, 1.02e1.12,P ¼ 0.010) and 5% (95% CI, 1.00e1.10,P ¼ 0.05) higher risk of incident cataract surgery, respectively.This demonstrates a significant increase in cataract surgery risk with the highest frequency of intake compared with moderate frequency, supporting a Ushaped association.

Analysis of Alcoholic Beverage Subtypes
We then examined the association of consumption of different alcoholic beverage types with incident cataract surgery.In EPIC-Norfolk, wine consumption was most strongly associated with a  reduced risk of cataract surgery (Table 3).The risk for incident cataract surgery decreased in a doseeresponse manner with increasing wine consumption (P < 0.001).Compared with nondrinkers, wine consumption in the second tertile and third tertile had 19% and 23% lower risk of incident cataract, respectively.Beer consumption in the second tertile and spirits consumption in the third tertile showed a 13% and 14% lower risk of incident cataract surgery, respectively.Table 4 shows the association between different types of alcohol and incident cataract surgery in UK Biobank.Compared with nondrinkers, the risk of cataract surgery was 14% lower among red wine consumers, regardless of amount of consumption.Likewise, compared with nondrinkers, white wine/champagne consumers had at least 10% lower risk of incident cataract surgery regardless of amount of consumption.In contrast, although moderate consumers of beer and cider or spirits had a lower risk of incident cataract surgery compared with nondrinkers, the most frequent consumers did not have a significantly different risk.

Discussion
In this analysis of British adults, we report low to moderate consumption of alcohol to be associated with a reduced risk of undergoing subsequent cataract surgery; this finding was consistent between 2 independent studies with contrasting methods of ascertaining alcohol intake.The protective association was apparent whether any consumption of alcohol was compared with nonconsumption and whether the amount or frequency of alcohol intake was compared among drinkers only in doseeresponse analyses.We found the strongest protective association among wine drinkers.2][13] The Beaver Dam Eye Study reported that wine consumption was associated with less severe nuclear sclerosis and cortical opacities, whereas drinking beer was associated with increased prevalence of cortical opacities. 13In the BMES, compared with nondrinkers, alcohol consumption was associated with reduced prevalence of cortical cataract (OR, 0.70; 95% CI, 0.60e0.90). 11There have been only a small number of longitudinal studies that examined the relationship between alcohol consumption and cataract. 8,9,15These studies have a smaller sample size, were mainly evaluated in women, and have reported inconsistent findings.The BMES reported that moderate alcohol consumption was associated with 50% lower incidence of cataract surgery compared with abstinence or heavy alcohol consumption. 9n contrast, an increase of 1 drink per day was associated with a 7% increased risk of cataract extraction in a Swedish Mammography cohort, 8 and the Nurses Health Study found no relationship between alcohol intake and cataract surgery in women. 15Furthermore, these studies did not report an association between different types of alcoholic beverage and cataract extraction, which may have been limited by the smaller sample size in each subgroup analysis.Our study is longitudinal in design and has a very large sample size.The alcohol intake doseeresponse analyses are different in EPIC-Norfolk (doses defined by quantity of intake) and UK Biobank (doses defined by frequency of intake) due to differences in data collection.Despite this difference, we demonstrated a doseeresponse relationship between alcohol intake and cataract surgery in both cohorts.Unlike previous studies, we excluded participants who had undergone cataract surgery up to 1 year from baseline to minimize the chance of reverse causality underlying our identified associations.Additionally, we evaluated the association between the amount or frequency of alcohol intake and cataract surgery among drinkers only, because nondrinkers may differ from drinkers in ways other than their alcohol consumption (e.g., unwell participants may stop drinking alcohol 30 ); these doseeresponse analyses further support an association between alcohol intake and cataract surgery.The findings of our study have to be taken in the context of our primary outcome, cataract surgery, which is our surrogate for visually significant cataract.Factors other than visual impairment may determine whether a person undergoes cataract surgery.Access to health care and attitudes toward surgery will have an influence.The threshold of visual impairment required to prompt a decision to undergo surgery will also vary by individual.Furthermore, given the observational nature of our study, it is not possible to determine if the protective association we observed of alcohol intake on cataract surgery is causal.The fact that the association is present whether comparing drinkers with nondrinkers, or in doseeresponse analyses among drinkers only, increases the chance that this association is causal.However, the association may also be due to confounding.For example, alcohol consumers may be of higher social class than nonconsumers, and it is other aspects of lifestyle and healthcare access associated with social class that is driving the association. 33Although we adjusted for sociodemographic factors, it is possible that these measures did not fully account for differences in social class between drinkers and nondrinkers.However, it seems unlikely that social class differences completely explain the differential cataract surgery risk across the different doses of alcohol intake; the doseeresponse relationship we observe supports a causal relationship.Although drinking patterns may vary by ethnicity-related cultures, this is unlikely to underlie our observed associations in EPIC-Norfolk as the participants are almost entirely White.
The majority of alcohol consumers in both EPIC-Norfolk and UK Biobank reported only low to moderate amounts of alcohol intake, which may be reflective of the healthier nature of participants in cohort studies.Therefore, we cannot make inference regarding the potential protective association of greater than moderate alcohol intake on cataract.Although we observed a doseeresponse association of progressively reduced cataract surgery risk with increasing alcohol intake across the low to moderate quantity or frequency range, the most frequent drinkers in UK Biobank (daily or almost daily intake) did not have a different risk of cataract surgery compared with the least frequent drinkers (Table 2).Results from the UK Biobank subset suggest a U-shaped relationship between alcohol intake and cataract surgery within the alcohol intake frequency range observed in UK Biobank; this may be analogous to the J-shaped relationship observed between alcohol intake and cardiovascular disease 7 but truncated because of a paucity of heavy drinkers in UK Biobank.In EPIC-Norfolk, few participants reported heavy drinking (only 3.4% reported >42 units/week or >336 g/week of alcohol intake), 34 and therefore it was not possible to examine for a U-or J-shaped relationship with sufficient statistical power.It will be a challenge for future cohort studies to ascertain the prospective effect of heavy alcohol intake, because it may be less likely for heavy drinkers to volunteer for such studies.The current guidelines for safe alcohol intake quantity are up to 14 units/week (equivalent to 112 g/week, as 1 unit is equivalent to 8 g of alcohol) for both men and women in the United Kingdom, 34 and 14 standard drinks per week (equivalent to 196 g/week, because 1 standard drink is equivalent to 14 g of alcohol) for men and 7 standard drinks week (equivalent to 98 g/ week) for women in the United States. 35The range of maximum recommended alcohol intake is encompassed by the highest intake quartile in EPIC-Norfolk (Table 2); participants in the highest quartile consumed 88.78 g/ week or 11.09 units/week.The results suggest that alcohol intake within the recommended range, in either the United States or United Kingdom, would be associated with a reduced chance of undergoing cataract surgery.
The mechanism via which alcoholic beverages may protect against cataract development is not clear.Although the fact that some degree of association was present for all types of alcohol beverage suggests that alcohol itself is mediating any potential effect, our observation of strongest associations among wine drinkers, and especially red wine drinkers, also suggests that other components of alcoholic beverages may be contributing.Age-related cataract may result, in part, from oxidative stress to lens proteins. 36ietary intake of antioxidants in alcoholic beverages has been shown to increase plasma antioxidant activity, and this has been hypothesized to reduce cataract formation. 37olyphenols are micronutrients that have antioxidant properties and are present in varying degrees in alcoholic drinks but particularly in wine. 38Resveratrol is a natural polyphenol that is found in highest concentrations in red wine.It has strong antioxidant properties and has been hypothesized to potentially protect against several agerelated ocular diseases, including cataract. 39In a rat model of diabetes, resveratrol supplementation of drinking water delayed the progression of diabetic cataract compared with controls. 40Conversely, heavy alcohol consumption induces the expression of microsomal enzyme cytochrome CYP2E1 in the liver.Ethanol metabolism by this enzyme leads to the production of reactive oxygen species, 41 which in turn may lead to aggregation of lens protein, resulting in cataract development. 42Another possible mechanism by which alcohol consumption may reduce cataract risk is via altered cholesterol levels.Alcohol intake has been associated with lower levels of lowdensity lipoprotein cholesterol (LDL-C), 43 and LDL-C levels are positively associated with cataract risk. 44herefore, an increase in alcohol intake may lower the risk of cataract via reduced LDL-C.Alcohol intake may reduce LDL-C by decreasing the conversion of very-lowdensity lipoprotein to low-density lipoprotein apolipoprotein B or increase the clearance of low-density lipoprotein apolipoprotein B. 45,46 The biochemical mechanisms may explain the U-shaped association we observed between alcohol intake and cataract surgery in UK Biobank.

Study Strengths and Limitations
Strengths of our study include its longitudinal design with long-term follow-up and the large sample size of 2 cohort studies, which allowed us to examine the different types of alcoholic beverages in subgroup analyses.Limitations of our study include the self-reported nature of alcohol intake in the 2 cohorts.Participants may underreport or may not accurately recall the amount of alcohol they have consumed or consume combinations of different alcoholic beverage types.However, the misclassification bias is most likely to be nondifferential because information on alcohol consumption was obtained before cataract surgery and thus may bias the effect estimates toward the null.Given our study outcome, cataract is a slowly developing process, and we cannot exclude the possibility that cataract development preceded our exposure assessment of alcohol intake.However, cataract surgery is a hard end point and did follow the exposure measurement timepoint.Although it is not possible to determine direction of causality based on observational studies, it is unlikely that our results are due to cataracts causing reduced alcohol intake, given our longitudinal study design and the significant findings in the doseeresponse analyses.Because of the chronicity of cataract development, if alcohol has a causal effect, it is likely that this occurs cumulatively over a long period of time.We only ascertained alcohol intake at baseline in both studies and are using this as a surrogate for average intake over a lifetime (i.e., both before and after the baseline assessment).Despite this limitation of ascertainment at only 1 time point, we still identify significant signals that are consistent across 2 studies.Although we adjusted for sociodemographic and lifestyle factors in the multivariable models, it is possible that our imperfectly measured confounders are not fully accounted for and that there are unmeasured confounders we could not account for.Thus, residual confounding may explain our observational associations.However, the clear dose response we have observed may reduce this possibility.Further analysis suggests there is no evidence of multicollinearity between the independent variables.Although we diagnosed cataract by linking to Hospital Episode Statistics data, there was lack of information on the different types of cataract.Therefore, we were unable to examine the associations of alcohol consumption on the various cataract subtypes.Furthermore, as already discussed, cataract surgery is an imperfect surrogate for the development of visually significant cataract.
In conclusion, long-term follow-up data from 2 large longitudinal observational UK cohorts suggest that low to moderate consumption of alcohol may reduce the likelihood of incident cataract requiring surgery.The protective association was particularly pronounced for consumption of polyphenol-rich wine.

Figure 1 .
Figure 1.Flowchart of participants included in the European Prospective Investigation of Cancer (EPIC)-Norfolk and UK Biobank cohorts.

Figure 2 .
Figure 2. KaplaneMeier survival curves for incident cataract surgery among drinkers and nondrinkers in (A) EPIC-Norfolk and (B) UK Biobank cohorts.EPIC ¼ European Prospective Investigation of Cancer.

Table 1 .
Comparison of Baseline Characteristics between EPIC-Norfolk and UK Biobank Participants BMI ¼ body mass index; EPIC ¼ European Prospective Investigation of Cancer; N ¼ sample size; SD ¼ standard deviation.

Table 2 .
Multivariable DoseeResponse Associations of Alcohol Consumption with Incident Cataract Surgery among Alcohol Drinkers in EPIC-Norfolk and UK Biobank European Prospective Investigation of Cancer.Multivariable models were adjusted for age, sex, ethnicity, Townsend deprivation index, BMI, smoking, and diabetes status.Bold values denote statistical significance at the P < 0.05 level.Alcohol consumption was quantified by absolute intake in EPIC-Norfolk (presented in both grams and units per week) and by frequency of intake in UK Biobank.One unit of alcohol (8 g) is equivalent to 1 glass of wine; half a pint of beer, lager, or cider; or 1 single measure of spirits.

Table 3 .
Hazard Ratio of Incident Cataract Surgery Across Different Alcohol Beverages among Drinkers Compared with Nondrinkers in EPIC-Norfolk