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Antonella Cingolani, Alessandro Cozzi Lepri, Luciana Teofili, Laura Galli, Valentina Mazzotta, Gian Maria Baldin, Stefan Hohaus, Alessandra Bandera, Lucia Alba, Nadia Galizzi, Antonella Castagna, Antonella D'arminio Monforte, Andrea Antinori, on behalf of ICONA Foundation Study group
Survival and predictors of death in people with HIV-associated lymphoma compared to those with a diagnosis of lymphoma in general population
www.plosone.org
www.plosone.org
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(A)Tj
0.9071 0 Td
(in)Tj
0.83 0.64 0.02 0 k
1.0374 0 Td
(S1)Tj
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(File)Tj
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(no)Tj
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(model)Tj
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(staging)Tj
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q
1 j
1 J
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11.9999 0 0 11.9999 200.0125 600.7181 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
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(Results)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 583.7102 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
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(A)Tj
0.9014 0 Td
(total)Tj
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(1,331)Tj
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(patients)Tj
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(\(465)Tj
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(HIV-L,)Tj
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(\(34%\))Tj
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(866)Tj
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(nHIV-L)Tj
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(lymphoma)Tj
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(diagnosed)Tj
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(2000)Tj
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(and)Tj
1.7291 0 Td
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(2013)Tj
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(contributed)Tj
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(characteristics)Tj
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(HIV-L;)Tj
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(IQR:)Tj
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4.541 0 Td
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1.389 0 Td
(nHIV-L\).)Tj
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3.3165 0 Td
(CD4+)Tj
2.6759 0 Td
(cell)Tj
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(count)Tj
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(lymphoma)Tj
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(232/mmc)Tj
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Q
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1 j
1 J
0 w
7.4999 0 0 6.6659 400.9322 517.0393 cm
BT
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1 TL
-0.0053 Tc
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(10)Tj
ET
Q
q
1 j
1 J
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(1.694.74\),)Tj
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(tumour)Tj
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(characteristics)Tj
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(accounted)Tj
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(\(SNCCL\))Tj
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(\(54%\))Tj
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(nHIV-L)Tj
3.4582 0 Td
(\(66%\))Tj
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(=)Tj
0.7994 0 Td
(0.001;)Tj
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-34.7694 -1.2983 Td
(Table)Tj
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(1)Tj
0 g
(\).)Tj
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(1)Tj
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(HIV-positive)Tj
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(patients)Tj
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(autolo-)Tj
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(hematopoietic)Tj
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(the)Tj
1.4683 0 Td
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(0.001\):)Tj
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1.474 0 Td
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(sclerosis)Tj
3.5433 0 Td
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(1)Tj
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(\).)Tj
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(HIV-L,)Tj
3.1351 0 Td
(125)Tj
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(patients)Tj
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2.1203 0 Td
(cART-naive)Tj
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(diagnosis)Tj
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(started)Tj
-33.5505 -1.2983 Td
(cART)Tj
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(during)Tj
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(chemotherapy)Tj
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0.9525 0 Td
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(median)Tj
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(1)Tj
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2.9196 0 Td
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(the)Tj
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(diagnosis)Tj
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(lymphoma)Tj
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(0.43\),)Tj
2.9536 0 Td
(while)Tj
2.3698 0 Td
(292)Tj
1.6441 0 Td
(patients)Tj
3.3675 0 Td
(\(62%\))Tj
2.6135 0 Td
(developed)Tj
4.269 0 Td
(lymphoma)Tj
4.5466 0 Td
(while)Tj
2.3698 0 Td
(already)Tj
3.1067 0 Td
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1.2756 0 Td
(cART)Tj
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(\(IQR)Tj
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(11127\);)Tj
3.685 0 Td
(45)Tj
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(patients)Tj
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(\(10%\))Tj
2.6136 0 Td
(never)Tj
2.4377 0 Td
(started)Tj
2.9366 0 Td
(cART)Tj
2.5569 0 Td
(during)Tj
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(chemotherapy.)Tj
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(976)Tj
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(the)Tj
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-34.8261 -1.2983 Td
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1.1736 0 Td
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(freezing)Tj
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(the)Tj
1.474 0 Td
(database)Tj
3.634 0 Td
(\(this)Tj
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(23%)Tj
-35.6255 -1.3039 Td
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1.4741 0 Td
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(and)Tj
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(50%)Tj
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1.389 0 Td
(the)Tj
1.4683 0 Td
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5.6863 0 Td
(population,)Tj
4.8187 0 Td
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(=)Tj
0.7994 0 Td
(0.0001\))Tj
3.1634 0 Td
(and)Tj
1.7292 0 Td
(460)Tj
1.6497 0 Td
(\(47%\))Tj
-33.4201 -1.2983 Td
(more)Tj
2.3414 0 Td
(than)Tj
2.0295 0 Td
(12)Tj
1.1679 0 Td
(months)Tj
3.2825 0 Td
(\(30%)Tj
2.2677 0 Td
(vs.)Tj
1.2643 0 Td
(55%,)Tj
2.1543 0 Td
(respectively,)Tj
5.108 0 Td
(p)Tj
0.737 0 Td
(=)Tj
0.7992 0 Td
(0.0001\).)Tj
3.3903 0 Td
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0.856 0 Td
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0.8504 0 Td
(possible)Tj
3.4072 0 Td
(that)Tj
1.7802 0 Td
(after)Tj
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(sometime)Tj
-33.4711 -1.2982 Td
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2.6532 0 Td
(HIV-negative)Tj
5.6862 0 Td
(participants)Tj
4.9606 0 Td
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2.058 0 Td
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2.1203 0 Td
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(remission,)Tj
4.3709 0 Td
(follow-up)Tj
4.0932 0 Td
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1.0375 0 Td
(the)Tj
1.4684 0 Td
(hospital)Tj
3.3788 0 Td
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-33.8963 -1.2983 Td
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(interrupted.)Tj
5.0229 0 Td
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1.9843 0 Td
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2.7155 0 Td
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(violation)Tj
3.7474 0 Td
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1.4683 0 Td
(non-informative)Tj
6.854 0 Td
(censoring)Tj
4.1386 0 Td
(assumption)Tj
-31.3225 -1.3039 Td
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1.7291 0 Td
(potential)Tj
3.7587 0 Td
(introduction)Tj
5.3121 0 Td
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1.0148 0 Td
(collision)Tj
3.5943 0 Td
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4.2576 0 Td
(with)Tj
1.9956 0 Td
(a)Tj
0.652 0 Td
(lower)Tj
2.4547 0 Td
(risk)Tj
1.7122 0 Td
(of)Tj
1.0148 0 Td
(death\).)Tj
-34.6107 -1.2983 Td
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4.0761 0 Td
(results)Tj
2.8063 0 Td
(where)Tj
2.6532 0 Td
(similar)Tj
2.9877 0 Td
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1.0318 0 Td
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0.6577 0 Td
(weighted)Tj
3.8381 0 Td
(Cox)Tj
1.8538 0 Td
(regression)Tj
4.3199 0 Td
(model)Tj
2.7439 0 Td
(with)Tj
1.9956 0 Td
(weights)Tj
3.2485 0 Td
(the)Tj
1.4683 0 Td
(inverse)Tj
-33.6809 -1.2982 Td
(probability)Tj
4.5977 0 Td
(of)Tj
1.0148 0 Td
(censoring)Tj
4.1329 0 Td
(which)Tj
2.6532 0 Td
(should)Tj
2.914 0 Td
(account)Tj
3.3846 0 Td
(for)Tj
1.3833 0 Td
(this)Tj
1.678 0 Td
(potential)Tj
3.7587 0 Td
(bias)Tj
1.7858 0 Td
(\(Table)Tj
2.7836 0 Td
(B)Tj
0.7994 0 Td
(in)Tj
0.83 0.64 0.02 0 k
1.0374 0 Td
(S1)Tj
1.1679 0 Td
(File)Tj
0 g
(\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 164.9763 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
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3.3496 0 Td
(survival)Tj
3.5669 0 Td
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487.5117 178.8919 l
576 178.8919 l
f*
230.1959 178.3919 m
230.1959 165.892 l
229.6959 165.892 l
229.6959 178.3919 l
f*
229.6959 165.892 m
36 165.892 l
36 166.392 l
229.6959 166.392 l
f*
319.1842 178.3919 m
319.1842 165.892 l
318.6842 165.892 l
318.6842 178.3919 l
f*
318.6842 165.892 m
230.1959 165.892 l
230.1959 166.392 l
318.6842 166.392 l
f*
406.3326 178.3919 m
406.3326 165.892 l
405.8325 165.892 l
405.8325 178.3919 l
f*
405.8325 165.892 m
319.1842 165.892 l
319.1842 166.392 l
405.8325 166.392 l
f*
576 165.892 m
487.5117 165.892 l
487.5117 166.392 l
576 166.392 l
f*
230.1959 165.892 m
230.1959 153.392 l
229.6959 153.392 l
229.6959 165.892 l
f*
229.6959 153.392 m
36 153.392 l
36 153.8921 l
229.6959 153.8921 l
f*
319.1842 165.892 m
319.1842 153.392 l
318.6842 153.392 l
318.6842 165.892 l
f*
318.6842 153.392 m
230.1959 153.392 l
230.1959 153.8921 l
318.6842 153.8921 l
f*
406.3326 165.892 m
406.3326 153.392 l
405.8325 153.392 l
405.8325 165.892 l
f*
405.8325 153.392 m
319.1842 153.392 l
319.1842 153.8921 l
405.8325 153.8921 l
f*
576 153.392 m
487.5117 153.392 l
487.5117 153.8921 l
576 153.8921 l
f*
230.1959 153.392 m
230.1959 140.8921 l
229.6959 140.8921 l
229.6959 153.392 l
f*
229.6959 140.8921 m
36 140.8921 l
36 141.3921 l
229.6959 141.3921 l
f*
319.1842 153.392 m
319.1842 140.8921 l
318.6842 140.8921 l
318.6842 153.392 l
f*
318.6842 140.8921 m
230.1959 140.8921 l
230.1959 141.3921 l
318.6842 141.3921 l
f*
406.3326 153.392 m
406.3326 140.8921 l
405.8325 140.8921 l
405.8325 153.392 l
f*
405.8325 140.8921 m
319.1842 140.8921 l
319.1842 141.3921 l
405.8325 141.3921 l
f*
576 140.8921 m
487.5117 140.8921 l
487.5117 141.3921 l
576 141.3921 l
f*
406.3326 140.8921 m
406.3326 128.3922 l
405.8325 128.3922 l
405.8325 140.8921 l
f*
405.8325 128.3922 m
36 128.3922 l
36 128.8922 l
405.8325 128.8922 l
f*
487.5117 140.8921 m
487.5117 128.3922 l
487.0117 128.3922 l
487.0117 140.8921 l
f*
487.0117 128.3922 m
406.3326 128.3922 l
406.3326 128.8922 l
487.0117 128.8922 l
f*
576 128.3922 m
487.5117 128.3922 l
487.5117 128.8922 l
576 128.8922 l
f*
36 128.3922 m
576 128.3922 l
576 127.8921 l
36 127.8921 l
f*
0 g
1 j
1 J
7.9999 0 0 7.9999 36 708.7181 cm
BT
/F2 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.7992 0 Td
(1.)Tj
1.2614 0 Td
(Baseline)Tj
4.2733 0 Td
(tumor)Tj
3.0189 0 Td
(characte)Tj
4.0394 0 Td
(ristics)Tj
3.111 0 Td
(according)Tj
4.9465 0 Td
(with)Tj
2.204 0 Td
(type)Tj
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(of)Tj
1.1551 0 Td
(lympho)Tj
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(ma)Tj
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(and)Tj
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(HIV)Tj
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(status.)Tj
0 Tc
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(HIV-L)Tj
11.119 0 Td
(nHIV-L)Tj
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(P-)Tj
1.226 0 Td
(value)Tj
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(total)Tj
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(Non)Tj
2.1685 0 Td
(Hodgkin)Tj
4.2307 0 Td
(Lymphoma)Tj
/F2 1 Tf
5.315 0 Td
(,)Tj
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0.5103 0 Td
(n)Tj
0.8433 0 Td
(\(%\))Tj
/F0 1 Tf
11.5796 0 Td
(321)Tj
1.885 0 Td
(\(35\))Tj
9.2411 0 Td
(588)Tj
1.8779 0 Td
(\(64\))Tj
19.1624 0 Td
(909)Tj
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(Median)Tj
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(Age,)Tj
2.2748 0 Td
(\(IQR\))Tj
18.8931 0 Td
(46)Tj
1.3323 0 Td
(\(3952\))Tj
9.7938 0 Td
(63\(4972)Tj
4.1811 0 Td
(\))Tj
/F4 1 Tf
9.8505 0 Td
[( )]TJ
/F0 1 Tf
(0.001)Tj
7.0087 0 Td
(54)Tj
1.3323 0 Td
(\(4468\))Tj
-58.1461 -1.559 Td
(Female,)Tj
24.6474 0 Td
(54)Tj
1.3323 0 Td
(\(17\))Tj
9.7938 0 Td
(308)Tj
1.8779 0 Td
(\(52\))Tj
/F4 1 Tf
12.1537 0 Td
[( )]TJ
/F0 1 Tf
(0.001)Tj
7.0087 0 Td
(362)Tj
1.885 0 Td
(\(39.8\))Tj
-58.6988 -1.5662 Td
(HIV)Tj
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(transmis)Tj
3.7559 0 Td
(sion)Tj
2.0481 0 Td
(route)Tj
/F13 1 Tf
-7.6961 -1.5591 Td
(IDU)Tj
/F0 1 Tf
24.6474 0 Td
(63)Tj
1.3323 0 Td
(\(21\))Tj
/F13 1 Tf
-25.9797 -1.559 Td
(MSM)Tj
/F0 1 Tf
24.6474 0 Td
(55)Tj
1.3323 0 Td
(\(18\))Tj
/F13 1 Tf
-25.9797 -1.5662 Td
(Heterosexua)Tj
5.6268 0 Td
(l)Tj
/F0 1 Tf
19.0206 0 Td
(74)Tj
1.3323 0 Td
(\(24\))Tj
/F13 1 Tf
-25.9797 -1.5591 Td
(Other/unkno)Tj
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(wn)Tj
/F0 1 Tf
19.1765 0 Td
(114)Tj
1.885 0 Td
(\(37\))Tj
9.2411 0 Td
(588)Tj
1.8779 0 Td
(\(100\))Tj
-37.6514 -1.5661 Td
(HbsAg+)Tj
24.6474 0 Td
(23)Tj
1.3323 0 Td
(\(7\))Tj
/F13 1 Tf
-25.9797 -1.5591 Td
(Unknown)Tj
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24.6474 0 Td
(88)Tj
1.3323 0 Td
(\(27\))Tj
9.7938 0 Td
(588)Tj
1.8779 0 Td
(\(100\))Tj
-37.6514 -1.5661 Td
(HCVAb+)Tj
24.6474 0 Td
(80)Tj
1.3323 0 Td
(\(25\))Tj
/F13 1 Tf
-24.9805 -1.5591 Td
(Unknow)Tj
3.5787 0 Td
(n)Tj
/F0 1 Tf
20.0695 0 Td
(52)Tj
1.3323 0 Td
(\(16\))Tj
9.7938 0 Td
(588)Tj
1.8779 0 Td
(\(100\))Tj
-37.6514 -1.5662 Td
(IPI)Tj
/F5 1 Tf
[()]TJ
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2.0055 0 Td
(score)Tj
2.6575 0 Td
(\(n)Tj
1.1126 0 Td
(=)Tj
0.815 0 Td
(549\))Tj
/F13 1 Tf
-5.5914 -1.559 Td
(Low)Tj
/F0 1 Tf
23.6482 0 Td
(56)Tj
1.3323 0 Td
(\(17\))Tj
9.7938 0 Td
(149)Tj
1.8779 0 Td
(\(25\))Tj
12.7348 0 Td
(0.02)Tj
6.4276 0 Td
(205)Tj
1.885 0 Td
(\(23\))Tj
/F13 1 Tf
-57.6996 -1.5662 Td
(intermedia)Tj
4.6276 0 Td
(te)Tj
/F0 1 Tf
19.0206 0 Td
(98)Tj
1.3323 0 Td
(\(30\))Tj
9.7938 0 Td
(183)Tj
1.8779 0 Td
(\(31\))Tj
19.1624 0 Td
(281)Tj
1.885 0 Td
(\(31\))Tj
-57.6996 -1.559 Td
(High)Tj
23.6482 0 Td
(24)Tj
1.3323 0 Td
(\(7\))Tj
9.7938 0 Td
(39)Tj
1.3323 0 Td
(\(7\))Tj
19.708 0 Td
(63)Tj
1.3323 0 Td
(\(7\))Tj
-58.1461 -1.5662 Td
(Histotype)Tj
4.3724 0 Td
(\(n)Tj
1.1126 0 Td
(=)Tj
0.815 0 Td
(901\))Tj
/F13 1 Tf
-6.3 -1.5591 Td
(DLBCL)Tj
/F5 1 Tf
[()]TJ
/F0 1 Tf
24.6474 0 Td
(202\(65\))Tj
11.1261 0 Td
(559)Tj
1.8779 0 Td
(\(95\))Tj
/F4 1 Tf
12.1537 0 Td
[( )]TJ
/F0 1 Tf
(0.001)Tj
7.0087 0 Td
(761)Tj
1.885 0 Td
(\(84\))Tj
/F13 1 Tf
-58.6988 -1.5661 Td
(SNCCL)Tj
/F5 1 Tf
3.5929 0 Td
[()]TJ
/F13 1 Tf
(\(Burkitt)Tj
/F0 1 Tf
(,)Tj
/F13 1 Tf
5.3221 0 Td
(Burkitt-lik)Tj
4.089 0 Td
(e)Tj
/F0 1 Tf
(\))Tj
11.6434 0 Td
(84)Tj
1.3323 0 Td
(\(27\))Tj
9.7938 0 Td
(27)Tj
1.3323 0 Td
(\(5\))Tj
19.708 0 Td
(111)Tj
1.885 0 Td
(\(12\))Tj
/F13 1 Tf
-58.6988 -1.5591 Td
(IBL)Tj
/F0 1 Tf
()Tj
24.6474 0 Td
(21)Tj
1.3323 0 Td
(\(6\))Tj
9.7938 0 Td
(2)Tj
0.7795 0 Td
(\(0.3\))Tj
20.2608 0 Td
(23)Tj
1.3323 0 Td
(\(3\))Tj
/F13 1 Tf
-58.1461 -1.5661 Td
(PBL)Tj
/F0 1 Tf
()Tj
24.6474 0 Td
(6)Tj
0.7795 0 Td
(\(2\))Tj
10.3466 0 Td
(0)Tj
0.7795 0 Td
(\(0\))Tj
20.2608 0 Td
(6)Tj
0.7795 0 Td
(\(1\))Tj
-57.5933 -1.5591 Td
(First)Tj
2.1685 0 Td
(line)Tj
1.7716 0 Td
(chemothe)Tj
4.3583 0 Td
(rapy)Tj
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(\(n)Tj
1.1126 0 Td
(=)Tj
0.8149 0 Td
(868\))Tj
12.26 0 Td
(300)Tj
1.885 0 Td
(\(93\))Tj
9.2411 0 Td
(551)Tj
1.8779 0 Td
(\(94\))Tj
/F4 1 Tf
12.1537 0 Td
[( )]TJ
/F0 1 Tf
(0.001)Tj
7.0087 0 Td
(851)Tj
1.885 0 Td
(\(94\))Tj
-58.6988 -1.5662 Td
(SNC)Tj
2.9905 0 Td
(prophylaxis)Tj
5.2442 0 Td
(\(n)Tj
1.1126 0 Td
(=)Tj
0.8149 0 Td
(607\))Tj
14.4852 0 Td
(145)Tj
1.885 0 Td
(\(45\))Tj
9.2411 0 Td
(109)Tj
1.8779 0 Td
(\(18\))Tj
/F4 1 Tf
12.1537 0 Td
[( )]TJ
/F0 1 Tf
(0.001)Tj
7.0087 0 Td
(254)Tj
1.885 0 Td
(\(28\))Tj
-58.6988 -1.559 Td
(CHOP+,)Tj
3.9685 0 Td
(CHOP-l)Tj
3.4228 0 Td
(ike++)Tj
2.6646 0 Td
(regimen)Tj
3.5788 0 Td
(s)Tj
0.7299 0 Td
(\(n)Tj
1.1126 0 Td
(=)Tj
0.815 0 Td
(809\))Tj
8.3552 0 Td
(230)Tj
1.885 0 Td
(\(72\))Tj
9.2411 0 Td
(419)Tj
1.8779 0 Td
(\(71\))Tj
12.7348 0 Td
(0.001)Tj
6.4276 0 Td
(649)Tj
1.885 0 Td
(\(71\))Tj
-58.6988 -1.5662 Td
(Other)Tj
2.7212 0 Td
(regimens)Tj
4.3087 0 Td
(\(n)Tj
1.1126 0 Td
(=)Tj
0.815 0 Td
(909\))Tj
15.6899 0 Td
(82)Tj
1.3323 0 Td
(\(25\))Tj
9.7938 0 Td
(116)Tj
1.8779 0 Td
(\(20\))Tj
12.7348 0 Td
(0.04)Tj
6.4276 0 Td
(198)Tj
1.885 0 Td
(\(22\))Tj
-58.6988 -1.559 Td
(Use)Tj
1.9984 0 Td
(of)Tj
1.0559 0 Td
(rituximab)Tj
4.2591 0 Td
(\(n)Tj
1.1126 0 Td
(=)Tj
0.815 0 Td
(762\))Tj
15.4064 0 Td
(172)Tj
1.885 0 Td
(\(54\))Tj
9.2411 0 Td
(387)Tj
1.8779 0 Td
(\(66\))Tj
12.7348 0 Td
(0.001)Tj
6.4276 0 Td
(599)Tj
1.885 0 Td
(\(61\))Tj
/F12 1 Tf
-58.6988 -1.5662 Td
(Hodgkin's)Tj
5.0598 0 Td
(lymphom)Tj
4.4292 0 Td
(a)Tj
/F2 1 Tf
(,)Tj
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1.063 0 Td
(n)Tj
0.8433 0 Td
(\(%\))Tj
/F0 1 Tf
13.2521 0 Td
(145)Tj
1.885 0 Td
(\(32\))Tj
9.2411 0 Td
(278)Tj
1.8779 0 Td
(\(32\))Tj
19.1624 0 Td
(423)Tj
-56.8138 -1.5591 Td
(Median)Tj
3.4795 0 Td
(Age,)Tj
2.2748 0 Td
(\(IQR\))Tj
18.8931 0 Td
(46)Tj
1.3323 0 Td
(\(3952\))Tj
9.7938 0 Td
(63\(4972)Tj
4.1811 0 Td
(\))Tj
/F4 1 Tf
9.8505 0 Td
[( )]TJ
/F0 1 Tf
(0.001)Tj
7.0087 0 Td
(54)Tj
1.3323 0 Td
(\(4468\))Tj
-58.1461 -1.5661 Td
(Female,)Tj
24.6474 0 Td
(16)Tj
1.3323 0 Td
(\(11\))Tj
9.7938 0 Td
(140)Tj
1.8779 0 Td
(\(50\))Tj
/F4 1 Tf
12.1537 0 Td
[( )]TJ
/F0 1 Tf
(0.001)Tj
7.0087 0 Td
(156)Tj
1.885 0 Td
(\(37\))Tj
-58.6988 -1.5591 Td
(HIV)Tj
1.8921 0 Td
(transmis)Tj
3.7559 0 Td
(sion)Tj
2.0481 0 Td
(route)Tj
/F13 1 Tf
-7.6961 -1.5661 Td
(IDU)Tj
/F0 1 Tf
24.6474 0 Td
(23)Tj
1.3323 0 Td
(\(16.5\))Tj
/F13 1 Tf
-25.9797 -1.5591 Td
(MSM)Tj
/F0 1 Tf
24.6474 0 Td
(33)Tj
1.3323 0 Td
(\(24\))Tj
/F13 1 Tf
-25.9797 -1.5662 Td
(Heterosexua)Tj
5.6268 0 Td
(l)Tj
/F0 1 Tf
19.0206 0 Td
(42)Tj
1.3323 0 Td
(\(30\))Tj
/F13 1 Tf
-25.9797 -1.559 Td
(Other/unkno)Tj
5.4709 0 Td
(wn)Tj
/F0 1 Tf
19.1765 0 Td
(41)Tj
1.3323 0 Td
(\(29\))Tj
9.7938 0 Td
(278)Tj
1.8779 0 Td
(\(100\))Tj
-37.6514 -1.5662 Td
(HbsAg+)Tj
24.6474 0 Td
(14)Tj
1.3323 0 Td
(\(10\))Tj
/F13 1 Tf
-25.9797 -1.5591 Td
(Unknown)Tj
/F0 1 Tf
24.6474 0 Td
(36)Tj
1.3323 0 Td
(\(25\))Tj
9.7938 0 Td
(278)Tj
1.8779 0 Td
(\(100\))Tj
-37.6514 -1.5661 Td
(HCVAb+)Tj
24.6474 0 Td
(35)Tj
1.3323 0 Td
(\(24\))Tj
/F13 1 Tf
-25.9797 -1.5591 Td
(Unknown)Tj
/F0 1 Tf
24.6474 0 Td
(14)Tj
1.3323 0 Td
(\(10\))Tj
9.7938 0 Td
(278)Tj
1.8779 0 Td
(\(100\))Tj
-37.6514 -1.559 Td
(Histotype)Tj
4.3724 0 Td
(\(n)Tj
1.1126 0 Td
(=)Tj
0.815 0 Td
(422\))Tj
/F13 1 Tf
-6.3 -1.5662 Td
(Nodular)Tj
3.6992 0 Td
(sclerosin)Tj
3.9118 0 Td
(g)Tj
/F0 1 Tf
17.0364 0 Td
(32\(22\))Tj
11.1261 0 Td
(195)Tj
1.8779 0 Td
(\(70\))Tj
/F4 1 Tf
12.1537 0 Td
[( )]TJ
/F0 1 Tf
(0.001)Tj
7.0087 0 Td
(227)Tj
1.885 0 Td
(\(54\))Tj
/F13 1 Tf
-58.6988 -1.5591 Td
(Mixed)Tj
2.8771 0 Td
(cellular)Tj
/F0 1 Tf
21.7703 0 Td
(51)Tj
1.3323 0 Td
(\(35\))Tj
9.7938 0 Td
(15)Tj
1.3323 0 Td
(\(5\))Tj
19.708 0 Td
(66)Tj
1.3323 0 Td
(\(16\))Tj
/F13 1 Tf
-58.1461 -1.5661 Td
(Lymphocyt)Tj
4.8047 0 Td
(e-depleted)Tj
/F0 1 Tf
19.8427 0 Td
(4)Tj
0.7795 0 Td
(\(3\))Tj
10.3466 0 Td
(5)Tj
0.7795 0 Td
(\(2\))Tj
20.2608 0 Td
(9)Tj
0.7795 0 Td
(\(2\))Tj
/F13 1 Tf
-57.5933 -1.5591 Td
(Lymphocyt)Tj
4.8047 0 Td
(e-rich)Tj
/F0 1 Tf
19.8427 0 Td
(7)Tj
0.7795 0 Td
(\(5\))Tj
10.3466 0 Td
(15)Tj
1.3323 0 Td
(\(5\))Tj
19.708 0 Td
(22)Tj
1.3323 0 Td
(\(5\))Tj
/F13 1 Tf
-58.1461 -1.5661 Td
(unspecifi)Tj
3.9118 0 Td
(ed)Tj
/F0 1 Tf
20.7356 0 Td
(50)Tj
1.3323 0 Td
(\(34\))Tj
9.7938 0 Td
(48)Tj
1.3323 0 Td
(\(17\))Tj
19.708 0 Td
(98)Tj
1.3323 0 Td
(\(23\))Tj
-58.1461 -1.5591 Td
(Ann)Tj
1.9984 0 Td
(Arbor)Tj
2.6575 0 Td
(stage)Tj
2.6575 0 Td
(\(n)Tj
1.1126 0 Td
(=)Tj
0.815 0 Td
(405\))Tj
52.9799 -1.8142 Td
(\()Tj
/F13 1 Tf
(Continue)Tj
4.2945 0 Td
(d)Tj
/F0 1 Tf
0.652 0 Td
(\))Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 443.0551 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Survival)Tj
3.7134 0 Td
(in)Tj
0.9779 0 Td
(HIV-assoc)Tj
4.5426 0 Td
(iated)Tj
2.3457 0 Td
(lymphomas)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
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