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Article

Abalkhail, H; Mitchell, J; Habgood, J; Orrell, R; de Belleroche, J; (2003) A new familial amyotrophic lateral sclerosis locus on chromosome 16q12.1-16q12.2. Am J Hum Genet , 73 (2) pp. 383-389. 10.1086/377156.

Abhinav, K; Stanton, B; Johnston, C; Hardstaff, J; Orrell, RW; Howard, R; Clarke, J; (2007) Amyotrophic lateral sclerosis in south-east England: A population-based study - The south-east England register for amyotrophic lateral sclerosis (SEALS registry). NEUROEPIDEMIOLOGY , 29 (1-2) 44 - 48. 10.1159/000108917.

Ahmad-Annuar, A; Shah, P; Hafezparast, M; Hummerich, H; Witherden, AS; Morrison, KE; Shaw, PJ; (2003) No association with common Caucasian genotypes in exons 8, 13 and 14 of the human cytoplasmic dynein heavy chain gene (DNCHC1) and familial motor neuron disorders. AMYOTROPH LATERAL SC , 4 (3) 150 - 157.

Al-Chalabi, A; Calvo, A; Chio, A; Colville, S; Ellis, CM; Hardiman, O; Heverin, M; (2014) Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study. Lancet Neurol , 13 (11) pp. 1108-1113. 10.1016/S1474-4422(14)70219-4.

Ates, K; Yang, SY; Orrell, RW; Sinanan, ACM; Simons, P; Solomon, A; Beech, S; (2007) The IGF-I splice variant MGF increases progenitor cells in ALS, dystrophic, and normal muscle. FEBS LETT , 581 (14) 2727 - 2732. 10.1016/j.febslet.2007.05.030.

Bajaj, NPS; Waldman, A; Orrell, R; Wood, NW; Bhatia, KP; (2002) Familial adult onset of Krabbe's disease resembling hereditary spastic paraplegia with normal neuroimaging. J NEUROL NEUROSUR PS , 72 (5) 635 - 638.

Banerji, CR; Knopp, P; Moyle, LA; Severini, S; Orrell, RW; Teschendorff, AE; Zammit, PS; (2015) β-Catenin is central to DUX4-driven network rewiring in facioscapulohumeral muscular dystrophy. J R Soc Interface , 12 (102) 20140797-.

Bartolome, F; Wu, HC; Burchell, VS; Preza, E; Wray, S; Mahoney, CJ; Fox, NC; (2013) Pathogenic VCP Mutations Induce Mitochondrial Uncoupling and Reduced ATP Levels. Neuron , 78 (1) pp. 57-64. 10.1016/j.neuron.2013.02.028.

Bartolome, F; Wu, HC; Burchell, VS; Preza, E; Wray, S; Mahoney, CJ; Fox, NC; (2013) Pathogenic VCP mutations induce mitochondrial uncoupling and reduced ATP levels. Neuron , 78 (1) 57 - 64. 10.1016/j.neuron.2013.02.028. Green open access
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Beck, J; Poulter, M; Hensman, D; Rohrer, JD; Mahoney, CJ; Adamson, G; Campbell, T; (2013) Large C9orf72 hexanucleotide repeat expansions are seen in multiple neurodegenerative syndromes and are more frequent than expected in the UK population. Am J Hum Genet , 92 (3) 345 - 353. 10.1016/j.ajhg.2013.01.011.

Beck, J; Poulter, M; Hensman, D; Rohrer, JD; Mahoney, CJ; Adamson, G; Campbell, T; (2013) Large C9orf72 hexanucleotide repeat expansions are seen in multiple neurodegenerative syndromes and are more frequent than expected in the UK population. Am J Hum Genet , 92 (3) pp. 345-353. 10.1016/j.ajhg.2013.01.011.

Bennett, DLH; Groves, M; Blake, J; Holton, JL; King, RHM; Orrell, RW; Ginsberg, L; (2008) The use of nerve and muscle biopsy in the diagnosis of vasculitis: a 5 year retrospective study. J NEUROL NEUROSUR PS , 79 (12) 1376 - 1381.

Bradley, LJ; Muddle, JR; Taanman, JW; Orrell, R; (2003) Investigation of intercellular differences of mitochondrial protein expression in amyotrophic lateral sclerosis. ALS and other Motor Neuron Disorders , 4S1 pp. 87-88.

Bradley, LJ; Taanman, JW; Kallis, C; Orrell, RW; (2009) Increased sensitivity of myoblasts to oxidative stress in amyotrophic lateral sclerosis peripheral tissues. EXP NEUROL , 218 (1) 92 - 97. 10.1016/j.expneurol.2009.04.007.

Bradley, LJ; Taanman, JW; Kallis, C; Orrell, RW; (2009) Increased sensitivity of myoblasts to oxidative stress in amyotrophic lateral sclerosis peripheral tissues. Experimental Neurology , 218 (1) pp. 92-97. 10.1016/j.expneurol.2009.04.007.

Bradley, LJ; Wilhelm, T; King, RHM; Ginsberg, L; Orrell, RW; (2006) Brachial plexus hypertrophy in chronic inflammatory demyelinating polyradiculoneuropathy. NEUROMUSCULAR DISORD , 16 (2) 126 - 131. 10.1016/j.nmd.2005.11.006.

Bradley, M; Bradley, L; de Belleroche, J; Orrell, RW; (2005) Patterns of inheritance in familial ALS. NEUROLOGY , 64 (9) 1628 - 1631.

Bradley, M.; Bradley, L.; de Belleroche, J.; Orrell, R.W.; (2005) Patterns of inheritance in familial ALS. Neurology , 64 (9) pp. 1628-1631. 10.1212/01.WNL.0000160395.43761.AC.

Bradley, MD; Orrell, RW; Clarke, J; Davidson, AC; Williams, AJ; Kullmann, DM; Hirsch, N; (2002) Outcome of ventilatory support for acute respiratory failure in motor neurone disease. J NEUROL NEUROSUR PS , 72 (6) 752 - 756.

Canepari, M; Rossi, R; Pellegrino, MA; Orrell, RW; Cobbold, M; Harridge, S; Bottinelli, R; (2005) Effects of resistance training on myosin function studied by the in vitro motility assay in young and older men. J APPL PHYSIOL , 98 (6) 2390 - 2395. 10.1152/japplphysiol.01103.2004.

Chio, A; Schymick, JC; Restagno, G; Scholz, SW; Lombardo, F; Lai, SL; Mora, G; (2009) A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis. HUM MOL GENET , 18 (8) 1524 - 1532. 10.1093/hmg/ddp059.

Ciccarelli, O; Behrens, TE; Altmann, DR; Orrell, RW; Howard, RS; Johansen-Berg, H; Miller, DH; (2006) Probabilistic diffusion tractography: a potential tool to assess the rate of disease progression in amyotrophic lateral sclerosis. BRAIN , 129 1859 - 1871. 10.1093/brain/awl100.

Ciccarelli, O; Behrens, TE; Johansen-Berg, H; Talbot, K; Orrell, RW; Howard, RS; Nunes, RG; (2009) Investigation of White Matter Pathology in ALS and PLS Using Tract-Based Spatial Statistics. HUM BRAIN MAPP , 30 (2) 615 - 624. 10.1002/hbm.20527.

Demestre, M; Howard, RS; Orrell, RW; Pullen, AH; (2006) Serine proteases purified from sera of patients with amyotrophic lateral sclerosis (ALS) induce contrasting cytopathology in murine motoneurones to IgG. NEUROPATH APPL NEURO , 32 (2) 141 - 156. 10.1111/j.1365-2990.2006.00712.x.

Demestre, M; Pullen, A; Orrell, RW; Orth, M; (2005) ALS-IgG-induced selective motor neurone apoptosis in rat mixed primary spinal cord cultures. J NEUROCHEM , 94 (1) 268 - 275. 10.1111/j.1471-4159.2005.03184.x.

Docherty, RJ; Ginsberg, L; Jadoon, S; Orrell, RW; Bhattacharjee, A; (2013) TRPA1 insensitivity of human sural nerve axons after exposure to lidocaine. Pain , 154 (9) pp. 1569-1577. 10.1016/j.pain.2013.04.030.

Docherty, RJ; Ginsberg, L; Jadoon, S; Orrell, RW; Bhattacharjee, A; (2013) TRPA1 insensitivity of human sural nerve axons after exposure to lidocaine. Pain , 154 (9) pp. 1569-1577. 10.1016/j.pain.2013.04.030.

ENAYAT, ZE; ORRELL, RW; CLAUS, A; LUDOLPH, A; BACHUS, R; BROCKMULLER, J; RAYCHAUDHURI, K; (1995) 2 NOVEL MUTATIONS IN THE GENE FOR COPPER-ZINC SUPEROXIDE-DISMUTASE IN UK FAMILIES WITH AMYOTROPHIC-LATERAL-SCLEROSIS. HUM MOL GENET , 4 (7) 1239 - 1240.

Evans, RM; Harridge, SD; Velloso, CP; Yang, SY; Goldspink, G; Orrell, RW; (2010) Investigation of MGF mRNA expression in patients with amyotrophic lateral sclerosis using parallel in vivo and in vitro approaches. Amyotroph Lateral Scler , 11 (1-2) pp. 172-177. 10.3109/17482960903089775.

Evans, RM; Harridge, SDR; Velloso, CP; Yang, SY; Goldspink, G; Orrell, RW; (2010) Investigation of MGF mRNA expression in patients with amyotrophic lateral sclerosis using parallel in vivo and in vitro approaches. AMYOTROPH LATERAL SC , 11 (1-2) 172 - 177. 10.3109/17482960903089775.

Figlewicz, DA; Orrell, RW; (2003) The genetics of motor neuron diseases. AMYOTROPH LATERAL SC , 4 (4) 225 - 231. 10.1080/14660820310011287.

Fratta, P; Charnock, J; Collins, T; Devoy, A; Howard, R; Malaspina, A; Orrell, R; (2013) Profilin1 E117G is a moderate risk factor for amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry , 85 pp. 506-508. 10.1136/jnnp-2013-306761. Green open access
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Fratta, P; Polke, JM; Newcombe, J; Mizielinska, S; Lashley, T; Poulter, M; Beck, J; (2015) Screening a UK amyotrophic lateral sclerosis cohort provides evidence of multiple origins of the C9orf72 expansion. Neurobiology of Aging , 36 (1) 546.e1-546.e7. 10.1016/j.neurobiolaging.2014.07.037. Green open access
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Ginsberg, L; King, R; Orrell, R; (2003) Nerve biopsy. Practical Neurology , 3 (5) pp. 306-313.

Ginsberg, L; King, RHM; Orrell, R; (2003) Nerve biopsy - how to do it. Practical Neurology , 3 (3) 306 - 313.

Ginsberg, L; Malik, O; Kenton, AR; Sharp, D; Muddle, JR; Davis, MB; Winer, JB; (2004) Coexistent hereditary and inflammatory neuropathy. Brain , 127 (Pt 1) pp. 193-202. 10.1093/brain/awh017.

Ginsberg, L; Malik, O; Kenton, AR; Sharp, D; Muddle, JR; Davis, MB; Winer, JB; (2004) Coexistent hereditary and inflammatory neuropathy. BRAIN , 127 193 - 202. 10.1093/brain/awh017.

Hameed, M; Orrell, RW; Cobbold, M; Goldspink, G; Harridge, SDR; (2003) Erratum: (Journal of Physiology (2003) vol. 547 (247-254)). Journal of Physiology , 549 (3) p. 995. 10.1113/jphysiol.2003.549001.

Hameed, M; Orrell, RW; Cobbold, M; Goldspink, G; Harridge, SDR; (2003) Expression of IGF-I splice variants in young and old human skeletal muscle after high resistance exercise (vol 547, pg 247, 2003). J PHYSIOL-LONDON , 549 (3) 995 - 995. 10.1113/jphysiol.2003.594001.

Hameed, M; Orrell, RW; Cobbold, M; Goldspink, G; Harridge, SDR; (2003) Expression of IGF-I splice variants in young and old human skeletal muscle after high resistance exercise. J PHYSIOL-LONDON , 547 (1) 247 - 254. 10.1113/jphysiol.2002.032136.

Hobson, EV; McGeachan, A; Al-Chalabi, A; Chandran, S; Crawley, F; Dick, D; Donaghy, C; (2013) Management of sialorrhoea in motor neuron disease: a survey of current UK practice. Amyotroph Lateral Scler Frontotemporal Degener , 14 (7-8) pp. 521-527. 10.3109/21678421.2013.790452.

Hosler, BA; Nicholson, GA; Sapp, PC; Chin, W; Orrell, RW; DeBelleroche, JS; Esteban, J; (1996) Three novel mutations and two variants in the gene for Cu/Zn superoxide dismutase in familial amyotrophic lateral sclerosis. NEUROMUSCULAR DISORD , 6 (5) 361 - 366.

Houlden, H; King, RHM; Muddle, JR; Warner, TT; Reilly, MM; Orrell, RW; Ginsberg, L; (2004) A novel RAB7 mutation associated with ulcero-mutilating neuropathy. ANN NEUROL , 56 (4) 586 - 590. 10.1002/ana.20281.

Houlden, H; Lincoln, S; Farrer, M; Cleland, PG; Hardy, J; Orrell, RW; (2003) Compound heterozygous PANK2 mutations confirm HARP and Hallervorden-Spatz syndromes are allelic. NEUROLOGY , 61 (10) 1423 - 1426.

Howard, RS; Orrell, RW; (2002) Management of motor neurone disease. POSTGRAD MED J , 78 (926) 736 - 741.

Irani, SR; Mathias, CJ; Orrell, RW; (2007) Pure autonomic failure followed by amyotrophy. NEUROLOGY , 68 (10) 792 - 793.

Johnson, JO; Pioro, EP; Boehringer, A; Chia, R; Feit, H; Renton, AE; Pliner, HA; (2014) Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis. Nature Neuroscience , 17 (5) pp. 664-666. 10.1038/nn.3688.

Johnson, JO; Pioro, EP; Boehringer, A; Chia, R; Feit, H; Renton, AE; Pliner, HA; (2014) Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis. Nat Neurosci , 17 (5) pp. 664-666. 10.1038/nn.3688.

Kasperaviciute, D; Weale, ME; Shianna, KV; Banks, GT; Simpson, CL; Hansen, VK; Turner, MR; (2007) Large-scale pathways-based association study in amyotrophic lateral sclerosis. BRAIN , 130 2292 - 2301. 10.1093/brain/awm055.

Kearney, M; Orrell, RW; Fahey, M; Pandolfo, M; (2012) Antioxidants and other pharmacological treatments for Friedreich ataxia. COCHRANE DATABASE OF SYSTEMATIC REVIEWS (4) 10.1002/14651858.CD007791.pub3.

Kearney, M; Orrell, RW; Fahey, M; Pandolfo, M; (2009) Antioxidants and other pharmacological treatments for Friedreich ataxia. COCHRANE DB SYST REV (4) , Article CD007791. 10.1002/14651858.CD007791.pub2.

Kimber, TE; Orrel, RW; King, RHM; Ginsberg, L; (2003) Pathological findings in a patient with ventilatory failure and chronic inflammatory demyelinating polyneuropathy. J PERIPHER NERV SYST , 8 (1) 13 - 16.

Lacomblez, L; Bensimon, G; Leigh, PN; Guillet, P; Meininger, V; for, TALSRSGII; (1996) Dose-ranging study of riluzole in amyotrophic lateral sclerosis. The Lancet , 347 (9013) pp. 1425-1431.

Lane, R; Carey, N; Orrell, R; Moxley, RT; (1997) Claude Monet's vision. Lancet , 349 (9053) 734-. 10.1016/S0140-6736(05)60177-8.

Lane, RJ; Roncaroli, F; Charles, P; McGonagle, DG; Orrell, RW; (2012) Acetylcholine receptor antibodies in patients with genetic myopathies: clinical and biological significance. Neuromuscul Disord , 22 (2) pp. 122-128. 10.1016/j.nmd.2011.06.751.

Lu, CH; Petzold, A; Topping, J; Allen, K; Macdonald-Wallis, C; Clarke, J; Pearce, N; (2015) Plasma neurofilament heavy chain levels and disease progression in amyotrophic lateral sclerosis: Insights from a longitudinal study. Journal of Neurology, Neurosurgery and Psychiatry , 86 (5) pp. 565-573. 10.1136/jnnp-2014-307672.

Lu, CH; Petzold, A; Topping, J; Allen, K; Macdonald-Wallis, C; Clarke, J; Pearce, N; (2014) Plasma neurofilament heavy chain levels and disease progression in amyotrophic lateral sclerosis: insights from a longitudinal study. Journal of Neurology, Neurosurgery & Psychiatry 10.1136/jnnp-2014-307672. Green open access
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Majounie, E; Renton, AE; Mok, K; Dopper, EG; Waite, A; Rollinson, S; Chiò, A; (2012) Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study. Lancet Neurology , 11 (4) 323 - 330. 10.1016/S1474-4422(12)70043-1. Green open access
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Majumdar, A; Hartley, L; Manzur, AY; King, RHM; Orrell, RW; Muntoni, F; (2004) A case of severe congenital chronic inflammatory demyelinating polyneuropathy with complete spontaneous remission. NEUROMUSCULAR DISORD , 14 (12) 818 - 821. 10.1016/j.nmd.2004.09.003.

Manjaly, ZR; Scott, KM; Abhinav, K; Wijesekera, L; Ganesalingam, J; Goldstein, LH; Janssen, A; (2010) The sex ratio in amyotrophic lateral sclerosis: A population based study. AMYOTROPH LATERAL SC , 11 (5) 439 - 442. 10.3109/17482961003610853.

Meininger, V; Pradat, PF; Corse, A; Al-Sarraj, S; Rix Brooks, B; Caress, JB; Cudkowicz, M; (2014) Safety, pharmacokinetic, and functional effects of the nogo-a monoclonal antibody in amyotrophic lateral sclerosis: a randomized, first-in-human clinical trial. PLoS One , 9 (5) , Article e97803. 10.1371/journal.pone.0097803.

Mitchell, J; Habgood, JJ; Orrell, RW; Kaushik, N; Malaspina, A; Gardiner, IM; Greenwood, JS; (2000) Identifying gene defects in motor neurone disease /amyotrophic lateral sclerosis families that lack Cu/Zn superoxide dismutase mutations. EUR J NEUROSCI , 12 226 - 226.

Mok, K; Laaksovirta, H; Tienari, PJ; Peuralinna, T; Myllykangas, L; Chiò, A; Traynor, BJ; (2013) Homozygosity analysis in amyotrophic lateral sclerosis. European Journal of Human Genetics , 21 (12) 1429 - 1435. 10.1038/ejhg.2013.59.

Mok, K; Traynor, BJ; Schymick, J; Tienari, PJ; Laaksovirta, H; Peuralinna, T; Myllykangas, L; (2012) Chromosome 9 ALS and FTD locus is probably derived from a single founder. Neurobiology of Disease , 33 (1) 209.e3 - 209.e8. 10.1016/j.neurobiolaging.2011.08.005. Green open access
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Morgan, S; Shoai, M; Fratta, P; Sidle, K; Orrell, R; Sweeney, MG; Shatunov, A; (2015) Investigation of next-generation sequencing technologies as a diagnostic tool for amyotrophic lateral sclerosis. Neurobiology of Aging , 36 (3) 1600.e5-1600.e8. 10.1016/j.neurobiolaging.2014.12.017.

Morgan, S; Shoai, M; Fratta, P; Sidle, K; Orrell, R; Sweeney, MG; Shatunov, A; (2015) Investigation of next-generation sequencing technologies as a diagnostic tool for amyotrophic lateral sclerosis. Neurobiol Aging , 36 (3) 1600.e5-1600.e8. 10.1016/j.neurobiolaging.2014.12.017.

ORRELL, RW; (1991) SODIUM VALPROATE IN PREGNANCY. BRIT MED J , 303 (6793) 56 - 56.

ORRELL, RW; AMROLIA, PJ; HEALD, A; CLELAND, PG; OWEN, JS; MORGANHUGHES, JA; HARDING, AE; (1995) ACANTHOCYTOSIS, RETINITIS-PIGMENTOSA, AND PALLIDAL DEGENERATION - A REPORT OF 3 PATIENTS, INCLUDING THE 2ND REPORTED CASE WITH HYPOPREBETALIPOPROTEINEMIA (HARP-SYNDROME). NEUROLOGY , 45 (3) 487 - 492.

ORRELL, RW; DEBELLEROCHE, J; MARKLUND, SL; BOWE, FA; HALLEWELL, RA; (1995) TOXIC MUTANTS IN CHARCOTS SCLEROSIS - REPLY. NATURE , 378 (6555) 343 - 343.

ORRELL, RW; DEBELLEROCHE, JS; (1994) SUPEROXIDE-DISMUTASE AND ALS. LANCET , 344 (8938) 1651 - 1652.

ORRELL, RW; GUTHRIE, JA; LAMB, JT; (1991) NOSE-BLOWING AND CSF RHINORRHEA. LANCET , 337 (8744) 804 - 804.

ORRELL, RW; JAMESGALTON, M; STEVENS, JM; ROSSOR, MN; (1995) CEREBRAL ACHROMATOPSIA AS A PRESENTATION OF TROUSSEAUS-SYNDROME. POSTGRAD MED J , 71 (831) 44 - 46.

ORRELL, RW; JOHNSON, MH; (1993) PLASMA VISCOSITY AND THE DIAGNOSIS OF GIANT-CELL ARTERITIS. BRIT J CLIN PRACT , 47 (2) 71 - 72.

ORRELL, RW; KING, AW; DEBELLEROCHE, JS; (1995) PARENTAL INFLUENCE ON INHERITANCE OF FAMILIAL AMYOTROPHIC-LATERAL-SCLEROSIS. LANCET , 345 (8946) 391 - 392.

ORRELL, RW; KING, AW; HILTON, DA; CAMPBELL, MJ; LANE, RJM; DEBELLEROCHE, JS; (1995) FAMILIAL AMYOTROPHIC-LATERAL-SCLEROSIS WITH A POINT MUTATION OF SOD-1 - INTRAFAMILIAL HETEROGENEITY OF DISEASE DURATION ASSOCIATED WITH NEUROFIBRILLARY TANGLES. J NEUROL NEUROSUR PS , 59 (3) 266 - 270.

ORRELL, RW; KING, AW; LANE, RJM; DEBELLEROCHE, JS; (1995) INVESTIGATION OF A NULL MUTATION OF THE CNTF GENE IN FAMILIAL AMYOTROPHIC-LATERAL-SCLEROSIS. J NEUROL SCI , 132 (2) 126 - 128.

ORRELL, RW; LANE, RJM; GUILOFF, RJ; (1994) RECENT DEVELOPMENTS IN THE DRUG-TREATMENT OF MOTOR-NEURON DISEASE. BRIT MED J , 309 (6948) 140 - 141.

ORRELL, RW; LANE, RJM; MAITLAND, J; LESLIE, RDG; (1994) ANTIBODIES TO GLUTAMIC-ACID DECARBOXYLASE AS PREDICTORS OF INSULIN-DEPENDENT DIABETES-MELLITUS - REPLY. LANCET , 344 (8917) 267 - 267.

ORRELL, RW; LILFORD, RJ; (1990) CHORIONIC VILLUS SAMPLING AND RARE SIDE-EFFECTS - WILL A RANDOMIZED CONTROLLED TRIAL DETECT THEM. INT J GYNECOL OBSTET , 32 (1) 29 - 34.

ORRELL, RW; MARSDEN, CD; (1994) THE NECK-TONGUE SYNDROME. J NEUROL NEUROSUR PS , 57 (3) 348 - 352.

ORRELL, RW; OMER, S; BURT, AA; GALVIN, MC; (1991) PSEUDOTUMOR CEREBRI AND PARAPROTEINEMIA. LEUKEMIA LYMPHOMA , 5 (2-3) 211 - 213.

ORRELL, RW; TROMANS, AM; BURT, AA; (1991) MYOTONIC-DYSTROPHY AND TRAUMATIC QUADRIPLEGIA - CASE-REPORT. PARAPLEGIA , 29 (6) 419 - 422.

ORRELL, RW; WOODROW, DF; BARRETT, MC; PRESS, M; DICK, DJ; ROWE, RCG; LANE, RJM; (1995) TESTOSTERONE DEFICIENCY MYOPATHY. J ROY SOC MED , 88 (8) 454 - 456.

Orrell, R; (1997) Amyotrophic Lateral Sclerosis. Neuromuscular Disorders , 7 pp. 71-72.

Orrell, R; (1996) Amyotrophic Lateral Sclerosis. Lancet , 348 p. 1227.

Orrell, R; Schapira, AH; (2002) Mitochondria and amyotrophic lateral sclerosis. International Review of Neurobiology , 53 pp. 411-424.

Orrell, R; de Belleroche, J; Marklund, S; Bowe, F; Hallewell, R; (1995) A novel SOD mutant and ALS. Nature , 374 (6522) pp. 504-505. 10.1038/374504a0.

Orrell, RW; (2012) Diagnosing and managing muscular dystrophy. Practitioner , 256 (1754) pp. 21-3.

Orrell, RW; (2011) GPs have key role in managing motor neurone disease. Practitioner , 255 (1743) pp. 19-2.

Orrell, RW; (2011) Facioscapulohumeral dystrophy and scapuloperoneal syndromes. Handb Clin Neurol , 101 pp. 167-180. 10.1016/B978-0-08-045031-5.00013-X.

Orrell, RW; (2010) What is the clinical significance of SOD1 mutations in amyotrophic lateral sclerosis? J NEUROL NEUROSUR PS , 81 (5) 473 - 473. 10.1136/jnnp.2010.205575.

Orrell, RW; (2010) Motor neuron disease: systematic reviews of treatment for ALS and SMA. BRIT MED BULL , 93 (1) 145 - 159. 10.1093/bmb/ldp049.

Orrell, RW; (2010) What is the clinical significance of SOD1 mutations in amyotrophic lateral sclerosis? Journal of Neurology, Neurosurgery and Psychiatry , 81 (5) 473-.

Orrell, RW; (2007) Understanding the causes of amyotrophic lateral sclerosis. NEW ENGL J MED , 357 (8) 822 - 823. 10.1056/NEJMe078146.

Orrell, RW; (2007) Book review. Palliative care in amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery and Pschiatry , 78 778-. 10.1136/jnnp.2007.115808.

Orrell, RW; (2006) AEOL-10150 (Aeolus). Curr Opin Investig Drugs , 7 (1) pp. 70-80.

Orrell, RW; (2006) AEOL-10150 aeolus. CURR OPIN INVEST DR , 7 (1) 70 - 80.

Orrell, RW; (2005) Book review. Atlas of neuromuscular disorders. Journal of Neurology, Neurosurgery and Psychiatry , 76 1312-. 10.1136/jnnp.2005.65920.

Orrell, RW; (2005) Book review. Multiple Sclerosis: the history of a disease. Journal of the Royal Society of Medicine , 98 (6) p. 289.

Orrell, RW; (2004) Book review. Fascioscapulohumeral dystrophy. Neuromuscular Disorders , 14 (11) p. 775. 10.1016/j.nmd.2004.07.001.

Orrell, RW; (2004) Facioscapulohumeral dystrophy. Practical Neurology , 4 (4) pp. 238-241.

Orrell, RW; (2004) Book review. Neurological therapeutics: principles and practice. Volumes I and II. Brain , 127 (6) pp. 1456-1457. 10.1093/brain/awh122.

Orrell, RW; (2000) Amyotrophic lateral sclerosis: copper/zinc superoxide dismutase (SOD1) gene mutations. NEUROMUSCULAR DISORD , 10 (1) 63 - 68.

Orrell, RW; (1999) Book review: Cell transplantation for neurological disorders. Brain , 122 (9) pp. 1791-1792. 10.1093/brain/122.9.1791.

Orrell, RW; (1996) Grand rounds--Hammersmith Hospitals. Distinguishing acute disseminated encephalomyelitis from multiple sclerosis. BMJ , 313 (7060) pp. 802-804.

Orrell, RW; (1995) The genetics of motor neuron disease. Current Medical Literature - Neurology and Neurosurgery , 11 pp. 95-102.

Orrell, RW; Motor Neuron Disease: Systematic reviews of treatment for ALS and SMA. British Medical Bulletin. British Medical Bulletin

Orrell, RW; Clark, AJL; (2002) ALADIN, but where's the Genie? NEUROLOGY , 58 (6) 847 - 848.

Orrell, RW; Copeland, S; Rose, MR; (2010) Scapular fixation in muscular dystrophy. COCHRANE DB SYST REV (1) , Article CD003278. 10.1002/14651858.CD003278.pub2.

Orrell, RW; De Belleroche, J; Marklund, SL; Bowe, FA; Hallewell, RA; (1995) Toxic mutants in Charcot's sclerosis [8]. Nature , 378 (6555) 343-.

Orrell, RW; Figlewicz, DA; (2001) Clinical implications of the genetics of ALS and other motor neuron diseases. NEUROLOGY , 57 (1) 9 - 17.

Orrell, RW; Habgood, J; Rudge, P; Lane, RJM; deBelleroche, JS; (1996) Difficulties in distinguishing sporadic from familial amyotrophic lateral sclerosis. ANN NEUROL , 39 (6) 810 - 812.

Orrell, RW; Habgood, JJ; Gardiner, I; King, AW; Bowe, FA; Hallewell, RA; Marklund, SL; (1997) Clinical and functional investigation of 10 missense mutations and a novel frameshift insertion mutation of the gene for copper-zinc superoxide dismutase in UK families with amyotrophic lateral sclerosis. NEUROLOGY , 48 (3) 746 - 751.

Orrell, RW; Habgood, JJ; Malaspina, A; Mitchell, J; Greenwood, J; Lane, RJM; deBelleroche, JS; (1999) Clinical characteristics of SOD1 gene mutations in UK families with ALS. JOURNAL OF THE NEUROLOGICAL SCIENCES , 169 (1-2) 56 - 60.

Orrell, RW; Habgood, JJ; Shepherd, DI; Donnai, D; deBelleroche, J; (1997) A novel mutation of SOD-1 (Gly 108 Val) in familial amyotrophic lateral sclerosis. EUR J NEUROL , 4 (1) 48 - 51.

Orrell, RW; Habgood, JJ; deBelleroche, JS; Lane, RJM; (1997) The relationship of spinal muscular atrophy to motor neuron disease: Investigation of SMN and NAIP gene deletions in sporadic and familial ALS. J NEUROL SCI , 145 (1) 55 - 61.

Orrell, RW; Johnston, HM; Gibson, C; Cass, RM; Griggs, RC; (1998) Spontaneous abdominal hematoma in dermatomyositis. Muscle Nerve , 21 (12) pp. 1800-1803.

Orrell, RW; Jurkat-Rott, K; Lehmann-Horn, F; Lane, RJM; (1998) Familial cramp due to potassium-aggravated myotonia. J NEUROL NEUROSUR PS , 65 (4) 569 - 572.

Orrell, RW; King, R; Bowler, JV; Ginsberg, L; (2003) Peripheral nerve granuloma in a patient with tuberculosis. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY , 74 (3) 410 - 410.

Orrell, RW; King, RHM; Bowler, JV; Ginsberg, L; (2002) Peripheral nerve granuloma in a patient with tuberculosis. J NEUROL NEUROSUR PS , 73 (6) 769 - 771.

Orrell, RW; Lane, JM; Ross, MA; (2005) Antioxidant treatment for amyotrophic lateral sclerosis / motor neuron disease. Cochrane Database Syst Rev. 2004 Oct 18;(4):CD002829. Review. Update in:. Cochrane Database of Systematic Reviews (1) CD002829-.

Orrell, RW; Lane, JM; Ross, MA; (2004) Antioxidant treatment for amyotrophic lateral sclerosis / motor neuron disease. Cochrane database of systematic reviews (Online) (4) CD002829-.

Orrell, RW; Lane, JM; Ross, MA; (2004) Antioxidant treatment for amyotrophic lateral sclerosis / motor neuron disease. Cochrane Database Syst Rev (4) CD002829-. 10.1002/14651858.CD002829.pub2.

Orrell, RW; Lane, RJ; Maitland, J; Leslie, RD; (1994) Antibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus. Lancet , 344 (8917) 267-.

Orrell, RW; Lane, RJ; Ross, M; (2007) Antioxidant treatment for amyotrophic lateral sclerosis / motor neuron disease. Cochrane database of systematic reviews (Online) (1) CD002829-.

Orrell, RW; Lane, RJM; Ross, M; (2008) A systematic review of antioxidant treatment for amyotrophic lateral sclerosis/motor neuron disease. AMYOTROPH LATERAL SC , 9 (4) 195 - 211. 10.1080/17482960801900032.

Orrell, RW; Lane, RJM; Ross, M; (2007) Antioxidant treatment for amyotrophic lateral sclerosis / motor neuron disease. Cochrane Database of Systematic Reviews (1) 10.1002/14651858.CD002829.pub4.

Orrell, RW; Lane, RJM; Ross, M; (2007) Antioxidant treatment for amyotrophic lateral sclerosis/motor neuron disease. COCHRANE DB SYST REV (1) , Article CD002829. 10.1002/14651858.CD002829.pub4.

Orrell, RW; Lane, RJM; Ross, M; (2005) Antioxidant treatment for amyotrophic lateral sclerosis/motor neuron disease. COCHRANE DB SYST REV (1) , Article CD002829.pub3. 10.1002/14651858.CD002829.pub3.

Orrell, RW; Marklund, SL; deBelleroche, JS; (1997) Familial ALS is associated with mutations in all exons of SOD1: a novel mutation in exon 3 (Gly72Ser). J NEUROL SCI , 153 (1) 46 - 49.

Orrell, RW; Marsden, CD; (1994) The neck-tongue syndrome. Journal of Neurology Neurosurgery and Psychiatry , 57 (3) pp. 348-352.

Orrell, RW; Peatfield, RC; Collins, CE; Woodrow, DF; Moss, J; Press, M; Lane, RJ; (1995) Myopathy in acquired partial lipodystrophy. Clin Neurol Neurosurg , 97 (2) pp. 181-186.

Orrell, RW; Shakir, R; Lane, RJM; Kennard, C; Wade, JPH; Poser, CM; (1996) Grand rounds - Hammersmith Hospitals - Distinguishing acute disseminated encephalomyelitis from multiple sclerosis - Genetic predisposition may differ. BRIT MED J , 313 (7060) 802 - 804.

Orrell, RW; Shakir, R; Lane, RJM; Kennard, C; Wade, JPH; Poser, CM; (1996) Distinguishing acute disseminated encephalomyelitis from multiple sclerosis. British Medical Journal , 313 (7060) pp. 802-804.

Orrell, RW; Tawil, R; Forrester, J; Kissel, JT; Mendell, JR; Figlewicz, DA; (1999) Definitive molecular diagnosis of facioscapulohumeral dystrophy. NEUROLOGY , 52 (9) 1822 - 1826.

Orrell, RW; Tromans, AM; Burt, AA; (1991) Myotonic dystrophy and traumatic quadriplegia. Paraplegia , 29 pp. 419-422.

Orrell, RW; deBelleroche, J; (1994) Superoxide dismutase and amyotrophic lateral sclerosis. The Lancet , 344 pp. 1651-1652.

Pearson, SJ; Cobbold, M; Orrell, RW; Harridge, SD; (2006) Power output and muscle myosin heavy chain composition in young and elderly men. Med Sci Sports Exerc , 38 (9) pp. 1601-1607. 10.1249/01.mss.0000227638.75983.9d.

Pearson, SJ; Cobbold, M; Orrell, RW; Harridge, SDR; (2006) Power output and muscle myosin heavy chain composition in young and elderly men. MED SCI SPORT EXER , 38 (9) 1601 - 1607. 10.1249/01.mss.0000227638.75938.9d.

Pullen, AH; Demestre, M; Howard, RS; Orrell, RW; (2004) Passive transfer of purified IgG from patients with amyotrophic lateral sclerosis to mice results in degeneration of motor neurons accompanied by Ca2+ enhancement. ACTA NEUROPATHOL , 107 (1) 35 - 46. 10.1007/s00401-003-0777-z.

Pullen, AH; Demestre, M; Orrell, R; Schwaller, B; (2003) Ectopic expression of parvalbumin in motor neurons of mice attenuates development of cytopathology following passive transfer of purified and dialysed IgG from sera of patients with amyotrophic lateral sclerosis. ALS and Other Motor Neuron Disorders , 4S1 (4S1) pp. 131-132.

Renton, AE; Majounie, E; Waite, A; Simon-Sanchez, J; Rollinson, S; Gibbs, JR; Schymick, JC; (2011) A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD. NEURON , 72 (2) 257 - 268. 10.1016/j.neuron.2011.09.010.

Riddoch-Contreras, J; Yang, SY; Dick, JRT; Goldspink, G; Orrell, RW; Greensmith, L; (2009) Mechano-growth factor, an IGF-I splice variant, rescues motoneurons and improves muscle function in SOD1(G93A) mice. EXP NEUROL , 215 (2) 281 - 289. 10.1016/j.expneurol.2008.10.014.

Rohrer, JD; Isaacs, AM; Mizielinska, S; Mead, S; Lashley, T; Wray, S; Sidle, K; (2015) C9orf72 expansions in frontotemporal dementia and amyotrophic lateral sclerosis. Lancet Neurol , 14 (3) pp. 291-301. 10.1016/S1474-4422(14)70233-9.

Rohrer, JD; Isaacs, AM; Mizlienska, S; Mead, S; Lashley, T; Wray, S; Sidle, K; (2015) C9orf72 expansions in frontotemporal dementia and amyotrophic lateral sclerosis. The Lancet Neurology , 14 (3) pp. 291-301. 10.1016/S1474-4422(14)70233-9.

SHAUNAK, S; ORRELL, RW; OSULLIVAN, E; HAWKEN, MB; LANE, RJM; HENDERSON, L; KENNARD, C; (1995) OCULOMOTOR FUNCTION IN AMYOTROPHIC-LATERAL-SCLEROSIS - EVIDENCE FOR FRONTAL IMPAIRMENT. ANN NEUROL , 38 (1) 38 - 44.

Scott, KM; Abhinav, K; Stanton, BR; Johnston, C; Turner, MR; Ampong, MA; Sakel, M; (2009) Geographical Clustering of Amyotrophic Lateral Sclerosis in South-East England: A Population Study. NEUROEPIDEMIOLOGY , 32 (2) 81 - 88. 10.1159/000177032.

Scott, KM; Abhinav, K; Wijesekera, L; Ganesalingam, J; Goldstein, LH; Janssen, A; Dougherty, A; (2010) The association between ALS and population density: A population based study. Amyotroph Lateral Scler , 11 (5) pp. 435-438. 10.3109/17482961003754552.

Scott, KM; Abinav, KM; Wijesekera, L; Ganesalingam, J; Goldestein, LH; Janssen, A; Dougherty, A; The sex ratio in amyotrophic lateral sclerosis: a population based study. Amyotrophic Lateral Sclerosis

Shatunov, A; Mok, K; Newhouse, S; Weale, ME; Smith, B; Vance, C; Johnson, L; (2010) Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study. LANCET NEUROL , 9 (10) 986 - 994. 10.1016/S1474-4422(10)70197-6.

Shaunak, S; Orrell, R; Henderson, L; Kennard, C; (1999) Saccades and smooth pursuit in myotonic dystrophy. J Neurol , 246 (7) pp. 600-606.

Toosy, AT; Werring, DJ; Orrell, RW; Howard, RS; King, MD; Barker, GJ; Miller, DH; (2003) Diffusion tensor imaging detects corticospinal tract involvement at multiple levels in amyotrophic lateral sclerosis. J NEUROL NEUROSUR PS , 74 (9) 1250 - 1257.

UKMND-LiCALS Study Group, ; Morrison, KE; Dhariwal, S; Hornabrook, R; Savage, L; Burn, DJ; Khoo, TK; (2013) Lithium in patients with amyotrophic lateral sclerosis (LiCALS): a phase 3 multicentre, randomised, double-blind, placebo-controlled trial. Lancet Neurol , 12 (4) pp. 339-345. 10.1016/S1474-4422(13)70037-1.

Wood, L; Evangelista, T; Norwood, F; Orrell, R; Pohlschmidt, M; Busby, M; Graham, A; (2014) UK Facioscapulohumeral Muscular Dystrophy (FSHD) Patient Registry. Orphanet J Rare Dis , 9 (1) 858-. 10.1186/1750-1172-9-S1-P6.

de Belleroche, J; Orrell, R; King, A; (1995) Familial amyotrophic lateral sclerosis/motor neurone disease (FALS): a review of current developments. J Med Genet , 32 (11) pp. 841-847.

de Belleroche, J; Orrell, RW; Virgo, L; Habgood, J; Gardiner, IM; Malaspina, A; Kaushik, N; (1998) Copper, zinc superoxide dismutase (SOD1) and its role in neuronal function and disease with particular relevance to motor neurone disease amyotrophic lateral sclerosis. BIOCHEMICAL SOCIETY TRANSACTIONS , 26 (3) 476 - 480.

deBelleroche, J; Orrell, RW; Virgo, L; (1996) Amyotrophic lateral sclerosis: Recent advances in understanding disease mechanisms. J NEUROPATH EXP NEUR , 55 (7) 747 - 757.

Book chapter

Howard, RS; Orrell, RW; (2006) Management of motor neurone disease. In: Neurology Reviews. (pp. 155-168). Radcliffe Publishing Limited

Lane, RJM; Orrell, RW; Tappouni, H; (1996) Diagnostic Index of neuromuscular disorders. In: Lane, RJM, (ed.) Handbook of Muscle Disease. (pp. 705-726). Marcel Dekker: New York.

Orrell, R; (1996) Compartment syndromes. In: Lane, RJM, (ed.) Handbook of Muscle Disease. (pp. 605-606). Marcel Dekker: New York.

Orrell, R; (1996) Myositis ossificans. In: Lane, RJM, (ed.) Handbook of Muscle Disease. (pp. 599-601). Marcel Dekker: New York.

Orrell, R; (1996) Nutritional myopathies. In: Lane, RJM, (ed.) Handbook of Muscle Disease. (pp. 613-615). Marcel Dekker: New York.

Orrell, R; (1996) Polymyalgia rheumatica. In: Lane, RJM, (ed.) Handbook of Muscle Disease. (pp. 595-597). Marcel Dekker: New York.

Orrell, R; Schapira, AHV; (2001) Asymmetric muscle weakness. In: Schapira, AHV and Rowland, LP, (eds.) Clinical cases in neurology. (pp. 239-245). Butterworth-Heinemann: Oxford.

Orrell, R; Schapira, AHV; (2001) Muscle weakness and dysphagia. In: Schapira, AHV and Rowland, LP, (eds.) Clinical cases in neurology. (pp. 99-106). Butterworth-Heinemann: Oxford.

Orrell, RW; (2007) Endocrine myopathies. In: UNSPECIFIED (pp. 343-355).

Orrell, RW; Facioscapulohumeral dystrophy. In: Amato, A and Griggs, RC, (eds.) Muscular dystrophy. Elsevier: Edinburgh.

Orrell, RW; HARP syndrome. In: Kompoliti, K and Verhagen, L, (eds.) Encyclopedia of Movement Disorders. Elsevier

Orrell, RW; Clarke, J; Howard, RS; (2007) Standards of care in motor neuron disease. In: Kiernan, MC, (ed.) The Motor Neurone Disease Handbook. (pp. 74-88). Australian Medical Publishing Company Limited

Orrell, RW; Darras, BT; Griggs, RC; (2002) FSHD and distal myopathies. In: Jones, HR and De Vivo, DC and Darras, BT, (eds.) Neuromuscular disorders of infancy, childhood, and adolescence a clinician's approach. (pp. 701-716). Butterworth-Heinemann

Orrell, RW; Fuller, GN; (1996) Arthrogryposis multiplex congenita. In: Lane, RJM, (ed.) Handbook of Muscle Disease. (pp. 603-604). Marcel Dekker

Orrell, RW; Griggs, RC; (2003) Myopathies. In: Neurological Disorders: Course and Treatment: Second Edition. (pp. 1369-1383).

Orrell, RW; Griggs, RC; (2002) Disorders of striated muscle. In: Asbury, AK and McKhann, G, (eds.) Diseases of the Nervous System: Clinical Neuroscience and Therapeutic Principles. (pp. 1163-1182). Cambridge University Press: Cambridge.

Orrell, RW; Griggs, RC; (1999) Muscular dystrophies: clinical and molecular approaches. In: Schapira, AHV and Griggs, RC, (eds.) Muscle Diseases. (pp. 59-82). Butterworth Heinemann: Oxford.

Orrell, RW; Guiloff, RJ; (2001) Myopathies: ethics, outcome variables and clinical scales. In: Neurological Disease. (pp. 505-513). Springer

Orrell, RW; Habgood, JJ; Malaspina, A; Mitchell, J; Gardiner, I; Greenwood, J; Lane, RJM; (1999) Mutations of the SOD1 gene in familial amyotrophic lateral sclerosis. In: Edeas, MA, (ed.) Superoxide Dismutase: Recent advances and clinical application. (pp. 100-102). Editions MEL: Paris.

Orrell, RW; Lane, RJM; (1996) Myoglobinuria. In: Lane, RJM, (ed.) Handbook of Muscle Disease. (pp. 607-611). Marcel Dem

Orrell, RW; Lane, RJM; (1996) Myopathies in infections and systemic diseases. In: Handbook of Muscle Disease. (pp. 391-406). Marcel Dekker: New York.

Orrell, RW; Lane, RJM; Hudgson, P; (1996) Muscle dysfunction in endocrine disease. In: Lane, RJM, (ed.) Handbook of Muscle Disease. (pp. 365-378). Marcel Dekker: New York.

Orrell, RW; Lane, RJM; deBelleroche, JS; (1996) Ciliary neurotrophic factor (CNTF): Possible implications in the pathogenesis of amyotrophic lateral sclerosis. In: Fiskum, G, (ed.) UNSPECIFIED (401 - 403). PLENUM PRESS DIV PLENUM PUBLISHING CORP

Orrell, RW; Schapira, AHV; (2002) Mitochondria and amyotrophic lateral sclerosis. In: UNSPECIFIED (411 - 426). ACADEMIC PRESS INC

Orrell, RW; Wade, JPH; (1996) Vascular dementia: clinical diagnosis - how good is it and how should it be done? In: Prohovnik, I and Wade, J and Knezevic, S and Tatemichi, T and Erkinjunti, T, (eds.) Vascular dementia - current concepts. (pp. 143-163). John Wiley and Sons: Chichester,.

Schapira, AHV; Orrell, R; (2001) Young onset stroke. In: Schapira, AHV and Rowland, LP, (eds.) Clinical cases in neurology. (pp. 177-182). Butterworth-Heinemann: Oxford.

Proceedings paper

Bacsi, AM; Ginsberg, L; Orrell, RW; (2008) Reversible dysphagia in facioscapulohumeral dystrophy caused by myasthenia gravis. In: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. (pp. 358 - 358). B M J PUBLISHING GROUP

Bennett, DLH; Groves, M; Blake, J; Holton, JL; King, RHM; Orrell, RW; Ginsberg, L; (2007) The use of nerve and muscle biopsy in the diagnosis of vasculitis: a 5-year retrospective study of 53 cases. In: JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM. (pp. 9 - 10). BLACKWELL PUBLISHING

Bennett, DLH; Groves, M; King, R; Orrell, RW; Ginsberg, L; Reilly, MM; (2004) The use of targeted nerve and muscle biopsy in the diagnosis of vasculitis. In: JOURNAL OF NEUROLOGY. (pp. 138 - 138). DR DIETRICH STEINKOPFF VERLAG

Bradley, LJ; Wilhelm, T; King, RHM; Ginsberg, L; Orrell, RW; (2004) Brachius plexus hypertrophy in chronic inflammatory demyelinating polyneuropathy. In: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. (pp. 806 - 806). B M J PUBLISHING GROUP

Bradley, MD; Orrell, RW; Williams, AJ; Davidson, C; Kullman, D; Hirsch, N; Howard, RS; (2001) The management of motor neuron disease presenting with respiratory failure. In: J NEUROL NEUROSUR PS. (pp. 276 - 276). BRITISH MED JOURNAL PUBL GROUP

Hameed, M; Orrell, R; Cobbold, M; Goldspink, G; Harridge, SDR; (2002) Weightlifting exercise increases the mRNA expression of a mechanosensitive IGF-I (MGF) in the muscles of young, but not old men. In: JOURNAL OF PHYSIOLOGY-LONDON. (pp. 87P - 87P). CAMBRIDGE UNIV PRESS

Houlden, H; King, RHM; Muddle, JR; Warner, TT; Reilly, MM; Orrell, RW; Ginsberg, L; (2004) Ulcero-mutilating neuropathy: Clinical, pathological and molecular genetic study of a family with a novel RAB7 mutation. In: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. (pp. 1228 - 1228). B M J PUBLISHING GROUP

KING, AW; ORRELL, RW; LANE, R; DEBELLEROCHE, JS; (1994) MORE THAN ONE LOCUS FOR FAMILIAL AMYOTROPHIC-LATERAL-SCLEROSIS - ABSENCE OF LINKAGE TO THE SMA LOCUS. In: BIOCHEMICAL SOCIETY TRANSACTIONS. (pp. S149 - S149). PORTLAND PRESS

Kearney, M; Orrell, RW; Fahey, M; Pandolfo, M; (2010) Antioxidants and other pharmacological treatment for Friedreich ataxia. In: MOVEMENT DISORDERS. (pp. S193 - S193). WILEY-LISS

King, RHM; Blake, J; Muddle, JR; Orrell, RW; Morahan, G; Kalaydjieva, L; (2007) Pathological and electrophysiological studies of NDRG1 mutant mice. In: JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM. (pp. 44 - 44). BLACKWELL PUBLISHING

King, RHM; Nourallah, M; Muddle, JR; Orrell, RW; (2009) ULTRASTRUCTURAL STUDIES OF PERIPHERAL NERVES IN NDRG1 MUTANT MICE. In: JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM. (pp. 74 - 75). WILEY-BLACKWELL PUBLISHING, INC

Lacomblez, L; Bensimon, G; Leigh, PN; Guillet, P; Powe, L; Durrleman, S; Delumeau, JC; (1996) A confirmatory dose-ranging study of riluzole in ALS. In: NEUROLOGY. (pp. S242 - S250). LITTLE BROWN CO

Lu, C; Malaspina, A; Orrell, R; Kalmar, B; Petzold, A; Greensmith, L; (2010) PLASMA NEUROFILAMENT HEAVY CHAIN LEVELS AS A DISEASE BIOMARKER IN THE SOD1 MOUSE MODEL OF AMYOTROPHIC LATERAL SCLEROSIS. In: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. (pp. E62 - E62). B M J PUBLISHING GROUP

Miller, RG; Bouchard, JP; Duquette, P; Eisen, A; Gelinas, DF; Harati, Y; Munsat, TL; (1996) Clinical trials of riluzole in patients with ALS. In: NEUROLOGY. (pp. S86 - S90). LITTLE BROWN CO

Orrell, RW; Forrester, JD; Tawil, R; Kissel, JT; Mendell, JR; Figlewicz, DA; Griggs, RC; (1997) Application of definitive molecular diagnostic criteria in facioscapulohumeral dystrophy: Clinical implications of position effect variegation. In: ANN NEUROL. (pp. 986 - 986). LIPPINCOTT WILLIAMS & WILKINS

Orrell, RW; Johnston, HM; Gibson, C; Cass, RM; Griggs, RC; (1998) Case of the month - Spontaneous abdominal hematoma in dermatomyositis. In: MUSCLE & NERVE. (pp. 1800 - 1803). JOHN WILEY & SONS INC

Wain, LV; Shrine, NRG; Shaw, C; Powell, JF; Hardy, J; Shaw, P; Morrison, KE; (2010) The Role of Common Copy Number Variation in Amyotrophic Lateral Sclerosis (ALS). In: GENETIC EPIDEMIOLOGY. (pp. 929 - 930). WILEY-BLACKWELL

Conference item

Bajaj, NPS; Waldman, AD; Orrell, RW; Bhatia, KP; (2001) A unique family with adult onset Krabbe disease and normal neuroimaging. Presented at: UNSPECIFIED.

Bradley, LJ; Muddle, JR; Taanman, JW; Orrell, RW; (2004) Conflicting evidence for mitochondrial dysfunction in patients with amytrophic lateral sclerosis. Presented at: UNSPECIFIED.

Bradley, MD; Orrell, RW; Williams, AJ; Davidson, C; Kullman, D; Hirsch, N; Howard, RS; (2000) Motor neurone disease presenting with acute respiratory failure. Presented at: UNSPECIFIED.

De Belleroche, J; Virgo, L; Orrell, R; Samarasinghe, S; (1995) Neuronal death in amyotrophic lateral sclerosis. Presented at: UNSPECIFIED.

Demestre, M; Pullen, AH; Orrell, R; Howard, RS; (2002) Measurement of pro- and active forms of matrix metalloproteinase-9 (MMP9) in serum of patients with amyotrophic lateral sclerosis. Presented at: UNSPECIFIED.

Enayat, ZE; Claus, A; Orrell, R; King, A; de, BJ; Ludolph, A; Bachus, R; (1995) Three new SOD-1 mutations in familial ALS. Presented at: UNSPECIFIED.

Goonetilleke, A; Guiloff, RJ; Nikhar, N; Orrell, RW; Tan, SV; (1997) The clinical assessment of muscle force. Presented at: UNSPECIFIED.

Goonetilleke, A; Nikhar, N; Tan, SV; Orrell, RW; Guiloff, RJ; (1997) Clinical assessment of muscle force. Presented at: UNSPECIFIED.

Jaffer, F; Reilly, MM; Quinlivan, RR; Muntoni, F; Orrell, R; Wraige, E; Saha, R; (2012) AVOIDING UNPLANNED HOSPITAL ADMISSIONS IN PATIENTS WITH NEUROMUSCULAR DISEASES: A REGIONAL COLLABORATIVE AUDIT OF HOSPITAL ADMISSIONS. Presented at: UNSPECIFIED.

King, AW; Orrell, RW; Lane, R; de Belleroche, JS; (1994) More than one locus for familial amyotrophic lateral sclerosis: absence of linkage to the SMA locus. Presented at: UNSPECIFIED, ENGLAND.

Lu, C; Petzold, A; Kalmar, B; Orrell, R; Malaspina, A; Greensmith, L; (2010) Plasma neurofilament heavy chain levels as a disease biomarker in SOD1 mice. Presented at: 20th International Symposium on ALS/MND, Berlin Germany, 8-10 December 2001, SW336..

Mitchell, J; Habgood, JJ; Orrell, RW; Kaushik, N; Malaspina, A; Gardiner, IM; Greenwood, JS; (2000) Identifying gene defects in motor neurone disease / amyotrophic lateral sclerosis families that lack Cu/Zn superoxide dismutase mutations. Presented at: UNSPECIFIED.

Ng, K; Orrell, R; (2005) Extensive heroin myelopathy associated with Adamkiewicz artery territory infarction. Presented at: UNSPECIFIED.

Orrell, RW; Bowe, FA; Hallewell, RA; Marklund, S; Lane, RJM; deBelleroche, J; (1997) SOD-1 mutations in United Kingdom families with amyotrophic lateral sclerosis. Presented at: UNSPECIFIED.

Orrell, RW; Fuller, GN; Leslie, RDG; Maitland, J; Lane, RJM; (1994) Partial stiff-person syndrome with exaggerated and sustained knee jerks. Movement Disorders. Presented at: UNSPECIFIED.

Orrell, RW; Habgood, JJ; Lane, RJM; deBelleroche, J; (1996) Potential underdiagnosis of familial amyotrophic lateral sclerosis: clinical genetic implications. Presented at: UNSPECIFIED.

Orrell, RW; Hilton, DA; Lane, RJM; deBelleroche, JS; (1995) Neuropathology of familial amyotrophic lateral sclerosis with a mutation of SOD-1. Presented at: UNSPECIFIED.

Orrell, RW; King, AW; Hilton, DA; Campbell, MJ; Lane, RJM; de, BJ; (1995) A clinicopathological study of familial amyotrophic lateral sclerosis with a mutation of SOD-1. Presented at: UNSPECIFIED.

Orrell, RW; King, AW; Lane, RJM; de, BJS; (1995) Investigation of a null mutation of the CNTF gene in familial amyotrophic lateral sclerosis. Presented at: UNSPECIFIED.

Orrell, RW; King, AW; Lane, RJM; deBelleroche, J; (1996) Patterns of inheritance in United Kingdom families with amyotrophic lateral sclerosis. Presented at: UNSPECIFIED.

Orrell, RW; Lehmann-Horn, F; Lane, RJM; (1997) Familial cramp with a mutation of the adult skeletal muscle sodium channel a subunit gene: sodium channel myotonia. Presented at: UNSPECIFIED.

Orrell, RW; Lehmann-Horn, F; Lane, RJM; (1997) The short exercise test in the diagnosis of sodium channel disease. Presented at: UNSPECIFIED.

Orrell, RW; Ross, M; Lane, RJM; (2004) A systematic review of antioxidant treatment of amyotrophic lateral sclerosis. Cochrane Review. Presented at: UNSPECIFIED.

Pearson, SJ; Cobbold, MJ; Orrell, R; Harridge, SDR; (2002) A lesser proportion of fast myosin heavy chain isoforms in older men is closely related to a lower velocity at which peak power occurs during inertial sprint cycling. Presented at: UNSPECIFIED.

Pullen, AH; Howard, R; Orrell, R; (2001) Necrotic and apoptotic-like degeneration in motor neurons following passive transfer of ALS/MND derived IgG. Presented at: UNSPECIFIED.

Riddoch-Contreras, J; Yang, SY; Goldspink, G; Orrell, RW; Greensmith, L; (2005) Treatment with mechano-growth factor, an IGF-1 splice variant, rescues motoneurons and delays disease progression in SOD1 G93A mice. Presented at: UNSPECIFIED.

Riddoch-Contreras, J; Yang, SY; Goldspink, G; Orrell, RW; Greensmith, L; (2005) Treatment with mechano-growth factor, an IGF-1 splice variant, rescues motoneurons and delays disease progression in SOD1 G93A mice. Presented at: UNSPECIFIED.

Sakel, M; Chalabi, A; Leigh, N; Shaw, C; Howard, R; Orrell, RW; Ampong, M; (2008) Amyotrophic lateral sclerosis in South-East England: a population based study [South-East England Amyotrophic Lateral Sclerosis (SEALS) Registry]. Presented at: UNSPECIFIED.

Shaunak, S; O'Sullivan, E; Orrell, R; Lane, R; Kennard, C; (1995) Oculomotor function in motor neuron disease. Presented at: UNSPECIFIED.

Solomon, AM; Hoffman, EP; Chimbovschi, SD; Wang, Z; Orrell, RW; Goldspink, G; Harridge, SD; (2006) Molecular mechanisms of idiopathic muscle hypertrophy in humans. Presented at: UNSPECIFIED.

Toosy, AT; Orrell, RW; Werring, DJ; Howard, RS; King, MD; Barker, GJ; Miller, DH; (2003) Diffusion tensor imaging detects corticospinal tract involvement at multiple levels in ALS. Presented at: UNSPECIFIED.

Other

Orrell, R; (2003) Images on BBC programme related to growth factors. UNSPECIFIED

Orrell, R; (1996) Riluzole: a new treatment for motor neuron disease. Multiple radio interviews, Radio 5 feature, BBC News images, Newspaper quotes. UNSPECIFIED

Orrell, R; (1991) International radio interviews and media references on article in Lancet. UNSPECIFIED

Orrell, RW; (2005) Horizon programme. The Doctor who can make people walk again. Guardian Films / BBC TV. UNSPECIFIED

This list was generated on Sun Feb 7 08:47:58 2016 GMT.