UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Browse by UCL people

Export as [feed] RSS 2.0 [feed] RSS 1.0 [feed] Atom
Group by: Type | Date
Jump to: Article | Book chapter | Other | Proceedings paper
Number of items: 219.

Article

Abalkhail, H and Mitchell, J and Habgood, J and Orrell, R and de Belleroche, J (2003) A new familial amyotrophic lateral sclerosis locus on chromosome 16q12.1-16q12.2. Am J Hum Genet , 73 (2) 383 - 389. 10.1086/377156.

Abhinav, K and Stanton, B and Johnston, C and Hardstaff, J and Orrell, RW and Howard, R and Clarke, J and Sakel, M and Ampong, MA and Shaw, CE and Leigh, PN and Al-Chalabi, A (2007) Amyotrophic lateral sclerosis in south-east England: A population-based study - The south-east England register for amyotrophic lateral sclerosis (SEALS registry). NEUROEPIDEMIOLOGY , 29 (1-2) 44 - 48. 10.1159/000108917.

Ahmad-Annuar, A and Shah, P and Hafezparast, M and Hummerich, H and Witherden, AS and Morrison, KE and Shaw, PJ and Kirby, J and Warner, TT and Crosby, A and Proukakis, C and Wilkinson, P and Orrell, RW and Bradley, L and Martin, JE and Fisher, EMC (2003) No association with common Caucasian genotypes in exons 8, 13 and 14 of the human cytoplasmic dynein heavy chain gene (DNCHC1) and familial motor neuron disorders. AMYOTROPH LATERAL SC , 4 (3) 150 - 157.

Ates, K and Yang, SY and Orrell, RW and Sinanan, ACM and Simons, P and Solomon, A and Beech, S and Goldspink, G and Lewis, MP (2007) The IGF-I splice variant MGF increases progenitor cells in ALS, dystrophic, and normal muscle. FEBS LETT , 581 (14) 2727 - 2732. 10.1016/j.febslet.2007.05.030.

Bajaj, NPS and Waldman, A and Orrell, R and Wood, NW and Bhatia, KP (2002) Familial adult onset of Krabbe's disease resembling hereditary spastic paraplegia with normal neuroimaging. J NEUROL NEUROSUR PS , 72 (5) 635 - 638.

Bartolome, F and Wu, H-C and Burchell, VS and Preza, E and Wray, S and Mahoney, CJ and Fox, NC and Calvo, A and Canosa, A and Moglia, C and Mandrioli, J and Chiò, A and Orrell, RW and Houlden, H and Hardy, J and Abramov, AY and Plun-Favreau, H (2013) Pathogenic VCP Mutations Induce Mitochondrial Uncoupling and Reduced ATP Levels. Neuron , 78 (1) 57 - 64.

Bartolome, F and Wu, HC and Burchell, VS and Preza, E and Wray, S and Mahoney, CJ and Fox, NC and Calvo, A and Canosa, A and Moglia, C and Mandrioli, J and Chiò, A and Orrell, RW and Houlden, H and Hardy, J and Abramov, AY and Plun-Favreau, H (2013) Pathogenic VCP Mutations Induce Mitochondrial Uncoupling and Reduced ATP Levels. Neuron , 78 (1) 57 - 64. 10.1016/j.neuron.2013.02.028.

Beck, J and Poulter, M and Hensman, D and Rohrer, JD and Mahoney, CJ and Adamson, G and Campbell, T and Uphill, J and Borg, A and Fratta, P and Orrell, RW and Malaspina, A and Rowe, J and Brown, J and Hodges, J and Sidle, K and Polke, JM and Houlden, H and Schott, JM and Fox, NC and Rossor, MN and Tabrizi, SJ and Isaacs, AM and Hardy, J and Warren, JD and Collinge, J and Mead, S (2013) Large C9orf72 hexanucleotide repeat expansions are seen in multiple neurodegenerative syndromes and are more frequent than expected in the UK population. Am J Hum Genet , 92 (3) 345 - 353. 10.1016/j.ajhg.2013.01.011.

Beck, J and Poulter, M and Hensman, D and Rohrer, JD and Mahoney, CJ and Adamson, G and Campbell, T and Uphill, J and Borg, A and Fratta, P and Orrell, RW and Malaspina, A and Rowe, J and Brown, J and Hodges, J and Sidle, K and Polke, JM and Houlden, H and Schott, JM and Fox, NC and Rossor, MN and Tabrizi, SJ and Isaacs, AM and Hardy, J and Warren, JD and Collinge, J and Mead, S (2013) Large C9orf72 hexanucleotide repeat expansions are seen in multiple neurodegenerative syndromes and are more frequent than expected in the UK population. American Journal of Human Genetics , 92 (3) 345 - 353.

Bennett, DLH and Groves, M and Blake, J and Holton, JL and King, RHM and Orrell, RW and Ginsberg, L and Reilly, MM (2008) The use of nerve and muscle biopsy in the diagnosis of vasculitis: a 5 year retrospective study. J NEUROL NEUROSUR PS , 79 (12) 1376 - 1381.

Bradley, LJ and Muddle, JR and Taanman, JW and Orrell, R (2003) Investigation of intercellular differences of mitochondrial protein expression in amyotrophic lateral sclerosis. ALS and other Motor Neuron Disorders , 4S1 87 - 88.

Bradley, LJ and Taanman, JW and Kallis, C and Orrell, RW (2009) Increased sensitivity of myoblasts to oxidative stress in amyotrophic lateral sclerosis peripheral tissues. Experimental Neurology , 218 (1) 92 - 97. 10.1016/j.expneurol.2009.04.007.

Bradley, LJ and Taanman, JW and Kallis, C and Orrell, RW (2009) Increased sensitivity of myoblasts to oxidative stress in amyotrophic lateral sclerosis peripheral tissues. EXP NEUROL , 218 (1) 92 - 97. 10.1016/j.expneurol.2009.04.007.

Bradley, LJ and Wilhelm, T and King, RHM and Ginsberg, L and Orrell, RW (2006) Brachial plexus hypertrophy in chronic inflammatory demyelinating polyradiculoneuropathy. NEUROMUSCULAR DISORD , 16 (2) 126 - 131. 10.1016/j.nmd.2005.11.006.

Bradley, M and Bradley, L and de Belleroche, J and Orrell, RW (2005) Patterns of inheritance in familial ALS. NEUROLOGY , 64 (9) 1628 - 1631.

Bradley, M. and Bradley, L. and de Belleroche, J. and Orrell, R.W. (2005) Patterns of inheritance in familial ALS. Neurology , 64 (9) pp. 1628-1631. 10.1212/01.WNL.0000160395.43761.AC.

Bradley, MD and Orrell, RW and Clarke, J and Davidson, AC and Williams, AJ and Kullmann, DM and Hirsch, N and Howard, RS (2002) Outcome of ventilatory support for acute respiratory failure in motor neurone disease. J NEUROL NEUROSUR PS , 72 (6) 752 - 756.

Canepari, M and Rossi, R and Pellegrino, MA and Orrell, RW and Cobbold, M and Harridge, S and Bottinelli, R (2005) Effects of resistance training on myosin function studied by the in vitro motility assay in young and older men. J APPL PHYSIOL , 98 (6) 2390 - 2395. 10.1152/japplphysiol.01103.2004.

Chio, A and Schymick, JC and Restagno, G and Scholz, SW and Lombardo, F and Lai, SL and Mora, G and Fung, HC and Britton, A and Arepalli, S and Gibbs, JR and Nalls, M and Berger, S and Kwee, LC and Oddone, EZ and Ding, JH and Crews, C and Rafferty, I and Washecka, N and Hernandez, D and Ferrucci, L and Bandinelli, S and Guralnik, J and Macciardi, F and Torri, F and Lupoli, S and Chanock, SJ and Thomas, G and Hunter, DJ and Gieger, C and Wichmann, HE and Calvo, A and Mutani, R and Battistini, S and Giannini, F and Caponnetto, C and Mancardi, GL and La Bella, V and Valentino, F and Monsurro, MR and Tedeschi, G and Marinou, K and Sabatelli, M and Conte, A and Mandrioli, J and Sola, P and Salvi, F and Bartolomei, I and Siciliano, G and Carlesi, C and Orrell, RW and Talbot, K and Simmons, Z and Connor, J and Pioro, EP and Dunkley, T and Stephan, DA and Kasperaviciute, D and Fisher, EM and Jabonka, S and Sendtner, M and Beck, M and Bruijn, L and Rothstein, J and Schmidt, S and Singleton, A and Hardy, J and Traynor, BJ (2009) A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis. HUM MOL GENET , 18 (8) 1524 - 1532. 10.1093/hmg/ddp059.

Ciccarelli, O and Behrens, TE and Altmann, DR and Orrell, RW and Howard, RS and Johansen-Berg, H and Miller, DH and Matthews, PM and Thompson, AJ (2006) Probabilistic diffusion tractography: a potential tool to assess the rate of disease progression in amyotrophic lateral sclerosis. BRAIN , 129 1859 - 1871. 10.1093/brain/awl100.

Ciccarelli, O and Behrens, TE and Johansen-Berg, H and Talbot, K and Orrell, RW and Howard, RS and Nunes, RG and Miller, DH and Matthews, PM and Thompson, AJ and Smith, SM (2009) Investigation of White Matter Pathology in ALS and PLS Using Tract-Based Spatial Statistics. HUM BRAIN MAPP , 30 (2) 615 - 624. 10.1002/hbm.20527.

de Belleroche, J and Orrell, R and King, A (1995) Familial amyotrophic lateral sclerosis/motor neurone disease (FALS): a review of current developments. J Med Genet , 32 (11) 841 - 847.

de Belleroche, J and Orrell, RW and Virgo, L and Habgood, J and Gardiner, IM and Malaspina, A and Kaushik, N and Mitchell, J and Greenwood, J (1998) Copper, zinc superoxide dismutase (SOD1) and its role in neuronal function and disease with particular relevance to motor neurone disease amyotrophic lateral sclerosis. BIOCHEMICAL SOCIETY TRANSACTIONS , 26 (3) 476 - 480.

deBelleroche, J and Orrell, RW and Virgo, L (1996) Amyotrophic lateral sclerosis: Recent advances in understanding disease mechanisms. J NEUROPATH EXP NEUR , 55 (7) 747 - 757.

Demestre, M and Howard, RS and Orrell, RW and Pullen, AH (2006) Serine proteases purified from sera of patients with amyotrophic lateral sclerosis (ALS) induce contrasting cytopathology in murine motoneurones to IgG. NEUROPATH APPL NEURO , 32 (2) 141 - 156. 10.1111/j.1365-2990.2006.00712.x.

Demestre, M and Pullen, A and Orrell, RW and Orth, M (2005) ALS-IgG-induced selective motor neurone apoptosis in rat mixed primary spinal cord cultures. J NEUROCHEM , 94 (1) 268 - 275. 10.1111/j.1471-4159.2005.03184.x.

ENAYAT, ZE and ORRELL, RW and CLAUS, A and LUDOLPH, A and BACHUS, R and BROCKMULLER, J and RAYCHAUDHURI, K and RADUNOVIC, A and SHAW, C and WILKINSON, J and KING, A and SWASH, M and LEIGH, PN and DEBELLEROCHE, J and POWELL, J (1995) 2 NOVEL MUTATIONS IN THE GENE FOR COPPER-ZINC SUPEROXIDE-DISMUTASE IN UK FAMILIES WITH AMYOTROPHIC-LATERAL-SCLEROSIS. HUM MOL GENET , 4 (7) 1239 - 1240.

Evans, RM and Harridge, SD and Velloso, CP and Yang, SY and Goldspink, G and Orrell, RW (2010) Investigation of MGF mRNA expression in patients with amyotrophic lateral sclerosis using parallel in vivo and in vitro approaches. Amyotroph Lateral Scler , 11 (1-2) 172 - 177. 10.3109/17482960903089775.

Evans, RM and Harridge, SDR and Velloso, CP and Yang, SY and Goldspink, G and Orrell, RW (2010) Investigation of MGF mRNA expression in patients with amyotrophic lateral sclerosis using parallel in vivo and in vitro approaches. AMYOTROPH LATERAL SC , 11 (1-2) 172 - 177. 10.3109/17482960903089775.

Figlewicz, DA and Orrell, RW (2003) The genetics of motor neuron diseases. AMYOTROPH LATERAL SC , 4 (4) 225 - 231. 10.1080/14660820310011287.

Ginsberg, L and King, RHM and Orrell, R (2003) Nerve biopsy - how to do it. Practical Neurology , 3 (3) 306 - 313.

Ginsberg, L and King, RHM and Orrell, R (2003) Nerve biopsy - how to do it. Practical Neurology , 3 (5) 306 - 313.

Ginsberg, L and Malik, O and Kenton, AR and Sharp, D and Muddle, JR and Davis, MB and Winer, JB and Orrell, RW and King, RH (2004) Coexistent hereditary and inflammatory neuropathy. Brain , 127 (Pt 1) 193 - 202. 10.1093/brain/awh017.

Ginsberg, L and Malik, O and Kenton, AR and Sharp, D and Muddle, JR and Davis, MB and Winer, JB and Orrell, RW and King, RHM (2004) Coexistent hereditary and inflammatory neuropathy. BRAIN , 127 193 - 202. 10.1093/brain/awh017.

Hameed, M and Orrell, RW and Cobbold, M and Goldspink, G and Harridge, SDR (2003) Expression of IGF-I splice variants in young and old human skeletal muscle after high resistance exercise (vol 547, pg 247, 2003). J PHYSIOL-LONDON , 549 (3) 995 - 995. 10.1113/jphysiol.2003.594001.

Hameed, M and Orrell, RW and Cobbold, M and Goldspink, G and Harridge, SDR (2003) Expression of IGF-I splice variants in young and old human skeletal muscle after high resistance exercise. J PHYSIOL-LONDON , 547 (1) 247 - 254. 10.1113/jphysiol.2002.032136.

Hameed, M and Orrell, RW and Cobbold, M and Goldspink, G and Harridge, SDR (2003) Erratum: (Journal of Physiology (2003) vol. 547 (247-254)). Journal of Physiology , 549 (3) 995 - 995.

Hosler, BA and Nicholson, GA and Sapp, PC and Chin, W and Orrell, RW and DeBelleroche, JS and Esteban, J and Hayward, LJ and McKennaYasek, D and Yeung, L and Cherryson, AK and Dench, JE and Wilton, SD and Laing, NG and Horvitz, HR and Brown, RH (1996) Three novel mutations and two variants in the gene for Cu/Zn superoxide dismutase in familial amyotrophic lateral sclerosis. NEUROMUSCULAR DISORD , 6 (5) 361 - 366.

Houlden, H and King, RHM and Muddle, JR and Warner, TT and Reilly, MM and Orrell, RW and Ginsberg, L (2004) A novel RAB7 mutation associated with ulcero-mutilating neuropathy. ANN NEUROL , 56 (4) 586 - 590. 10.1002/ana.20281.

Houlden, H and Lincoln, S and Farrer, M and Cleland, PG and Hardy, J and Orrell, RW (2003) Compound heterozygous PANK2 mutations confirm HARP and Hallervorden-Spatz syndromes are allelic. NEUROLOGY , 61 (10) 1423 - 1426.

Howard, RS and Orrell, RW (2002) Management of motor neurone disease. POSTGRAD MED J , 78 (926) 736 - 741.

Irani, SR and Mathias, CJ and Orrell, RW (2007) Pure autonomic failure followed by amyotrophy. NEUROLOGY , 68 (10) 792 - 793.

Kasperaviciute, D and Weale, ME and Shianna, KV and Banks, GT and Simpson, CL and Hansen, VK and Turner, MR and Shaw, CE and Al-Chalabi, A and Pall, HS and Goodall, EF and Morrison, KE and Orrell, RW and Beck, M and Jablonka, S and Sendtner, M and Brockington, A and Ince, PG and Hartley, J and Nixon, H and Shaw, PJ and Schiavo, G and Wood, NW and Goldstein, DB and Fisher, EMC (2007) Large-scale pathways-based association study in amyotrophic lateral sclerosis. BRAIN , 130 2292 - 2301. 10.1093/brain/awm055.

Kearney, M and Orrell, RW and Fahey, M and Pandolfo, M (2012) Antioxidants and other pharmacological treatments for Friedreich ataxia. COCHRANE DATABASE OF SYSTEMATIC REVIEWS (4) , Article ARTN CD007791. 10.1002/14651858.CD007791.pub3.

Kearney, M and Orrell, RW and Fahey, M and Pandolfo, M (2009) Antioxidants and other pharmacological treatments for Friedreich ataxia. COCHRANE DB SYST REV (4) , Article CD007791. 10.1002/14651858.CD007791.pub2.

Kimber, TE and Orrel, RW and King, RHM and Ginsberg, L (2003) Pathological findings in a patient with ventilatory failure and chronic inflammatory demyelinating polyneuropathy. J PERIPHER NERV SYST , 8 (1) 13 - 16.

Lacomblez, L and Bensimon, G and Leigh, PN and Guillet, P and Meininger, V and for, TALSRSGII (1996) Dose-ranging study of riluzole in amyotrophic lateral sclerosis. The Lancet , 347 (9013) 1425 - 1431.

Lane, R and Carey, N and Orrell, R and Moxley, RT (1997) Claude Monet's vision. Lancet , 349 (9053) 734 - ?. 10.1016/S0140-6736(05)60177-8.

Lane, RJ and Roncaroli, F and Charles, P and McGonagle, DG and Orrell, RW (2012) Acetylcholine receptor antibodies in patients with genetic myopathies: clinical and biological significance. Neuromuscul Disord , 22 (2) 122 - 128. 10.1016/j.nmd.2011.06.751.

Majounie, E and Renton, AE and Mok, K and Dopper, EG and Waite, A and Rollinson, S and Chiò, A and Restagno, G and Nicolaou, N and Simon-Sanchez, J and van Swieten, JC and Abramzon, Y and Johnson, JO and Sendtner, M and Pamphlett, R and Orrell, RW and Mead, S and Sidle, KC and Houlden, H and Rohrer, JD and Morrison, KE and Pall, H and Talbot, K and Ansorge, O and Chromosome 9-ALS/FTD Consortium, and French research network on FTLD/FTLD/ALS, and ITALSGEN Consortium, and Hernandez, DG and Arepalli, S and Sabatelli, M and Mora, G and Corbo, M and Giannini, F and Calvo, A and Englund, E and Borghero, G and Floris, GL and Remes, AM and Laaksovirta, H and McCluskey, L and Trojanowski, JQ and Van Deerlin, VM and Schellenberg, GD and Nalls, MA and Drory, VE and Lu, CS and Yeh, TH and Ishiura, H and Takahashi, Y and Tsuji, S and Le Ber, I and Brice, A and Drepper, C and Williams, N and Kirby, J and Shaw, P and Hardy, J and Tienari, PJ and Heutink, P and Morris, HR and Pickering-Brown, S and Traynor, BJ (2012) Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study. Lancet Neurol , 11 (4) 323 - 330. 10.1016/S1474-4422(12)70043-1.

Majounie, E and Renton, AE and Mok, K and Dopper, EGP and Waite, A and Rollinson, S and Chiò, A and Restagno, G and Nicolaou, N and Simon-Sanchez, J and van Swieten, JC and Abramzon, Y and Johnson, JO and Sendtner, M and Pamphlett, R and Orrell, RW and Mead, S and Sidle, KC and Houlden, H and Rohrer, JD and Morrison, KE and Pall, H and Talbot, K and Ansorge, O and Hernandez, DG and Arepalli, S and Sabatelli, M and Mora, G and Corbo, M and Giannini, F and Calvo, A and Englund, E and Borghero, G and Floris, GL and Remes, AM and Laaksovirta, H and McCluskey, L and Trojanowski, JQ and Van Deerlin, VM and Schellenberg, GD and Nalls, MA and Drory, VE and Lu, C-S and Yeh, T-H and Ishiura, H and Takahashi, Y and Tsuji, S and Le Ber, I and Brice, A and Drepper, C and Williams, N and Kirby, J and Shaw, P and Hardy, J and Tienari, PJ and Heutink, P and Morris, HR and Pickering-Brown, S and Traynor, BJ (2012) Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: A cross-sectional study. The Lancet Neurology , 11 (4) 323 - 330.

Majounie, E and Renton, AE and Mok, K and Dopper, EGP and Waite, A and Rollinson, S and Chiò, A and Restagno, G and Nicolaou, N and Simon-Sanchez, J and van Swieten, JC and Abramzon, Y and Johnson, JO and Sendtner, M and Pamphlett, R and Orrell, RW and Mead, S and Sidle, KC and Houlden, H and Rohrer, JD and Morrison, KE and Pall, H and Talbot, K and Ansorge, O and Hernandez, DG and Arepalli, S and Sabatelli, M and Mora, G and Corbo, M and Giannini, F and Calvo, A and Englund, E and Borghero, G and Floris, GL and Remes, AM and Laaksovirta, H and McCluskey, L and Trojanowski, JQ and Van Deerlin, VM and Schellenberg, GD and Nalls, MA and Drory, VE and Lu, C-S and Yeh, T-H and Ishiura, H and Takahashi, Y and Tsuji, S and Le Ber, I and Brice, A and Drepper, C and Williams, N and Kirby, J and Shaw, P and Hardy, J and Tienari, PJ and Heutink, P and Morris, HR and Pickering-Brown, S and Traynor, BJ (2012) Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: A cross-sectional study. The Lancet Neurology , 11 (4) 323 - 330.

Majumdar, A and Hartley, L and Manzur, AY and King, RHM and Orrell, RW and Muntoni, F (2004) A case of severe congenital chronic inflammatory demyelinating polyneuropathy with complete spontaneous remission. NEUROMUSCULAR DISORD , 14 (12) 818 - 821. 10.1016/j.nmd.2004.09.003.

Manjaly, ZR and Scott, KM and Abhinav, K and Wijesekera, L and Ganesalingam, J and Goldstein, LH and Janssen, A and Dougherty, A and Willey, E and Stanton, BR and Turner, MR and Ampong, MA and Sakel, M and Orrell, RW and Howard, R and Shaw, CE and Leigh, PN and Al-Chalabi, A (2010) The sex ratio in amyotrophic lateral sclerosis: A population based study. AMYOTROPH LATERAL SC , 11 (5) 439 - 442. 10.3109/17482961003610853.

Mitchell, J and Habgood, JJ and Orrell, RW and Kaushik, N and Malaspina, A and Gardiner, IM and Greenwood, JS and de Belleroche, JS (2000) Identifying gene defects in motor neurone disease /amyotrophic lateral sclerosis families that lack Cu/Zn superoxide dismutase mutations. EUR J NEUROSCI , 12 226 - 226.

Mok, K and Laaksovirta, H and Tienari, PJ and Peuralinna, T and Myllykangas, L and Chiò, A and Traynor, BJ and Nalls, MA and Gurunlian, N and Shatunov, A and Restagno, G and Mora, G and Nigel Leigh, P and Shaw, CE and Morrison, KE and Shaw, PJ and Al-Chalabi, A and Hardy, J and Orrell, RW (2013) Homozygosity analysis in amyotrophic lateral sclerosis. Eur J Hum Genet 10.1038/ejhg.2013.59.

Mok, K and Traynor, BJ and Schymick, J and Tienari, PJ and Laaksovirta, H and Peuralinna, T and Myllykangas, L and Chiò, A and Shatunov, A and Boeve, BF and Boxer, AL and DeJesus-Hernandez, M and Mackenzie, IR and Waite, A and Williams, N and Morris, HR and Simón-Sánchez, J and van Swieten, JC and Heutink, P and Restagno, G and Mora, G and Morrison, KE and Shaw, PJ and Rollinson, PS and Al-Chalabi, A and Rademakers, R and Pickering-Brown, S and Orrell, RW and Nalls, MA and Hardy, J (2012) Chromosome 9 ALS and FTD locus is probably derived from a single founder. Neurobiol Aging , 33 (1) 209.e3 - 209.e8. 10.1016/j.neurobiolaging.2011.08.005.

Orrell, R (1997) Amyotrophic Lateral Sclerosis. Neuromuscular Disorders , 7 71 - 72.

Orrell, R (1996) Amyotrophic Lateral Sclerosis. Lancet , 348 1227 - 1227.

Orrell, R and de Belleroche, J and Marklund, S and Bowe, F and Hallewell, R (1995) A novel SOD mutant and ALS. Nature , 374 (6522) 504 - 505. 10.1038/374504a0.

Orrell, R and Schapira, AH (2002) Mitochondria and amyotrophic lateral sclerosis. International Review of Neurobiology , 53 411 - 424.

Orrell, RW (2012) Diagnosing and managing muscular dystrop. Practitioner , 256 (1754) 21 - 3.

Orrell, RW (2011) GPs have key role in managing motor neurone disease. Practitioner , 255 (1743) 19 - 2.

Orrell, RW (2011) Facioscapulohumeral dystrophy and scapuloperoneal syndromes. Handb Clin Neurol , 101 167 - 180. 10.1016/B978-0-08-045031-5.00013-X.

Orrell, RW (2010) What is the clinical significance of SOD1 mutations in amyotrophic lateral sclerosis? J NEUROL NEUROSUR PS , 81 (5) 473 - 473. 10.1136/jnnp.2010.205575.

Orrell, RW (2010) Motor neuron disease: systematic reviews of treatment for ALS and SMA. BRIT MED BULL , 93 (1) 145 - 159. 10.1093/bmb/ldp049.

Orrell, RW (2010) What is the clinical significance of SOD1 mutations in amyotrophic lateral sclerosis? Journal of Neurology, Neurosurgery and Psychiatry , 81 (5) 473 - ?.

Orrell, RW (2007) Understanding the causes of amyotrophic lateral sclerosis. NEW ENGL J MED , 357 (8) 822 - 823. 10.1056/NEJMe078146.

Orrell, RW (2007) Book review. Palliative care in amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery and Pschiatry , 78 778 - ?. 10.1136/jnnp.2007.115808.

Orrell, RW (2006) AEOL-10150 (Aeolus). Curr Opin Investig Drugs , 7 (1) 70 - 80.

Orrell, RW (2006) AEOL-10150 aeolus. CURR OPIN INVEST DR , 7 (1) 70 - 80.

Orrell, RW (2005) Book review. Atlas of neuromuscular disorders. Journal of Neurology, Neurosurgery and Psychiatry , 76 1312 - ?. 10.1136/jnnp.2005.65920.

Orrell, RW (2005) Book review. Multiple Sclerosis: the history of a disease. Journal of the Royal Society of Medicine , 98 (6) 289 - 289.

Orrell, RW (2004) Book review. Fascioscapulohumeral dystrophy. Neuromuscular Disorders , 14 (11) 775 - 775. 10.1016/j.nmd.2004.07.001.

Orrell, RW (2004) Book review. Neurological therapeutics: principles and practice. Volumes I and II. Brain , 127 (6) 1456 - 1457. 10.1093/brain/awh122.

Orrell, RW (2004) Facioscapulohumeral dystrophy. Practical Neurology , 4 (4) 238 - 241.

Orrell, RW (2000) Amyotrophic lateral sclerosis: copper/zinc superoxide dismutase (SOD1) gene mutations. NEUROMUSCULAR DISORD , 10 (1) 63 - 68.

Orrell, RW (1999) Book review: Cell transplantation for neurological disorders. Brain , 122 (9) 1791 - 1792. 10.1093/brain/122.9.1791.

Orrell, RW (1996) Grand rounds--Hammersmith Hospitals. Distinguishing acute disseminated encephalomyelitis from multiple sclerosis. BMJ , 313 (7060) 802 - 804.

Orrell, RW (1995) The genetics of motor neuron disease. Current Medical Literature - Neurology and Neurosurgery , 11 95 - 102.

ORRELL, RW (1991) SODIUM VALPROATE IN PREGNANCY. BRIT MED J , 303 (6793) 56 - 56.

Orrell, RW Motor Neuron Disease: Systematic reviews of treatment for ALS and SMA. British Medical Bulletin. British Medical Bulletin

ORRELL, RW and AMROLIA, PJ and HEALD, A and CLELAND, PG and OWEN, JS and MORGANHUGHES, JA and HARDING, AE and MARSDEN, CD (1995) ACANTHOCYTOSIS, RETINITIS-PIGMENTOSA, AND PALLIDAL DEGENERATION - A REPORT OF 3 PATIENTS, INCLUDING THE 2ND REPORTED CASE WITH HYPOPREBETALIPOPROTEINEMIA (HARP-SYNDROME). NEUROLOGY , 45 (3) 487 - 492.

Orrell, RW and Clark, AJL (2002) ALADIN, but where's the Genie? NEUROLOGY , 58 (6) 847 - 848.

Orrell, RW and Copeland, S and Rose, MR (2010) Scapular fixation in muscular dystrophy. COCHRANE DB SYST REV (1) , Article CD003278. 10.1002/14651858.CD003278.pub2.

Orrell, RW and De Belleroche, J and Marklund, SL and Bowe, FA and Hallewell, RA (1995) Toxic mutants in Charcot's sclerosis [8]. Nature , 378 (6555) 343 - 343.

Orrell, RW and deBelleroche, J (1994) Superoxide dismutase and amyotrophic lateral sclerosis. The Lancet , 344 1651 - 1652.

ORRELL, RW and DEBELLEROCHE, J and MARKLUND, SL and BOWE, FA and HALLEWELL, RA (1995) TOXIC MUTANTS IN CHARCOTS SCLEROSIS - REPLY. NATURE , 378 (6555) 343 - 343.

ORRELL, RW and DEBELLEROCHE, JS (1994) SUPEROXIDE-DISMUTASE AND ALS. LANCET , 344 (8938) 1651 - 1652.

Orrell, RW and Figlewicz, DA (2001) Clinical implications of the genetics of ALS and other motor neuron diseases. NEUROLOGY , 57 (1) 9 - 17.

ORRELL, RW and GUTHRIE, JA and LAMB, JT (1991) NOSE-BLOWING AND CSF RHINORRHEA. LANCET , 337 (8744) 804 - 804.

Orrell, RW and Habgood, J and Rudge, P and Lane, RJM and deBelleroche, JS (1996) Difficulties in distinguishing sporadic from familial amyotrophic lateral sclerosis. ANN NEUROL , 39 (6) 810 - 812.

Orrell, RW and Habgood, JJ and deBelleroche, JS and Lane, RJM (1997) The relationship of spinal muscular atrophy to motor neuron disease: Investigation of SMN and NAIP gene deletions in sporadic and familial ALS. J NEUROL SCI , 145 (1) 55 - 61.

Orrell, RW and Habgood, JJ and Gardiner, I and King, AW and Bowe, FA and Hallewell, RA and Marklund, SL and Greenwood, J and Lane, RJM and deBelleroche, J (1997) Clinical and functional investigation of 10 missense mutations and a novel frameshift insertion mutation of the gene for copper-zinc superoxide dismutase in UK families with amyotrophic lateral sclerosis. NEUROLOGY , 48 (3) 746 - 751.

Orrell, RW and Habgood, JJ and Malaspina, A and Mitchell, J and Greenwood, J and Lane, RJM and deBelleroche, JS (1999) Clinical characteristics of SOD1 gene mutations in UK families with ALS. JOURNAL OF THE NEUROLOGICAL SCIENCES , 169 (1-2) 56 - 60.

Orrell, RW and Habgood, JJ and Shepherd, DI and Donnai, D and deBelleroche, J (1997) A novel mutation of SOD-1 (Gly 108 Val) in familial amyotrophic lateral sclerosis. EUR J NEUROL , 4 (1) 48 - 51.

ORRELL, RW and JAMESGALTON, M and STEVENS, JM and ROSSOR, MN (1995) CEREBRAL ACHROMATOPSIA AS A PRESENTATION OF TROUSSEAUS-SYNDROME. POSTGRAD MED J , 71 (831) 44 - 46.

ORRELL, RW and JOHNSON, MH (1993) PLASMA VISCOSITY AND THE DIAGNOSIS OF GIANT-CELL ARTERITIS. BRIT J CLIN PRACT , 47 (2) 71 - 72.

Orrell, RW and Johnston, HM and Gibson, C and Cass, RM and Griggs, RC (1998) Spontaneous abdominal hematoma in dermatomyositis. Muscle Nerve , 21 (12) 1800 - 1803.

Orrell, RW and Jurkat-Rott, K and Lehmann-Horn, F and Lane, RJM (1998) Familial cramp due to potassium-aggravated myotonia. J NEUROL NEUROSUR PS , 65 (4) 569 - 572.

ORRELL, RW and KING, AW and DEBELLEROCHE, JS (1995) PARENTAL INFLUENCE ON INHERITANCE OF FAMILIAL AMYOTROPHIC-LATERAL-SCLEROSIS. LANCET , 345 (8946) 391 - 392.

ORRELL, RW and KING, AW and HILTON, DA and CAMPBELL, MJ and LANE, RJM and DEBELLEROCHE, JS (1995) FAMILIAL AMYOTROPHIC-LATERAL-SCLEROSIS WITH A POINT MUTATION OF SOD-1 - INTRAFAMILIAL HETEROGENEITY OF DISEASE DURATION ASSOCIATED WITH NEUROFIBRILLARY TANGLES. J NEUROL NEUROSUR PS , 59 (3) 266 - 270.

ORRELL, RW and KING, AW and LANE, RJM and DEBELLEROCHE, JS (1995) INVESTIGATION OF A NULL MUTATION OF THE CNTF GENE IN FAMILIAL AMYOTROPHIC-LATERAL-SCLEROSIS. J NEUROL SCI , 132 (2) 126 - 128.

Orrell, RW and King, R and Bowler, JV and Ginsberg, L (2003) Peripheral nerve granuloma in a patient with tuberculosis. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY , 74 (3) 410 - 410.

Orrell, RW and King, RHM and Bowler, JV and Ginsberg, L (2002) Peripheral nerve granuloma in a patient with tuberculosis. J NEUROL NEUROSUR PS , 73 (6) 769 - 771.

Orrell, RW and Lane, JM and Ross, MA (2005) Antioxidant treatment for amyotrophic lateral sclerosis / motor neuron disease. Cochrane Database Syst Rev. 2004 Oct 18;(4):CD002829. Review. Update in:. Cochrane Database of Systematic Reviews (1) CD002829 - ?.

Orrell, RW and Lane, JM and Ross, MA (2004) Antioxidant treatment for amyotrophic lateral sclerosis / motor neuron disease. Cochrane Database Syst Rev (4) CD002829 - ?. 10.1002/14651858.CD002829.pub2.

Orrell, RW and Lane, JM and Ross, MA (2004) Antioxidant treatment for amyotrophic lateral sclerosis / motor neuron disease. Cochrane database of systematic reviews (Online) (4)

Orrell, RW and Lane, RJ and Maitland, J and Leslie, RD (1994) Antibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus. Lancet , 344 (8917) 267 - 267.

Orrell, RW and Lane, RJ and Ross, M (2007) Antioxidant treatment for amyotrophic lateral sclerosis / motor neuron disease. Cochrane database of systematic reviews (Online) (1)

ORRELL, RW and LANE, RJM and GUILOFF, RJ (1994) RECENT DEVELOPMENTS IN THE DRUG-TREATMENT OF MOTOR-NEURON DISEASE. BRIT MED J , 309 (6948) 140 - 141.

ORRELL, RW and LANE, RJM and MAITLAND, J and LESLIE, RDG (1994) ANTIBODIES TO GLUTAMIC-ACID DECARBOXYLASE AS PREDICTORS OF INSULIN-DEPENDENT DIABETES-MELLITUS - REPLY. LANCET , 344 (8917) 267 - 267.

Orrell, RW and Lane, RJM and Ross, M (2008) A systematic review of antioxidant treatment for amyotrophic lateral sclerosis/motor neuron disease. AMYOTROPH LATERAL SC , 9 (4) 195 - 211. 10.1080/17482960801900032.

Orrell, RW and Lane, RJM and Ross, M (2007) Antioxidant treatment for amyotrophic lateral sclerosis / motor neuron disease. Cochrane Database of Systematic Reviews (1)

Orrell, RW and Lane, RJM and Ross, M (2007) Antioxidant treatment for amyotrophic lateral sclerosis/motor neuron disease. COCHRANE DB SYST REV (1) , Article CD002829. 10.1002/14651858.CD002829.pub4.

Orrell, RW and Lane, RJM and Ross, M (2005) Antioxidant treatment for amyotrophic lateral sclerosis/motor neuron disease. COCHRANE DB SYST REV (1) , Article CD002829.pub3. 10.1002/14651858.CD002829.pub3.

ORRELL, RW and LILFORD, RJ (1990) CHORIONIC VILLUS SAMPLING AND RARE SIDE-EFFECTS - WILL A RANDOMIZED CONTROLLED TRIAL DETECT THEM. INT J GYNECOL OBSTET , 32 (1) 29 - 34.

Orrell, RW and Marklund, SL and deBelleroche, JS (1997) Familial ALS is associated with mutations in all exons of SOD1: a novel mutation in exon 3 (Gly72Ser). J NEUROL SCI , 153 (1) 46 - 49.

ORRELL, RW and MARSDEN, CD (1994) THE NECK-TONGUE SYNDROME. J NEUROL NEUROSUR PS , 57 (3) 348 - 352.

Orrell, RW and Marsden, CD (1994) The neck-tongue syndrome. Journal of Neurology Neurosurgery and Psychiatry , 57 (3) 348 - 352.

ORRELL, RW and OMER, S and BURT, AA and GALVIN, MC (1991) PSEUDOTUMOR CEREBRI AND PARAPROTEINEMIA. LEUKEMIA LYMPHOMA , 5 (2-3) 211 - 213.

Orrell, RW and Peatfield, RC and Collins, CE and Woodrow, DF and Moss, J and Press, M and Lane, RJ (1995) Myopathy in acquired partial lipodystrophy. Clin Neurol Neurosurg , 97 (2) 181 - 186.

Orrell, RW and Shakir, R and Lane, RJM and Kennard, C and Wade, JPH and Poser, CM (1996) Grand rounds - Hammersmith Hospitals - Distinguishing acute disseminated encephalomyelitis from multiple sclerosis - Genetic predisposition may differ. BRIT MED J , 313 (7060) 802 - 804.

Orrell, RW and Shakir, R and Lane, RJM and Kennard, C and Wade, JPH and Poser, CM (1996) Distinguishing acute disseminated encephalomyelitis from multiple sclerosis. British Medical Journal , 313 (7060) 802 - 804.

Orrell, RW and Tawil, R and Forrester, J and Kissel, JT and Mendell, JR and Figlewicz, DA (1999) Definitive molecular diagnosis of facioscapulohumeral dystrophy. NEUROLOGY , 52 (9) 1822 - 1826.

ORRELL, RW and TROMANS, AM and BURT, AA (1991) MYOTONIC-DYSTROPHY AND TRAUMATIC QUADRIPLEGIA - CASE-REPORT. PARAPLEGIA , 29 (6) 419 - 422.

Orrell, RW and Tromans, AM and Burt, AA (1991) Myotonic dystrophy and traumatic quadriplegia. Paraplegia , 29 419 - 422.

ORRELL, RW and WOODROW, DF and BARRETT, MC and PRESS, M and DICK, DJ and ROWE, RCG and LANE, RJM (1995) TESTOSTERONE DEFICIENCY MYOPATHY. J ROY SOC MED , 88 (8) 454 - 456.

Pearson, SJ and Cobbold, M and Orrell, RW and Harridge, SD (2006) Power output and muscle myosin heavy chain composition in young and elderly men. Med Sci Sports Exerc , 38 (9) 1601 - 1607. 10.1249/01.mss.0000227638.75983.9d.

Pearson, SJ and Cobbold, M and Orrell, RW and Harridge, SDR (2006) Power output and muscle myosin heavy chain composition in young and elderly men. MED SCI SPORT EXER , 38 (9) 1601 - 1607. 10.1249/01.mss.0000227638.75938.9d.

Pullen, AH and Demestre, M and Howard, RS and Orrell, RW (2004) Passive transfer of purified IgG from patients with amyotrophic lateral sclerosis to mice results in degeneration of motor neurons accompanied by Ca2+ enhancement. ACTA NEUROPATHOL , 107 (1) 35 - 46. 10.1007/s00401-003-0777-z.

Pullen, AH and Demestre, M and Orrell, R and Schwaller, B (2003) Ectopic expression of parvalbumin in motor neurons of mice attenuates development of cytopathology following passive transfer of purified and dialysed IgG from sera of patients with amyotrophic lateral sclerosis. ALS and Other Motor Neuron Disorders , 4S1 (4S1) 131 - 132.

Renton, AE and Majounie, E and Waite, A and Simon-Sanchez, J and Rollinson, S and Gibbs, JR and Schymick, JC and Laaksovirta, H and van Swieten, JC and Myllykangas, L and Kalimo, H and Paetau, A and Abramzon, Y and Remes, AM and Kaganovich, A and Scholz, SW and Duckworth, J and Ding, JH and Harmer, DW and Hernandez, DG and Johnson, JO and Mok, K and Ryten, M and Trabzuni, D and Guerreiro, RJ and Orrell, RW and Neal, J and Murray, A and Pearson, J and Jansen, IE and Sondervan, D and Seelaar, H and Blake, D and Young, K and Halliwell, N and Callister, JB and Toulson, G and Richardson, A and Gerhard, A and Snowden, J and Mann, D and Neary, D and Nalls, MA and Peuralinna, T and Jansson, L and Isoviita, VM and Kaivorinne, AL and Holtta-Vuori, M and Ikonen, E and Sulkava, R and Benatar, M and Wuu, J and Chio, A and Restagno, G and Borghero, G and Sabatelli, M and Heckerman, D and Rogaeva, E and Zinman, L and Rothstein, JD and Sendtner, M and Drepper, C and Eichler, EE and Alkan, C and Abdullaev, Z and Pack, SD and Dutra, A and Pak, E and Hardy, J and Singleton, A and Williams, NM and Heutink, P and Pickering-Brown, S and Morris, HR and Tienari, PJ and Traynor, BJ and ITALSGEN Consortium, (2011) A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD. NEURON , 72 (2) 257 - 268. 10.1016/j.neuron.2011.09.010.

Riddoch-Contreras, J and Yang, SY and Dick, JRT and Goldspink, G and Orrell, RW and Greensmith, L (2009) Mechano-growth factor, an IGF-I splice variant, rescues motoneurons and improves muscle function in SOD1(G93A) mice. EXP NEUROL , 215 (2) 281 - 289. 10.1016/j.expneurol.2008.10.014.

Scott, KM and Abhinav, K and Stanton, BR and Johnston, C and Turner, MR and Ampong, MA and Sakel, M and Orrell, RW and Howard, R and Shaw, CE and Leigh, PN and Al-Chalabi, A (2009) Geographical Clustering of Amyotrophic Lateral Sclerosis in South-East England: A Population Study. NEUROEPIDEMIOLOGY , 32 (2) 81 - 88. 10.1159/000177032.

Scott, KM and Abhinav, K and Wijesekera, L and Ganesalingam, J and Goldstein, LH and Janssen, A and Dougherty, A and Willey, E and Stanton, BR and Turner, MR and Ampong, MA and Sakel, M and Orrell, R and Howard, R and Shaw, CE and Nigel Leigh, P and Al-Chalabi, A (2010) The association between ALS and population density: A population based study. Amyotroph Lateral Scler , 11 (5) 435 - 438. 10.3109/17482961003754552.

Scott, KM and Abinav, KM and Wijesekera, L and Ganesalingam, J and Goldestein, LH and Janssen, A and Dougherty, A and Willey, E and Stanton, BR and Turner, MR and Ampong, MA and Sakel, M and Orrell, RW and Howard, R and Shaw, CE and Leigh, PN and Al-Chalabi, A The sex ratio in amyotrophic lateral sclerosis: a population based study. Amyotrophic Lateral Sclerosis

Shatunov, A and Mok, K and Newhouse, S and Weale, ME and Smith, B and Vance, C and Johnson, L and Veldink, JH and van Es, MA and van den Berg, LH and Robberecht, W and Van Damme, P and Hardiman, O and Farmer, AE and Lewis, CM and Butler, AW and Abel, O and Andersen, PM and Fogh, I and Silani, V and Chio, A and Traynor, BJ and Melki, J and Meininger, V and Landers, JE and McGuffin, P and Glass, JD and Pall, H and Leigh, PN and Hardy, J and Brown, RH and Powell, JF and Orrell, RW and Morrison, KE and Shaw, PJ and Shaw, CE and Al-Chalabi, A (2010) Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study. LANCET NEUROL , 9 (10) 986 - 994. 10.1016/S1474-4422(10)70197-6.

Shaunak, S and Orrell, R and Henderson, L and Kennard, C (1999) Saccades and smooth pursuit in myotonic dystrophy. J Neurol , 246 (7) 600 - 606.

SHAUNAK, S and ORRELL, RW and OSULLIVAN, E and HAWKEN, MB and LANE, RJM and HENDERSON, L and KENNARD, C (1995) OCULOMOTOR FUNCTION IN AMYOTROPHIC-LATERAL-SCLEROSIS - EVIDENCE FOR FRONTAL IMPAIRMENT. ANN NEUROL , 38 (1) 38 - 44.

Toosy, AT and Werring, DJ and Orrell, RW and Howard, RS and King, MD and Barker, GJ and Miller, DH and Thompson, AJ (2003) Diffusion tensor imaging detects corticospinal tract involvement at multiple levels in amyotrophic lateral sclerosis. J NEUROL NEUROSUR PS , 74 (9) 1250 - 1257.

UKMND-LiCALS Study Group, and Morrison, KE and Dhariwal, S and Hornabrook, R and Savage, L and Burn, DJ and Khoo, TK and Kelly, J and Murphy, CL and Al-Chalabi, A and Dougherty, A and Leigh, PN and Wijesekera, L and Thornhill, M and Ellis, CM and O'Hanlon, K and Panicker, J and Pate, L and Ray, P and Wyatt, L and Young, CA and Copeland, L and Ealing, J and Hamdalla, H and Leroi, I and Murphy, C and O'Keeffe, F and Oughton, E and Partington, L and Paterson, P and Rog, D and Sathish, A and Sexton, D and Smith, J and Vanek, H and Dodds, S and Williams, TL and Steen, IN and Clarke, J and Eziefula, C and Howard, R and Orrell, R and Sidle, K and Sylvester, R and Barrett, W and Merritt, C and Talbot, K and Turner, MR and Whatley, C and Williams, C and Williams, J and Cosby, C and Hanemann, CO and Iman, I and Philips, C and Timings, L and Crawford, SE and Hewamadduma, C and Hibberd, R and Hollinger, H and McDermott, C and Mils, G and Rafiq, M and Shaw, PJ and Taylor, A and Waines, E and Walsh, T and Addison-Jones, R and Birt, J and Hare, M and Majid, T (2013) Lithium in patients with amyotrophic lateral sclerosis (LiCALS): a phase 3 multicentre, randomised, double-blind, placebo-controlled trial. Lancet Neurol , 12 (4) 339 - 345. 10.1016/S1474-4422(13)70037-1.

Book chapter

Howard, RS and Orrell, RW (2006) Management of motor neurone disease. In: Neurology Reviews. (155 - 168). Radcliffe Publishing Limited

Lane, RJM and Orrell, RW and Tappouni, H (1996) Diagnostic Index of neuromuscular disorders. In: Lane, RJM, (ed.) Handbook of Muscle Disease. (705 - 726). Marcel Dekker: New York.

Orrell, R (1996) Compartment syndromes. In: Lane, RJM, (ed.) Handbook of Muscle Disease. (605 - 606). Marcel Dekker: New York.

Orrell, R (1996) Myositis ossificans. In: Lane, RJM, (ed.) Handbook of Muscle Disease. (599 - 601). Marcel Dekker: New York.

Orrell, R (1996) Nutritional myopathies. In: Lane, RJM, (ed.) Handbook of Muscle Disease. (613 - 615). Marcel Dekker: New York.

Orrell, R (1996) Polymyalgia rheumatica. In: Lane, RJM, (ed.) Handbook of Muscle Disease. (595 - 597). Marcel Dekker: New York.

Orrell, R and Griggs, RC (2003) Myopathies. In: Brandt, TC and Dichgans, J and Diener, HC and Kennard, C, (eds.) Neurological Disorders: Course and treatment. (1369 - 1383). Academic Press

Orrell, R and Schapira, AHV (2001) Asymmetric muscle weakness. In: Schapira, AHV and Rowland, LP, (eds.) Clinical cases in neurology. (239 - 245). Butterworth-Heinemann: Oxford.

Orrell, R and Schapira, AHV (2001) Muscle weakness and dysphagia. In: Schapira, AHV and Rowland, LP, (eds.) Clinical cases in neurology. (99 - 106). Butterworth-Heinemann: Oxford.

Orrell, RW (2007) Endocrine myopathies. In: UNSPECIFIED (343 - 355).

Orrell, RW Facioscapulohumeral dystrophy. In: Amato, A and Griggs, RC, (eds.) Muscular dystrophy. Elsevier: Edinburgh.

Orrell, RW HARP syndrome. In: Kompoliti, K and Verhagen, L, (eds.) Encyclopedia of Movement Disorders. Elsevier

Orrell, RW and Clarke, J and Howard, RS (2007) Standards of care in motor neuron disease. In: Kiernan, MC, (ed.) The Motor Neurone Disease Handbook. (74 - 88). Australian Medical Publishing Company Limited

Orrell, RW and Darras, BT and Griggs, RC (2002) FSHD and distal myopathies. In: Jones, HR and De Vivo, DC and Darras, BT, (eds.) Neuromuscular disorders of infancy, childhood, and adolescence a clinician's approach. (701 - 716). Butterworth-Heinemann

Orrell, RW and Fuller, GN (1996) Arthrogryposis multiplex congenita. In: Lane, RJM, (ed.) Handbook of Muscle Disease. (603 - 604). Marcel Dekker

Orrell, RW and Griggs, RC (2002) Disorders of striated muscle. In: Asbury, AK and McKhann, G, (eds.) Diseases of the Nervous System: Clinical Neuroscience and Therapeutic Principles. (1163 - 1182). Cambridge University Press: Cambridge.

Orrell, RW and Griggs, RC (1999) Muscular dystrophies: clinical and molecular approaches. In: Schapira, AHV and Griggs, RC, (eds.) Muscle Diseases. (59 - 82). Butterworth Heinemann: Oxford.

Orrell, RW and Guiloff, RJ (2001) Myopathies: ethics, outcome variables and clinical scales. In: Neurological Disease. (505 - 513). Springer

Orrell, RW and Habgood, JJ and Malaspina, A and Mitchell, J and Gardiner, I and Greenwood, J and Lane, RJM and Hallewell, RA and Marklund, SL and deBelleroche, JS (1999) Mutations of the SOD1 gene in familial amyotrophic lateral sclerosis. In: Edeas, MA, (ed.) Superoxide Dismutase: Recent advances and clinical application. (100 - 102). Editions MEL: Paris.

Orrell, RW and Lane, RJM (1996) Myoglobinuria. In: Lane, RJM, (ed.) Handbook of Muscle Disease. (607 - 611). Marcel Dem

Orrell, RW and Lane, RJM (1996) Myopathies in infections and systemic diseases. In: Handbook of Muscle Disease. (391 - 406). Marcel Dekker: New York.

Orrell, RW and Lane, RJM and deBelleroche, JS (1996) Ciliary neurotrophic factor (CNTF): Possible implications in the pathogenesis of amyotrophic lateral sclerosis. In: Fiskum, G, (ed.) UNSPECIFIED (401 - 403). PLENUM PRESS DIV PLENUM PUBLISHING CORP

Orrell, RW and Lane, RJM and Hudgson, P (1996) Muscle dysfunction in endocrine disease. In: Lane, RJM, (ed.) Handbook of Muscle Disease. (365 - 378). Marcel Dekker: New York.

Orrell, RW and Schapira, AHV (2002) Mitochondria and amyotrophic lateral sclerosis. In: UNSPECIFIED (411 - 426). ACADEMIC PRESS INC

Orrell, RW and Wade, JPH (1996) Vascular dementia: clinical diagnosis - how good is it and how should it be done? In: Prohovnik, I and Wade, J and Knezevic, S and Tatemichi, T and Erkinjunti, T, (eds.) Vascular dementia - current concepts. (143 - 163). John Wiley and Sons: Chichester,.

Schapira, AHV and Orrell, R (2001) Young onset stroke. In: Schapira, AHV and Rowland, LP, (eds.) Clinical cases in neurology. (177 - 182). Butterworth-Heinemann: Oxford.

Other

Orrell, R (2003) Images on BBC programme related to growth factors. UNSPECIFIED

Orrell, R (1996) Riluzole: a new treatment for motor neuron disease. Multiple radio interviews, Radio 5 feature, BBC News images, Newspaper quotes. UNSPECIFIED

Orrell, R (1991) International radio interviews and media references on article in Lancet. UNSPECIFIED

Orrell, RW (2005) Horizon programme. The Doctor who can make people walk again. Guardian Films / BBC TV. UNSPECIFIED

Proceedings paper

Bacsi, AM and Ginsberg, L and Orrell, RW (2008) Reversible dysphagia in facioscapulohumeral dystrophy caused by myasthenia gravis. In: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. (pp. 358 - 358). B M J PUBLISHING GROUP

Bajaj, NPS and Waldman, AD and Orrell, RW and Bhatia, KP (2001) A unique family with adult onset Krabbe disease and normal neuroimaging. In: Journal of Neurology. (pp. 19 - ?).

Bennett, DLH and Groves, M and Blake, J and Holton, JL and King, RHM and Orrell, RW and Ginsberg, L and Reilly, MM (2007) The use of nerve and muscle biopsy in the diagnosis of vasculitis: a 5-year retrospective study of 53 cases. In: JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM. (pp. 9 - 10). BLACKWELL PUBLISHING

Bennett, DLH and Groves, M and King, R and Orrell, RW and Ginsberg, L and Reilly, MM (2004) The use of targeted nerve and muscle biopsy in the diagnosis of vasculitis. In: JOURNAL OF NEUROLOGY. (pp. 138 - 138). DR DIETRICH STEINKOPFF VERLAG

Bradley, LJ and Muddle, JR and Taanman, JW and Orrell, RW (2004) Conflicting evidence for mitochondrial dysfunction in patients with amytrophic lateral sclerosis. In: ALS and Other Motor Neuron Disorders. (pp. 70 - ?).

Bradley, LJ and Wilhelm, T and King, RHM and Ginsberg, L and Orrell, RW (2004) Brachius plexus hypertrophy in chronic inflammatory demyelinating polyneuropathy. In: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. (pp. 806 - 806). B M J PUBLISHING GROUP

Bradley, MD and Orrell, RW and Williams, AJ and Davidson, C and Kullman, D and Hirsch, N and Howard, RS (2001) The management of motor neuron disease presenting with respiratory failure. In: J NEUROL NEUROSUR PS. (pp. 276 - 276). BRITISH MED JOURNAL PUBL GROUP

Bradley, MD and Orrell, RW and Williams, AJ and Davidson, C and Kullman, D and Hirsch, N and Howard, RS (2000) Motor neurone disease presenting with acute respiratory failure. In: Amyotrophic Lateral Sclerosis. (pp. 21 - 22).

De Belleroche, J and Virgo, L and Orrell, R and Samarasinghe, S (1995) Neuronal death in amyotrophic lateral sclerosis. In: Journal of Neuropathology and Experimental Neurology. (pp. 14S - 15S).

Demestre, M and Pullen, AH and Orrell, R and Howard, RS (2002) Measurement of pro- and active forms of matrix metalloproteinase-9 (MMP9) in serum of patients with amyotrophic lateral sclerosis. In: FENS - Federation of European Neurosciences. (pp. A152.4:304 - ?).

Enayat, ZE and Claus, A and Orrell, R and King, A and de, BJ and Ludolph, A and Bachus, R and Brockmuller, J and Chaudhuri, R and Radunovic, A and Shaw, C and Wilkinson, I and Leigh, PN and Powell, JF (1995) Three new SOD-1 mutations in familial ALS. In: Journal of Neurology. (pp. S29 - ?).

Goonetilleke, A and Guiloff, RJ and Nikhar, N and Orrell, RW and Tan, SV (1997) The clinical assessment of muscle force. In: Journal of the Neurological Sciences. (pp. S4 - ?).

Goonetilleke, A and Nikhar, N and Tan, SV and Orrell, RW and Guiloff, RJ (1997) Clinical assessment of muscle force. In: Journal of Neurology, Neurosurgery and Psychiatry. (pp. 213 - ?).

Hameed, M and Orrell, R and Cobbold, M and Goldspink, G and Harridge, SDR (2002) Weightlifting exercise increases the mRNA expression of a mechanosensitive IGF-I (MGF) in the muscles of young, but not old men. In: JOURNAL OF PHYSIOLOGY-LONDON. (pp. 87P - 87P). CAMBRIDGE UNIV PRESS

Houlden, H and King, RHM and Muddle, JR and Warner, TT and Reilly, MM and Orrell, RW and Ginsberg, L (2004) Ulcero-mutilating neuropathy: Clinical, pathological and molecular genetic study of a family with a novel RAB7 mutation. In: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. (pp. 1228 - 1228). B M J PUBLISHING GROUP

Kearney, M and Orrell, RW and Fahey, M and Pandolfo, M (2010) Antioxidants and other pharmacological treatment for Friedreich ataxia. In: MOVEMENT DISORDERS. (pp. S193 - S193). WILEY-LISS

King, AW and Orrell, RW and Lane, R and de Belleroche, JS (1994) More than one locus for familial amyotrophic lateral sclerosis: absence of linkage to the SMA locus. In: Biochem Soc Trans. (pp. 149S - ?).

KING, AW and ORRELL, RW and LANE, R and DEBELLEROCHE, JS (1994) MORE THAN ONE LOCUS FOR FAMILIAL AMYOTROPHIC-LATERAL-SCLEROSIS - ABSENCE OF LINKAGE TO THE SMA LOCUS. In: BIOCHEMICAL SOCIETY TRANSACTIONS. (pp. S149 - S149). PORTLAND PRESS

King, RHM and Blake, J and Muddle, JR and Orrell, RW and Morahan, G and Kalaydjieva, L (2007) Pathological and electrophysiological studies of NDRG1 mutant mice. In: JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM. (pp. 44 - 44). BLACKWELL PUBLISHING

King, RHM and Nourallah, M and Muddle, JR and Orrell, RW (2009) ULTRASTRUCTURAL STUDIES OF PERIPHERAL NERVES IN NDRG1 MUTANT MICE. In: JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM. (pp. 74 - 75). WILEY-BLACKWELL PUBLISHING, INC

Lacomblez, L and Bensimon, G and Leigh, PN and Guillet, P and Powe, L and Durrleman, S and Delumeau, JC and Meininger, V and Puech, AJ and Whitehead, J and Asselain, B and Cesaro, P and Larrey, D and Rossor, M and Zimmerman, HJ and Salzman, P and Doppler, V and Lloyd, CM and Maloteaux, JM and Delwaide, C and Laterre, EC and Bouchard, JP and Duquette, P and Girard, M and Masse, C and Eisen, A and Blin, O and Azulay, JP and BilleTurc, F and Pouget, J and Bouche, P and Camu, M and Carlander, B and Billiard, M and Clanet, M and Angibaud, G and ArneBes, MC and Benazet, M and Couratier, P and Vallat, JM and Desnuelle, C and Lagueny, A and Ellie, E and Dib, M and Rozier, A and Salachas, F and Viader, F and Delaunay, D and Dengler, R and Kuther, G and Troger, M and Ludolph, A and Bachus, R and Gericke, C and Przuntek, H and Langkafel, M and Schimrigk, K and Jost, WH and Osterhage, J and Prudlo, J and Mora, J and Chaverri, D and Saenz, E and Jefferson, D and Orpe, V and Lane, RJM and Orrell, RW and Barbie, T and Mitchell, JD and Kilshaw, J and Pall, HS and Goodwin, M and Schady, W and Duncan, S and Moore, C and Richards, C and Shaw, PJ and Chari, G and Pickering, B and Swash, M and Harati, Y and Gooch, CL and Echols, CW and Miller, RG and Gelinas, DF and Quien, A and Munstat, TL and Thornell, B and Rothstein, JD and Clawson, L and Sufit, R and Casey, P and Delumeau, J and Truffinet, P and Debove, C and Enfrin, P and Hampton, G and Muller, F and Nguyen, T and Rothfuss, D and Senechal, A and Shu, C and Leswell, P and Whitworth, P and DeBoe, M and DeBruyckere, M and Fisher, W and Konig, M and Verdugo, L and delosTerreros, MS and Deakin, D and Giguere, M and Adair, K and Franco, M and Skarinsky, D and Wexler, M and Pizzato, M and Ledoux, L and Campagnes, E and Hartnett, M and Bastien, P and Bejuit, R and Kim, Y and LeLann, L and Leroy, F and Papillon, C and OrvoenFrija, E (1996) A confirmatory dose-ranging study of riluzole in ALS. In: NEUROLOGY. (pp. S242 - S250). LITTLE BROWN CO

Lu, C and Malaspina, A and Orrell, R and Kalmar, B and Petzold, A and Greensmith, L (2010) PLASMA NEUROFILAMENT HEAVY CHAIN LEVELS AS A DISEASE BIOMARKER IN THE SOD1 MOUSE MODEL OF AMYOTROPHIC LATERAL SCLEROSIS. In: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. (pp. E62 - E62). B M J PUBLISHING GROUP

Lu, C and Petzold, A and Kalmar, B and Orrell, R and Malaspina, A and Greensmith, L (2010) Plasma neurofilament heavy chain levels as a disease biomarker in SOD1 mice. In: (Proceedings) 20th International Symposium on ALS/MND, Berlin Germany, 8-10 December 2001, SW336.. (pp. SW336 - ?).

Miller, RG and Bouchard, JP and Duquette, P and Eisen, A and Gelinas, DF and Harati, Y and Munsat, TL and Powe, L and Rothstein, J and Salzman, P and Sufit, RL and Guillet, P and Bensimon, G and Delumeau, JC and Durrleman, S and Lacomblez, L and Leigh, PN and Meininger, V and Maloteaux, JM and Delwaide, C and Girard, M and Masse, C and Blin, O and Azulay, JP and Billeturc, F and Pouget, J and Bouche, P and Camu, W and Carlander, B and Clanet, M and Angibaud, G and ArneBes, MC and Benazet, M and Couratier, P and Desnuelle, C and Lagueny, A and Ellie, E and Dib, M and Rozier, A and Salachas, F and Viader, F and Delaunay, D and Dengler, R and Guther, G and Troger, M and Ludolph, A and Bachus, R and Gericke, C and Przuntek, H and Langkafel, M and Schimrigk, K and Jost, WH and Osterhage, J and Prudlo, J and Mora, J and Chaverri, D and Saenz, E and Jefferson, D and Orpe, V and Lane, RJM and Orrell, RW and Lloyd, CM and Barbie, T and Mitchell, JD and Kilshaw, J and Pall, HS and Goodwin, M and Schady, W and Duncan, S and Moore, C and Rickards, C and Shaw, PJ and Pickering, CB and Swash, M and Gooch, CL and Echols, CW and Quien, A and Thornell, B and Rothstein, JD and Clawson, L and Sufit, R and Casey, P (1996) Clinical trials of riluzole in patients with ALS. In: NEUROLOGY. (pp. S86 - S90). LITTLE BROWN CO

Mitchell, J and Habgood, JJ and Orrell, RW and Kaushik, N and Malaspina, A and Gardiner, IM and Greenwood, JS and deBelleroche, JS (2000) Identifying gene defects in motor neurone disease / amyotrophic lateral sclerosis families that lack Cu/Zn superoxide dismutase mutations. In: (pp. S226 - ?).

Ng, K and Orrell, R (2005) Extensive heroin myelopathy associated with Adamkiewicz artery territory infarction. In: Neurol J Thai. (pp. 118 - ?).

Orrell, RW and Bowe, FA and Hallewell, RA and Marklund, S and Lane, RJM and deBelleroche, J (1997) SOD-1 mutations in United Kingdom families with amyotrophic lateral sclerosis. In: Journal of Neurology, Neurosurgery and Psychiatry. (pp. 205 - ?).

Orrell, RW and Forrester, JD and Tawil, R and Kissel, JT and Mendell, JR and Figlewicz, DA and Griggs, RC (1997) Application of definitive molecular diagnostic criteria in facioscapulohumeral dystrophy: Clinical implications of position effect variegation. In: ANN NEUROL. (pp. 986 - 986). LIPPINCOTT WILLIAMS & WILKINS

Orrell, RW and Fuller, GN and Leslie, RDG and Maitland, J and Lane, RJM (1994) Partial stiff-person syndrome with exaggerated and sustained knee jerks. Movement Disorders. In: Movement Disorders. (pp. 128 - ?).

Orrell, RW and Habgood, JJ and Lane, RJM and deBelleroche, J (1996) Potential underdiagnosis of familial amyotrophic lateral sclerosis: clinical genetic implications. In: Journal of Neurology. (pp. S25 - ?).

Orrell, RW and Hilton, DA and Lane, RJM and deBelleroche, JS (1995) Neuropathology of familial amyotrophic lateral sclerosis with a mutation of SOD-1. In: Neuropathology and Applied Neurobiology. (pp. 448 - 449).

Orrell, RW and Johnston, HM and Gibson, C and Cass, RM and Griggs, RC (1998) Case of the month - Spontaneous abdominal hematoma in dermatomyositis. In: MUSCLE & NERVE. (pp. 1800 - 1803). JOHN WILEY & SONS INC

Orrell, RW and King, AW and Hilton, DA and Campbell, MJ and Lane, RJM and de, BJ (1995) A clinicopathological study of familial amyotrophic lateral sclerosis with a mutation of SOD-1. In: Journal of Neurology. (pp. S29 - ?).

Orrell, RW and King, AW and Lane, RJM and de, BJS (1995) Investigation of a null mutation of the CNTF gene in familial amyotrophic lateral sclerosis. In: (pp. S132 - ?).

Orrell, RW and King, AW and Lane, RJM and deBelleroche, J (1996) Patterns of inheritance in United Kingdom families with amyotrophic lateral sclerosis. In: Journal of Neurology, Neurosurgery and Psychiatry. (pp. 539 - ?).

Orrell, RW and Lehmann-Horn, F and Lane, RJM (1997) Familial cramp with a mutation of the adult skeletal muscle sodium channel a subunit gene: sodium channel myotonia. In: Journal of Neurology, Neurosurgery and Psychiatry. (pp. 208 - ?).

Orrell, RW and Lehmann-Horn, F and Lane, RJM (1997) The short exercise test in the diagnosis of sodium channel disease. In: Electroencephalography and Clinical Neurophysiology. (pp. 36P - ?).

Orrell, RW and Ross, M and Lane, RJM (2004) A systematic review of antioxidant treatment of amyotrophic lateral sclerosis. Cochrane Review. In: ALS and Other Motor Neuron Disorders. (pp. 139 - ?).

Pearson, SJ and Cobbold, MJ and Orrell, R and Harridge, SDR (2002) A lesser proportion of fast myosin heavy chain isoforms in older men is closely related to a lower velocity at which peak power occurs during inertial sprint cycling. In: JOURNAL OF PHYSIOLOGY-LONDON. (pp. 107P - 108P).

Pullen, AH and Howard, R and Orrell, R (2001) Necrotic and apoptotic-like degeneration in motor neurons following passive transfer of ALS/MND derived IgG. In: Amyotrophic Lateral Sclerosis and Related Motor Neuron Diseases. (pp. 143 - 144).

Riddoch-Contreras, J and Yang, SY and Goldspink, G and Orrell, RW and Greensmith, L (2005) Treatment with mechano-growth factor, an IGF-1 splice variant, rescues motoneurons and delays disease progression in SOD1 G93A mice. In: ALS and Other Motor Neuron Disorders. (pp. 42 - 43).

Riddoch-Contreras, J and Yang, SY and Goldspink, G and Orrell, RW and Greensmith, L (2005) Treatment with mechano-growth factor, an IGF-1 splice variant, rescues motoneurons and delays disease progression in SOD1 G93A mice. In: Society for Neuroscience, Washington DC, online. (pp. 332.15 - ?).

Sakel, M and Chalabi, A and Leigh, N and Shaw, C and Howard, R and Orrell, RW and Ampong, M and Turner, MR and Johnston, C and Stanton, B and Scott, KM and Abhinav, K (2008) Amyotrophic lateral sclerosis in South-East England: a population based study [South-East England Amyotrophic Lateral Sclerosis (SEALS) Registry]. In: Neurorehabilitation and Neural Repair. (pp. 582 - ?).

Shaunak, S and O'Sullivan, E and Orrell, R and Lane, R and Kennard, C (1995) Oculomotor function in motor neuron disease. In: Journal of Neurology, Neurosurgery and Psychiatry. (pp. 202 - ?).

Solomon, AM and Hoffman, EP and Chimbovschi, SD and Wang, Z and Orrell, RW and Goldspink, G and Harridge, SD and Bouloux, PMG (2006) Molecular mechanisms of idiopathic muscle hypertrophy in humans. In: Endocrine Abstracts. (pp. P243 - ?).

Toosy, AT and Orrell, RW and Werring, DJ and Howard, RS and King, MD and Barker, GJ and Miller, DH and Thompson, AJ (2003) Diffusion tensor imaging detects corticospinal tract involvement at multiple levels in ALS. In: ALS and other Motor Neuron Disorders. (pp. 161 - 162).

Wain, LV and Shrine, NRG and Shaw, C and Powell, JF and Hardy, J and Shaw, P and Morrison, KE and Brown, RH and Orrell, R and Mok, B and Palmer, LJ and Hui, J and James, AL and Musk, B and Al-Chalabi, A and Tobin, MD (2010) The Role of Common Copy Number Variation in Amyotrophic Lateral Sclerosis (ALS). In: GENETIC EPIDEMIOLOGY. (pp. 929 - 930). WILEY-BLACKWELL

This list was generated on Fri May 17 21:53:45 2013 BST.