Browse by UCL people
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Number of items: 73.
Article
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Bandres-Ciga, S;
Saez-Atienzar, S;
Bonet-Ponce, L;
Billingsley, K;
Vitale, D;
Blauwendraat, C;
Gibbs, JR;
... Singleton, AB; + view all
(2019)
The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease.
Movement Disorders
, 34
(4)
pp. 460-468.
10.1002/mds.27614.
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Bhore, Noopur;
Bogacki, Erin C;
O'Callaghan, Benjamin;
Plun-Favreau, Helene;
Lewis, Patrick A;
Herbst, Susanne;
(2024)
Common genetic risk for Parkinson's disease and dysfunction of the endo-lysosomal system.
Philosophical Transactions of the Royal Society B: Biological Sciences
, 379
(1899)
, Article 20220517. 10.1098/rstb.2022.0517.
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Billingsley, KJ;
Barbosa, IA;
Bandrés-Ciga, S;
Quinn, JP;
Bubb, VJ;
Deshpande, C;
Botia, JA;
... Koks, S; + view all
(2019)
Mitochondria function associated genes contribute to Parkinson's Disease risk and later age at onset.
npj Parkinson's Disease
, 5
, Article 8. 10.1038/s41531-019-0080-x.
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Blackstone, C;
Elwood, F;
Plun-Favreau, H;
Lewis, PA;
(2021)
Vesicle trafficking and pathways to neurodegeneration.
Molecular Neurodegeneration
, 16
(1)
, Article 56. 10.1186/s13024-021-00480-1.
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Blauwendraat, C;
Bras, JM;
Nalls, MA;
Lewis, PA;
Hernandez, DG;
Singleton, AB;
International Parkinson's Disease Genomics Consortium;
(2018)
Coding variation in GBA explains the majority of the SYT11-GBA Parkinson's disease GWAS locus.
Movement Disorders
10.1002/mds.103.
(In press).
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Blauwendraat, C;
Kia, DA;
Pihlstrom, L;
Gan-Or, Z;
Lesage, S;
Gibbs, JR;
Ding, J;
... Wood, NW; + view all
(2018)
Insufficient evidence for pathogenicity of SNCA His50Gln (H50Q) in Parkinson's disease.
Neurobiology of Aging
, 64
159.e5-159.e8.
10.1016/j.neurobiolaging.2017.12.012.
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Blauwendraat, C;
Reed, X;
Kia, DA;
Gan-Or, Z;
Lesage, S;
Pihlstrøm, L;
Guerreiro, R;
... COURAGE-PD (Comprehensive Unbiased Risk Factor Assessment for Ge; + view all
(2018)
Frequency of Loss of Function Variants in LRRK2 in Parkinson Disease.
JAMA Neurology
10.1001/jamaneurol.2018.1885.
(In press).
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Bonham, LW;
Steele, NZR;
Karch, CM;
Broce, I;
Geier, EG;
Wen, NL;
Momeni, P;
... International FTD-Genomics Consortium (IFGC), .; + view all
(2019)
Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia.
Scientific Reports
, 9
, Article 10854. 10.1038/s41598-019-46415-1.
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Burchell, VS;
Nelson, DE;
Sanchez-Martinez, A;
Delgado-Camprubi, M;
Ivatt, RM;
Pogson, JH;
Randle, SJ;
... Plun-Favreau, H; + view all
(2013)
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy.
Nature Neuroscience
, 16
(9)
pp. 1257-1265.
10.1038/nn.3489.
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Chandler, RJ;
Cogo, S;
Lewis, PA;
Kevei, E;
(2021)
Modelling the functional genomics of Parkinson’s disease in Caenorhabditis elegans: LRRK2 and beyond.
Bioscience Reports
, 41
(9)
, Article BSR20203672. 10.1042/bsr20203672.
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Civiero, L;
Cogo, S;
Kiekens, A;
Morganti, C;
Tessari, I;
Lobbestael, E;
Baekelandt, V;
... Greggio, E; + view all
(2017)
PAK6 Phosphorylates 14-3-3 gamma to Regulate Steady State Phosphorylation of LRRK2.
Frontiers in Molecular Neuroscience
, 10
, Article 417. 10.3389/fnmol.2017.00417.
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Cogo, Susanna;
Ho, Franz Y;
Tosoni, Elena;
Tomkins, James E;
Tessari, Isabella;
Iannotta, Lucia;
Montine, Thomas J;
... Greggio, Elisa; + view all
(2022)
The Roc domain of LRRK2 as a hub for protein-protein interactions: a focus on PAK6 and its impact on RAB phosphorylation.
Brain Research
, 1778
, Article 147781. 10.1016/j.brainres.2022.147781.
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Devine, MJ;
Kaganovich, A;
Ryten, M;
Mamais, A;
Trabzuni, D;
Manzoni, C;
McGoldrick, P;
... Lewis, PA; + view all
(2012)
Correction: Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue.
PLOS ONE
, 7
(1)
, Article e22489. 10.1371/annotation/c12e4f9e-5aae-424b-a69f-fddf16976dc5.
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Devine, MJ;
Kaganovich, A;
Ryten, M;
Mamais, A;
Trabzuni, D;
Manzoni, C;
McGoldrick, P;
... Lewis, PA; + view all
(2011)
Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue.
PLOS ONE
, 6
(7)
, Article e22489. 10.1371/journal.pone.0022489.
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Dihanich, S;
Civiero, L;
Manzoni, C;
Mamais, A;
Bandopadhyay, R;
Greggio, E;
Lewis, PA;
(2014)
GTP binding controls complex formation by the human ROCO protein MASL1.
FEBS J
, 281
(1)
pp. 261-274.
10.1111/febs.12593.
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Ebanks, K;
Lewis, P;
Bandopadhyay, R;
(2020)
Vesicular dysfunction and the pathogenesis of Parkinson’s disease: clues from genetic studies.
Fontiers in Neuroscience
, 13
, Article 1381. 10.3389/fnins.2019.01381.
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Ferrari, R;
Kia, DA;
Tomkins, JE;
Hardy, J;
Wood, NW;
Lovering, RC;
Lewis, PA;
(2018)
Stratification of candidate genes for Parkinson's disease using weighted protein-protein interaction network analysis.
BMC Genomics
, 19
, Article 452. 10.1186/s12864-018-4804-9.
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Ferrari, R;
Lovering, RC;
Hardy, J;
Lewis, PA;
Manzoni, C;
(2017)
Weighted Protein Interaction Network Analysis of Frontotemporal Dementia.
Journal of Proteome Research
, 16
(2)
pp. 999-1013.
10.1021/acs.jproteome.6b00934.
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Guelfi, S;
D'Sa, K;
Botía, JA;
Vandrovcova, J;
Reynolds, RH;
Zhang, D;
Trabzuni, D;
... Ryten, M; + view all
(2020)
Regulatory sites for splicing in human basal ganglia are enriched for disease-relevant information.
Nature Communications
, 11
, Article 1041. 10.1038/s41467-020-14483-x.
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Härtlova, A;
Herbst, S;
Peltier, J;
Rodgers, A;
Bilkei-Gorzo, O;
Fearns, A;
Dill, BD;
... Gutierrez, MG; + view all
(2018)
LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages.
The EMBO Journal
, 37
(12)
, Article e98694. 10.15252/embj.201798694.
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Herbst, Susanne;
Lewis, Patrick A;
Morris, Huw R;
(2022)
The emerging role of LRRK2 in tauopathies.
Clinical Science
, 136
(13)
pp. 1071-1079.
10.1042/CS20220067.
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Herbst, S;
Lewis, PA;
(2021)
From structure to ae tiology: a new window on the biology of leucine-rich repeat kinase 2 and Parkinson's disease.
Biochemical Journal
, 478
(14)
pp. 2945-2951.
10.1042/BCJ20210383.
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Kara, E;
Crimi, A;
Wiedmer, A;
Emmenegger, M;
Manzoni, C;
Bandres-Ciga, S;
D'Sa, K;
... Aguzzi, A; + view all
(2021)
An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein.
Cell Reports
, 35
(10)
, Article 109189. 10.1016/j.celrep.2021.109189.
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Kara, E;
Lewis, PA;
Ling, H;
Proukakis, C;
Houlden, H;
Hardy, J;
(2013)
α-Synuclein mutations cluster around a putative protein loop.
Neurosci Lett
, 546
67 - 70.
10.1016/j.neulet.2013.04.058.
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Kara, E;
Tucci, A;
Manzoni, C;
Lynch, DS;
Elpidorou, M;
Bettencourt, C;
Chelban, V;
... Houlden, H; + view all
(2016)
Genetic and phenotypic characterization of complex hereditary spastic paraplegia.
Brain
, 139
(7)
pp. 1904-1918.
10.1093/brain/aww111.
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Kelly, Katie;
Lewis, Patrick A;
Plun-Favreau, Helene;
Manzoni, Claudia;
(2023)
Protein network analysis links the NSL complex to Parkinson's disease via mitochondrial and nuclear biology.
Molecular Omics
10.1039/d2mo00325b.
(In press).
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Kia, DA;
Zhang, D;
Guelfi, S;
Manzoni, C;
Hubbard, L;
Reynolds, RH;
Botía, J;
... Botiá, JA; + view all
(2021)
Identification of Candidate Parkinson Disease Genes by Integrating Genome-Wide Association Study, Expression, and Epigenetic Data Sets.
JAMA Neurology
, 78
(4)
pp. 464-472.
10.1001/jamaneurol.2020.5257.
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Kiely, AP;
Asi, YT;
Kara, E;
Limousin, P;
Ling, H;
Lewis, P;
Proukakis, C;
... Holton, JL; + view all
(2013)
α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?
Acta Neuropathologica
, 125
(5)
753 - 769.
10.1007/s00401-013-1096-7.
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Kiely, AP;
Ling, H;
Asi, YT;
Kara, E;
Proukakis, C;
Schapira, AH;
Morris, HR;
... Holton, JL; + view all
(2015)
Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation.
Molecular Neurodegeneration
, 10
, Article 41. 10.1186/s13024-015-0038-3.
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Klionsky, DJ;
Abdel-Aziz, AK;
Abdelfatah, S;
Abdellatif, M;
Abdoli, A;
Abel, S;
Abeliovich, H;
... Taylor, A; + view all
(2021)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Autophagy
, 17
(1)
pp. 1-382.
10.1080/15548627.2020.1797280.
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Kluss, Jillian H;
Beilina, Alexandra;
Williamson, Chad D;
Lewis, Patrick A;
Cookson, Mark R;
Bonet-Ponce, Luis;
(2022)
Lysosomal positioning regulates Rab10 phosphorylation at LRRK2+ lysosomes.
Proceedings of the National Academy of Sciences (PNAS)
, 119
(43)
, Article e2205492119. 10.1073/pnas.2205492119.
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Kluss, Jillian H;
Bonet-Ponce, Luis;
Lewis, Patrick A;
Cookson, Mark R;
(2022)
Directing LRRK2 to membranes of the endolysosomal pathway triggers RAB phosphorylation and JIP4 recruitment.
Neurobiology of Disease
, 170
, Article 105769. 10.1016/j.nbd.2022.105769.
(In press).
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Kluss, Jillian H;
Lewis, Patrick A;
Greggio, Elisa;
(2022)
Leucine-rich repeat kinase 2 (LRRK2): an update on the potential therapeutic target for Parkinson’s disease.
Expert Opinion on Therapeutic Targets
10.1080/14728222.2022.2082937.
(In press).
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Kluss, JH;
Mazza, MC;
Li, Y;
Manzoni, C;
Lewis, PA;
Cookson, MR;
Mamais, A;
(2021)
Preclinical modeling of chronic inhibition of the Parkinson's disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo.
Molecular Neurodegeneration
, 16
(1)
, Article 17. 10.1186/s13024-021-00441-8.
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Leksmono, CS;
Manzoni, C;
Tomkins, JE;
Lucchesi, W;
Cottrell, G;
Lewis, PA;
(2018)
Measuring Lactase Enzymatic Activity in the Teaching Lab.
JOVE-Journal Of Visualized Experiments
(138)
, Article e54377. 10.3791/54377.
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Lewis, Patrick A;
(2022)
A step forward for LRRK2 inhibitors in Parkinson's disease.
Science Translational Medicine
, 14
(648)
, Article eabq7374. 10.1126/scitranslmed.abq7374.
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Lewis, Patrick A;
(2021)
Vesicular dysfunction and pathways to neurodegeneration.
Essays in Biochemistry
, 65
(7)
pp. 941-948.
10.1042/EBC20210034.
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Lewis, P.A.;
Critchley, H.D.;
Rotshtein, P.;
Dolan, R.J.;
(2007)
Neural correlates of processing valence and arousal in affective words.
Cerebral Cortex
, 17
(3)
pp. 742-748.
10.1093/cercor/bhk024.
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Lewis, PA;
(2018)
Mutations in LRRK2 amplify cell-to-cell protein aggregate propagation: a hypothesis.
[Letter].
Acta Neuropathologica
, 135
(6)
pp. 973-976.
10.1007/s00401-018-1838-7.
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Lewis, PA;
Plun-Favreau, H;
Rowley, M;
Spillane, J;
(2020)
Pierre D. and the first photographs of Parkinson's disease.
Movement Disorders
10.1002/mds.27965.
(In press).
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Lubbe, SJ;
Escott-Price, V;
Gibbs, JR;
Nalls, MA;
Bras, J;
Price, TR;
Nicolas, A;
... for International Parkinson’s Disease Genomics Consortium, .; + view all
(2016)
Additional rare variant analysis in Parkinson's disease cases with and without known pathogenic mutations: evidence for oligogenic inheritance.
Human Molecular Genetics
, 25
(24)
pp. 5483-5489.
10.1093/hmg/ddw348.
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Magrinelli, F;
Mehta, S;
Di Lazzaro, G;
Latorre, A;
Edwards, MJ;
Balint, B;
Basu, P;
... Bhatia, KP; + view all
(2021)
Dissecting the Phenotype and Genotype of PLA2G6-Related Parkinsonism.
Movement Disorders
10.1002/mds.28807.
(In press).
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Mamais, A;
Chia, R;
Beilina, A;
Hauser, DN;
Hall, C;
Lewis, PA;
Cookson, MR;
(2014)
Arsenite Stress Downregulates Phosphorylation and 14-3-3 Binding of Leucine-rich Repeat Kinase 2 (LRRK2) Promoting Self-Association and Cellular Redistribution.
J Biol Chem
, 289
(31)
pp. 21386-21400.
10.1074/jbc.M113.528463.
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Mamais, A;
Manzoni, C;
Nazish, I;
Arber, C;
Sonustun, B;
Wray, S;
Warner, T;
... Bandopadhyay, R; + view all
(2018)
Analysis of macroautophagy related proteins in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology.
Brain Research
, 1701
pp. 75-84.
10.1016/j.brainres.2018.07.023.
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Mamais, A;
Raja, M;
Manzoni, C;
Dihanich, S;
Lees, A;
Moore, D;
Lewis, PA;
(2013)
Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases.
Neurobiol Dis
, 58
pp. 183-190.
10.1016/j.nbd.2013.05.017.
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Manzoni, C;
Denny, P;
Lovering, RC;
Lewis, PA;
(2015)
Computational analysis of the LRRK2 interactome.
PeerJ
, 3
, Article e778. 10.7717/peerj.778.
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Manzoni, C;
Kia, DA;
Vandrovcova, J;
Hardy, J;
Wood, NW;
Lewis, PA;
Ferrari, R;
(2018)
Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences.
Briefings in Bioinformatics
, 19
(2)
pp. 286-302.
10.1093/bib/bbw114.
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Manzoni, C;
Lewis, PA;
(2013)
Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies.
The FASEB Journal
, 27
(9)
3424 - 3429.
10.1096/fj.12-223842.
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Manzoni, C;
Mamais, A;
Dihanich, S;
Abeti, R;
Soutar, MP;
Plun-Favreau, H;
Giunti, P;
... Lewis, PA; + view all
(2013)
Inhibition of LRRK2 kinase activity stimulates macroautophagy.
Biochim Biophys Acta
, 1833
(12)
pp. 2900-2910.
10.1016/j.bbamcr.2013.07.020.
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Manzoni, C;
Mamais, A;
Dihanich, S;
McGoldrick, P;
Devine, MJ;
Zerle, J;
Kara, E;
... Lewis, PA; + view all
(2013)
Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation.
Biochemical and Biophysical Research Communications
, 441
(4)
pp. 862-866.
10.1016/j.bbrc.2013.10.159.
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Manzoni, C;
Mamais, A;
Dihanich, S;
Soutar, MPM;
Plun-Favreau, H;
Bandopadhyay, R;
Abeti, R;
... Lewis, PA; + view all
(2018)
mTOR independent alteration in ULK1 Ser758 phosphorylation following chronic LRRK2 kinase inhibition.
Bioscience Reports
, 38
(2)
, Article BSR20171669. 10.1042/BSR20171669.
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Manzoni, C;
Mamais, A;
Roosen, DA;
Dihanich, S;
Soutar, MPM;
Plun-Favreau, H;
Bandopadhyay, R;
... Lewis, PA; + view all
(2016)
mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1.
Scientific Reports
, 6
, Article 35106. 10.1038/srep35106.
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Marzi, Sarah J;
Schilder, Brian M;
Nott, Alexi;
Frigerio, Carlo Sala;
Willaime-Morawek, Sandrine;
Bucholc, Magda;
Hanger, Diane P;
... Llewellyn, David J; + view all
(2023)
Artificial intelligence for neurodegenerative experimental models.
Alzheimer's & Dementia
10.1002/alz.13479.
(In press).
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Murthy, MN;
Blauwendraat, C;
UKBEC;
Guelfi, S;
IPDGC;
Hardy, J;
Lewis, PA;
(2017)
Increased brain expression of GPNMB is associated with genome wide significant risk for Parkinson's disease on chromosome 7p15.3.
Neurogenetics
10.1007/s10048-017-0514-8.
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Nalls, MA;
Blauwendraat, C;
Vallerga, CL;
Heilbron, K;
Bandres-Ciga, S;
Chang, D;
Tan, M;
... Guerreiro, R; + view all
(2019)
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies.
The Lancet Neurology
, 18
(12)
pp. 1091-1102.
10.1016/S1474-4422(19)30320-5.
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Nazish, I;
Arber, C;
Piers, TM;
Warner, TT;
Hardy, JA;
Lewis, PA;
Pocock, JM;
(2021)
Abrogation of LRRK2 dependent Rab10 phosphorylation with TLR4 activation and alterations in evoked cytokine release in immune cells.
Neurochemistry International
, 147
, Article 105070. 10.1016/j.neuint.2021.105070.
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Nazish, Iqra;
Mamais, Adamantios;
Mallach, Anna;
Bettencourt, Conceisao;
Kaganovich, Alice;
Warner, Thomas;
Hardy, John;
... Bandopadhyay, Rina; + view all
(2024)
Differential LRRK2 signalling and gene expression in WT-LRRK2 and G2019S-LRRK2 mouse microglia treated with zymosan and MLi2.
Cells
, 13
(1)
, Article 53. 10.3390/cells13010053.
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Noyce, AJ;
Kia, DA;
Hemani, G;
Nicolas, A;
Price, TR;
De Pablo-Fernandez, E;
Haycock, PC;
... Wood, NW; + view all
(2017)
Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study.
PLoS Medicine
, 14
(6)
, Article e1002314. 10.1371/journal.pmed.1002314.
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Plun-Favreau, H;
Lewis, PA;
Hardy, J;
Martins, LM;
Wood, NW;
(2010)
Cancer and neurodegeneration: between the devil and the deep blue sea.
PLoS Genetics
, 6
(12)
, Article e1001257. 10.1371/journal.pgen.1001257.
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Price, A;
Manzoni, C;
Cookson, MR;
Lewis, PA;
(2018)
The LRRK2 signalling system.
Cell and Tissue Research
10.1007/s00441-017-2759-9.
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Reynolds, RH;
Botía, J;
Nalls, MA;
International Parkinson’s Disease Genomics Consortium (IPDGC), .;
System Genomics of Parkinson’s Disease (SGPD), .;
Hardy, J;
Gagliano Taliun, SA;
(2019)
Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson's disease heritability.
NPJ Parkinson's Disease
, 5
, Article 6. 10.1038/s41531-019-0076-6.
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Ruz, Clara;
Alcantud, José Luis;
Vives, Francisco;
Arrebola, Francisco;
Hardy, John;
Lewis, Patrick A;
Manzoni, Claudia;
(2022)
Seventy-Two-Hour LRRK2 Kinase Activity Inhibition Increases Lysosomal GBA Expression in H4, a Human Neuroglioma Cell Line.
International Journal of Molecular Sciences
, 23
(13)
, Article 6935. 10.3390/ijms23136935.
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Soutar, Marc PM;
Melandri, Daniela;
O'Callaghan, Benjamin;
Annuario, Emily;
Monaghan, Amy E;
Welsh, Natalie J;
D'Sa, Karishma;
... Plun-Favreau, Hélène; + view all
(2022)
Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at 16q11.2 and MAPT H1 loci.
Brain
10.1093/brain/awac325.
(In press).
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Storm, CS;
Kia, DA;
Almramhi, MM;
Bandres-Ciga, S;
Finan, C;
Hingorani, AD;
Wood, NW;
(2021)
Finding genetically-supported drug targets for Parkinson's disease using Mendelian randomization of the druggable genome.
Nature Communications
, 12
(1)
, Article 7342. 10.1038/s41467-021-26280-1.
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Tomkins, J;
Ferrari, R;
Vavouraki, N;
Hardy, J;
Lovering, R;
Lewis, P;
McGuffin, L;
(2020)
PINOT: An Intuitive Resource for Integrating Protein-Protein Interactions.
Cell Communication and Signaling
, 18
, Article 92. 10.1186/s12964-020-00554-5.
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Tomkins, JE;
Dihanich, S;
Beilina, A;
Ferrari, R;
Ilacqua, N;
Cookson, MR;
Lewis, PA;
(2018)
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