Browse by UCL people
Group by: Type | Date
Number of items: 96.
2023
Lange, Jenny;
Gillham, Olivia;
Flower, Michael;
Ging, Heather;
Eaton, Simon;
Kapadia, Sneha;
Neueder, Andreas;
... Tabrizi, Sarah J; + view all
(2023)
PolyQ length-dependent metabolic alterations and DNA damage drive human astrocyte dysfunction in Huntington's disease.
Progress in Neurobiology
, Article 102448. 10.1016/j.pneurobio.2023.102448.
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Valdebenito, Gabriel E;
Chacko, Anitta R;
Duchen, Michael R;
(2023)
The mitochondrial ATP synthase as an ATP consumer—a surprising therapeutic target.
The EMBO Journal
, Article e114141. 10.15252/embj.2023114141.
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2022
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Almeida, Liliana M;
Pinho, Brígida R;
Duchen, Michael R;
Oliveira, Jorge MA;
(2022)
The PERKs of mitochondria protection during stress: insights for PERK modulation in neurodegenerative and metabolic diseases.
Biological Reviews
, 97
(5)
pp. 1737-1748.
10.1111/brv.12860.
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Bhosale, Gauri;
Duchen, Michael R;
(2022)
Investigating Mitochondrial Ca²⁺ Dynamics in Isolated Mitochondria and Intact Cells: Application of Fluorescent Dyes and Genetic Reporters.
Methods in Molecular Biology
, 2497
pp. 325-332.
10.1007/978-1-0716-2309-1_23.
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Chi, Haoyu;
Bhosale, Gauri;
Duchen, Michael R;
(2022)
Assessing the Redox Status of Mitochondria Through the NADH/FAD²⁺ Ratio in Intact Cells.
Methods in Molecular Biology
, 2497
pp. 313-318.
10.1007/978-1-0716-2309-1_21.
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Chung, Chih-Yao;
Duchen, Michael R;
(2022)
A Plate Reader-Based Measurement of the Cellular ROS Production Using Dihydroethidium and MitoSOX.
Methods in Molecular Biology
, 2497
pp. 333-337.
10.1007/978-1-0716-2309-1_24.
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D'Acunto, E;
Gianfrancesco, L;
Serangeli, I;
D'Orsi, M;
Sabato, V;
Guadagno, NA;
Bhosale, G;
... Miranda, E; + view all
(2022)
Polymerogenic neuroserpin causes mitochondrial alterations and activates NFκB but not the UPR in a neuronal model of neurodegeneration FENIB.
Cellular and Molecular Life Sciences
, 79
(8)
, Article 437. 10.1007/s00018-022-04463-3.
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De La Rossa, A;
Laporte, MH;
Astori, S;
Marissal, T;
Montessuit, S;
Sheshadri, P;
Ramos-Fernández, E;
... Martinou, JC; + view all
(2022)
Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency.
eLife
, 11
, Article e72595. 10.7554/eLife.72595.
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Singh, Kritarth;
Duchen, Michael R;
(2022)
Analysis of Organization and Activity of Mitochondrial Respiratory Chain Complexes in Primary Fibroblasts Using Blue Native PAGE.
Methods in Molecular Biology
, 2497
pp. 339-348.
10.1007/978-1-0716-2309-1_25.
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Valdebenito, Gabriel Esteban;
Duchen, Michael R;
(2022)
Monitoring Mitochondrial Membrane Potential in Live Cells Using Time-Lapse Fluorescence Imaging.
Methods in Molecular Biology
, 2497
pp. 319-324.
10.1007/978-1-0716-2309-1_22.
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2021
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Arulkumaran, N;
Pollen, SJ;
Tidswell, R;
Gaupp, C;
Peters, VBM;
Stanzani, G;
Snow, TAC;
... Singer, M; + view all
(2021)
Selective mitochondrial antioxidant MitoTEMPO reduces renal dysfunction and systemic inflammation in experimental sepsis in rats.
British Journal of Anaesthesia
, 127
(4)
pp. 577-586.
10.1016/j.bja.2021.05.036.
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Chung, C-Y;
Singh, K;
Kotiadis, VN;
Valdebenito, GE;
Ahn, JH;
Topley, E;
Tan, J;
... Duchen, MR; + view all
(2021)
Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243 A > G mtDNA mutation.
Nature Communications
, 12
(1)
, Article 6409. 10.1038/s41467-021-26746-2.
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Chung, C-Y;
Valdebenito, GE;
Chacko, AR;
Duchen, MR;
(2021)
Rewiring cell signalling pathways in pathogenic mtDNA mutations.
Trends in Cell Biology
10.1016/j.tcb.2021.10.005.
(In press).
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Deneubourg, C;
Ramm, M;
Smith, LJ;
Baron, O;
Singh, K;
Byrne, SC;
Duchen, MR;
... Jungbluth, H; + view all
(2021)
The spectrum of neurodevelopmental, neuromuscular and neurodegenerative disorders due to defective autophagy.
Autophagy
10.1080/15548627.2021.1943177.
(In press).
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Pinho, BR;
Almeida, LM;
Duchen, MR;
Oliveira, JMA;
(2021)
Allosteric activation of Hsp70 reduces mutant huntingtin levels, the clustering of N-terminal fragments, and their nuclear accumulation.
Life Sciences
, 285
, Article 120009. 10.1016/j.lfs.2021.120009.
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Plotegher, N;
Filadi, R;
Pizzo, P;
Duchen, MR;
(2021)
Excitotoxicity Revisited: Mitochondria on the Verge of a Nervous Breakdown.
Trends in Neurosciences
, 44
(5)
pp. 342-351.
10.1016/j.tins.2021.01.001.
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Saura-Esteller, J;
Sánchez-Vera, I;
Núñez-Vázquez, S;
Cosialls, AM;
Gama-Pérez, P;
Bhosale, G;
Mendive-Tapia, L;
... Gil, J; + view all
(2021)
Activation of the Integrated Stress Response and ER Stress Protect from Fluorizoline-Induced Apoptosis in HEK293T and U2OS Cell Lines.
International Journal of Molecular Sciences
, 22
(11)
, Article 6117. 10.3390/ijms22116117.
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2020
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Aguilar-López, BA;
Moreno-Altamirano, MMB;
Dockrell, HM;
Duchen, MR;
Sánchez-García, FJ;
(2020)
Mitochondria: An Integrative Hub Coordinating Circadian Rhythms, Metabolism, the Microbiome, and Immunity.
Frontiers in Cell and Developmental Biology
, 8
, Article 51. 10.3389/fcell.2020.00051.
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Fischer, CA;
Besora-Casals, L;
Rolland, SG;
Haeussler, S;
Singh, K;
Duchen, M;
Conradt, B;
(2020)
MitoSegNet: Easy-to-use Deep Learning Segmentation for Analyzing Mitochondrial Morphology.
iScience
, 23
(10)
, Article 101601. 10.1016/j.isci.2020.101601.
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Pérez-Hernández, CA;
Kern, CC;
Butkeviciute, E;
McCarthy, E;
Dockrell, HM;
Moreno-Altamirano, MMB;
Aguilar-López, BA;
... Sánchez-García, FJ; + view all
(2020)
Mitochondrial Signature in Human Monocytes and Resistance to Infection in C. elegans During Fumarate-Induced Innate Immune Training.
Frontiers in Immunology
, 11
, Article 1715. 10.3389/fimmu.2020.01715.
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Plotegher, N;
Perocheau, D;
Ferrazza, R;
Massaro, G;
Bhosale, G;
Zambon, F;
Rahim, AA;
... Duchen, MR; + view all
(2020)
Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload.
Cell Death & Differentiation
, 27
pp. 1588-1603.
10.1038/s41418-019-0442-2.
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2019
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Bhosale, G;
Duchen, MR;
(2019)
Investigating the Mitochondrial Permeability Transition Pore in Disease Phenotypes and Drug Screening.
Current Protocols in Pharmacology
, 85
(1)
, Article e59. 10.1002/cpph.59.
(In press).
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Blacker, TS;
Nicolaou, N;
Duchen, MR;
Bain, AJ;
(2019)
Polarized Two-Photon Absorption and Heterogeneous Fluorescence Dynamics in NAD(P)H.
The Journal of Physical Chemistry B
10.1021/acs.jpcb.9b01236.
(In press).
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Blacker, TS;
Sewell, MDE;
Szabadkai, G;
Duchen, MR;
(2019)
Metabolic Profiling of Live Cancer Tissues Using NAD(P)H Fluorescence Lifetime Imaging.
In: Haznadar, M, (ed.)
Cancer Metabolism.
(pp. 365-387).
Springer Nature: New York (NY), USA.
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Briston, T;
Selwood, DL;
Szabadkai, G;
Duchen, MR;
(2019)
Mitochondrial Permeability Transition: A Molecular Lesion with Multiple Drug Targets.
[Review].
Trends in Pharmacological Sciences
, 40
(1)
pp. 50-70.
10.1016/j.tips.2018.11.004.
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Davidson, SM;
Szabadkai, G;
Duchen, MR;
(2019)
Fantastic beasts and how to find them—Molecular identification of the mitochondrial ATP-sensitive potassium channel.
Cell Calcium
, 84
, Article 102100. 10.1016/j.ceca.2019.102100.
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Hawkins, KE;
Duchen, M;
(2019)
'Modelling mitochondrial dysfunction in Alzheimer's disease using human induced pluripotent stem cells.
[Review].
World Journal of Stem Cells
, 11
(5)
pp. 236-253.
10.4252/wjsc.v11.i5.236.
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Haythorne, E;
Rohm, M;
van de Bunt, M;
Brereton, MF;
Tarasov, AI;
Blacker, TS;
Sachse, G;
... Ashcroft, FM; + view all
(2019)
Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells.
Nature Communications
, 10
, Article 2474. 10.1038/s41467-019-10189-x.
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Majumder, P;
Blacker, TS;
Nolan, LS;
Duchen, MR;
Gale, JE;
(2019)
Multiphoton NAD(P)H FLIM reveals metabolic changes in individual cell types of the intact cochlea upon sensorineural hearing loss.
Scientific Reports
, 9
, Article 18907. 10.1038/s41598-019-55329-x.
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Pollard, AE;
Martins, L;
Muckett, PJ;
Khadayate, S;
Bornot, A;
Clausen, M;
Admyre, T;
... Carling, D; + view all
(2019)
AMPK activation protects against diet induced obesity through Ucp1-independent thermogenesis in subcutaneous white adipose tissue.
Nature Metabolism
, 1
(3)
pp. 340-349.
10.1038/s42255-019-0036-9.
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Soares, TR;
Reis, SD;
Pinho, BR;
Duchen, MR;
Oliveira, JMA;
(2019)
Targeting the proteostasis network in Huntington's disease.
Ageing Research Reviews
, 49
pp. 92-103.
10.1016/j.arr.2018.11.006.
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Stanzani, G;
Duchen, MR;
Singer, M;
(2019)
The role of mitochondria in sepsis-induced cardiomyopathy.
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
, 1865
(4)
pp. 759-773.
10.1016/j.bbadis.2018.10.011.
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2018
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Amior, N;
(2018)
Developing models to study the mechanisms of weakness and myotonia in Periodic Paralysis.
Doctoral thesis (Ph.D), UCL (University College London).
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Arulkumaran, N;
Pollen, S;
Greco, E;
Courtneidge, H;
Hall, AM;
Duchen, MR;
Tam, FWK;
... Singer, M; + view all
(2018)
Renal Tubular Cell Mitochondrial Dysfunction Occurs Despite Preserved Renal Oxygen Delivery in Experimental Septic Acute Kidney Injury.
Critical Care Medicine
, 46
(4)
e318-e325.
10.1097/CCM.0000000000002937.
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Boland, B;
Yu, WH;
Corti, O;
Mollereau, B;
Henriques, A;
Bezard, E;
Pastores, GM;
... Millan, MJ; + view all
(2018)
Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing.
Nature Reviews Drug Discovery
, 17
(9)
pp. 660-688.
10.1038/nrd.2018.109.
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Connolly, NMC;
Theurey, P;
Adam-Vizi, V;
Bazan, NG;
Bernardi, P;
Bolaños, JP;
Culmsee, C;
... Prehn, JHM; + view all
(2018)
Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.
Cell Death & Differentiation
, 25
pp. 542-572.
10.1038/s41418-017-0020-4.
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Corrochano, S;
Blanco, G;
Williams, D;
Wettstein, J;
Simon, M;
Kumar, S;
Moir, L;
... Acevedo-Arozena, A; + view all
(2018)
A genetic modifier suggests that endurance exercise exacerbates Huntington's disease.
Human Molecular Genetics
, 27
(10)
pp. 1723-1731.
10.1093/hmg/ddy077.
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Davidson, SM;
Duchen, MR;
(2018)
Imaging Mitochondrial Calcium Fluxes with Fluorescent Probes and Single- or Two-Photon Confocal Microscopy.
Methods in Molecular Biology
, 1782
pp. 171-186.
10.1007/978-1-4939-7831-1_10.
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Maffioletti, SM;
Sarcar, S;
Henderson, ABH;
Mannhardt, I;
Pinton, L;
Moyle, LA;
Steele-Stallard, H;
... Tedesco, FS; + view all
(2018)
Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering.
Cell Reports
, 23
(3)
pp. 899-908.
10.1016/j.celrep.2018.03.091.
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Martin-de-Saavedra, MD;
Navarro, E;
Moreno-Ortega, AJ;
Cunha, MP;
Buendia, I;
Hernansanz-Agustín, P;
León, R;
... López, MG; + view all
(2018)
The APPswe/PS1A246E mutations in an astrocytic cell line leads to increased vulnerability to oxygen and glucose deprivation, Ca2+ dysregulation and mitochondrial abnormalities.
Journal of Neurochemistry
10.1111/jnc.14293.
(In press).
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Nicholson, MW;
Sweeney, A;
Pekle, E;
Alam, S;
Ali, AB;
Duchen, M;
Jovanovic, JN;
(2018)
Diazepam-induced loss of inhibitory synapses mediated by PLCδ/ Ca²⁺/calcineurin signalling downstream of GABAA receptors.
Molecular Psychiatry
, 23
pp. 1851-1867.
10.1038/s41380-018-0100-y.
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Sajic, M;
Ida, KK;
Canning, R;
Gregson, NA;
Duchen, MR;
Smith, KJ;
(2018)
Mitochondrial damage and "plugging" of transport selectively in myelinated, small-diameter axons are major early events in peripheral neuroinflammation.
Journal of Neuroinflammation
, 15
, Article 61. 10.1186/s12974-018-1094-8.
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Suman, M;
Sharpe, JA;
Bentham, RB;
Kotiadis, VN;
Menegollo, M;
Pignataro, V;
Molgó, J;
... Szabadkai, G; + view all
(2018)
Inositol Trisphosphate Receptor Mediated Ca2+ Signalling Stimulates Mitochondrial Function and Gene Expression in Core Myopathy Patients.
Human Molecular Genetics
, 27
(13)
pp. 2367-2382.
10.1093/hmg/ddy149.
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Vas, WJ;
Shah, M;
Blacker, TS;
Duchen, MR;
Sibbons, P;
Roberts, SJ;
(2018)
Decellularised cartilage directs chondrogenic differentiation: creation of a fracture callus mimetic.
Tissue engineering Part A
10.1089/ten.TEA.2017.0450.
(In press).
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2017
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Bhosale, G;
Sharpe, JA;
Koh, A;
Kouli, A;
Szabadkai, G;
Duchen, MR;
(2017)
Pathological consequences of MICU1 mutations on mitochondrial calcium signalling and bioenergetics.
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
, 1864
(6)
pp. 1009-1017.
10.1016/j.bbamcr.2017.01.015.
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Blacker, TS;
Berecz, T;
Duchen, MR;
Szabadkai, G;
(2017)
Assessment of Cellular Redox State Using NAD(P)H Fluorescence Intensity and Lifetime.
Bio Protocol
, 7
(2)
, Article e2105. 10.21769/BioProtoc.2105.
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Blacker, TS;
Chen, W;
Avezov, E;
Marsh, RJ;
Duchen, MR;
Kaminski, CF;
Bain, AJ;
(2017)
Investigating State Restriction in Fluorescent Protein FRET Using Time-Resolved Fluorescence and Anisotropy.
Journal of Physical Chemistry C
, 121
(3)
pp. 1507-1514.
10.1021/acs.jpcc.6b11235.
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Briston, T;
Roberts, M;
Lewis, S;
Powney, B;
M Staddon, J;
Szabadkai, G;
Duchen, MR;
(2017)
Mitochondrial permeability transition pore: sensitivity to opening and mechanistic dependence on substrate availability.
Scientific Reports
, 7
, Article 10492. 10.1038/s41598-017-10673-8.
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Foote, JR;
Levine, AP;
Behe, P;
Duchen, MR;
Segal, AW;
(2017)
Imaging the Neutrophil Phagosome and Cytoplasm Using a Ratiometric pH Indicator.
Journal of Visualized Experiments
(122)
, Article e55107. 10.3791/55107.
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Ida, KK;
Chisholm, KI;
Malbouisson, LMS;
Papkovsky, DB;
Dyson, A;
Singer, M;
Duchen, MR;
(2017)
Protection of cerebral microcirculation, mitochondrial function and electrocortical activity by small-volume resuscitation with terlipressin in a model of haemorrhagic shock.
British Journal of Anaesthesia
10.1016/j.bja.2017.11.074.
(In press).
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Kon, S;
Ishibashi, K;
Katoh, H;
Kitamoto, S;
Shirai, T;
Tanaka, S;
Kajita, M;
... Fujita, Y; + view all
(2017)
Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes.
Nature Cell Biology
, 19
(5)
pp. 530-541.
10.1038/ncb3509.
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McKenzie, M;
Lim, SC;
Duchen, MR;
(2017)
Simultaneous Measurement of Mitochondrial Calcium and Mitochondrial Membrane Potential in Live Cells by Fluorescent Microscopy.
Journal of Visualized Experiments
(119)
, Article e55166. 10.3791/55166.
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Pinto, BB;
Dyson, A;
Umbrello, M;
Carre, JE;
Ritter, C;
Clatworthy, I;
Duchen, MR;
(2017)
Improved Survival in a Long-Term Rat Model of Sepsis Is Associated With Reduced Mitochondrial Calcium Uptake Despite Increased Energetic Demand.
Critical Care Medicine
, 45
(8)
e840-e848.
10.1097/CCM.0000000000002448.
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Plotegher, N;
Duchen, MR;
(2017)
Crosstalk between Lysosomes and Mitochondria in Parkinson's Disease.
Frontiers in Cell and Developmental Biology
, 5
, Article 110. 10.3389/fcell.2017.00110.
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Plotegher, N;
Duchen, MR;
(2017)
Mitochondrial Dysfunction and Neurodegeneration in Lysosomal Storage Disorders.
Trends in Molecular Medicine
, 23
(2)
pp. 116-134.
10.1016/j.molmed.2016.12.003.
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Tsuchiya, Y;
Peak-Chew, S;
Newell, C;
Miller-Aidoo, S;
Mangal, S;
Zhyvoloup, A;
Baković, J;
... Gout, I; + view all
(2017)
Protein CoAlation: a redox-regulated protein modification by coenzyme A in mammalian cells.
Biochemical Journal
, 474
(14)
pp. 2489-2508.
10.1042/BCJ20170129.
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2016
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Bain, AJ;
Blacker, TS;
Duchen, M;
(2016)
Heterogeneity and restricted state selection in FRET with fluorescent proteins.
In:
Single Molecule Spectroscopy and Superresolution Imaging IX.
Society of Photo-Optical Instrumentation Engineers (SPIE): San Francisco, CA, USA.
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Blacker, TS;
Duchen, MR;
(2016)
Investigating mitochondrial redox state using NADH and NADPH autofluorescence.
Free Radical Biology and Medicine
, 100
pp. 53-65.
10.1016/j.freeradbiomed.2016.08.010.
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Bolaños, JP;
Cadenas, E;
Duchen, MR;
Hampton, MB;
Mann, GE;
Murphy, MP;
(2016)
Introduction to Special Issue on Mitochondrial Redox Signaling in Health and Disease.
Free Radical Biology and Medicine
, 100
pp. 1-4.
10.1016/j.freeradbiomed.2016.08.004.
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Briston, T;
Lewis, S;
Koglin, M;
Mistry, K;
Shen, Y;
Hartopp, N;
Katsumata, R;
... Powney, B; + view all
(2016)
Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria.
Scientific Reports
, 6
, Article 37798. 10.1038/srep37798.
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Chisholm, KI;
Ida, KK;
Davies, AL;
Papkovsky, DB;
Singer, M;
Dyson, A;
Tachtsidis, I;
... Smith, KJ; + view all
(2016)
In Vivo Imaging of Flavoprotein Fluorescence During Hypoxia Reveals the Importance of Direct Arterial Oxygen Supply to Cerebral Cortex Tissue.
Advances in Experimental Medicine and Biology
, 876
pp. 233-239.
10.1007/978-1-4939-3023-4_29.
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Corona, JC;
Duchen, MR;
(2016)
PPARγ as a therapeutic target to rescue mitochondrial function in neurological disease.
Free Radical Biology & Medicine
, 100
pp. 153-163.
10.1016/j.freeradbiomed.2016.06.023.
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Guedes-Dias, P;
Pinho, BR;
Soares, TR;
de Proença, J;
Duchen, MR;
Oliveira, JM;
(2016)
Mitochondrial dynamics and quality control in Huntington's disease.
Neurobiology of Disease
, 90
pp. 51-57.
10.1016/j.nbd.2015.09.008.
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Hawkins, KE;
Joy, S;
Delhove, JM;
Kotiadis, VN;
Fernandez, E;
Fitzpatrick, LM;
Whiteford, JR;
... McKay, TR; + view all
(2016)
NRF2 Orchestrates the Metabolic Shift during Induced Pluripotent Stem Cell Reprogramming.
Cell Reports
, 14
(8)
pp. 1883-1891.
10.1016/j.celrep.2016.02.003.
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Hill, JM;
(2016)
Mitochondrial calcium uptake pathways as a potential therapeutic target.
Doctoral thesis , UCL (University College London).
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Kilpatrick, BS;
Magalhaes, J;
Beavan, MS;
McNeill, A;
Gegg, ME;
Cleeter, MW;
Bloor-Young, D;
... Patel, S; + view all
(2016)
Endoplasmic reticulum and lysosomal Ca(2+) stores are remodelled in GBA1-linked Parkinson disease patient fibroblasts.
Cell Calcium
, 59
(1)
pp. 12-20.
10.1016/j.ceca.2015.11.002.
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McKenzie, M;
Duchen, MR;
(2016)
Impaired Cellular Bioenergetics Causes Mitochondrial Calcium Handling Defects in MT-ND5 Mutant Cybrids.
PLOS One
, 11
(4)
, Article e0154371. 10.1371/journal.pone.0154371.
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Sadeghian, M;
Mastrolia, V;
Haddad, AR;
Mosley, A;
Mullali, G;
Schiza, D;
Sajic, M;
... Smith, KJ; + view all
(2016)
Mitochondrial dysfunction is an important cause of neurological deficits in an inflammatory model of multiple sclerosis.
Scientific Reports
, 6
, Article 33249. 10.1038/srep33249.
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Tosatto, A;
Sommaggio, R;
Kummerow, C;
Bentham, RB;
Blacker, TS;
Berecz, T;
Duchen, MR;
... Mammucari, C; + view all
(2016)
The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1α.
EMBO Molecular Medicine
, 8
(5)
pp. 569-585.
10.15252/emmm.201606255.
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Warne, J;
Pryce, G;
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