Browse by UCL people
Group by: Type | Date
Number of items: 401.
2024
Blumenreich, Shani;
Nehushtan, Tamar;
Kupervaser, Meital;
Shalit, Tali;
Gabashvili, Alexandra;
Joseph, Tammar;
Milenkovic, Ivan;
... Futerman, Anthony H; + view all
(2024)
Large-scale proteomics analysis of five brain regions from Parkinson’s disease patients with a GBA1 mutation.
npj Parkinson's Disease
, 10
, Article 33. 10.1038/s41531-024-00645-x.
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Jiang, Y;
Uhm, H;
Ip, FC;
Ouyang, L;
Lo, RMN;
Cheng, EYL;
Cao, X;
... Ip, NY; + view all
(2024)
A blood-based multi-pathway biomarker assay for early detection and staging of Alzheimer's disease across ethnic groups.
Alzheimer's and Dementia
10.1002/alz.13676.
(In press).
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Luo, Huihui;
Gustavsson, Emil K;
Macpherson, Hannah;
Dominik, Natalia;
Zhelcheska, Kristina;
Montgomery, Kylie;
Anderson, Claire;
... Chen, Zhongbo; + view all
(2024)
Letter to the editor on: Hornerin deposits in neuronal intranuclear inclusion disease: direct identification of proteins with compositionally biased regions in inclusions by Park et al. (2022).
Acta Neuropathol Commun
, 12
(1)
, Article 2. 10.1186/s40478-023-01706-7.
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Nazish, Iqra;
Mamais, Adamantios;
Mallach, Anna;
Bettencourt, Conceisao;
Kaganovich, Alice;
Warner, Thomas;
Hardy, John;
... Bandopadhyay, Rina; + view all
(2024)
Differential LRRK2 signalling and gene expression in WT-LRRK2 and G2019S-LRRK2 mouse microglia treated with zymosan and MLi2.
Cells
, 13
(1)
, Article 53. 10.3390/cells13010053.
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Zhong, H;
Zhou, X;
Uhm, H;
Jiang, Y;
Cao, H;
Chen, Y;
Mak, TTW;
... Ip, NY; + view all
(2024)
Using blood transcriptome analysis for Alzheimer's disease diagnosis and patient stratification.
Alzheimer's and Dementia
10.1002/alz.13691.
(In press).
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2023
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Baker, Emily;
Leonenko, Ganna;
Schmidt, Karl Michael;
Hill, Matthew;
Myers, Amanda J;
Shoai, Maryam;
de Rojas, Itziar;
... Escott-Price, Valentina; + view all
(2023)
What does heritability of Alzheimer's disease represent?
PLOS ONE
, 18
(4)
, Article e0281440. 10.1371/journal.pone.0281440.
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Bandres-Ciga, Sara;
Faghri, Faraz;
Majounie, Elisa;
Koretsky, Mathew J;
Kim, Jeffrey;
Levine, Kristin S;
Leonard, Hampton;
... Vitale, Dan; + view all
(2023)
NeuroBooster Array: A Genome-Wide Genotyping Platform to Study Neurological Disorders Across Diverse Populations.
medRxiv.org: Cold Spring Harbor, NY, USA.
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Hampel, Harald;
Hu, Yan;
Hardy, John;
Blennow, Kaj;
Chen, Christopher;
Perry, George;
Kim, Seung Hyun;
... Vergallo, Andrea; + view all
(2023)
The amyloid-β pathway in Alzheimer's disease: a plain language summary.
Neurodegenerative Disease Management
10.2217/nmt-2022-0037.
(In press).
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Hardy, J;
(2023)
Anti-amyloid therapies work for Alzheimer's disease.
Brain Communications
, 5
(4)
, Article fcad204. 10.1093/braincomms/fcad204.
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Hardy, John;
Mummery, Catherine;
(2023)
Reply: Unblinding in the lecanemab trial in Alzheimer's disease.
Brain
, Article awad201. 10.1093/brain/awad201.
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Hardy, John;
Mummery, Catherine;
(2023)
An anti-amyloid therapy works for Alzheimer's disease: why has it taken so long and what is next?
Brain
, 146
(4)
pp. 1240-1242.
10.1093/brain/awad049.
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Hardy, John;
Mummery, Catherine;
(2023)
Reply: Lecanemab: turning point, or status quo? An ethics perspective.
Brain
, Article awad102. 10.1093/brain/awad102.
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Kaivola, K;
Chia, R;
Ding, J;
Rasheed, M;
Fujita, M;
Menon, V;
Walton, RL;
... Lopez, G; + view all
(2023)
Genome-wide structural variant analysis identifies risk loci for non-Alzheimer's dementias.
Cell Genomics
, 3
(6)
, Article 100316. 10.1016/j.xgen.2023.100316.
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Langworth-Green, C;
Patel, S;
Jaunmuktane, Z;
Jabbari, E;
Morris, H;
Thom, M;
Lees, A;
... Duff, K; + view all
(2023)
Chronic effects of inflammation on tauopathies.
The Lancet Neurology
, 22
(5)
pp. 430-442.
10.1016/S1474-4422(23)00038-8.
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Okunoye, Olaitan;
Ojo, Oluwadamilola O;
Abiodun, Oladunni;
Abubakar, Sani;
Achoru, Charles;
Adeniji, Olaleye;
Agabi, Osigwe;
... Okubadejo, Njideka; + view all
(2023)
MAPT allele and haplotype frequencies in Nigerian Africans: Population distribution and association with Parkinson's disease risk and age at onset.
Parkinsonism & Related Disorders
, 113
, Article 105517. 10.1016/j.parkreldis.2023.105517.
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Outeiro, TF;
Alcalay, RN;
Antonini, A;
Attems, J;
Bonifati, V;
Cardoso, F;
Chesselet, MF;
... Ferreira, JJ; + view all
(2023)
Defining the Riddle in Order to Solve It: There Is More Than One “Parkinson's Disease”.
Movement Disorders
10.1002/mds.29419.
(In press).
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Rizig, Mie;
Bandres-Ciga, Sara;
Makarious, Mary B;
Ojo, Oluwadamilola Omolara;
Crea, Peter Wild;
Abiodun, Oladunni Victoria;
Levine, Kristin S;
... Global Parkinson's Genetics, Program; + view all
(2023)
Identification of genetic risk loci and causal insights associated with Parkinson's disease in African and African admixed populations: a genome-wide association study.
The Lancet Neurology
, 22
(11)
pp. 1015-1025.
10.1016/S1474-4422(23)00283-1.
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Rollo, J;
Crawford, J;
Hardy, J;
(2023)
A dynamical systems approach for multiscale synthesis of Alzheimer's pathogenesis.
Neuron
, 111
(14)
pp. 2126-2139.
10.1016/j.neuron.2023.04.018.
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Rueda-Carrasco, Javier;
Sokolova, Dimitra;
Lee, Sang-Eun;
Childs, Thomas;
Jurčáková, Natália;
Crowley, Gerard;
De Schepper, Sebastiaan;
... Hong, Soyon; + view all
(2023)
Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models.
The EMBO Journal
, Article e113246. 10.15252/embj.2022113246.
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Soreq, L;
Bird, H;
Mohamed, W;
Hardy, J;
(2023)
Single-cell RNA sequencing analysis of human Alzheimer’s disease brain samples reveals neuronal and glial specific cells differential expression.
PLOS ONE
, 18
(2)
, Article e0277630. 10.1371/journal.pone.0277630.
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Stevenson-Hoare, J;
Schalkamp, AK;
Sandor, C;
Hardy, J;
Escott-Price, V;
(2023)
New cases of dementia are rising in elderly populations in Wales, UK.
Journal of the Neurological Sciences
, 451
, Article 120715. 10.1016/j.jns.2023.120715.
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Zhou, Xiaopu;
Chen, Yu;
Ip, Fanny CF;
Jiang, Yuanbing;
Cao, Han;
Lv, Ge;
Zhong, Huan;
... Ip, Nancy Y; + view all
(2023)
Deep learning-based polygenic risk analysis for Alzheimer's disease prediction.
communications medicine
, 3
, Article 49. 10.1038/s43856-023-00269-x.
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2022
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Adhikari, UK;
Khan, R;
Mikhael, M;
Balez, R;
David, MA;
Mahns, D;
Hardy, J;
(2022)
Therapeutic anti-amyloid β antibodies cause neuronal disturbances.
Alzheimer's & Dementia
10.1002/alz.12833.
(In press).
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Andersen, Maren Stolp;
Tan, Manuela;
Holtman, Inge R;
Hardy, John;
Pihlstrom, Lasse;
(2022)
Dissecting the limited genetic overlap of Parkinson's and Alzheimer's disease.
Annals of Clinical and Translational Neurology
10.1002/acn3.51606.
(In press).
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Blumenreich, Shani;
Nehushtan, Tamar;
Barav, Or B;
Saville, Jennifer T;
Dingjan, Tamir;
Hardy, John;
Fuller, Maria;
(2022)
Elevation of gangliosides in four brain regions from Parkinson’s disease patients with a GBA mutation.
npj Parkinson's Disease
, 8
, Article 99. 10.1038/s41531-022-00363-2.
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Bracher-Smith, Matthew;
Leonenko, Ganna;
Baker, Emily;
Crawford, Karen;
Graham, Andrew C;
Salih, Dervis A;
Howell, Brian W;
... Escott-Price, Valentina; + view all
(2022)
Whole genome analysis in APOE4 homozygotes identifies the DAB1-RELN pathway in Alzheimer's disease pathogenesis.
Neurobiology of Aging
, 119
pp. 67-76.
10.1016/j.neurobiolaging.2022.07.009.
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Escott-Price, Valentina;
Hardy, John;
(2022)
Genome-wide association studies for Alzheimer's disease: bigger is not always better.
Brain Communications
, 4
(3)
, Article fcac125. 10.1093/braincomms/fcac125.
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Hardy, J;
De Strooper, B;
Escott-Price, V;
(2022)
Diabetes and Alzheimer's disease: shared genetic susceptibility?
The Lancet Neurology
, 21
(11)
pp. 962-964.
10.1016/S1474-4422(22)00395-7.
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Hatton, Christopher;
Ghanem, Simona S;
Koss, David J;
Abdi, Ilham Y;
Gibbons, Elizabeth;
Guerreiro, Rita;
Bras, Jose;
... Erskine, Daniel; + view all
(2022)
Prion-like α-synuclein pathology in the brain of infants with Krabbe disease.
Brain
, 145
(4)
pp. 1257-1263.
10.1093/brain/awac002.
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Ibañez, Kristina;
Polke, James;
Hagelstrom, R Tanner;
Dolzhenko, Egor;
Pasko, Dorota;
Thomas, Ellen Rachel Amy;
Daugherty, Louise C;
... Genomics England Research Consortium, .; + view all
(2022)
Whole genome sequencing for the diagnosis of neurological repeat expansion disorders in the UK: a retrospective diagnostic accuracy and prospective clinical validation study.
The Lancet Neurology
, 21
(3)
pp. 234-245.
10.1016/S1474-4422(21)00462-2.
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Jiang, Y;
Zhou, X;
Ip, FC;
Chan, P;
Chen, Y;
Lai, NCH;
Cheung, K;
... Ip, NY; + view all
(2022)
Large-scale plasma proteomic profiling identifies a high-performance biomarker panel for Alzheimer's disease screening and staging.
Alzheimer's & Dementia
, 18
(1)
pp. 88-102.
10.1002/alz.12369.
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Jiang, Y;
Zhou, X;
Wong, HY;
Ouyang, L;
Ip, FCF;
Chau, VMN;
Lau, SF;
... Albers, CS; + view all
(2022)
An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease.
Nature Aging
, 2
pp. 616-634.
10.1038/s43587-022-00241-9.
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Kaivola, K;
Shah, Z;
Chia, R;
Black, SE;
Gan-Or, Z;
Keith, J;
Masellis, M;
... Scholz, SW; + view all
(2022)
Genetic evaluation of dementia with Lewy bodies implicates distinct disease subgroups.
Brain
, 145
(5)
pp. 1757-1762.
10.1093/brain/awab402.
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Karlsson, Ida K;
Escott-Price, Valentina;
Gatz, Margaret;
Hardy, John;
Pedersen, Nancy L;
Shoai, Maryam;
Reynolds, Chandra A;
(2022)
Measuring heritable contributions to Alzheimer's disease: polygenic risk score analysis with twins.
Brain Communications
, 4
(1)
, Article fcab308. 10.1093/braincomms/fcab308.
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Park, Jong-Chan;
Barahona-Torres, Natalia;
Jang, So-Young;
Mok, Kin Y;
Kim, Haeng Jun;
Han, Sun-Ho;
Cho, Kwang-Hyun;
... Hardy, John; + view all
(2022)
Multi-Omics-Based Autophagy-Related Untypical Subtypes in Patients with Cerebral Amyloid Pathology.
Advanced Science
, Article 2201212. 10.1002/advs.202201212.
(In press).
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Wong, Hiu Yi;
Zhong, Huan;
Zhong, Mingqian;
Zhou, Xiaopu;
Chan, Phillip YC;
Kwok, Timothy CY;
Mok, Kin;
... Ip, Nancy Y; + view all
(2022)
Demographics and Medication Use of Patients with Late-Onset Alzheimer's Disease in Hong Kong.
Journal of Alzheimer's Disease
10.3233/JAD-215312.
(In press).
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2021
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Andersen, MS;
Bandres-Ciga, S;
Reynolds, RH;
Hardy, J;
Ryten, M;
Krohn, L;
Gan-Or, Z;
... Pihlstrøm, L; + view all
(2021)
Heritability enrichment implicates microglia in Parkinson's disease pathogenesis.
Annals of Neurology
, 89
(5)
pp. 942-951.
10.1002/ana.26032.
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Arber, C;
Lovejoy, C;
Harris, L;
Willumsen, N;
Alatza, A;
Casey, JM;
Lines, G;
... Wray, S; + view all
(2021)
Familial Alzheimer's Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis.
Cell Reports
, 34
(2)
, Article 108615. 10.1016/j.celrep.2020.108615.
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Benitez, DP;
Jiang, S;
Wood, J;
Wang, R;
Hall, CM;
Peerboom, C;
Wong, N;
... Cummings, DM; + view all
(2021)
Knock-in models related to Alzheimer’s disease: synaptic transmission, plaques and the role of microglia.
Molecular Neurodegeneration
, 16
(1)
, Article 47. 10.1186/s13024-021-00457-0.
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Blauwendraat, C;
Iwaki, H;
Makarious, MB;
Bandres-Ciga, S;
Leonard, H;
Grenn, FP;
Lake, J;
... Lynch, TL; + view all
(2021)
Investigation of Autosomal Genetic Sex Differences in Parkinson's disease.
Annals of Neurology
, 90
(1)
pp. 35-42.
10.1002/ana.26090.
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Chelban, V;
Breza, M;
Szaruga, M;
Vandrovcova, J;
Murphy, D;
Lee, C-J;
Alikhwan, S;
... Koutsis, G; + view all
(2021)
Spastic paraplegia preceding PSEN1-related familial Alzheimer's disease.
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
, 13
(1)
, Article e12186. 10.1002/dad2.12186.
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Chen, Z;
Zhang, D;
Reynolds, RH;
Gustavsson, EK;
García-Ruiz, S;
D'Sa, K;
Fairbrother-Browne, A;
... Ryten, M; + view all
(2021)
Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage.
Nature Communications
, 12
, Article 2076. 10.1038/s41467-021-22262-5.
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Chia, R;
Sabir, MS;
Bandres-Ciga, S;
Saez-Atienzar, S;
Reynolds, RH;
Gustavsson, E;
Walton, RL;
... Scholz, SW; + view all
(2021)
Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture.
Nature Genetics
, 53
pp. 294-30353.
10.1038/s41588-021-00785-3.
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Cosker, K;
Mallach, A;
Limaye, J;
Piers, TM;
Staddon, J;
Neame, SJ;
Hardy, J;
(2021)
Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome.
Scientific Reports
, 11
(1)
, Article 13316. 10.1038/s41598-021-91207-1.
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Dewan, R;
Chia, R;
Ding, J;
Hickman, RA;
Stein, TD;
Abramzon, Y;
Ahmed, S;
... Traynor, BJ; + view all
(2021)
Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.
Neuron
, 109
(3)
448-460.e4.
10.1016/j.neuron.2020.11.005.
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Feleke, R;
Reynolds, RH;
Smith, AM;
Tilley, B;
Taliun, SAG;
Hardy, J;
Matthews, PM;
... Ryten, M; + view all
(2021)
Cross-platform transcriptional profiling identifies common and distinct molecular pathologies in Lewy body diseases.
Acta Neuropathologica
10.1007/s00401-021-02343-x.
(In press).
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García-Ruiz, S;
Gil-Martínez, AL;
Cisterna, A;
Jurado-Ruiz, F;
Reynolds, RH;
NABEC (North America Brain Expression Consortium), .;
Cookson, MR;
... Botía, JA; + view all
(2021)
CoExp: A Web Tool for the Exploitation of Co-expression Networks.
Frontiers in Gentics
, 12
, Article 630187. 10.3389/fgene.2021.630187.
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Gillard, S;
Dare, C;
Hardy, J;
Nyikavaranda, P;
Rowan Olive, R;
Shah, P;
Birken, M;
... NIHR Mental Health Policy Research Unit Covid coproduction resea; + view all
(2021)
Experiences of living with mental health problems during the COVID-19 pandemic in the UK: a coproduced, participatory qualitative interview study.
Social Psychiatry and Psychiatric Epidemiology
, 56
pp. 1447-1457.
10.1007/s00127-021-02051-7.
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Hampel, H;
Hardy, J;
Blennow, K;
Chen, C;
Perry, G;
Kim, SH;
Villemagne, VL;
... Vergallo, A; + view all
(2021)
The Amyloid-beta Pathway in Alzheimer's Disease.
Molecular Psychiatry
10.1038/s41380-021-01249-0.
(In press).
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Hardy, J;
Salih, D;
(2021)
TREM2-mediated activation of microglia breaks link between amyloid and tau.
The Lancet Neurology
, 20
(6)
pp. 416-417.
10.1016/s1474-4422(21)00133-2.
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Hung, C;
Tuck, E;
Stubbs, V;
Van der Lee, SJ;
Aalfs, C;
Van Spaendonk, R;
Scheltens, P;
... Livesey, FJ; + view all
(2021)
SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network.
Cell Reports
, 35
(11)
, Article 109259. 10.1016/j.celrep.2021.109259.
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Jabbari, E;
Koga, S;
Valentino, R;
Reynolds, R;
Ferrari, R;
Tan, M;
Rowe, J;
... Morris, H; + view all
(2021)
Genetic determinants of survival in progressive supranuclear palsy: a genome-wide association study.
The Lancet Neurology
, 20
(2)
pp. 107-116.
10.1016/S1474-4422(20)30394-X.
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Johnson, JO;
Chia, R;
Miller, DE;
Li, R;
Kumaran, R;
Abramzon, Y;
Alahmady, N;
... Turner, MR; + view all
(2021)
Association of Variants in the SPTLC1 Gene with Juvenile Amyotrophic Lateral Sclerosis.
JAMA Neurology
10.1001/jamaneurol.2021.2598.
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Kaiyrzhanov, R;
Aitkulova, A;
Vandrovcova, J;
Murphy, D;
Zharkinbekova, N;
Shashkin, C;
Akhmetzhanov, V;
... Houlden, H; + view all
(2021)
A glimpse of the genetics of young-onset Parkinson's disease in Central Asia.
Molecular Genetics & Genomic Medicine
10.1002/mgg3.1671.
(In press).
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Kara, E;
Crimi, A;
Wiedmer, A;
Emmenegger, M;
Manzoni, C;
Bandres-Ciga, S;
D'Sa, K;
... Aguzzi, A; + view all
(2021)
An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein.
Cell Reports
, 35
(10)
, Article 109189. 10.1016/j.celrep.2021.109189.
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Khani, M;
Shamshiri, H;
Taheri, H;
Hardy, J;
Bras, JT;
Carmona, S;
Moazzeni, H;
... Elahi, E; + view all
(2021)
BVVL/ FL: features caused by SLC52A3 mutations; WDFY4 and TNFSF13B may be novel causative genes.
Neurobiology of Aging
, 99
102.e1-102.e10.
10.1016/j.neurobiolaging.2020.09.021.
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Khani, M;
Taheri, H;
Shamshiri, H;
Moazzeni, H;
Hardy, J;
Bras, JT;
InanlooRahatloo, K;
... Elahi, E; + view all
(2021)
Deep geno- and phenotyping in two consanguineous families with CMT2 reveals HADHA as an unusual disease-causing gene and an intronic variant in GDAP1 as an unusual mutation.
Journal of Neurology
, 268
pp. 640-650.
10.1007/s00415-020-10171-4.
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Kia, DA;
Zhang, D;
Guelfi, S;
Manzoni, C;
Hubbard, L;
Reynolds, RH;
Botía, J;
... Botiá, JA; + view all
(2021)
Identification of Candidate Parkinson Disease Genes by Integrating Genome-Wide Association Study, Expression, and Epigenetic Data Sets.
JAMA Neurology
, 78
(4)
pp. 464-472.
10.1001/jamaneurol.2020.5257.
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Kumar, A;
Shoai, M;
Palmqvist, S;
Stomrud, E;
Hardy, J;
Mattsson-Carlgren, N;
Hansson, O;
(2021)
Genetic effects on longitudinal cognitive decline during the early stages of Alzheimer's disease.
Scientific Reports
, 11
, Article 19853. 10.1038/s41598-021-99310-z.
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Lalli, G;
Schott, JM;
Hardy, J;
De Strooper, B;
(2021)
Aducanumab: a new phase in therapeutic development for Alzheimer’s disease?
EMBO Molecular Medicine
, 13
, Article e14781. 10.15252/emmm.202114781.
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Lawingco, T;
Chaudhury, S;
Brookes, KJ;
Guetta-Baranes, T;
Guerreiro, R;
Bras, J;
Hardy, J;
... Morgan, K; + view all
(2021)
Genetic variants in glutamate-, Aβ-, and tau-related pathways determine polygenic risk for Alzheimer's disease.
Neurobiology of Aging
, 101
299.e13-299.e21.
10.1016/j.neurobiolaging.2020.11.009.
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Ly, H;
Verma, N;
Sharma, S;
Kotiya, D;
Despa, S;
Abner, EL;
Nelson, PT;
... Despa, F; + view all
(2021)
The association of circulating amylin with β‐amyloid in familial Alzheimer's disease.
Alzheimer's & Dementia
, 7
(1)
, Article e12130. 10.1002/trc2.12130.
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Magrinelli, F;
Mehta, S;
Di Lazzaro, G;
Latorre, A;
Edwards, MJ;
Balint, B;
Basu, P;
... Bhatia, KP; + view all
(2021)
Dissecting the Phenotype and Genotype of PLA2G6-Related Parkinsonism.
Movement Disorders
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