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Article

Bal, W; Christodoulou, J; Sadler, PJ; Tucker, A; (1998) Multi-metal binding site of serum albumin. J Inorg Biochem , 7 33 - 39. 10.1016/S0162-0134(98)00010-5.

Bal, W; Christodoulou, J; Sadler, PJ; Tucker, A; (1994) multi-metal binding site on serum albumin. Metal Ions in Biology and Medicine 43 - 45.

Baldwin, AJ; Anthony-Cahill, SJ; Knowles, TP; Lippens, G; Christodoulou, J; Barker, PD; Dobson, CM; (2008) Measurement of amyloid fibril length distributions by inclusion of rotational motion in solution NMR diffusion measurements. Angew Chem Int Ed Engl , 47 (18) 3385 - 3387. 10.1002/anie.200703915.

Baldwin, AJ; Bader, R; Christodoulou, J; MacPhee, CE; Dobson, CM; Barker, PD; (2006) Cytochrome display on amyloid fibrils. J Am Chem Soc , 128 (7) 2162 - 2163. 10.1021/ja0565673.

Baldwin, AJ; Christodoulou, J; Barker, PD; Dobson, CM; Lippens, G; (2007) Contribution of rotational diffusion to pulsed field gradient diffusion measurements. J Chem Phys , 127 (11) 114505 - ?. 10.1063/1.2759211.

Baldwin, AJ; Knowles, TPJ; Tartaglia, GG; Fitzpatrick, AW; Devlin, GL; Shammas, SL; ... Dobson, CM; + view all (2011) Metastability of Native Proteins and the Phenomenon of Amyloid Formation. J AM CHEM SOC , 133 (36) 14160 - 14163. 10.1021/ja2017703.

Blombach, F; Launay, H; Zorraquino, V; Swarts, DC; Cabrita, LD; Benelli, D; ... van der Oost, J; + view all (2011) An HflX-Type GTPase from Sulfolobus solfataricus Binds to the 50S Ribosomal Subunit in All Nucleotide-Bound States. J BACTERIOL , 193 (11) 2861 - 2867. 10.1128/JB.01552-10.

Cabrita, LD; Dobson, CM; Christodoulou, J; (2010) Early Nascent Chain Folding Events on the Ribosome. ISR J CHEM , 50 (1) 99 - 108. 10.1002/ijch.201000015.

Cabrita, LD; Dobson, CM; Christodoulou, J; (2010) Protein folding on the ribosome. CURR OPIN STRUC BIOL , 20 (1) 33 - 45. 10.1016/j.sbi.2010.01.005.

Cabrita, LD; Hsu, STD; Launay, H; Dobson, CM; Christodoulou, J; (2009) Probing ribosome-nascent chain complexes produced in vivo by NMR spectroscopy. P NATL ACAD SCI USA , 106 (52) 22239 - 22244. 10.1073/pnas.0903750106.

Cabrita, LD; Waudby, CA; Dobson, CM; Christodoulou, J; (2011) Solution-state nuclear magnetic resonance spectroscopy and protein folding. Methods Mol Biol , 752 97 - 120. 10.1007/978-1-60327-223-0_7.

Chan, PH; Pardon, E; Menzer, L; De Genst, E; Kumita, JR; Christodoulou, J; ... Dumoulin, M; + view all (2008) Engineering a camelid antibody fragment that binds to the active site of human lysozyme and inhibits its conversion into amyloid fibrils. Biochemistry , 47 (42) 11041 - 11054. 10.1021/bi8005797.

Chandran, V; Stollar, EJ; Lindorff-Larsen, K; Harper, JF; Chazin, WJ; Dobson, CM; ... Christodoulou, J; + view all (2006) Structure of the regulatory apparatus of a calcium-dependent protein kinase (CDPK): a novel mode of calmodulin-target recognition. J Mol Biol , 357 (2) 400 - 410. 10.1016/j.jmb.2005.11.093.

Chang, Y-P; Mahadeva, R; Patschull, AOM; Nobeli, I; Ekeowa, UI; McKay, AR; ... Gooptu, B; + view all (2011) TARGETING SERPINS IN HIGH-THROUGHPUT AND STRUCTURE-BASED DRUG DESIGN. METHODS IN ENZYMOLOGY, VOL 501: SERPIN STRUCTURE AND EVOLUTION , 501 139 - 175. 10.1016/B978-0-12-385950-1.00008-0.

Christodoulou, J; (2012) Translational Protein Folding on the Ribosome: Using NMR Spectroscopy to Provide Structure and Dynamics of Ribosome-Nascent Chains. John Christodoulou. BIOPHYSICAL JOURNAL , 102 (3) 67A - 67A.

Christodoulou, J; Hu, H; Chung, J; Rance, M; Harper, JF; Chazin, WJ; (2002) 1H, 15N and 13C assignments of the regulatory domains of calcium-dependent protein kinase (CDPK). J Biomol NMR (23) 249 - 250. 10.1023/A:1019875822571.

Christodoulou, J; Kashani, M; Keohane, B; Sadler, PJ; (1996) Determination of gold and platinum in the presence of blood plasma proteins using ICP-MS. J Anal At Spec , 11 1031 - 1035.

Christodoulou, J; Larsson, G; Fucini, P; Connell, SR; Pertinhez, TA; Hanson, CL; ... Dobson, CM; + view all (2004) Heteronuclear NMR investigations of dynamic regions of intact Escherichia coli ribosomes. Proc Natl Acad Sci U S A , 101 (30) 10949 - 10954. 10.1073/pnas.0400928101.

Christodoulou, J; Malmendal, A; Harper, JF; Chazin, WJ; (2004) Evidence for differing roles for each lobe of the calmodulin-like domain in a calcium-dependent protein Kinase (CDPK). J Biol Chem , 279 (28) 29092 - 29100. 10.1074/jbc.M401297200. Gold open access

Christodoulou, J; Sadler, PJ; Tucker, A; (1995) 1H NMR of albumin in human blood plasma: drug binding and redox reactions at Cys34. FEBS Lett , 376 (1-2) 1 - 5.

CHRISTODOULOU, J; Sadler, PJ; Tucker, A; A new structural transition of serum albumin dependent on the state of Cys34: detection by 1H-NMR spectroscopy. Eur J Biochem , 225 363 - 368.

CHRISTODOULOU, J; Sadler, PJ; Tucker, A; Gold-induced structural switch of cys34 in albumin: comparison of auranofin with aurothiomalate. Metal Based Drugs , 527 5 - 6.

Christodoulou, J; Waudby, CA; (2013) NMR of Biomolecules: Towards Mechanistic Systems Biology. Edited by Ivano Bertini, Kathleen S. McGreevy and Giacomo Parigi. ChemBioChem , 14 (14) 1906 - 1906. 10.1002/cbic.201300209.

De Genst, E; Chan, PH; Pardon, E; Hsu, ST; Kumita, JR; Christodoulou, J; ... Dumoulin, M; + view all (2013) A Nanobody Binding to Non-Amyloidogenic Regions of the Protein Human Lysozyme Enhances Partial Unfolding but Inhibits Amyloid Fibril Formation. J Phys Chem B 10.1021/jp403425z.

De Genst, EJ; Guilliams, T; Wellens, J; O'Day, EM; Waudby, CA; Meehan, S; ... Dobson, CM; + view all (2010) Structure and Properties of a Complex of alpha-Synuclein and a Single-Domain Camelid Antibody. J MOL BIOL , 402 (2) 326 - 343. 10.1016/j.jmb.2010.07.001.

Dedmon, MM; Christodoulou, J; Wilson, MR; Dobson, CM; (2005) Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species. J Biol Chem , 280 (15) 14733 - 14740. 10.1074/jbc.M413024200. Gold open access

Dedmon, MM; Lindorff-Larsen, K; Christodoulou, J; Vendruscolo, M; Dobson, CM; (2005) Mapping long-range interactions in alpha-synuclein using spin-label NMR and ensemble molecular dynamics simulations. J Am Chem Soc , 127 (2) 476 - 477. 10.1021/ja044834j.

Gsponer, J; Christodoulou, J; Cavalli, A; Bui, JM; Richter, B; Dobson, CM; Vendruscolo, M; (2008) A coupled equilibrium shift mechanism in calmodulin-mediated signal transduction. Structure , 16 (5) 736 - 746. 10.1016/j.str.2008.02.017.

Guilliams, T; El-Turk, F; Buell, AK; O'Day, EM; Aprile, FA; Esbjörner, EK; ... De Genst, E; + view all (2013) Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages. J Mol Biol , 425 (14) 2397 - 2411. 10.1016/j.jmb.2013.01.040.

Hagan, CL; Johnson, RJ; Dhulesia, A; Dumoulin, M; Dumont, J; De Genst, E; ... Kumita, JR; + view all (2010) A non-natural variant of human lysozyme (I59T) mimics the in vitro behaviour of the I56T variant that is responsible for a form of familial amyloidosis. Protein Eng Des Sel , 23 (7) 499 - 506. 10.1093/protein/gzq023.

Hsu, ST; Cabrita, LD; Christodoulou, J; Dobson, CM; (2009) 1H, 15N and 13C assignments of domain 5 of Dictyostelium discoideum gelation factor (ABP-120) in its native and 8M urea-denatured states. Biomol NMR Assign , 3 (1) 29 - 31. 10.1007/s12104-008-9134-4.

Hsu, ST; Fucini, P; Cabrita, LD; Launay, H; Dobson, CM; Christodoulou, J; (2007) Structure and dynamics of a ribosome-bound nascent chain by NMR spectroscopy. Proc Natl Acad Sci U S A , 104 (42) 16516 - 16521. 10.1073/pnas.0704664104.

Hsu, STD; Cabrita, LD; Fucini, P; Christodoulou, J; Dobson, CM; (2009) Probing Side-Chain Dynamics of a Ribosome-Bound Nascent Chain Using Methyl NMR Spectroscopy. J AM CHEM SOC , 131 (24) 8366 - +. 10.1021/ja902778n.

Hsu, STD; Cabrita, LD; Fucini, P; Dobson, CM; Christodoulou, J; (2009) Probing Protein Folding on the Ribosome by Solution State NMR Spectroscopy. J BIOMOL STRUCT DYN , 26 (6) 846 - 846.

Hsu, STD; Cabrita, LD; Fucini, P; Dobson, CM; Christodoulou, J; (2009) Structure, Dynamics and Folding of an Immunoglobulin Domain of the Gelation Factor (ABP-120) from Dictyostelium discoideum. J MOL BIOL , 388 (4) 865 - 879. 10.1016/j.jmb.2009.02.063.

Huang, JR; Craggs, TD; Christodoulou, J; Jackson, SE; (2007) Stable intermediate states and high energy barriers in the unfolding of GFP. J Mol Biol , 370 (2) 356 - 371. 10.1016/j.jmb.2007.04.039.

Huang, JR; Hsu, STD; Christodoulou, J; Jackson, SE; (2008) The extremely slow-exchanging core and acid-denatured state of green fluorescent protein. HFSP J , 2 (6) 378 - 387. 10.2976/1.2976660.

Ivanov, AI; Christodoulou, J; Parkinson, JA; Barnham, KJ; Tucker, A; Woodrow J, S; P, J; (1998) Cisplatin binding sites on human albumin. J Biol Chem , 273 14721 - 14730. Gold open access

Johnson, RJ; Christodoulou, J; Dumoulin, M; Caddy, GL; Alcocer, MJ; Murtagh, GJ; ... Dobson, CM; + view all (2005) Rationalising lysozyme amyloidosis: insights from the structure and solution dynamics of T70N lysozyme. J Mol Biol , 352 (4) 823 - 836. 10.1016/j.jmb.2005.07.040.

Keetch, CA; Bromley, EH; McCammon, MG; Wang, N; Christodoulou, J; Robinson, CV; (2005) L55P transthyretin accelerates subunit exchange and leads to rapid formation of hybrid tetramers. J Biol Chem , 280 (50) 41667 - 41674. 10.1074/jbc.M508753200. Gold open access

Lendel, C; Bertoncini, CW; Cremades, N; Waudby, CA; Vendruscolo, M; Dobson, CM; ... Toth, G; + view all (2009) On the Mechanism of Nonspecific Inhibitors of Protein Aggregation: Dissecting the Interactions of alpha-Synuclein with Congo Red and Lacmoid. BIOCHEMISTRY-US , 48 (35) 8322 - 8334. 10.1021/bi901285x.

Nyon, MP; Kirkpatrick, J; Cabrita, LD; Christodoulou, J; Gooptu, B; (2012) 1H, 15N and 13C backbone resonance assignments of the archetypal serpin α1-antitrypsin. Biomol NMR Assign , 6 (2) 153 - 156. 10.1007/s12104-011-9345-y.

Nyon, MP; Segu, L; Cabrita, LD; Lévy, GR; Kirkpatrick, J; Roussel, BD; ... Gooptu, B; + view all (2012) Structural dynamics associated with intermediate formation in an archetypal conformational disease. Structure , 20 (3) 504 - 512. 10.1016/j.str.2012.01.012.

O'Brien, EP; Christodoulou, J; Vendruscolo, M; Dobson, CM; (2012) Trigger factor slows co-translational folding through kinetic trapping while sterically protecting the nascent chain from aberrant cytosolic interactions. J Am Chem Soc , 134 (26) 10920 - 10932. 10.1021/ja302305u.

O'Brien, EP; Christodoulou, J; Vendruscolo, M; Dobson, CM; (2011) New Scenarios of Protein Folding Can Occur on the Ribosome. J AM CHEM SOC , 133 (3) 513 - 526. 10.1021/ja107863z.

O'Brien, EP; Hsu, STD; Christodoulou, J; Vendruscolo, M; Dobson, CM; (2010) Transient Tertiary Structure Formation within the Ribosome Exit Port. J AM CHEM SOC , 132 (47) 16928 - 16937. 10.1021/ja106530y.

Rivers, RC; Kumita, JR; Tartaglia, GG; Dedmon, MM; Pawar, A; Vendruscolo, M; ... Christodoulou, J; + view all (2008) Molecular determinants of the aggregation behavior of alpha- and beta-synuclein. PROTEIN SCI , 17 (5) 887 - 898. 10.1110/ps.073181508.

Roodveldt, C; Bertoncini, CW; Andersson, A; van der Goot, AT; Hsu, ST; Fernandez-Montesinos, R; ... Dobson, CM; + view all (2009) Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip. EMBO J , 28 (23) 3758 - 3770. 10.1038/emboj.2009.298.

Roodveldt, C; Christodoulou, J; Dobson, CM; (2008) Immunological features of alpha-synuclein in Parkinson's disease. J CELL MOL MED , 12 (5B) 1820 - 1829. 10.1111/j.1582-4934.2008.00450.x.

Tóth, G; Gardai, SJ; Zago, W; Bertoncini, CW; Cremades, N; Roy, SL; ... McConlogue, L; + view all (2014) Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson's Disease. PLoS One , 9 (2) e87133 - ?. 10.1371/journal.pone.0087133.

Vitart, V; Christodoulou, J; Huang, J-F; Chazin, WJ; (2000) Intramolecular activation of a Ca2+-dependent protein kinase is disrupted by insertions in the tether that connects the calmodulin-like domain to the kinase. Biochemistry , 39 4004 - 4011. 10.1021/bi992373m.

Vuchelen, A; O'Day, E; De Genst, E; Pardon, E; Wyns, L; Dumoulin, M; ... Hsu, STD; + view all (2009) H-1, C-13 and N-15 assignments of a camelid nanobody directed against human alpha-synuclein. BIOMOL NMR ASSIGN , 3 (2) 231 - 233. 10.1007/s12104-009-9182-4.

Waudby, CA; Camilloni, C; Fitzpatrick, AW; Cabrita, LD; Dobson, CM; Vendruscolo, M; Christodoulou, J; (2013) In-Cell NMR Characterization of the Secondary Structure Populations of a Disordered Conformation of α-Synuclein within E. coli Cells. PLoS One , 8 (8) , Article e72286 . 10.1371/journal.pone.0072286. Green and gold open access
file

Waudby, CA; Christodoulou, J; (2012) An analysis of NMR sensitivity enhancements obtained using non-uniform weighted sampling, and the application to protein NMR. J Magn Reson , 219 46 - 52. 10.1016/j.jmr.2012.04.013.

Waudby, CA; Christodoulou, J; (2011) GPU accelerated Monte Carlo simulation of pulsed-field gradient NMR experiments. J MAGN RESON , 211 (1) 67 - 73. 10.1016/j.jmr.2011.04.004.

Waudby, CA; Knowles, TPJ; Devlin, GL; Skepper, JN; Ecroyd, H; Carver, JA; ... Meehan, S; + view all (2010) The Interaction of alpha B-Crystallin with Mature alpha-Synuclein Amyloid Fibrils Inhibits Their Elongation. BIOPHYS J , 98 (5) 843 - 851. 10.1016/j.bpj.2009.10.056.

Waudby, CA; Launay, H; Cabrita, LD; Christodoulou, J; (2013) Protein folding on the ribosome studied using NMR spectroscopy. Prog Nucl Magn Reson Spectrosc , 74C 57 - 75. 10.1016/j.pnmrs.2013.07.003.

Waudby, CA; Mantle, MD; Cabrita, LD; Gladden, LF; Dobson, CM; Christodoulou, J; (2012) Rapid distinction of intracellular and extracellular proteins using NMR diffusion measurements. J Am Chem Soc , 134 (28) 11312 - 11315. 10.1021/ja304912c.

Wright, CF; Christodoulou, J; Dobson, CM; Clarke, J; (2004) The importance of loop length in the folding of an immunoglobulin domain. Protein Eng Des Sel , 17 (5) 443 - 453. 10.1093/protein/gzh052.

Proceedings paper

Christodoulou, J; (2013) Co-Translational Protein Folding on the Ribosome: using NMR Spectroscopy to Provide Structure and Dynamics of Ribosome-Nascent Chains. In: BIOPHYSICAL JOURNAL. (pp. 258A - 258A).

O'Brien, EP; Christodoulou, J; Dobson, C; Vendruscolo, M; (2011) On the Effect of the Ribosome and Trigger Factor on Nascent Chain Protein Folding. In: BIOPHYSICAL JOURNAL. (pp. 17 - 17).

This list was generated on Wed Jul 23 18:02:08 2014 BST.