Browse by UCL people
Group by: Type | Date
Number of items: 44.
2023
Pálmadóttir, Tinna;
Waudby, Christopher A;
Bernfur, Katja;
Christodoulou, John;
Linse, Sara;
Malmendal, Anders;
(2023)
Morphology-Dependent Interactions between α-Synuclein Monomers and Fibrils.
International Journal of Molecular Sciences
, 24
(6)
, Article 5191. 10.3390/ijms24065191.
|
2022
Ahn, Minkoo;
Włodarski, Tomasz;
Mitropoulou, Alkistis;
Chan, Sammy HS;
Sidhu, Haneesh;
Plessa, Elena;
Becker, Thomas A;
... Christodoulou, John; + view all
(2022)
Modulating co-translational protein folding by rational design and ribosome engineering.
Nature Communications
, 13
, Article 4243. 10.1038/s41467-022-31906-z.
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Ahn, Minkoo;
Włodarski, Tomasz;
Mitropoulou, Alkistis;
Chan, Sammy HS;
Sidhu, Haneesh;
Plessa, Elena;
Becker, Thomas A;
... Christodoulou, John; + view all
(2022)
Author Correction: Modulating co-translational protein folding by rational design and ribosome engineering.
[Corrigendum].
Nature Communications
, 13
(1)
, Article 5441. 10.1038/s41467-022-33270-4.
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Chan, Sammy HS;
Włodarski, Tomasz;
Streit, Julian O;
Cassaignau, Anaïs ME;
Woodburn, Lauren F;
Ahn, Minkoo;
Freiherr von Sass, Georg Johannes;
... Christodoulou, John; + view all
(2022)
The ribosome stabilizes partially folded intermediates of a nascent multi-domain protein.
Nature Chemistry
10.1038/s41557-022-01004-0.
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Waudby, CA;
Burridge, C;
Cabrita, LD;
Christodoulou, J;
(2022)
Thermodynamics of co-translational folding and ribosome–nascent chain interactions.
Current Opinion in Structural Biology
, 74
, Article 102357. 10.1016/j.sbi.2022.102357.
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Waudby, Christopher A;
Alvarez-Teijeiro, Saul;
Josue Ruiz, E;
Suppinger, Simon;
Pinotsis, Nikos;
Brown, Paul R;
Behrens, Axel;
... Mylona, Anastasia; + view all
(2022)
An intrinsic temporal order of c-JUN N-terminal phosphorylation regulates its activity by orchestrating co-factor recruitment.
Nature Communications
, 13
(1)
, Article 6133. 10.1038/s41467-022-33866-w.
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2021
Burridge, C;
Waudby, CA;
Wlodarski, T;
Cassaignau, AME;
Cabrita, LD;
Christodoulou, J;
(2021)
Nascent chain dynamics and ribosome interactions within folded ribosome-nascent chain complexes observed by NMR spectroscopy.
Chemical Science
10.1039/d1sc04313g.
(In press).
|
Cassaignau, AME;
Wlodarski, T;
Chan, SHS;
Woodburn, LF;
Bukvin, IV;
Streit, JO;
Cabrita, LD;
... Christodoulou, J; + view all
(2021)
Interactions between nascent proteins and the ribosome surface inhibit co-translational folding.
Nature Chemistry
10.1038/s41557-021-00796-x.
(In press).
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Deckert, A;
Cassaignau, AME;
Wang, X;
Włodarski, T;
Chan, SHS;
Waudby, CA;
Kirkpatrick, JP;
... Christodoulou, J; + view all
(2021)
Common sequence motifs of nascent chains engage the ribosome surface and trigger factor.
Proceedings of the National Academy of Sciences
, 118
(52)
, Article e2103015118. 10.1073/pnas.2103015118.
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Jordan, SF;
Ioannou, I;
Rammu, H;
Halpern, A;
Bogart, LK;
Ahn, M;
Vasiliadou, R;
... Lane, N; + view all
(2021)
Spontaneous assembly of redox-active iron-sulfur clusters at low concentrations of cysteine.
Nature Communications
, 12
(1)
, Article 5925. 10.1038/s41467-021-26158-2.
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Plessa, E;
Chu, LP;
Chan, SHS;
Thomas, OL;
Cassaignau, AME;
Waudby, CA;
Christodoulou, J;
(2021)
Nascent chains can form co-translational folding intermediates that promote post-translational folding outcomes in a disease-causing protein.
Nature Communications
, 12
(1)
, Article 6447. 10.1038/s41467-021-26531-1.
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Waudby, CA;
Burridge, C;
Christodoulou, J;
(2021)
Optimal design of adaptively sampled NMR experiments for measurement of methyl group dynamics with application to a ribosome-nascent chain complex.
Journal of Magnetic Resonance
, 326
, Article 106937. 10.1016/j.jmr.2021.106937.
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2020
Capitini, C;
Fani, G;
Vega, MV;
Penco, A;
Canale, C;
Cabrita, LD;
Calamai, M;
... Chiti, F; + view all
(2020)
Full-length TDP-43 and its C-terminal domain form filamentsin vitrohaving non-amyloid properties.
Amyloid
, 28
(1)
pp. 56-65.
10.1080/13506129.2020.1826425.
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Cassaignau, AME;
Cabrita, LD;
Christodoulou, J;
(2020)
How Does the Ribosome Fold the Proteome?
Annual Review of Biochemistry
, 89
pp. 389-415.
10.1146/annurev-biochem-062917-012226.
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Jagger, AM;
Waudby, CA;
Irving, JA;
Christodoulou, J;
Lomas, DA;
(2020)
High-resolution ex vivo NMR spectroscopy of human Z α1-antitrypsin.
Nature Communications
, 11
, Article 6371. 10.1038/s41467-020-20147-7.
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Waudby, CA;
Christodoulou, J;
(2020)
NMR Lineshape Analysis of Intrinsically Disordered Protein Interactions.
Intrinsically Disordered Proteins
, 2141
pp. 477-504.
10.1007/978-1-0716-0524-0_24.
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Waudby, CA;
Ouvry, M;
Davis, B;
Christodoulou, J;
(2020)
Two-dimensional NMR lineshape analysis of single, multiple, zero and double quantum correlation experiments.
Journal of Biomolecular NMR
, 74
pp. 95-109.
10.1007/s10858-019-00297-7.
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2019
Corazza, A;
Verona, G;
Waudby, CA;
Mangione, PP;
Bingham, RP;
Uings, I;
Canetti, D;
... Bellotti, V; + view all
(2019)
Binding of monovalent and bivalent ligands by transthyretin causes different short and long distance conformational changes.
Journal of Medicinal Chemistry
, 62
(17)
pp. 8274-8283.
10.1021/acs.jmedchem.9b01037.
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Tóth, G;
Neumann, T;
Berthet, A;
Masliah, E;
Spencer, B;
Tao, J;
Jobling, MF;
... McConlogue, L; + view all
(2019)
Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions.
Scientific Reports
, 9
(1)
, Article 16947. 10.1038/s41598-019-52598-4.
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Wang, X;
Kirkpatrick, JP;
Launay, HMM;
De Simone, A;
Häussinger, D;
Dobson, CM;
Vendruscolo, M;
... Christodoulou, J; + view all
(2019)
Probing the dynamic stalk region of the ribosome using solution NMR.
Scientific Reports
, 9
, Article 13528. 10.1038/s41598-019-49190-1.
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Waudby, CA;
Dobson, CM;
Christodoulou, J;
(2019)
Nature and Regulation of Protein Folding on the Ribosome.
Trends in Biochemical Sciences
, 44
(11)
pp. 914-926.
10.1016/j.tibs.2019.06.008.
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Waudby, CA;
Frenkiel, T;
Christodoulou, J;
(2019)
Cross‐peaks in simple 2D NMR experiments from chemical exchange of transverse magnetization.
Angewandte Chemie International Edition
, 58
(26)
pp. 8784-8788.
10.1002/anie.201903245.
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Waudby, CA;
Frenkiel, T;
Christodoulou, J;
(2019)
Cross‐Peaks in Simple Two‐Dimensional NMR Experiments from Chemical Exchange of Transverse Magnetisation.
Angewandte Chemie
, 131
(26)
pp. 8876-8880.
10.1002/ange.201903245.
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2018
Chu, Phuong Lien;
(2018)
Studying co-translational folding of alpha-1-antitrypsin.
Doctoral thesis (Ph.D), UCL (University College London).
|
Waudby, CA;
Wlodarski, T;
Karyadi, M-E;
Cassaignau, AME;
Chan, SHS;
Wentink, AS;
Schmidt-Engler, JM;
... Christodoulou, J; + view all
(2018)
Systematic mapping of free energy landscapes of a growing filamin domain during biosynthesis.
Proceedings of the National Academy of Sciences
, 115
(39)
pp. 9744-9749.
10.1073/pnas.1716252115.
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2017
Ahn, M;
Waudby, CA;
Bernardo-Gancedo, A;
De Genst, E;
Dhulesia, A;
Salvatella, X;
Christodoulou, J;
... Kumita, JR; + view all
(2017)
Application of Lysine-specific Labeling to Detect Transient Interactions Present During Human Lysozyme Amyloid Fibril Formation.
Scientific Reports
, 7
(1)
, Article 15018. 10.1038/s41598-017-14739-5.
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Cassaignau, AME;
(2017)
Structural investigation of the folding of an immunoglobulin domain during biosynthesis on the ribosome.
Doctoral thesis , UCL (University College London).
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Javed, A;
Christodoulou, J;
Cabrita, LD;
Orlova, EV;
(2017)
The ribosome and its role in protein folding: looking through a magnifying glass.
Acta crystallographica. Section D, Structural biology
, D73
pp. 509-521.
10.1107/S2059798317007446.
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2016
Ahn, M;
Hagan, CL;
Bernardo-Gancedo, A;
De Genst, E;
Newby, FN;
Christodoulou, J;
Dhulesia, A;
... Kumita, JR; + view all
(2016)
The Significance of the Location of Mutations for the Native-State Dynamics of Human Lysozyme.
Biophysical Journal
, 111
(11)
pp. 2358-2367.
10.1016/j.bpj.2016.10.028.
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Cabrita, LD;
Cassaignau, AM;
Launay, HM;
Waudby, CA;
Wlodarski, T;
Camilloni, C;
Karyadi, ME;
... Christodoulou, J; + view all
(2016)
A structural ensemble of a ribosome-nascent chain complex during cotranslational protein folding.
Nature Structural and Molecular Biology
, 23
(4)
pp. 278-285.
10.1038/nsmb.3182.
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Cassaignau, AM;
Launay, HM;
Karyadi, ME;
Wang, X;
Waudby, CA;
Deckert, A;
Robertson, AL;
... Cabrita, LD; + view all
(2016)
A strategy for co-translational folding studies of ribosome-bound nascent chain complexes using NMR spectroscopy.
Nature Protocols
, 11
(8)
pp. 1492-1507.
10.1038/nprot.2016.101.
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Deckert, A;
Waudby, CA;
Wlodarski, T;
Wentink, AS;
Wang, X;
Kirkpatrick, JP;
Paton, JF;
... Christodoulou, J; + view all
(2016)
Structural characterization of the interaction of α-synuclein nascent chains with the ribosomal surface and trigger factor.
Proceedings of the National Academy of Sciences of the United States of America
, 113
(18)
pp. 5012-5017.
10.1073/pnas.1519124113.
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Valleix, S;
Verona, G;
Jourde-Chiche, N;
Nédelec, B;
Mangione, PP;
Bridoux, F;
Mangé, A;
... Bellotti, V; + view all
(2016)
D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile.
Nature Communications
, 7
, Article 10353. 10.1038/ncomms10353.
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Waudby, CA;
Ramos, A;
Cabrita, LD;
Christodoulou, J;
(2016)
Two-Dimensional NMR Lineshape Analysis.
Scientific Reports
, 6
, Article 24826. 10.1038/srep24826.
|
2015
Chan, SH;
Waudby, CA;
Cassaignau, AM;
Cabrita, LD;
Christodoulou, J;
(2015)
Increasing the sensitivity of NMR diffusion measurements by paramagnetic longitudinal relaxation enhancement, with application to ribosome-nascent chain complexes.
Journal of Biomolecular NMR
, 63
pp. 151-163.
10.1007/s10858-015-9968-x.
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Nyon, MP;
Prentice, T;
Day, J;
Kirkpatrick, J;
Sivalingam, GN;
Levy, G;
Haq, I;
... Thalassinos, K; + view all
(2015)
An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1 -antitrypsin upon ligand binding.
Protein Science
, 24
(8)
pp. 1301-1312.
10.1002/pro.2706.
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Porcari, R;
Proukakis, C;
Waudby, CA;
Bolognesi, B;
Mangione, PP;
Paton, JF;
Mullin, S;
... Bellotti, V; + view all
(2015)
The H50Q mutation induces a 10-fold decrease in the solubility of α-synuclein.
J Biol Chem
, 290
(4)
2395 - 2404.
10.1074/jbc.M114.610527.
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Weise, A;
(2015)
Structural investigations of intrinsically disordered polypeptides: biosynthesis on the ribosome and protein misfolding disease.
Doctoral thesis , UCL (University College London).
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2013
Waudby, CA;
Camilloni, C;
Fitzpatrick, AW;
Cabrita, LD;
Dobson, CM;
Vendruscolo, M;
Christodoulou, J;
(2013)
In-Cell NMR Characterization of the Secondary Structure Populations of a Disordered Conformation of α-Synuclein within E. coli Cells.
PLoS One
, 8
(8)
, Article e72286. 10.1371/journal.pone.0072286.
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Waudby, CA;
Launay, H;
Cabrita, LD;
Christodoulou, J;
(2013)
Protein folding on the ribosome studied using NMR spectroscopy.
Prog Nucl Magn Reson Spectrosc
, 74
57 - 75.
10.1016/j.pnmrs.2013.07.003.
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2012
Nyon, MP;
Segu, L;
Cabrita, LD;
Lévy, GR;
Kirkpatrick, J;
Roussel, BD;
Patschull, AO;
... Gooptu, B; + view all
(2012)
Structural dynamics associated with intermediate formation in an archetypal conformational disease.
Structure
, 20
(3)
pp. 504-512.
10.1016/j.str.2012.01.012.
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Waudby, CA;
Christodoulou, J;
(2012)
An analysis of NMR sensitivity enhancements obtained using non-uniform weighted sampling, and the application to protein NMR.
Journal of Magnetic Resonance
, 219
pp. 46-52.
10.1016/j.jmr.2012.04.013.
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Waudby, CA;
Mantle, MD;
Cabrita, LD;
Gladden, LF;
Dobson, CM;
Christodoulou, J;
(2012)
Rapid distinction of intracellular and extracellular proteins using NMR diffusion measurements.
Journal of the American Chemical Society
, 134
(28)
pp. 11312-11315.
10.1021/ja304912c.
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2011
Waudby, CA;
Christodoulou, J;
(2011)
GPU accelerated Monte Carlo simulation of pulsed-field gradient NMR experiments.
Journal of Magnetic Resonance
, 211
(1)
67 - 73.
10.1016/j.jmr.2011.04.004.
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