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Number of items: 44.

2023

Pálmadóttir, Tinna; Waudby, Christopher A; Bernfur, Katja; Christodoulou, John; Linse, Sara; Malmendal, Anders; (2023) Morphology-Dependent Interactions between α-Synuclein Monomers and Fibrils. International Journal of Molecular Sciences , 24 (6) , Article 5191. 10.3390/ijms24065191. Green open access
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2022

Ahn, Minkoo; Włodarski, Tomasz; Mitropoulou, Alkistis; Chan, Sammy HS; Sidhu, Haneesh; Plessa, Elena; Becker, Thomas A; ... Christodoulou, John; + view all (2022) Modulating co-translational protein folding by rational design and ribosome engineering. Nature Communications , 13 , Article 4243. 10.1038/s41467-022-31906-z. Green open access
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Ahn, Minkoo; Włodarski, Tomasz; Mitropoulou, Alkistis; Chan, Sammy HS; Sidhu, Haneesh; Plessa, Elena; Becker, Thomas A; ... Christodoulou, John; + view all (2022) Author Correction: Modulating co-translational protein folding by rational design and ribosome engineering. [Corrigendum]. Nature Communications , 13 (1) , Article 5441. 10.1038/s41467-022-33270-4. Green open access
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Chan, Sammy HS; Włodarski, Tomasz; Streit, Julian O; Cassaignau, Anaïs ME; Woodburn, Lauren F; Ahn, Minkoo; Freiherr von Sass, Georg Johannes; ... Christodoulou, John; + view all (2022) The ribosome stabilizes partially folded intermediates of a nascent multi-domain protein. Nature Chemistry 10.1038/s41557-022-01004-0. Green open access
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Waudby, CA; Burridge, C; Cabrita, LD; Christodoulou, J; (2022) Thermodynamics of co-translational folding and ribosome–nascent chain interactions. Current Opinion in Structural Biology , 74 , Article 102357. 10.1016/j.sbi.2022.102357. Green open access
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Waudby, Christopher A; Alvarez-Teijeiro, Saul; Josue Ruiz, E; Suppinger, Simon; Pinotsis, Nikos; Brown, Paul R; Behrens, Axel; ... Mylona, Anastasia; + view all (2022) An intrinsic temporal order of c-JUN N-terminal phosphorylation regulates its activity by orchestrating co-factor recruitment. Nature Communications , 13 (1) , Article 6133. 10.1038/s41467-022-33866-w. Green open access
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2021

Burridge, C; Waudby, CA; Wlodarski, T; Cassaignau, AME; Cabrita, LD; Christodoulou, J; (2021) Nascent chain dynamics and ribosome interactions within folded ribosome-nascent chain complexes observed by NMR spectroscopy. Chemical Science 10.1039/d1sc04313g. (In press). Green open access
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Cassaignau, AME; Wlodarski, T; Chan, SHS; Woodburn, LF; Bukvin, IV; Streit, JO; Cabrita, LD; ... Christodoulou, J; + view all (2021) Interactions between nascent proteins and the ribosome surface inhibit co-translational folding. Nature Chemistry 10.1038/s41557-021-00796-x. (In press). Green open access
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Deckert, A; Cassaignau, AME; Wang, X; Włodarski, T; Chan, SHS; Waudby, CA; Kirkpatrick, JP; ... Christodoulou, J; + view all (2021) Common sequence motifs of nascent chains engage the ribosome surface and trigger factor. Proceedings of the National Academy of Sciences , 118 (52) , Article e2103015118. 10.1073/pnas.2103015118. Green open access
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Jordan, SF; Ioannou, I; Rammu, H; Halpern, A; Bogart, LK; Ahn, M; Vasiliadou, R; ... Lane, N; + view all (2021) Spontaneous assembly of redox-active iron-sulfur clusters at low concentrations of cysteine. Nature Communications , 12 (1) , Article 5925. 10.1038/s41467-021-26158-2. Green open access
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Plessa, E; Chu, LP; Chan, SHS; Thomas, OL; Cassaignau, AME; Waudby, CA; Christodoulou, J; (2021) Nascent chains can form co-translational folding intermediates that promote post-translational folding outcomes in a disease-causing protein. Nature Communications , 12 (1) , Article 6447. 10.1038/s41467-021-26531-1. Green open access
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Waudby, CA; Burridge, C; Christodoulou, J; (2021) Optimal design of adaptively sampled NMR experiments for measurement of methyl group dynamics with application to a ribosome-nascent chain complex. Journal of Magnetic Resonance , 326 , Article 106937. 10.1016/j.jmr.2021.106937. Green open access
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2020

Capitini, C; Fani, G; Vega, MV; Penco, A; Canale, C; Cabrita, LD; Calamai, M; ... Chiti, F; + view all (2020) Full-length TDP-43 and its C-terminal domain form filamentsin vitrohaving non-amyloid properties. Amyloid , 28 (1) pp. 56-65. 10.1080/13506129.2020.1826425. Green open access
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Cassaignau, AME; Cabrita, LD; Christodoulou, J; (2020) How Does the Ribosome Fold the Proteome? Annual Review of Biochemistry , 89 pp. 389-415. 10.1146/annurev-biochem-062917-012226.

Jagger, AM; Waudby, CA; Irving, JA; Christodoulou, J; Lomas, DA; (2020) High-resolution ex vivo NMR spectroscopy of human Z α1-antitrypsin. Nature Communications , 11 , Article 6371. 10.1038/s41467-020-20147-7. Green open access
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Waudby, CA; Christodoulou, J; (2020) NMR Lineshape Analysis of Intrinsically Disordered Protein Interactions. Intrinsically Disordered Proteins , 2141 pp. 477-504. 10.1007/978-1-0716-0524-0_24. Green open access
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Waudby, CA; Ouvry, M; Davis, B; Christodoulou, J; (2020) Two-dimensional NMR lineshape analysis of single, multiple, zero and double quantum correlation experiments. Journal of Biomolecular NMR , 74 pp. 95-109. 10.1007/s10858-019-00297-7. Green open access
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2019

Corazza, A; Verona, G; Waudby, CA; Mangione, PP; Bingham, RP; Uings, I; Canetti, D; ... Bellotti, V; + view all (2019) Binding of monovalent and bivalent ligands by transthyretin causes different short and long distance conformational changes. Journal of Medicinal Chemistry , 62 (17) pp. 8274-8283. 10.1021/acs.jmedchem.9b01037. Green open access
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Tóth, G; Neumann, T; Berthet, A; Masliah, E; Spencer, B; Tao, J; Jobling, MF; ... McConlogue, L; + view all (2019) Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions. Scientific Reports , 9 (1) , Article 16947. 10.1038/s41598-019-52598-4. Green open access
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Wang, X; Kirkpatrick, JP; Launay, HMM; De Simone, A; Häussinger, D; Dobson, CM; Vendruscolo, M; ... Christodoulou, J; + view all (2019) Probing the dynamic stalk region of the ribosome using solution NMR. Scientific Reports , 9 , Article 13528. 10.1038/s41598-019-49190-1. Green open access
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Waudby, CA; Dobson, CM; Christodoulou, J; (2019) Nature and Regulation of Protein Folding on the Ribosome. Trends in Biochemical Sciences , 44 (11) pp. 914-926. 10.1016/j.tibs.2019.06.008. Green open access
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Waudby, CA; Frenkiel, T; Christodoulou, J; (2019) Cross‐peaks in simple 2D NMR experiments from chemical exchange of transverse magnetization. Angewandte Chemie International Edition , 58 (26) pp. 8784-8788. 10.1002/anie.201903245. Green open access
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Waudby, CA; Frenkiel, T; Christodoulou, J; (2019) Cross‐Peaks in Simple Two‐Dimensional NMR Experiments from Chemical Exchange of Transverse Magnetisation. Angewandte Chemie , 131 (26) pp. 8876-8880. 10.1002/ange.201903245. Green open access
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2018

Chu, Phuong Lien; (2018) Studying co-translational folding of alpha-1-antitrypsin. Doctoral thesis (Ph.D), UCL (University College London). Green open access
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Waudby, CA; Wlodarski, T; Karyadi, M-E; Cassaignau, AME; Chan, SHS; Wentink, AS; Schmidt-Engler, JM; ... Christodoulou, J; + view all (2018) Systematic mapping of free energy landscapes of a growing filamin domain during biosynthesis. Proceedings of the National Academy of Sciences , 115 (39) pp. 9744-9749. 10.1073/pnas.1716252115. Green open access
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2017

Ahn, M; Waudby, CA; Bernardo-Gancedo, A; De Genst, E; Dhulesia, A; Salvatella, X; Christodoulou, J; ... Kumita, JR; + view all (2017) Application of Lysine-specific Labeling to Detect Transient Interactions Present During Human Lysozyme Amyloid Fibril Formation. Scientific Reports , 7 (1) , Article 15018. 10.1038/s41598-017-14739-5. Green open access
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Cassaignau, AME; (2017) Structural investigation of the folding of an immunoglobulin domain during biosynthesis on the ribosome. Doctoral thesis , UCL (University College London). Green open access
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Javed, A; Christodoulou, J; Cabrita, LD; Orlova, EV; (2017) The ribosome and its role in protein folding: looking through a magnifying glass. Acta crystallographica. Section D, Structural biology , D73 pp. 509-521. 10.1107/S2059798317007446. Green open access
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2016

Ahn, M; Hagan, CL; Bernardo-Gancedo, A; De Genst, E; Newby, FN; Christodoulou, J; Dhulesia, A; ... Kumita, JR; + view all (2016) The Significance of the Location of Mutations for the Native-State Dynamics of Human Lysozyme. Biophysical Journal , 111 (11) pp. 2358-2367. 10.1016/j.bpj.2016.10.028. Green open access
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Cabrita, LD; Cassaignau, AM; Launay, HM; Waudby, CA; Wlodarski, T; Camilloni, C; Karyadi, ME; ... Christodoulou, J; + view all (2016) A structural ensemble of a ribosome-nascent chain complex during cotranslational protein folding. Nature Structural and Molecular Biology , 23 (4) pp. 278-285. 10.1038/nsmb.3182. Green open access
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Cassaignau, AM; Launay, HM; Karyadi, ME; Wang, X; Waudby, CA; Deckert, A; Robertson, AL; ... Cabrita, LD; + view all (2016) A strategy for co-translational folding studies of ribosome-bound nascent chain complexes using NMR spectroscopy. Nature Protocols , 11 (8) pp. 1492-1507. 10.1038/nprot.2016.101. Green open access
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Deckert, A; Waudby, CA; Wlodarski, T; Wentink, AS; Wang, X; Kirkpatrick, JP; Paton, JF; ... Christodoulou, J; + view all (2016) Structural characterization of the interaction of α-synuclein nascent chains with the ribosomal surface and trigger factor. Proceedings of the National Academy of Sciences of the United States of America , 113 (18) pp. 5012-5017. 10.1073/pnas.1519124113. Green open access
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Valleix, S; Verona, G; Jourde-Chiche, N; Nédelec, B; Mangione, PP; Bridoux, F; Mangé, A; ... Bellotti, V; + view all (2016) D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile. Nature Communications , 7 , Article 10353. 10.1038/ncomms10353. Green open access
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Waudby, CA; Ramos, A; Cabrita, LD; Christodoulou, J; (2016) Two-Dimensional NMR Lineshape Analysis. Scientific Reports , 6 , Article 24826. 10.1038/srep24826. Green open access
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2015

Chan, SH; Waudby, CA; Cassaignau, AM; Cabrita, LD; Christodoulou, J; (2015) Increasing the sensitivity of NMR diffusion measurements by paramagnetic longitudinal relaxation enhancement, with application to ribosome-nascent chain complexes. Journal of Biomolecular NMR , 63 pp. 151-163. 10.1007/s10858-015-9968-x. Green open access
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Nyon, MP; Prentice, T; Day, J; Kirkpatrick, J; Sivalingam, GN; Levy, G; Haq, I; ... Thalassinos, K; + view all (2015) An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1 -antitrypsin upon ligand binding. Protein Science , 24 (8) pp. 1301-1312. 10.1002/pro.2706. Green open access
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Porcari, R; Proukakis, C; Waudby, CA; Bolognesi, B; Mangione, PP; Paton, JF; Mullin, S; ... Bellotti, V; + view all (2015) The H50Q mutation induces a 10-fold decrease in the solubility of α-synuclein. J Biol Chem , 290 (4) 2395 - 2404. 10.1074/jbc.M114.610527. Green open access
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Weise, A; (2015) Structural investigations of intrinsically disordered polypeptides: biosynthesis on the ribosome and protein misfolding disease. Doctoral thesis , UCL (University College London). Green open access
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2013

Waudby, CA; Camilloni, C; Fitzpatrick, AW; Cabrita, LD; Dobson, CM; Vendruscolo, M; Christodoulou, J; (2013) In-Cell NMR Characterization of the Secondary Structure Populations of a Disordered Conformation of α-Synuclein within E. coli Cells. PLoS One , 8 (8) , Article e72286. 10.1371/journal.pone.0072286. Green open access
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Waudby, CA; Launay, H; Cabrita, LD; Christodoulou, J; (2013) Protein folding on the ribosome studied using NMR spectroscopy. Prog Nucl Magn Reson Spectrosc , 74 57 - 75. 10.1016/j.pnmrs.2013.07.003. Green open access
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2012

Nyon, MP; Segu, L; Cabrita, LD; Lévy, GR; Kirkpatrick, J; Roussel, BD; Patschull, AO; ... Gooptu, B; + view all (2012) Structural dynamics associated with intermediate formation in an archetypal conformational disease. Structure , 20 (3) pp. 504-512. 10.1016/j.str.2012.01.012. Green open access
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Waudby, CA; Christodoulou, J; (2012) An analysis of NMR sensitivity enhancements obtained using non-uniform weighted sampling, and the application to protein NMR. Journal of Magnetic Resonance , 219 pp. 46-52. 10.1016/j.jmr.2012.04.013. Green open access
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Waudby, CA; Mantle, MD; Cabrita, LD; Gladden, LF; Dobson, CM; Christodoulou, J; (2012) Rapid distinction of intracellular and extracellular proteins using NMR diffusion measurements. Journal of the American Chemical Society , 134 (28) pp. 11312-11315. 10.1021/ja304912c. Green open access
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2011

Waudby, CA; Christodoulou, J; (2011) GPU accelerated Monte Carlo simulation of pulsed-field gradient NMR experiments. Journal of Magnetic Resonance , 211 (1) 67 - 73. 10.1016/j.jmr.2011.04.004.

This list was generated on Sun Mar 24 09:05:17 2024 GMT.