Browse by UCL people
Group by: Type | Date
Number of items: 127.
2024
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Potapova, Elena V;
Zherebtsov, Evgenii A;
Shupletsov, Valery V;
Dremin, Viktor V;
Kandurova, Ksenia Y;
Mamoshin, Andrian V;
Abramov, Andrey Y;
(2024)
Detection of NADH and NADPH levels in vivo identifies shift of glucose metabolism in cancer to energy production.
The FEBS Journal
10.1111/febs.17067.
(In press).
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Seryogina, Evgenia S;
Kamynina, Anna V;
Koroev, Dmitry O;
Volpina, Olga M;
Vinokurov, Andrey Y;
Abramov, Andrey Y;
(2024)
RAGE induces physiological activation of NADPH oxidase in neurons and astrocytes and neuroprotection.
The FEBS Journal
10.1111/febs.17086.
(In press).
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Vinokurov, Andrey Y;
Palalov, Alexander A;
Kritskaya, Kristina A;
Demyanenko, Svetlana V;
Garbuz, David G;
Evgen'ev, Michael B;
Esteras, Noemi;
(2024)
Cell-Permeable HSP70 Protects Neurons and Astrocytes Against Cell Death in the Rotenone-Induced and Familial Models of Parkinson’s Disease.
Molecular Neurobiology
10.1007/s12035-024-04077-9.
(In press).
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2023
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Bryanskaya, Ekaterina O;
Vinokurov, Andrey Y;
Dolgikh, Angelina I;
Dunaev, Andrey V;
Angelova, Plamena R;
Abramov, Andrey Y;
(2023)
High levels of FAD autofluorescence indicate pathology preceding cell death.
Biochimica et Biophysica Acta (BBA) - General Subjects
, Article 130520. 10.1016/j.bbagen.2023.130520.
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Dayalan Naidu, Sharadha;
Angelova, Plamena R;
Knatko, Elena V;
Leonardi, Chiara;
Novak, Miroslav;
De la Vega, Laureano;
Ganley, Ian G;
... Dinkova-Kostova, Albena T; + view all
(2023)
Nrf2 depletion in the context of loss-of-function Keap1 leads to mitolysosome accumulation.
Free Radical Biology and Medicine
, 208
pp. 478-493.
10.1016/j.freeradbiomed.2023.09.009.
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Esteras, Noemí;
Blacker, Thomas S;
Zherebtsov, Evgeny A;
Stelmashuk, Olga A;
Zhang, Ying;
Wigley, W Christian;
Duchen, Michael R;
... Abramov, Andrey Y; + view all
(2023)
Nrf2 regulates glucose uptake and metabolism in neurons and astrocytes.
Redox Biology
, 62
, Article 102672. 10.1016/j.redox.2023.102672.
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Vinokurov, AY;
Soldatov, VO;
Seregina, ES;
Dolgikh, AI;
Tagunov, PA;
Dunaev, AV;
Skorkina, MY;
... Abramov, AY; + view all
(2023)
HPRT1 Deficiency Induces Alteration of Mitochondrial Energy Metabolism in the Brain.
Molecular Neurobiology
10.1007/s12035-023-03266-2.
(In press).
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2022
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Angelova, Plamena R;
Kerbert, Annarein JC;
Habtesion, Abeba;
Hall, Andrew;
Abramov, Andrey Y;
Jalan, Rajiv;
(2022)
Hyperammonemia induces mitochondrial dysfunction and neuronal cell death.
JHEP Reports
, 4
(8)
, Article 100510. 10.1016/j.jhepr.2022.100510.
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Baev, Artyom Y;
Abramov, Andrey Y;
(2022)
Inorganic Polyphosphate and F0F1-ATP Synthase of Mammalian Mitochondria.
Progress in Molecular and Subcellular Biology
, 61
10.1007/978-3-031-01237-2_1.
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Baev, Artyom Y;
Vinokurov, Andrey Y;
Novikova, Irina N;
Dremin, Viktor V;
Potapova, Elena V;
Abramov, Andrey Y;
(2022)
Interaction of Mitochondrial Calcium and ROS in Neurodegeneration.
Cells
, 11
(4)
, Article 706. 10.3390/cells11040706.
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Choi, Minee L;
Chappard, Alexandre;
Singh, Bhanu P;
Maclachlan, Catherine;
Rodrigues, Margarida;
Fedotova, Evgeniya I;
Berezhnov, Alexey V;
... Gandhi, Sonia; + view all
(2022)
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity.
Nature Neuroscience
10.1038/s41593-022-01140-3.
(In press).
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Esteras, Noemí;
Abramov, Andrey Y;
(2022)
Nrf2 as a regulator of mitochondrial function: Energy metabolism and beyond.
Free Radical Biology and Medicine
, 189
pp. 136-153.
10.1016/j.freeradbiomed.2022.07.013.
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Fedotova, E;
Abramov, AY;
Berezhnov, A;
(2022)
Dopamine Protects Neurons against Glutamate-Induced Excitotoxicity.
Biologičeskie Membrany
, 39
(5)
pp. 446-456.
10.31857/S0233475522060056.
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Fedotova, E;
Dolgacheva, LP;
Abramov, AY;
Berezhnov, A;
(2022)
Lactate and Pyruvate Activate Autophagy and Mitophagy that Protect Cells in Toxic Model of Parkinson's Disease.
Molecular Neurobiology
, 59
pp. 177-190.
10.1007/s12035-021-02583-8.
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Novikova, Irina N;
Potapova, Elena V;
Dremin, Viktor V;
Dunaev, Andrey V;
Abramov, Andrey Y;
(2022)
Laser-induced singlet oxygen selectively triggers oscillatory mitochondrial permeability transition and apoptosis in melanoma cell lines.
Life Sciences
, 304
, Article 120720. 10.1016/j.lfs.2022.120720.
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Ryan, Dylan G;
Knatko, Elena;
Casey, Alva M;
Hukelmann, Jens L;
Naidu, Sharadha Dayalan;
Brenes, Alejandro J;
Ekkunagul, Thanapon;
... Dinkova-Kostova, Albena T; + view all
(2022)
Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the I interferon.
iScience
, 25
(2)
, Article 103827. 10.1016/j.isci.2022.103827.
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Shevtsova, Elena F;
Angelova, Plamena R;
Stelmashchuk, Olga A;
Esteras, Noemi;
Vasil'eva, Nataliia A;
Maltsev, Andrey V;
Shevtsov, Pavel N;
... Abramov, Andrey Y; + view all
(2022)
Pharmacological sequestration of mitochondrial calcium uptake protects against dementia and β-amyloid neurotoxicity.
Scientific Reports
, 12
, Article 12766. 10.1038/s41598-022-16817-9.
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Zherebtsov, Evgenii A;
Potapova, Elena;
Mamoshin, Andrian;
Shupletsov, Valery V;
Kandurova, Ksenia Y;
Dremin, Viktor V;
Abramov, Andrey Y;
(2022)
Fluorescence lifetime needle optical biopsy discriminates hepatocellular carcinoma.
Biomedical Optics Express
, 13
(2)
pp. 633-646.
10.1364/BOE.447687.
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2021
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Al-Menhali, AS;
Anderson, C;
Gourine, A;
Abramov, AY;
D'Souza, A;
Jaganjac, M;
(2021)
Proteomic Analysis of Cardiac Adaptation to Exercise by High Resolution Mass Spectrometry.
Frontiers in Molecular Biosciences
, 8
, Article 723858. 10.3389/fmolb.2021.723858.
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Barilani, M;
Lovejoy, C;
Piras, R;
Abramov, AY;
Lazzari, L;
Angelova, PR;
(2021)
Age-related changes in the energy of human mesenchymal stem cells.
Journal of Cellular Physiology
10.1002/jcp.30638.
(In press).
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Berezhnov, AV;
Fedotova, EI;
Sergeev, AI;
Teplov, IY;
Abramov, AY;
(2021)
Dopamine controls neuronal spontaneous calcium oscillations via astrocytic signal.
Cell Calcium
, 94
, Article 102359. 10.1016/j.ceca.2021.102359.
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Chen, X;
Vinokurov, AY;
Zherebtsov, EA;
Stelmashchuk, OA;
Angelova, PR;
Esteras, N;
Abramov, AY;
(2021)
Variability of mitochondrial energy balance across brain regions.
Journal of Neurochemistry
, 157
(4)
pp. 1234-1243.
10.1111/jnc.15239.
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Demyanenko, SV;
Pitinova, MA;
Dzreyan, VA;
Kalyuzhnaya, YN;
Eid, MA;
Abramov, AY;
Evgen’ev, MB;
(2021)
The Role of p53 Protein in the Realization of the Exogenous Heat Shock Protein 70 Anti-Apoptotic Effect during Axotomy.
Cells
, 11
(1)
, Article 93. 10.3390/cells11010093.
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Esteras, N;
Kopach, O;
Maiolino, M;
Lariccia, V;
Amoroso, S;
Qamar, S;
Wray, S;
... Abramov, AY; + view all
(2021)
Mitochondrial ROS control neuronal excitability and cell fate in frontotemporal dementia.
Alzheimer's Dementia
10.1002/alz.12394.
(In press).
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Kamynina, A;
Esteras, N;
Koroev, DO;
Angelova, PR;
Volpina, OM;
Abramov, AY;
(2021)
Activation of RAGE leads to the release of glutamate from astrocytes and stimulates calcium signal in neurons.
Journal of Cellular Physiology
10.1002/jcp.30324.
(In press).
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Kara, E;
Crimi, A;
Wiedmer, A;
Emmenegger, M;
Manzoni, C;
Bandres-Ciga, S;
D'Sa, K;
... Aguzzi, A; + view all
(2021)
An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein.
Cell Reports
, 35
(10)
, Article 109189. 10.1016/j.celrep.2021.109189.
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Komilova, NR;
Angelova, PR;
Berezhnov, A;
Stelmashchuk, OA;
Mirkhodjaev, UZ;
Houlden, H;
Gourine, A;
... Abramov, AY; + view all
(2021)
Metabolically induced intracellular pH changes activate mitophagy, autophagy, and cell protection in familial forms of Parkinson's disease.
The FEBS Journal
10.1111/febs.16198.
(In press).
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Kopach, O;
Esteras, N;
Wray, S;
Abramov, AY;
Rusakov, DA;
(2021)
Genetically engineered MAPT 10+16 mutation causes pathophysiological excitability of human iPSC-derived neurons related to 4R tau-induced dementia.
Cell Death & Disease
, 12
(8)
, Article 716. 10.1038/s41419-021-04007-w.
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Sokolovski, SG;
Rafailov, EU;
Abramov, AY;
Angelova, PR;
(2021)
Singlet oxygen stimulates mitochondrial bioenergetics in brain cells.
Free Radical Biology and Medicine
, 163
pp. 306-313.
10.1016/j.freeradbiomed.2020.12.022.
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Sun, W-Y;
Tyurin, VA;
Mikulska-Ruminska, K;
Shrivastava, IH;
Anthonymuthu, TS;
Zhai, Y-J;
Pan, M-H;
... Kagan, VE; + view all
(2021)
Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal.
Nature Chemical Biology
, 17
pp. 465-476.
10.1038/s41589-020-00734-x.
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Vinokurov, AY;
Dremin, VV;
Piavchenko, GA;
Stelmashchuk, OA;
Angelova, PR;
Abramov, AY;
(2021)
Assessment of Mitochondrial Membrane Potential and NADH Redox State in Acute Brain Slices.
Methods in Molecular Biology
, 2276
pp. 193-202.
10.1007/978-1-0716-1266-8_14.
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Vinokurov, AY;
Stelmashuk, OA;
Ukolova, PA;
Zherebtsov, EA;
Abramov, AY;
(2021)
Brain region specificity in reactive oxygen species production and maintenance of redox balance.
Free Radical Biology and Medicine
, 174
pp. 195-201.
10.1016/j.freeradbiomed.2021.08.014.
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2020
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Abramov, AY;
Potapova, EV;
Dremin, VV;
Dunaev, AV;
(2020)
Interaction of Oxidative Stress and Misfolded Proteins in the Mechanism of Neurodegeneration.
Life
, 10
(7)
, Article 101. 10.3390/life10070101.
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Al-Menhali, AS;
Banu, S;
Angelova, PR;
Barcaru, A;
Horvatovich, P;
Abramov, AY;
Jaganjac, M;
(2020)
Lipid peroxidation is involved in calcium dependent upregulation of mitochondrial metabolism in skeletal muscle.
Biochimica et Biophysica Acta (BBA) - General Subjects
, 1864
(3)
, Article 129487. 10.1016/j.bbagen.2019.129487.
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Angelova, PR;
Dinkova-Kostova, AT;
Abramov, AY;
(2020)
Assessment of ROS Production in the Mitochondria of Live Cells.
Methods in Molecular Biology
, 2202
pp. 33-42.
10.1007/978-1-0716-0896-8_2.
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Angelova, PR;
Choil, ML;
Berezhnov, A;
Horrocks, MH;
Hughes, CD;
De, S;
Rodrigues, M;
... Gandhi, S; + view all
(2020)
Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation.
Cell Death & Differentiation
, 27
pp. 2781-2796.
10.1038/s41418-020-0542-z.
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Angelova, PR;
Esteras, N;
Abramov, AY;
(2020)
Mitochondria and lipid peroxidation in the mechanism of neurodegeneration: Finding ways for prevention.
Medicinal Research Reviews
10.1002/med.21712.
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Bartolome, F;
Krzyzanowska, A;
de la Cueva, M;
Pascual, C;
Antequera, D;
Spuch, C;
Villarejo-Galende, A;
... Carro, E; + view all
(2020)
Annexin A5 prevents amyloid-β-induced toxicity in choroid plexus: implication for Alzheimer’s disease.
Scientific Reports
, 10
, Article 9391. 10.1038/s41598-020-66177-5.
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Bayev, AY;
Angelova, PR;
Abramov, AY;
(2020)
Inorganic polyphosphate is produced and hydrolysed in F0F1-ATP synthase of mammalian mitochondria.
Biochemical Journal
, 477
(8)
pp. 1515-1524.
10.1042/BCJ20200042.
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Britti, E;
Ros, J;
Esteras, N;
Abramov, AY;
(2020)
Tau inhibits mitochondrial calcium efflux and makes neurons vulnerable to calcium-induced cell death.
Cell Calcium
, 86
, Article 102150. 10.1016/j.ceca.2019.102150.
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Esteras, N;
Abramov, AY;
(2020)
Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology.
Cells
, 9
(9)
, Article 2135. 10.3390/cells9092135.
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Esteras, N;
Kundel, F;
Amodeo, GF;
Pavlov, EV;
Klenerman, D;
Abramov, AY;
(2020)
Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage‐gated calcium channels and NADPH oxidase.
The FEBS Journal
10.1111/febs.15340.
(In press).
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Ghosh, R;
Wood-Kaczmar, A;
Dobson, L;
Smith, EJ;
Sirinathsinghji, EC;
Kriston-Vizi, J;
Hargreaves, IP;
... Tabrizi, SJ; + view all
(2020)
Expression of mutant exon 1 huntingtin fragments in human neural stem cells and neurons causes inclusion formation and mitochondrial dysfunction.
FASEB Journal
10.1096/fj.201902277RR.
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Kopach, O;
Esteras, N;
Wray, S;
Rusakov, DA;
Abramov, AY;
(2020)
Maturation and phenotype of pathophysiological neuronal excitability of human cells in tau-related dementia.
Journal of Cell Science
, 133
(10)
, Article jcs241687. 10.1242/jcs.241687.
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Makovik, IN;
Manole, A;
Zherebtsov, EA;
Stavtsev, DD;
Vukolova, MN;
Dunaev, AV;
Angelova, PR;
(2020)
Adrenaline induces calcium signal in astrocytes and vasoconstriction via activation of monoamine oxidase.
Free Radical Biology and Medicine
, 159
pp. 15-22.
10.1016/j.freeradbiomed.2020.07.011.
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2019
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Abramov, AY;
Angelova, PR;
(2019)
Cellular mechanisms of complex I-associated pathology.
Biochemical Society Transactions
, 47
(6)
pp. 1963-1969.
10.1042/BST20191042.
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Abramov, AY;
Angelova, PR;
(2019)
Mitochondrial dysfunction and energy deprivation in the mechanism of neurodegeneration.
Turkish Journal of Biochemistry
, 44
(6)
pp. 723-729.
10.1515/tjb-2019-0255.
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Al-Menhali, Afnan Saleh;
(2019)
Exercise-Induced 4-Hydroxynonenal Alters Myotube Cellular Redox Homeostasis and Mitochondrial Metabolism.
Doctoral thesis (Ph.D), UCL (University College London).
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Dolgacheva, LP;
Berezhnov, AV;
Fedotova, EI;
Zinchenko, VP;
Abramov, AY;
(2019)
Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease.
Journal of Bioenergetics and Biomembranes
10.1007/s10863-019-09798-4.
(In press).
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Kovac, S;
Preza, E;
Houlden, H;
Walker, MC;
Abramov, AY;
(2019)
Impaired Bioenergetics in Mutant Mitochondrial DNA Determines Cell Fate During Seizure-Like Activity.
Molecular Neurobiology
, 56
(1)
pp. 321-334.
10.1007/s12035-018-1078-9.
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Ludtmann, MHR;
Kostic, M;
Horne, A;
Gandhi, S;
Sekler, I;
Abramov, AY;
(2019)
LRRK2 deficiency induced mitochondrial Ca2+ efflux inhibition can be rescued by Na+/Ca2+/Li+ exchanger upregulation.
Cell Death & Disease
, 10
(4)
, Article 265. 10.1038/s41419-019-1469-5.
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Maiolino, M;
O'Neill, N;
Lariccia, V;
Amoroso, S;
Sylantyev, S;
Angelova, PR;
Abramov, AY;
(2019)
Inorganic Polyphosphate Regulates AMPA and NMDA
Receptors and Protects Against Glutamate Excitotoxicity via
Activation of P2Y Receptors.
The Journal of Neuroscience
, 39
(31)
pp. 6038-6048.
10.1523/JNEUROSCI.0314-19.2019.
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Shekh-Ahmad, T;
Kovac, S;
Abramov, AY;
Walker, MC;
(2019)
Reactive oxygen species in status epilepticus.
Epilepsy & Behavior
, 101
(B)
, Article 106410. 10.1016/j.yebeh.2019.07.011.
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Shekh-Ahmad, T;
Lieb, A;
Kovac, S;
Gola, L;
Wigley, WC;
Abramov, AY;
Walker, MC;
(2019)
Combination antioxidant therapy prevents epileptogenesis and modifies chronic epilepsy.
Redox Biology
, 26
, Article 101278. 10.1016/j.redox.2019.101278.
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2018
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Abramov, AY;
(2018)
Different Faces of Neurodegeneration.
[Editorial comment].
FEBS Journal
, 285
(19)
pp. 3544-3546.
10.1111/febs.14646.
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Angelova, PR;
Abramov, AY;
(2018)
Role of mitochondrial ROS in the brain: from physiology to neurodegeneration.
FEBS Letters
, 592
(5)
pp. 692-702.
10.1002/1873-3468.12964.
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Angelova, PR;
Barilani, M;
Lovejoy, C;
Dossena, M;
Viganò, M;
Seresini, A;
Piga, D;
... Lazzari, L; + view all
(2018)
Mitochondrial dysfunction in Parkinsonian mesenchymal stem cells impairs differentiation.
Redox Biology
, 14
pp. 474-484.
10.1016/j.redox.2017.10.016.
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Angelova, PR;
Iversen, KZ;
Teschemacher, AG;
Kasparov, S;
Gourine, AV;
Abramov, AY;
(2018)
Signal transduction in astrocytes: Localization and release of inorganic polyphosphate.
GLIA
, 66
(10)
pp. 2126-2136.
10.1002/glia.23466.
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Angelova, PR;
Vinogradova, D;
Neganova, ME;
Serkova, TP;
Sokolov, VV;
Bachurin, SO;
Shevtsova, EF;
(2018)
Pharmacological Sequestration of Mitochondrial Calcium Uptake Protects Neurons Against Glutamate Excitotoxicity.
Molecular Neurobiology
, 56
(3)
pp. 2244-2255.
10.1007/s12035-018-1204-8.
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Berezhnaya, E;
Neginskaya, M;
Uzdensky, AB;
Abramov, AY;
(2018)
Photo-Induced Oxidative Stress Impairs Mitochondrial Metabolism in Neurons and Astrocytes.
Molecular Neurobiology
, 55
(1)
pp. 90-95.
10.1007/s12035-017-0720-2.
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Dolgacheva, LP;
Fedotova, EI;
Abramov, AY;
Berezhnov, AV;
(2018)
Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson Disease.
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology
, 34
(5)
pp. 4-14.
10.1134/S1990747818010038.
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Kaczara, P;
Proniewski, B;
Lovejoy, C;
Kuś, K;
Motterlini, R;
Abramov, AY;
Chlopicki, S;
(2018)
CORM-401 induces calcium signalling, NO increase and activation of pentose phosphate pathway in endothelial cells.
The FEBS Journal
, 285
(7)
pp. 1346-1358.
10.1111/febs.14411.
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Kamynina, AV;
Esteras, N;
Koroev, DO;
Bobkova, NV;
Balasanyants, SM;
Simonyan, RA;
Avetisyan, AV;
... Volpina, OM; + view all
(2018)
Synthetic Fragments of Receptor for Advanced Glycation End Products Bind Beta-Amyloid 1-40 and Protect Primary Brain Cells From Beta-Amyloid Toxicity.
Frontiers in Neuroscience
, 12
, Article 681. 10.3389/fnins.2018.00681.
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Kundel, F;
Hong, L;
Falcon, B;
McEwan, WA;
Michaels, TCT;
Meisl, G;
Esteras, N;
... Klenerman, D; + view all
(2018)
Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading.
ACS Chemical Neuroscience
10.1021/acschemneuro.8b00094.
(In press).
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Little, D;
Luft, C;
Mosaku, O;
Lorvellec, M;
Yao, Z;
Paillusson, S;
Kriston-Vizi, J;
... Gissen, P; + view all
(2018)
A single cell high content assay detects mitochondrial dysfunction in iPSC-derived neurons with mutations in SNCA.
Scientific Reports
, 8
, Article 9033. 10.1038/s41598-018-27058-0.
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Liu, Z;
Solesio, ME;
Schaffler, MB;
Frikha-Benayed, D;
Rosen, CJ;
Werner, H;
Kopchick, JJ;
... Yakar, S; + view all
(2018)
Mitochondrial Function Is Compromised in Cortical Bone Osteocytes of Long-Lived Growth Hormone Receptor Null Mice.
Journal of Bone and Mineral Research
10.1002/jbmr.3573.
(In press).
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Ludtmann, MHR;
Abramov, AY;
(2018)
Mitochondrial calcium imbalance in Parkinson's disease.
Neuroscience Letters
, 663
pp. 86-90.
10.1016/j.neulet.2017.08.044.
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Ludtmann, MHR;
Angelova, PR;
Horrocks, MH;
Choi, ML;
Rodrigues, M;
Baev, AY;
Berezhnov, AV;
... Gandhi, S; + view all
(2018)
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease.
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