UCL Discovery

A

Abe, Y; Gor, J; Bracewell, DG; Perkins, SJ; Dalby, PA; (2010) Masking of the Fc region in human IgG4 by constrained X-ray scattering modelling: implications for antibody function and therapy. BIOCHEM J , 432 101 - 111. 10.1042/BJ20100641.

Abhinandan, KR; Martin, ACR; (2010) Analysis and prediction of V-H/V-L packing in antibodies. PROTEIN ENG DES SEL , 23 (9) 689 - 697. 10.1093/protein/gzq043.

Arkov, AL; Ramos, A; (2010) Building RNA-protein granules: insight from the germline. Trends Cell Biol , 20 (8) pp. 482-490. 10.1016/j.tcb.2010.05.004.

Arnvig, KB; Young, DB; (2010) Regulation of pathogen metabolism by small RNA. Drug Discovery Today: Disease Mechanisms , 7 (1) 10.1016/j.ddmec.2010.09.001.

Attwater, J; Wochner, A; Pinheiro, VB; Coulson, A; Holliger, P; (2010) Ice as a protocellular medium for RNA replication. Nat Commun , 1 76-. 10.1038/ncomms1076.

Auer, R; Hansen, DF; Neudecker, P; Korzhnev, DM; Muhandiram, DR; Konrat, R; Kay, LE; (2010) Measurement of signs of chemical shift differences between ground and excited protein states: a comparison between H(S/M)QC and R1ρ methods. Journal of Biomolecular NMR , 46 (3) pp. 205-216. 10.1007/s10858-009-9394-z.

B

Baldwin, AJ; Religa, TL; Hansen, DF; Bouvignies, G; Kay, LE; (2010) 13CHD2 methyl group probes of millisecond time scale exchange in proteins by 1H relaxation dispersion: an application to proteasome gating residue dynamics. J Am Chem Soc , 132 (32) pp. 10992-10995. 10.1021/ja104578n.

Balenci, D; D'Amelio, N; Gaggelli, E; Gaggelli, N; Cellai, L; Molteni, E; Valensin, G; (2010) Structural features of apramycin bound at the bacterial ribosome a site as detected by NMR and CD spectroscopy. Chembiochem , 11 (2) pp. 166-169. 10.1002/cbic.200900629.

Balesaria, S; Bayele, H; Srai, K; (2010) Divalent Metal-Dependent Regulation of Hepcidin Expression by MTF-1. FASEB JOURNAL , 24

Balesaria, S; Ramesh, B; McArdle, H; Bayele, HK; Srai, SKS; (2010) Divalent metal-dependent regulation of hepcidin expression by MTF-1. FEBS LETT , 584 (4) 719 - 725. 10.1016/j.febslet.2009.12.023.

Baresic, A; Hopcroft, LEM; Rogers, HH; Hurst, JM; Martin, ACR; (2010) Compensated Pathogenic Deviations: Analysis of Structural Effects. J MOL BIOL , 396 (1) 19 - 30. 10.1016/j.jmb.2009.11.002.

Baron, M; Lakowski, J; Bainbridge, J; Barber, A; Pearson, R; Ali, R; Sowden, J; (2010) Retinal repair by photoreceptor precursor transplantation. In: GENETICS RESEARCH. (pp. 78 - 78). CAMBRIDGE UNIV PRESS

Basavannacharya, C; Moody, PR; Munshi, T; Cronin, N; Keep, NH; Bhakta, S; (2010) Essential residues for the enzyme activity of ATP-dependent MurE ligase from Mycobacterium tuberculosis. Protein Cell , 1 (11) pp. 1011-1022. 10.1007/s13238-010-0132-9.

Basavannacharya, C; Robertson, G; Munshi, T; Keep, NH; Bhakta, S; (2010) ATP-dependent MurE ligase in Mycobacterium tuberculosis: Biochemical and structural characterisation. TUBERCULOSIS , 90 (1) 16 - 24. 10.1016/j.tube.2009.10.007.

Bayele, HK; Chiti, A; Colina, R; Fernandes, O; Khan, B; Krishnamoorthy, R; Ozdag, H; Bayele, HK; Chiti, A; Colina, R; Fernandes, O; Khan, B; Krishnamoorthy, R; Ozdag, H; Padua, RA; - view fewer (2010) Isotopic biomarker discovery and application in translational medicine. DRUG DISCOVERY TODAY , 15 (3-4) pp. 127-136. 10.1016/j.drudis.2009.12.005.

Bayele, HK; Murdock, PJ; Pasi, KJ; (2010) Residual Factor VIII-like cofactor activity of thioredoxin and related oxidoreductases. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS , 1800 (3) pp. 398-404. 10.1016/j.bbagen.2009.12.006.

Bernardes Pinheiro, VB; Holliger, P; (2010) Compartmentalized self tagging. US2010/0184071 A1.

Binolfi, A; Rodriguez, EE; Valensin, D; D'Amelio, N; Ippoliti, E; Obal, G; Duran, R; ... Fernández, CO; + view all Binolfi, A; Rodriguez, EE; Valensin, D; D'Amelio, N; Ippoliti, E; Obal, G; Duran, R; Magistrato, A; Pritsch, O; Zweckstetter, M; Valensin, G; Carloni, P; Quintanar, L; Griesinger, C; Fernández, CO; - view fewer (2010) Bioinorganic chemistry of Parkinson's disease: structural determinants for the copper-mediated amyloid formation of alpha-synuclein. Inorg Chem , 49 (22) pp. 10668-10679. 10.1021/ic1016752.

Blassberg, R.A.; (2010) The mechanism of signal transduction by the GPI anchored Prod 1 protein. Doctoral thesis, UCL (University College London).

Boucrot, E; Saffarian, S; Zhang, R; Kirchhausen, T; (2010) Roles of AP-2 in clathrin-mediated endocytosis. PLOS One , 5 (5) , Article e10597. 10.1371/journal.pone.0010597.

Bouvignies, G; Korzhnev, DM; Neudecker, P; Hansen, DF; Cordes, MHJ; Kay, LE; (2010) A simple method for measuring signs of (1)H (N) chemical shift differences between ground and excited protein states. J Biomol NMR , 47 (2) pp. 135-141. 10.1007/s10858-010-9418-8.

Breus, O; Panasyuk, G; Gout, IT; Filonenko, V; Nemazanyy, I; (2010) CoA Synthase is phosphorylated on tyrosines in mammalian cells, interacts with and is dephosphorylated by Shp2PTP. MOL CELL BIOCHEM , 335 (1-2) 195 - 202. 10.1007/s11010-009-0255-6.

Brockes, JP; (2010) Evolution of mechanisms underlying limb regeneration in salamanders. In: (Proceedings) Annual Meeting of the Society-for-Integrative-and-Comparative-Biology. (pp. E18-E18). OXFORD UNIV PRESS INC

Brodsky, FM; Marsh, M; (2010) Life History of the Journal TRAFFIC, Celebrating Ten Years of Publication. TRAFFIC , 11 (1) pp. 1-3. 10.1111/j.1600-0854.2009.01004.x.

Bunney, TD; Katan, M; (2010) Phosphoinositide signalling in cancer: beyond PI3K and PTEN. NAT REV CANCER , 10 (5) 342 - 352. 10.1038/nrc2842.

Burton, J.A.; (2010) Functional specificity of the IP6 kinase isoforms. Doctoral thesis, UCL (University College London).

C

Cabreiro, F; Gems, D; (2010) Treating aging: progress toward dietary restriction mimetics. F1000 Biol Rep , 2 76-. 10.3410/B2-76.

Cabrita, LD; Dobson, CM; Christodoulou, J; (2010) Early Nascent Chain Folding Events on the Ribosome. ISR J CHEM , 50 (1) 99 - 108. 10.1002/ijch.201000015.

Cabrita, LD; Dobson, CM; Christodoulou, J; (2010) Protein folding on the ribosome. CURR OPIN STRUC BIOL , 20 (1) 33 - 45. 10.1016/j.sbi.2010.01.005.

Caldarini, M; Sutto, L; Camilloni, C; Vasile, F; Broglia, RA; Tiana, G; (2010) Identification of the folding inhibitors of hen-egg lysozyme: gathering the right tools. Eur Biophys J , 39 (6) pp. 911-919. 10.1007/s00249-009-0441-1.

Carnall, JMA; Waudby, CA; Belenguer, AM; Stuart, MCA; Peyralans, JJP; Otto, S; (2010) Mechanosensitive Self-Replication Driven by Self-Organization. SCIENCE , 327 (5972) 1502 - 1506. 10.1126/science.1182767.

Cauwood, J.D.; (2010) Identification of cis and trans factors that regulate genetic stability in Saccharomyces cerevisiae. Doctoral thesis, UCL (University College London).

Chichger, H; Marks, J; Srai, K; Debnam, ES; Unwin, RJ; (2010) Modulation Of Renal Glucose Transport By Sweet Taste Sensing At The Proximal Tubule Brush Border Membrane. FASEB JOURNAL , 24

Chorell, E; Pinkner, JS; Phan, G; Edvinsson, S; Buelens, F; Remaut, H; Waksman, G; ... Almqvist, F; + view all Chorell, E; Pinkner, JS; Phan, G; Edvinsson, S; Buelens, F; Remaut, H; Waksman, G; Hultgren, SJ; Almqvist, F; - view fewer (2010) Design and Synthesis of C-2 Substituted Thiazolo and Dihydrothiazolo Ring-Fused 2-Pyridones: Pilicides with Increased Antivirulence Activity. JOURNAL OF MEDICINAL CHEMISTRY , 53 (15) pp. 5690-5695. 10.1021/jm100470t.

Clare, DK; Orlova, EV; (2010) 4.6A Cryo-EM reconstruction of tobacco mosaic virus from images recorded at 300. J Struct Biol , 171 pp. 303-308. 10.1016/j.jsb.2010.06.011.

Cozier, GE; Leese, MP; Lloyd, MD; Baker, MD; Thiyagarajan, N; Acharya, KR; Potter, BVL; (2010) Structures of human carbonic anhydrase II/inhibitor complexes reveal a second binding site for steroidal and nonsteroidal inhibitors. Biochemistry , 49 (16) pp. 3464-3476. 10.1021/bi902178w.

Cukier, CD; Hollingworth, D; Martin, SR; Kelly, G; Díaz-Moreno, I; Ramos, A; (2010) Molecular basis of FIR-mediated c-myc transcriptional control. Nature Structural & Molecular Biology , 17 (9) pp. 1058-1064. 10.1038/nsmb.1883.

Cukier, CD; Ramos, A; (2010) Creating a Twin STAR. Structure , 18 (3) pp. 279-280. 10.1016/j.str.2010.02.003.

Cuollo, M; Caira, S; Fierro, O; Pinto, G; Picariello, G; Addeo, F; (2010) Toward milk speciation through the monitoring of casein proteotypic peptides. Rapid Communications in Mass Spectrometry , 24 (11) pp. 1687-1696. 10.1002/rcm.4564.

D

Dartnell, LR; Hunter, SJ; Lovell, KV; Coates, AJ; Ward, JM; (2010) Low-Temperature Ionizing Radiation Resistance of Deinococcus radiodurans and Antarctic Dry Valley Bacteria. ASTROBIOLOGY , 10 (7) 717 - 732. 10.1089/ast.2009.0439.

De Genst, EJ; Guilliams, T; Wellens, J; O'Day, EM; Waudby, CA; Meehan, S; Dumoulin, M; ... Dobson, CM; + view all De Genst, EJ; Guilliams, T; Wellens, J; O'Day, EM; Waudby, CA; Meehan, S; Dumoulin, M; Hsu, STD; Cremades, N; Verschueren, KHG; Pardon, E; Wyns, L; Steyaert, J; Christodoulou, J; Dobson, CM; - view fewer (2010) Structure and Properties of a Complex of alpha-Synuclein and a Single-Domain Camelid Antibody. J MOL BIOL , 402 (2) 326 - 343. 10.1016/j.jmb.2010.07.001.

Dedes, KJ; Wetterskog, D; Mendes-Pereira, AM; Natrajan, R; Lambros, MB; Geyer, FC; Vatcheva, R; ... Reis-Filho, JS; + view all Dedes, KJ; Wetterskog, D; Mendes-Pereira, AM; Natrajan, R; Lambros, MB; Geyer, FC; Vatcheva, R; Savage, K; Mackay, A; Lord, CJ; Ashworth, A; Reis-Filho, JS; - view fewer (2010) PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors. Sci Transl Med , 2 (53) 53ra75-. 10.1126/scitranslmed.3001538.

Dessailly, BH; Redfern, OC; Cuff, AL; Orengo, CA; (2010) Detailed Analysis of Function Divergence in a Large and Diverse Domain Superfamily: Toward a Refined Protocol of Function Classification. STRUCTURE , 18 (11) 1522 - 1535. 10.1016/j.str.2010.08.017.

Dessailly, BH; Redfern, OC; Cuff, AL; Orengo, CA; (2010) Detailed analysis of function divergence in a large and diverse domain superfamily: toward a refined protocol of function classification. Structure , 18 (11) 1522-35+-1522-35+. 10.1016/j.str.2010.08.017%20%5Bdoi%5D.

Diaz-Moreno, I; Hollingworth, D; Kelly, G; Martin, S; Garcia-Mayoral, M; Briata, P; Gherzi, R; Diaz-Moreno, I; Hollingworth, D; Kelly, G; Martin, S; Garcia-Mayoral, M; Briata, P; Gherzi, R; Ramos, A; - view fewer (2010) Orientation of the central domains of KSRP and its implications for the interaction with the RNA targets. Nucleic Acids Research , 38 (15) pp. 5193-5205. 10.1093/nar/gkq216.

Diboun, I.; (2010) Bioinformatics protocols for analysis of functional genomics data applied to neuropathy microarray datasets. Doctoral thesis, UCL (University College London).

Djordjevic, S; Zhang, XX; Bartlam, M; Ye, S; Rao, ZH; Danpure, CJ; (2010) Structural implications of a G170R mutation of alanine:glyoxylate aminotransferase that is associated with peroxisome-to-mitochondrion mistargeting. ACTA CRYSTALLOGR F , 66 233 - 236. 10.1107/S1744309109054645.

Drake, PMW; Barbi, T; Drever, MR; van Dolleweerd, CJ; Porter, AJR; Ma, JKC; (2010) Generation of transgenic plants expressing antibodies to the environmental pollutant microcystin-LR. FASEB J , 24 (3) 882 - 890. 10.1096/fj.09-140848.

Dumont, A; Boucrot, E; Drevensek, S; Daire, V; Gorvel, J-P; Poüs, C; Holden, DW; Dumont, A; Boucrot, E; Drevensek, S; Daire, V; Gorvel, J-P; Poüs, C; Holden, DW; Méresse, S; - view fewer (2010) SKIP, the host target of the Salmonella virulence factor SifA, promotes kinesin-1-dependent vacuolar membrane exchanges. Traffic , 11 (7) pp. 899-911. 10.1111/j.1600-0854.2010.01069.x.

Durand, E; Oomen, C; Waksman, G; (2010) Biochemical Dissection of the ATPase TraB, the VirB4 Homologue of the Escherichia coli pKM101 Conjugation Machinery. J BACTERIOL , 192 (9) 2315 - 2323. 10.1128/JB.01384-09.

Duval, S; Santini, JM; Nitschke, W; Hille, R; Schoepp-Cothenet, B; (2010) The Small Subunit AroB of Arsenite Oxidase LESSONS ON THE [2Fe-2S] RIESKE PROTEIN SUPERFAMILY. JOURNAL OF BIOLOGICAL CHEMISTRY , 285 (27) pp. 20442-20451. 10.1074/jbc.M110.113811.

de Koning, B; Blombach, F; Brouns, SJJ; van der Oost, J; (2010) Fidelity in Archaeal Information Processing. ARCHAEA , Article 960298. 10.1155/2010/960298.

E

Eddaoudi, A; Townsend-Nicholson, A; Timms, JF; Schorge, S; Jayasinghe, SN; (2010) Molecular characterisation of post-bio-electrosprayed human brain astrocytoma cells. ANALYST , 135 (10) 2600 - 2612. 10.1039/c0an00213e.

Esk, C; Chen, C-Y; Johannes, L; Brodsky, FM; (2010) The clathrin heavy chain isoform CHC22 functions in a novel endosomal sorting step. JOURNAL OF CELL BIOLOGY , 188 (1) pp. 131-144. 10.1083/jcb.200908057.

F

Fenton, TR; Gwalter, J; Cramer, R; Gout, IT; (2010) S6K1 is acetylated at lysine 516 in response to growth factor stimulation. BIOCHEM BIOPH RES CO , 398 (3) 400 - 405. 10.1016/j.bbrc.2010.06.081.

Fenton, TR; Gwalter, J; Ericsson, J; Gout, IT; (2010) Histone acetyltransferases interact with and acetylate p70 ribosomal S6 kinases in vitro and in vivo. INT J BIOCHEM CELL B , 42 (2) 359 - 366. 10.1016/j.biocel.2009.11.022.

Ford, B; Rego, AT; Ragan, TJ; Pinkner, J; Dodson, K; Driscoll, PC; Hultgren, S; Ford, B; Rego, AT; Ragan, TJ; Pinkner, J; Dodson, K; Driscoll, PC; Hultgren, S; Waksman, G; - view fewer (2010) Structural Homology between the C-Terminal Domain of the PapC Usher and Its Plug. J BACTERIOL , 192 (7) 1824 - 1831. 10.1128/JB.01677-09.

Francois, A.; (2010) Genetic variants of flavin-containing monooxygenases: consequences for drug metabolism. Doctoral thesis, UCL (University College London).

Fusté, JM; Wanrooij, S; Jemt, E; Granycome, CE; Cluett, TJ; Shi, Y; Atanassova, N; ... Falkenberg, M; + view all Fusté, JM; Wanrooij, S; Jemt, E; Granycome, CE; Cluett, TJ; Shi, Y; Atanassova, N; Holt, IJ; Gustafsson, CM; Falkenberg, M; - view fewer (2010) Mitochondrial RNA polymerase is needed for activation of the origin of light-strand DNA replication. Mol Cell , 37 (1) pp. 67-78. 10.1016/j.molcel.2009.12.021.

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Garza-Garcia, AA; Driscoll, PC; Brockes, JP; (2010) Evidence for the Local Evolution of Mechanisms Underlying Limb Regeneration in Salamanders. INTEGRATIVE AND COMPARATIVE BIOLOGY , 50 (4) pp. 528-535. 10.1093/icb/icq022.

Gherzi, R; Chen, C-Y; Trabucchi, M; Ramos, A; Briata, P; (2010) The role of KSRP in mRNA decay and microRNA precursor maturation. Wiley Interdiscip Rev RNA , 1 (2) pp. 230-239. 10.1002/wrna.2.

Gnjatic, S; Cao, Y; Reichelt, U; Yekebas, EF; Nölker, C; Marx, AH; Erbersdobler, A; ... Atanackovic, D; + view all Gnjatic, S; Cao, Y; Reichelt, U; Yekebas, EF; Nölker, C; Marx, AH; Erbersdobler, A; Nishikawa, H; Hildebrandt, Y; Bartels, K; Horn, C; Stahl, T; Gout, I; Filonenko, V; Ling, KL; Cerundolo, V; Luetkens, T; Ritter, G; Friedrichs, K; Leuwer, R; Hegewisch-Becker, S; Izbicki, JR; Bokemeyer, C; Old, LJ; Atanackovic, D; - view fewer (2010) NY-CO-58/KIF2C is overexpressed in a variety of solid tumors and induces frequent T cell responses in patients with colorectal cancer. International Journal of Cancer , 127 (2) pp. 381-393. 10.1002/ijc.25058.

Godwin, JW; Liem, KF; Brockes, JP; (2010) Tissue factor expression in newt iris coincides with thrombin activation and lens regeneration. MECHANISMS OF DEVELOPMENT , 127 (7-8) pp. 321-328. 10.1016/j.mod.2010.04.004.

Goh, E.T.H.; (2010) Investigation into the nuclear functions of ribosomal S6 kinases. Doctoral thesis, UCL (University College London).

Goh, ET; Pardo, OE; Michael, N; Niewiarowski, A; Totty, N; Volkova, D; Tsaneva, IR; ... Gout, I; + view all Goh, ET; Pardo, OE; Michael, N; Niewiarowski, A; Totty, N; Volkova, D; Tsaneva, IR; Seckl, MJ; Gout, I; - view fewer (2010) Involvement of heterogeneous ribonucleoprotein F in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway. J.Biol.Chem. , 285 (22) pp. 17065-17076.

Goh, ETH; Pardo, OE; Michael, N; Niewiarowski, A; Totty, N; Volkova, D; Tsaneva, IR; ... Gout, I; + view all Goh, ETH; Pardo, OE; Michael, N; Niewiarowski, A; Totty, N; Volkova, D; Tsaneva, IR; Seckl, MJ; Gout, I; - view fewer (2010) Involvement of Heterogeneous Ribonucleoprotein F in the Regulation of Cell Proliferation via the Mammalian Target of Rapamycin/S6 Kinase 2 Pathway. J BIOL CHEM , 285 (22) 17065 - 17076. 10.1074/jbc.M109.078782.

Gorbenko, O; Panayotou, G; Zhyvoloup, A; Volkova, D; Gout, I; Filonenko, V; (2010) Identification of novel PTEN-binding partners: PTEN interaction with fatty acid binding protein FABP4. Molecular and Cellular Biochemistry , 337 (1) pp. 299-305. 10.1007/s11010-009-0312-1.

Grohmann, D; Klose, D; Klare, JP; Kay, CWM; Steinhoff, HJ; Werner, F; (2010) RNA-Binding to Archaeal RNA Polymerase Subunits F/E: A DEER and FRET Study. J AM CHEM SOC , 132 (17) 5954 - +. 10.1021/ja101663d.

Grohmann, D; Werner, F; (2010) Hold on! RNA polymerase interactions with the nascent RNA modulate transcription elongation and termination. RNA BIOL , 7 (3) 310 - 315.

Grohmann, D.; Klose, D.; Klare, J.P.; Kay, C.W.M.; Steinhoff, H.-J.; Werner, F.; (2010) RNA-binding to archaeal RNA polymerase subunits F/E: a DEER and FRET study. Journal of the American Chemical Society , 132 (17) pp. 5954-5955. 10.1021/ja101663d.

Gualdoni, S; Baron, M; Lakowski, J; Decembrini, S; Smith, AJ; Pearson, RA; Ali, RR; Gualdoni, S; Baron, M; Lakowski, J; Decembrini, S; Smith, AJ; Pearson, RA; Ali, RR; Sowden, JC; - view fewer (2010) Adult Ciliary Epithelial Cells, Previously Identified as Retinal Stem Cells with Potential for Retinal Repair, Fail to Differentiate into New Rod Photoreceptors. STEM CELLS , 28 (6) 1048 - 1059. 10.1002/stem.423.

Guzman, JD; Gupta, A; Evangelopoulos, D; Basavannacharya, C; Pabon, LC; Plazas, EA; Munoz, DR; ... Bhakta, S; + view all Guzman, JD; Gupta, A; Evangelopoulos, D; Basavannacharya, C; Pabon, LC; Plazas, EA; Munoz, DR; Delgado, WA; Cuca, LE; Ribon, W; Gibbons, S; Bhakta, S; - view fewer (2010) Anti-tubercular screening of natural products from Colombian plants: 3-methoxynordomesticine, an inhibitor of MurE ligase of Mycobacterium tuberculosis. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY , 65 (10) pp. 2101-2107. 10.1093/jac/dkq313.

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Hagan, CL; Johnson, RJK; Dhulesia, A; Dumoulin, M; Dumont, J; De Genst, E; Christodoulou, J; ... Kumita, JR; + view all Hagan, CL; Johnson, RJK; Dhulesia, A; Dumoulin, M; Dumont, J; De Genst, E; Christodoulou, J; Robinson, CV; Dobson, CM; Kumita, JR; - view fewer (2010) A non-natural variant of human lysozyme (I59T) mimics the in vitro behaviour of the I56T variant that is responsible for a form of familial amyloidosis. Protein Eng Des Sel , 23 (7) pp. 499-506. 10.1093/protein/gzq023.

Hansen, DF; Neudecker, P; Kay, LE; (2010) Determination of isoleucine side-chain conformations in ground and excited states of proteins from chemical shifts. J Am Chem Soc , 132 (22) pp. 7589-7591. 10.1021/ja102090z.

Hansen, DF; Neudecker, P; Vallurupalli, P; Mulder, FAA; Kay, LE; (2010) Determination of Leu side-chain conformations in excited protein states by NMR relaxation dispersion. J Am Chem Soc , 132 (1) pp. 42-43. 10.1021/ja909294n.

Hayward, RD; Goguen, JD; Leong, JM; (2010) No better time to FRET: shedding light on host pathogen interactions. Journal of Biology , 9 , Article 12. 10.1186/jbiol225.

Hebecker, M; Okemefuna, AI; Perkins, SJ; Mihlan, M; Huber-Lang, M; Jozsi, M; (2010) Molecular basis of C-reactive protein binding and modulation of complement activation by factor H-related protein 4. MOL IMMUNOL , 47 (6) 1347 - 1355. 10.1016/j.molimm.2009.12.005.

Henne, WM; Boucrot, E; Meinecke, M; Evergren, E; Vallis, Y; Mittal, R; McMahon, HT; (2010) FCHo proteins are nucleators of clathrin-mediated endocytosis. Science , 328 (5983) pp. 1281-1284. 10.1126/science.1188462.

Hilton, GR; Thalassinos, K; Grabenauer, M; Sanghera, N; Slade, SE; Wyttenbach, T; Robinson, PJ; ... Scrivens, JH; + view all Hilton, GR; Thalassinos, K; Grabenauer, M; Sanghera, N; Slade, SE; Wyttenbach, T; Robinson, PJ; Pinheiro, TJT; Bowers, MT; Scrivens, JH; - view fewer (2010) Structural Analysis of Prion Proteins by Means of Drift Cell and Traveling Wave Ion Mobility Mass Spectrometry. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY , 21 (5) pp. 845-854. 10.1016/j.jasms.2010.01.017.

Hirtreiter, A; Damsma, GE; Cheung, ACM; Klose, D; Grohmann, D; Vojnic, E; Martin, ACR; ... Werner, F; + view all Hirtreiter, A; Damsma, GE; Cheung, ACM; Klose, D; Grohmann, D; Vojnic, E; Martin, ACR; Cramer, P; Werner, F; - view fewer (2010) Spt4/5 stimulates transcription elongation through the RNA polymerase clamp coiled-coil motif. NUCLEIC ACIDS RES , 38 (12) 4040 - 4051. 10.1093/nar/gkq135.

Hirtreiter, A; Grohmann, D; Werner, F; (2010) Molecular mechanisms of RNA polymerase-the F/E (RPB4/7) complex is required for high processivity in vitro. NUCLEIC ACIDS RES , 38 (2) 585 - 596. 10.1093/nar/gkp928.

Hirtreiter, A.; Grohmann, D.; Werner, F.; (2010) Molecular mechanisms of RNA polymerase - the F/E (RPB4/7) complex is required for high processivity in vitro. Nucleic Acids Research , 38 (2) pp. 585-596. 10.1093/nar/gkp928.

Hoffmann, A; Dannhauser, PN; Groos, S; Hinrichsen, L; Curth, U; Ungewickell, EJ; (2010) A comparison of GFP-tagged clathrin light chains with fluorochromated light chains in vivo and in vitro. Traffic , 11 (9) pp. 1129-1140. 10.1111/j.1600-0854.2010.01084.x.

Holt, IJ; (2010) Zen and the art of mitochondrial DNA maintenance. Trends Genet , 26 (3) pp. 103-109. 10.1016/j.tig.2009.12.011.

Hsu, S-TD; Blaser, G; Behrens, C; Cabrita, LD; Dobson, CM; Jackson, SE; (2010) Folding study of Venus reveals a strong ion dependence of its yellow fluorescence under mildly acidic conditions. J Biol Chem , 285 (7) pp. 4859-4869. 10.1074/jbc.M109.000695.

Huang, B; Wu, H; Hao, N; Blombach, F; van der Oost, J; Li, XM; Zhang, XJC; Huang, B; Wu, H; Hao, N; Blombach, F; van der Oost, J; Li, XM; Zhang, XJC; Rao, ZH; - view fewer (2010) Functional study on GTP hydrolysis by the GTP-binding protein from Sulfolobus solfataricus, a member of the HflX family. J BIOCHEM , 148 (1) 103 - 113. 10.1093/jb/mvq039.

J

Jackson, AT; Thalassinos, K; John, RO; McGuire, N; Freeman, D; Scrivens, JH; (2010) Characterisation of end groups in poly(2-hydroxyethyl methacrylate) by means of electrospray ionisation-mass spectrometry/mass spectrometry (ESI-MS/MS). POLYMER , 51 (6) pp. 1418-1424. 10.1016/j.polymer.2010.01.023.

Jarvis, A; Allerston, CK; Jia, HY; Herzog, B; Garza-Garcia, A; Winfield, N; Ellard, K; ... Selwood, DL; + view all Jarvis, A; Allerston, CK; Jia, HY; Herzog, B; Garza-Garcia, A; Winfield, N; Ellard, K; Aqil, R; Lynch, R; Chapman, C; Hartzoulakis, B; Nally, J; Stewart, M; Cheng, LL; Menon, M; Tickner, M; Djordjevic, S; Driscoll, PC; Zachary, I; Selwood, DL; - view fewer (2010) Small Molecule Inhibitors of the Neuropilin-1 Vascular Endothelial Growth Factor A (VEGF-A) Interaction. J MED CHEM , 53 (5) 2215 - 2226. 10.1021/jm901755g.

Jing, R; Vershinin, A; Grzebyta, J; Shaw, P; Smýkal, P; Marshall, D; Ambrose, MJ; ... Flavell, AJ; + view all Jing, R; Vershinin, A; Grzebyta, J; Shaw, P; Smýkal, P; Marshall, D; Ambrose, MJ; Ellis, THN; Flavell, AJ; - view fewer (2010) The genetic diversity and evolution of field pea (Pisum) studied by high throughput retrotransposon based insertion polymorphism (RBIP) marker analysis. BMC Evol Biol , 10 44-. 10.1186/1471-2148-10-44.

Johnson, SA; Williams, JM; Hakobyan, S; Richards, A; Perkins, SJ; Marchbank, KJ; Goodship, THJ; ... Savage, COS; + view all Johnson, SA; Williams, JM; Hakobyan, S; Richards, A; Perkins, SJ; Marchbank, KJ; Goodship, THJ; Morgan, BP; Taylor, CM; Savage, COS; - view fewer (2010) Impact of compound heterozygous complement factor H mutations on development of atypical hemolytic uremic syndrome-A pedigree revisited. MOL IMMUNOL , 47 (7-8) 1585 - 1591. 10.1016/j.molimm.2009.12.001.

K

Kappé, G; Purkiss, AG; van Genesen, ST; Slingsby, C; Lubsen, NH; (2010) Explosive expansion of betagamma-crystallin genes in the ancestral vertebrate. J Mol Evol , 71 pp. 219-230. 10.1007/s00239-010-9379-2.

Khalil, M.I.M.; (2010) The role of arginine methylation in regulating the function of ribosomal S6 kinase 2. Doctoral thesis, UCL (University College London).

Khan, S; Gor, J; Mulloy, B; Perkins, SJ; (2010) Semi-Rigid Solution Structures of Heparin by Constrained X-ray Scattering Modelling: New Insight into Heparin-Protein Complexes. J MOL BIOL , 395 (3) 504 - 521. 10.1016/j.jmb.2009.10.064.

Khan, S; Miller, A; Gor, J; Mulloy, B; Perkins, SJ; (2010) Oligomeric solution structures of factor H in the presence of heparin fragments. In: MOLECULAR IMMUNOLOGY. (pp. 2264 - 2264). PERGAMON-ELSEVIER SCIENCE LTD

King, MD; Rennie, AR; Pfrang, C; Hughes, AV; Thompson, KC; (2010) Interaction of nitrogen dioxide (NO2) with a monolayer of oleic acid at the air-water interface - A simple proxy for atmospheric aerosol. Atmospheric Environment , 44 pp. 1822-1825. 10.1016/j.atmosenv.2010.01.031.

Kiyamova, R; Kostianets, O; Malyuchik, S; Filonenko, V; Usenko, V; Gurtovyy, V; Khozayenko, Y; ... Gout, I; + view all Kiyamova, R; Kostianets, O; Malyuchik, S; Filonenko, V; Usenko, V; Gurtovyy, V; Khozayenko, Y; Antonuk, S; Old, L; Gout, I; - view fewer (2010) Identification of Tumor-Associated Antigens from Medullary Breast Carcinoma by a Modified SEREX Approach. MOLECULAR BIOTECHNOLOGY , 46 (2) pp. 105-112. 10.1007/s12033-010-9285-2.

Kumar, A; Godwin, JW; (2010) Preparation and culture of limb blastema stem cells from regenerating larval and adult salamanders. Cold Spring Harb Protoc , 2010 (1) pdb.prot5367-. 10.1101/pdb.prot5367.

Kumar, A; Nevill, G; Brockes, JP; Forge, A; (2010) A comparative study of gland cells implicated in the nerve dependence of salamander limb regeneration. J ANAT , 217 (1) 16 - 25. 10.1111/j.1469-7580.2010.01239.x.

L

Lakowski, J; Baron, M; Bainbridge, J; Barber, AC; Pearson, RA; Ali, RR; Sowden, JC; (2010) Cone and rod photoreceptor transplantation in models of the childhood retinopathy Leber congenital amaurosis using flow-sorted Crx-positive donor cells. HUM MOL GENET , 19 (23) 4545 - 4559. 10.1093/hmg/ddq378.

Larbi, A; Cabreiro, F; Zelba, H; Marthandan, S; Combet, E; Friguet, B; Petropoulos, I; ... Pawelec, G; + view all Larbi, A; Cabreiro, F; Zelba, H; Marthandan, S; Combet, E; Friguet, B; Petropoulos, I; Barnett, Y; Pawelec, G; - view fewer (2010) Reduced oxygen tension results in reduced human T cell proliferation and increased intracellular oxidative damage and susceptibility to apoptosis upon activation. FREE RADICAL BIO MED , 48 (1) 26 - 34. 10.1016/j.freeradbiomed.2009.09.025.

Law, RH; Lukoyanova, N; Voskoboinik, I; Caradoc-Davies, TT; Baran, K; Dunstone, MA; D'Angelo, ME; ... Whisstock, JC; + view all Law, RH; Lukoyanova, N; Voskoboinik, I; Caradoc-Davies, TT; Baran, K; Dunstone, MA; D'Angelo, ME; Orlova, EV; Coulibaly, F; Verschoor, S; Browne, KA; Ciccone, A; Kuiper, MJ; Bird, PI; Trapani, JA; Saibil, HR; Whisstock, JC; - view fewer (2010) The structural basis for membrane binding and pore formation by lymphocyte perforin. Nature , 468 pp. 447-451. 10.1038/nature09518.

Lawrence, SP; Bright, NA; Luzio, JP; Bowers, K; (2010) The Sodium/Proton Exchanger NHE8 Regulates Late Endosomal Morphology and Function. MOL BIOL CELL , 21 (20) 3540 - 3551.

Lee, D; Rentzsch, R; ORENGO, C; (2010) GeMMA: functional subfamily classification within superfamilies of predicted protein structural domains. Nucleic Acids Res , 38 (3) pp. 720-737. 10.1093/nar/gkp1049.

Lee, DA; Rentzsch, R; Orengo, C; (2010) GeMMA: functional subfamily classification within superfamilies of predicted protein structural domains. Nucleic Acids Res , 38 (3) 720-37+-720-37+. 10.1093/nar/gkp1049%20%5Bdoi%5D.

Lee, DA; Rentzsch, R; Orengo, C; (2010) GeMMA: functional subfamily classification within superfamilies of predicted protein structural domains. Nucleic Acids Res , 38 (3) pp. 720-737. 10.1093/nar/gkp1049.

Lees, J; Yeats, C; Redfern, O; Clegg, A; Orengo, C; (2010) Gene3D: merging structure and function for a Thousand genomes. NUCLEIC ACIDS RES , 38 D296 - D300. 10.1093/nar/gkp987.

Lees, J; Yeats, C; Redfern, O; Clegg, A; Orengo, C; (2010) Gene3D: merging structure and function for a Thousand genomes. Nucleic Acids Res , 38 (Database) D296-300+-D296-300+. 10.1093/nar/gkp987%20%5Bdoi%5D.

Leese, MP; Jourdan, F; Kimberley, MR; Cozier, GE; Thiyagarajan, N; Stengel, C; Regis-Lydi, S; ... Potter, BVL; + view all Leese, MP; Jourdan, F; Kimberley, MR; Cozier, GE; Thiyagarajan, N; Stengel, C; Regis-Lydi, S; Foster, PA; Newman, SP; Acharya, KR; Ferrandis, E; Purohit, A; Reed, MJ; Potter, BVL; - view fewer (2010) Chimeric microtubule disruptors. Chem Commun (Camb) , 46 (17) pp. 2907-2909. 10.1039/c002558e.

Leonard, PG; Parkinson, GN; Gor, J; Perkins, SJ; Ladbury, JE; (2010) The absence of inorganic salt is required for the crystallization of the complete oligomerization domain of Salmonella typhimurium histone-like nucleoid-structuring protein. ACTA CRYSTALLOGR F , 66 (4) 421 - 425. 10.1107/S1744309110004574.

Li, K.; (2010) Interactions of complement receptor type 2 with C3d and factor H with C3u. Doctoral thesis, UCL (University College London).

Li, KY; Gor, J; Perkins, SJ; (2010) Self-association and domain rearrangements between complement C3 and C3u provide insight into the activation mechanism of C3. BIOCHEM J , 431 63 - 72. 10.1042/BJ20100759.

Li, KY; Gor, J; Perkins, SJ; (2010) TED and CUB domain movements between complement C3 and C3u by constrained X-ray scattering modelling provide insight into C3 activation. In: MOLECULAR IMMUNOLOGY. (pp. 2262 - 2263). PERGAMON-ELSEVIER SCIENCE LTD

Lobley, A.E.; (2010) Human protein function prediction: application of machine learning for integration of heterogeneous data sources. Doctoral thesis, UCL (University College London).

Loney, R; Hinojos, C; Lane, M; Brodsky, FM; Powell, JW; (2010) Analysis of Clathrin Self-Assembly by Infrared Spectroscopy. BIOPHYSICAL JOURNAL , 98 (3) 500A-501A.

Lowe, AR; Siegel, JJ; Kalab, P; Siu, M; Weis, K; Liphardt, JT; (2010) Selectivity mechanism of the nuclear pore complex characterized by single cargo tracking. Nature , 467 pp. 600-603. 10.1038/nature09285.

Lowe, EC; Bydder, S; Hartshorne, RS; Tape, HLU; Dridge, EJ; Debieux, CM; Paszkiewicz, K; ... Butler, CS; + view all Lowe, EC; Bydder, S; Hartshorne, RS; Tape, HLU; Dridge, EJ; Debieux, CM; Paszkiewicz, K; Singleton, I; Lewis, RJ; Santini, JM; Richardson, DJ; Butler, CS; - view fewer (2010) Quinol-cytochrome c Oxidoreductase and Cytochrome c(4) Mediate Electron Transfer during Selenate Respiration in Thauera selenatis. JOURNAL OF BIOLOGICAL CHEMISTRY , 285 (24) pp. 18433-18442. 10.1074/jbc.M110.115873.

M

Marechal, A; Rich, PR; (2010) Fourier transform infrared spectroscopy reveals water molecules reorganization in cytochrome c oxidases. In: BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. (pp. 97 - 97). ELSEVIER SCIENCE BV

Martin, ACR; (2010) Protein sequence and structure analysis of antibody variable domains. In: Kontermann, R and Duebel, S, (eds.) Antibody Engineering. Springer Verlag

Maréchal, A; Mattioli, TA; Stuehr, DJ; Santolini, J; (2010) NO synthase isoforms specifically modify peroxynitrite reactivity. FEBS J , 277 (19) pp. 3963-3973. 10.1111/j.1742-4658.2010.07786.x.

Mason, K; Rowley, K; Marshall, CR; Atkinson, JR; Herman, R; Woll, B; Morgan, G; (2010) Identifying specific language impairment in deaf children acquiring British Sign Language: Implications for theory and practice. British Journal of Developmental Psychology , 28 (1) 33 - 49. 10.1348/026151009X484190.

Mehdi, Z; Wilkins, P; Ingrouille, M; Zarre, S; Chase, MW; (2010) The systematic importance of anatomical data in Gagea (Liliaceae) from the Flora Iranica area. Botanical Journal of the Linnean Society , 164 (2) pp. 155-177. 10.1111/j.1095-8339.2010.01081.x.

Meng, F; Abedini, A; Plesner, A; Verchere, CB; Raleigh, DP; (2010) The Flavanol (−)-Epigallocatechin 3-Gallate Inhibits Amyloid Formation by Islet Amyloid Polypeptide, Disaggregates Amyloid Fibrils, and Protects Cultured Cells against IAPP-Induced Toxicity. Biochemistry , 49 (37) pp. 8127-8133. 10.1021/bi100939a.

Menzel, R; Tran, MQ; Menner, A; Kay, CWM; Bismarck, A; Shaffer, MSP; (2010) A versatile, solvent-free methodology for the functionalisation of carbon nanotubes. CHEM SCI , 1 (5) 603 - 608. 10.1039/c0sc00287a.

Morilla, I; Lees, JG; Reid, AJ; Orengo, C; Ranea, JAG; (2010) Assessment of protein domain fusions in human protein interaction networks prediction Application to the human kinetochore model. NEW BIOTECHNOLOGY , 27 (6) pp. 755-765. 10.1016/j.nbt.2010.09.005.

Morilla, I; Ranea, J; Lees, J; ORENGO, C; (2010) Assessment of Protein Domain Fusions in Human Protein Interaction Networks Prediction: application to the human kinetochore model. New Biotechnology (27) pp. 755-765. 10.1002/gepi.20486.

Morley, GW; Warner, M; Stoneham, AM; Greenland, PT; van Tol, J; Kay, CWM; Aeppli, G; (2010) The initialization and manipulation of quantum information stored in silicon by bismuth dopants. NAT MATER , 9 (9) 725 - 729. 10.1038/NMAT2828.

Morley, GW; Warner, M; Stoneham, AM; Greenland, PT; van Tol, J; Kay, CWM; Aeppli, G; (2010) The initialization and manipulation of quantum information stored in silicon by bismuth dopants. Nat Mater , 9 (9) pp. 725-729. 10.1038/nmat2828.

Murphy, EJ; Marechal, A; Segal, AW; Rich, PR; (2010) CO Binding and Ligand Discrimination in Human Myeloperoxidase. BIOCHEMISTRY-US , 49 (10) 2150 - 2158. 10.1021/bi9021507.

N

Nagl, SCB; Patel, M; (2010) The role of model integration in complex systems modelling. [Book]. Springer Verlag

Nan, R; Ward, G; Gavigan, L; Miller, A; Gor, J; Lengyel, I; Perkins, SJ; (2010) The His402 allotype of complement factor H show similar self-association to the Tyr402 allotype but exhibits greater self-association in the presence of zinc. In: MOLECULAR IMMUNOLOGY. (pp. 2263 - 2263). PERGAMON-ELSEVIER SCIENCE LTD

Nan, R.; (2010) Self-association of complement factor H in the presence and absence of metals. Doctoral thesis, UCL (University College London).

Niewiarowski, A; Bradley, AS; Gor, J; McKay, AR; Perkins, SJ; Tsaneva, IR; (2010) Oligomeric assembly and interactions within the human RuvB-like RuvBL1 and RuvBL2 complexes. BIOCHEM J , 429 113 - 125. 10.1042/BJ20100489.

Nugent, T.C.O.; (2010) Transmembrane protein structure prediction using machine learning. Doctoral thesis, UCL (University College London).

Nyon, MP; Segu, L; Roussel, B; Kalsheker, N; Lomas, DA; Thalassinos, K; Gooptu, B; (2010) CHARACTERISATION OF A NOVEL "PSEUDO-Z" VARIANT OF alpha 1-ANTITRYPSIN. In: THORAX. (pp. A30 - A30). B M J PUBLISHING GROUP

O

O'Brien, EP; Hsu, STD; Christodoulou, J; Vendruscolo, M; Dobson, CM; (2010) Transient Tertiary Structure Formation within the Ribosome Exit Port. J AM CHEM SOC , 132 (47) 16928 - 16937. 10.1021/ja106530y.

Oke, M; Carter, LG; Johnson, KA; Liu, H; McMahon, SA; Yan, X; Kerou, M; ... Naismith, JH; + view all Oke, M; Carter, LG; Johnson, KA; Liu, H; McMahon, SA; Yan, X; Kerou, M; Weikart, ND; Kadi, N; Sheikh, MA; Schmelz, S; Dorward, M; Zawadzki, M; Cozens, C; Falconer, H; Powers, H; Overton, IM; van Niekerk, CAJ; Peng, X; Patel, P; Garrett, RA; Prangishvili, D; Botting, CH; Coote, PJ; Dryden, DTF; Barton, GJ; Schwarz-Linek, U; Challis, GL; Taylor, GL; White, MF; Naismith, JH; - view fewer (2010) The Scottish Structural Proteomics Facility: targets, methods and outputs. Journal of Structural and Functional Genomics , 11 (2) pp. 167-180. 10.1007/s10969-010-9090-y.

Okemefuna, AI; Nan, R; Miller, A; Gor, J; Perkins, SJ; (2010) Complement Factor H Binds at Two Independent Sites to C-reactive Protein in Acute Phase Concentrations. J BIOL CHEM , 285 (2) 1053 - 1065. 10.1074/jbc.M109.044529.

Okemefuna, AI; Nan, R; Miller, A; Gor, J; Perkins, SJ; (2010) Complement factor H binds at two independent sites to C-reactive protein in acute phase concentrations. In: MOLECULAR IMMUNOLOGY. (pp. 2263 - 2264). PERGAMON-ELSEVIER SCIENCE LTD

Okemefuna, AI; Stach, L; Rana, S; Buetas, AJZ; Gor, J; Perkins, SJ; (2010) C-reactive Protein Exists in an NaCl Concentration-dependent Pentamer-Decamer Equilibrium in Physiological Buffer. J BIOL CHEM , 285 (2) 1041 - 1052. 10.1074/jbc.M109.044495.

Orengo, C; (2010) Integrating wet and dry systems biology to detect novel genes associated with the mitotic spindle. NEW BIOTECHNOLOGY , 27 S10-S10. 10.1016/j.nbt.2010.01.310.

Osborne, AR; Speicher, KD; Tamez, PA; Bhattacharjee, S; Speicher, DW; Haldar, K; (2010) The host targeting motif in exported Plasmodium proteins is cleaved in the parasite endoplasmic reticulum. pp. 25-31.

Osborne, TH; Jamieson, HE; Hudson-Edwards, KA; Nordstrom, DK; Walker, SR; Ward, SA; Santini, JM; (2010) Microbial oxidation of arsenite in a subarctic environment: diversity of arsenite oxidase genes and identification of a psychrotolerant arsenite oxidiser. BMC Microbiology , 10 , Article 205. 10.1186/1471-2180-10-205.

P

Pancevac, C; Goldstone, DC; Ramos, A; Taylor, IA; (2010) Structure of the Rna15 RRM-RNA complex reveals the molecular basis of GU specificity in transcriptional 3'-end processing factors. Nucleic Acids Research , 38 (9) pp. 3119-3132. 10.1093/nar/gkq002.

Patel, S; Hussain, S; Harris, R; Sardiwal, S; Kelly, JM; Wilkinson, SR; Driscoll, PC; Patel, S; Hussain, S; Harris, R; Sardiwal, S; Kelly, JM; Wilkinson, SR; Driscoll, PC; Djordjevic, S; - view fewer (2010) Structural insights into the catalytic mechanism of Trypanosoma cruzi GPXI (glutathione peroxidase-like enzyme I). BIOCHEM J , 425 513 - 522. 10.1042/BJ20091167.

Pauwels, E; Declerck, R; Verstraelen, T; De Sterck, B; Kay, CWM; Van Speybroeck, V; Waroquier, M; (2010) Influence of Protein Environment on the Electron Paramagnetic Resonance Properties of Flavoprotein Radicals: A QM/MM Study. J PHYS CHEM B , 114 (49) 16655 - 16665. 10.1021/jp109763t.

Pergoli, R; Kubicek, K; Hobor, F; Pasulka, J; Stefl, R; (2010) 1H, 13C, and 15N chemical shift assignments for the RNA recognition motif of Nab3. Biomol NMR Assign , 4 (1) pp. 119-121. 10.1007/s12104-010-9221-1.

Perkins, JR; Diboun, I; Dessailly, BH; Lees, JG; ORENGO, C; (2010) Transient protein-protein interactions: structural, functional, and network properties. Structure , 18 (10) pp. 1233-1243. 10.1016/j.str.2010.08.007.

Perkins, JR; Diboun, I; Dessailly, BH; Lees, JG; Orengo, C; (2010) Transient Protein-Protein Interactions: Structural, Functional, and Network Properties. STRUCTURE , 18 (10) pp. 1233-1243. 10.1016/j.str.2010.08.007.

Perkins, JR; Diboun, I; Dessailly, BH; Lees, JG; Orengo, C; (2010) Transient protein-protein interactions: structural, functional, and network properties. Structure , 18 (10) 1233-43+-1233-43+. 10.1016/j.str.2010.08.007%20%5Bdoi%5D.

Perkins, SJ; Nan, RD; Okemefuna, AI; Li, KY; Khan, S; Miller, A; (2010) Multiple Interactions of Complement Factor H with Its Ligands in Solution: A Progress Report. INFLAMMATION AND RETINAL DISEASE: COMPLEMENT BIOLOGY AND PATHOLOGY , 703 25 - 47. 10.1007/978-1-4419-5635-4_3.

Perkins, SJ; Okemefuna, AI; Nan, RD; (2010) Unravelling protein-protein interactions between complement factor H and C-reactive protein using a multidisciplinary strategy. BIOCHEM SOC T , 38 894 - 900. 10.1042/BST0380894.

Pettifer, S; Ison, J; Kalas, M; Thorne, D; McDermott, P; Jonassen, I; Liaquat, A; ... INB-Partners, ; + view all Pettifer, S; Ison, J; Kalas, M; Thorne, D; McDermott, P; Jonassen, I; Liaquat, A; Fernandez, JM; Rodriguez, JM; Pisano, DG; Blanchet, C; Uludag, M; Rice, P; Bartaseviciute, E; Rapacki, K; Hekkelman, M; Sand, O; Stockinger, H; Clegg, AB; Bongcam-Rudloff, E; Salzemann, J; Breton, V; Attwood, TK; Cameron, G; Vriend, G; INB-Partners, ; - view fewer (2010) The EMBRACE web service collection. NUCLEIC ACIDS RES , 38 W683 - W688. 10.1093/nar/gkq297.

Pino-Angeles, A; Morreale, A; Negri, A; Sánchez-Jiménez, F; Moya-García, AA; (2010) Substrate uptake and protein stability relationship in mammalian histidine decarboxylase. Proteins , 78 (1) pp. 154-161. 10.1002/prot.22587.

Pinto, G; Caira, S; Cuollo, M; Lilla, S; Fierro, O; Addeo, F; (2010) Hydroxyapatite as a concentrating probe for phosphoproteomic analyses. Journal of Chromatography B , 878 (28) pp. 2669-2678. 10.1016/j.jchromb.2010.07.024.

Pohjoismäki, JLO; Holmes, JB; Wood, SR; Yang, M-Y; Yasukawa, T; Reyes, A; Bailey, LJ; ... Holt, IJ; + view all Pohjoismäki, JLO; Holmes, JB; Wood, SR; Yang, M-Y; Yasukawa, T; Reyes, A; Bailey, LJ; Cluett, TJ; Goffart, S; Willcox, S; Rigby, RE; Jackson, AP; Spelbrink, JN; Griffith, JD; Crouch, RJ; Jacobs, HT; Holt, IJ; - view fewer (2010) Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid. J Mol Biol , 397 (5) pp. 1144-1155. 10.1016/j.jmb.2010.02.029.

Potter, KJ; Abedini, A; Marek, P; Klimek, AM; Butterworth, S; Driscoll, M; Baker, R; ... Verchere, CB; + view all Potter, KJ; Abedini, A; Marek, P; Klimek, AM; Butterworth, S; Driscoll, M; Baker, R; Nilsson, MR; Warnock, GL; Oberholzer, J; Bertera, S; Trucco, M; Korbutt, GS; Fraser, PE; Raleigh, DP; Verchere, CB; - view fewer (2010) Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts. Proceedings of the National Academy of Sciences , 107 (9) pp. 4305-4310. 10.1073/pnas.0909024107.

Poulton, J; Chiaratti, MR; Meirelles, FV; Kennedy, S; Wells, D; Holt, IJ; (2010) Transmission of mitochondrial DNA diseases and ways to prevent them. PLoS Genet , 6 (8) 10.1371/journal.pgen.1001066.

Powl, AM; O'Reilly, AO; Miles, AJ; Wallace, BA; (2010) Synchrotron radiation circular dichroism spectroscopy-defined structure of the C-terminal domain of NaChBac and its role in channel assembly. Proc Natl Acad Sci U S A , 107 pp. 14064-14069. 10.1073/pnas.1001793107.

Pérez-Bermúdez, P; García, AAM; Tuñón, I; Gavidia, I; (2010) Digitalis purpurea P5 beta R2, encoding steroid 5 beta-reductase, is a novel defense-related gene involved in cardenolide biosynthesis. New Phytol , 185 (3) pp. 687-700. 10.1111/j.1469-8137.2009.03080.x.

R

Ranea, JAG; Morilla, I; Lees, JG; Reid, AJ; Yeats, C; Clegg, AB; Sanchez-Jimenez, F; Ranea, JAG; Morilla, I; Lees, JG; Reid, AJ; Yeats, C; Clegg, AB; Sanchez-Jimenez, F; Orengo, C; - view fewer (2010) Finding the "Dark Matter'' in Human and Yeast Protein Network Prediction and Modelling. PLOS COMPUT BIOL , 6 (9) , Article e1000945. 10.1371/journal.pcbi.1000945.

Rego, AT; Chandran, V; Waksman, G; (2010) Two-step and one-step secretion mechanisms in Gram-negative bacteria: contrasting the type IV secretion system and the chaperone-usher pathway of pilus biogenesis. BIOCHEM J , 425 475 - 488. 10.1042/BJ20091518.

Rego, AT; Fronzes, R; Waksman, G; (2010) SnapShot: Bacterial Appendages I. CELL , 140 (1) , Article 162.e1. 10.1016/j.cell.2009.12.047.

Rego, AT; Fronzes, R; Waksman, G; (2010) SnapShot: Bacterial Appendages II. CELL , 140 (2) , Article 294.e1. 10.1016/j.cell.2010.01.006.

Reid, AJ; Ranea, JAG; Clegg, AB; Orengo, CA; (2010) CODA: Accurate Detection of Functional Associations between Proteins in Eukaryotic Genomes Using Domain Fusion. PLOS ONE , 5 (6) , Article e10908. 10.1371/journal.pone.0010908.

Reid, AJ; Ranea, JAG; Orengo, CA; (2010) Comparative evolutionary analysis of protein complexes in E. coli and yeast. BMC GENOMICS , 11 , Article 79. 10.1186/1471-2164-11-79.

Riaz, S; Alam, SS; Srai, SK; Skinner, V; Riaz, A; Akhtar, MW; (2010) Proteomic Identification of Human Urinary Biomarkers in Diabetes Mellitus Type 2. DIABETES TECHNOL THE , 12 (12) 979 - 988. 10.1089/dia.2010.0078.

Rich, PR; Marechal, A; (2010) Roles of amino acids and waters in the protonmotive mechanism of cytochrome oxidase. In: BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. (pp. 93 - 93). ELSEVIER SCIENCE BV

Rich, PR; Marechal, A; (2010) The mitochondrial respiratory chain. ESSAYS BIOCHEM , 47 1 - 23. 10.1042/BSE0470001.

Roodveldt, C; Labrador-Garrido, A; Gonzalez-Rey, E; Fernandez-Montesinos, R; Caro, M; Lachaud, CC; Waudby, CA; ... Pozo, D; + view all Roodveldt, C; Labrador-Garrido, A; Gonzalez-Rey, E; Fernandez-Montesinos, R; Caro, M; Lachaud, CC; Waudby, CA; Delgado, M; Dobson, CM; Pozo, D; - view fewer (2010) Glial Innate Immunity Generated by Non-Aggregated Alpha-Synuclein in Mouse: Differences between Wild-type and Parkinson's Disease-Linked Mutants. PLOS ONE , 5 (10) , Article e13481. 10.1371/journal.pone.0013481.

S

Saiu, P.; (2010) Structural and functional studies on nucleotide binding to AMP-activated protein kinase. Doctoral thesis, UCL (University College London).

Salama, M.F.I.; (2010) Regulation of hepcidin and hemojuvelin expression and their role in iron homeostasis. Doctoral thesis, UCL (University College London).

Santabarbara, S; Kuprov, I; Poluektov, O; Casal, A; Russell, CA; Purton, S; Evans, MCW; (2010) Directionality of Electron-Transfer Reactions in Photosystem I of Prokaryotes: Universality of the Bidirectional Electron-Transfer Model. J PHYS CHEM B , 114 (46) 15158 - 15171. 10.1021/jp1044018.

Sardiwal, S; Santini, JM; Osborne, TH; Djordjevic, S; (2010) Characterization of a two-component signal transduction system that controls arsenite oxidation in the chemolithoautotroph NT-26. FEMS MICROBIOL LETT , 313 (1) 20 - 28. 10.1111/j.1574-6968.2010.02121.x.

Sardiwal, S; Santini, JM; Osborne, TH; Djordjevic, S; (2010) Characterization of a two-component signal transduction system that controls arsenite oxidation in the chemolithoautotroph NT-26. FEMS MICROBIOLOGY LETTERS , 313 (1) pp. 20-28. 10.1111/j.1574-6968.2010.02121.x.

Seyedarabi, A; (2010) The orchestrators of Shigella flexneri infection. CRYSTALLOGR REV , 16 (2) 145 - 165. 10.1080/08893110903563732.

Seyedarabi, A; Hutchison, T; To, TT; Deery, E; Brindley, A; Warren, MJ; Pickersgill, RW; (2010) Cloning, purification and preliminary crystallographic analysis of cobalamin methyltransferases from Rhodobacter capsulatus. ACTA CRYSTALLOGR F , 66 1652 - 1656. 10.1107/S1744309110042910.

Seyedarabi, A; Sullivan, JA; Sasakawa, C; Pickersgill, RW; (2010) A disulfide driven domain swap switches off the activity of Shigella IpaH9.8 E3 ligase. FEBS LETT , 584 (19) 4163 - 4168. 10.1016/j.febslet.2010.09.006.

Seyedarabi, A; To, TT; Ali, S; Hussain, S; Fries, M; Madsen, R; Clausen, MH; ... Pickersgill, RW; + view all Seyedarabi, A; To, TT; Ali, S; Hussain, S; Fries, M; Madsen, R; Clausen, MH; Teixteira, S; Brocklehurst, K; Pickersgill, RW; - view fewer (2010) Structural Insights into Substrate Specificity and the anti beta-Elimination Mechanism of Pectate Lyase. BIOCHEMISTRY-US , 49 (3) 539 - 546. 10.1021/bi901503g.

Shaikh, N.; (2010) Investigating the regulation and cellular functions of CoA Synthase. Doctoral thesis, UCL (University College London).

Shephard, EA; Phillips, IR; (2010) The potential of knockout mouse lines in defining the role of flavin-containing monooxygenases in drug metabolism. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY , 6 (9) pp. 1083-1094. 10.1517/17425255.2010.503705.

Smith, MEB; Schumacher, FF; Ryan, CP; Tedaldi, LM; Papaioannou, D; Waksman, G; Caddick, S; Smith, MEB; Schumacher, FF; Ryan, CP; Tedaldi, LM; Papaioannou, D; Waksman, G; Caddick, S; Baker, JR; - view fewer (2010) Protein Modification, Bioconjugation, and Disulfide Bridging Using Bromomaleimides. J AM CHEM SOC , 132 (6) 1960 - 1965. 10.1021/ja908610s.

Srai, SK; Chung, BM; Marks, J; Pourvali, K; Solanky, N; Rapisarda, C; Chaston, TB; ... Sharp, PA; + view all Srai, SK; Chung, BM; Marks, J; Pourvali, K; Solanky, N; Rapisarda, C; Chaston, TB; Hanif, R; Unwin, RJ; Debnam, ES; Sharp, PA; - view fewer (2010) Erythropoietin regulates intestinal iron absorption in a rat model of chronic renal failure. KIDNEY INT , 78 (7) 660 - 667. 10.1038/ki.2010.217.

Srai, SK; Sharp, PA; Marks, J; Unwin, RJ; Debnam, ES; (2010) The regulation of intestinal iron transport in a rat model of chronic renal failure. FASEB JOURNAL , 24

Stapleton, M; Haq, I; Hunt, DM; Arnvig, KB; Artymiuk, PJ; Buxton, RS; Green, J; (2010) Mycobacterium tuberculosis cAMP Receptor Protein (Rv3676) Differs from the Escherichia coli Paradigm in Its cAMP Binding and DNA Binding Properties and Transcription Activation Properties. JOURNAL OF BIOLOGICAL CHEMISTRY , 285 (10) pp. 7016-7027. 10.1074/jbc.M109.047720.

Sutto, L; D'Abramo, M; Luigi Gervasio, F; (2010) Comparing the Efficiency of Biased and Unbiased Molecular Dynamics in Reconstructing the Free Energy Landscape of Met-Enkephalin. JOURNAL OF CHEMICAL THEORY AND COMPUTATION , 6 (12) pp. 3640-3646. 10.1021/ct100413b.

Suzuki, Y; Holmes, JB; Cerritelli, SM; Sakhuja, K; Minczuk, M; Holt, IJ; Crouch, RJ; (2010) An upstream open reading frame and the context of the two AUG codons affect the abundance of mitochondrial and nuclear RNase H1. Mol Cell Biol , 30 (21) pp. 5123-5134. 10.1128/MCB.00619-10.

T

Taskent-Sezgin, H; Chung, J; Banerjee, PS; Nagarajan, S; Dyer, RB; Carrico, I; Raleigh, DP; (2010) Azidohomoalanine: A Conformationally Sensitive IR Probe of Protein Folding, Protein Structure, and Electrostatics. Angewandte Chemie International Edition , 49 (41) pp. 7473-7475. 10.1002/anie.201003325.

Tchepeleva, SN; Thurman, JM; Ruff, K; Perkins, SJ; Morel, L; Boackle, SA; (2010) An Allelic Variant of Crry in the Murine Sle1c Lupus Susceptibility Interval Is Not Impaired in Its Ability To Regulate Complement Activation. J IMMUNOL , 185 (4) 2331 - 2339. 10.4049/jimmunol.1000783.

Thiery, J; Keefe, D; Saffarian, S; Martinvalet, D; Walch, M; Boucrot, E; Kirchhausen, T; Thiery, J; Keefe, D; Saffarian, S; Martinvalet, D; Walch, M; Boucrot, E; Kirchhausen, T; Lieberman, J; - view fewer (2010) Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis. Blood , 115 (8) pp. 1582-1593. 10.1182/blood-2009-10-246116.

Thompson, KC; Rennie, AR; King, MD; Hardman, SJ; Lucas, CO; Pfrang, C; Hughes, BR; Thompson, KC; Rennie, AR; King, MD; Hardman, SJ; Lucas, CO; Pfrang, C; Hughes, BR; Hughes, AV; - view fewer (2010) Reaction of a phospholipid monolayer with gas-phase ozone at the air-water. Langmuir , 26 pp. 17295-17303. 10.1021/la1022714.

Thullier, P; Huish, O; Pelat, T; Martin, ACR; (2010) The Humanness of Macaque Antibody Sequences. J MOL BIOL , 396 (5) 1439 - 1450. 10.1016/j.jmb.2009.12.041.

Tomas, S; Milanesi, L; (2010) Mutual modulation between membrane-embedded receptor clustering and ligand binding in lipid membranes. NAT CHEM , 2 (12) 1077 - 1083. 10.1038/NCHEM.892.

Tsai, M.-L.; (2010) Structural investigation of human PP2A regulation by protein methylation. Doctoral thesis, UCL (University College London).

U

Urreizti, R; Moya-García, AA; Pino-Ángeles, A; Cozar, M; Langkilde, A; Fanhoe, U; Esteves, C; ... Balcells, S; + view all Urreizti, R; Moya-García, AA; Pino-Ángeles, A; Cozar, M; Langkilde, A; Fanhoe, U; Esteves, C; Arribas, J; Vilaseca, MA; Pérez-Dueñas, B; Pineda, M; González, V; Artuch, R; Baldellou, A; Vilarinho, L; Fowler, B; Ribes, A; Sánchez-Jiménez, F; Grinberg, D; Balcells, S; - view fewer (2010) Molecular characterization of five patients with homocystinuria due to severe methylenetetrahydrofolate reductase deficiency. Clin Genet , 78 (5) pp. 441-448. 10.1111/j.1399-0004.2010.01391.x.

V

Vassilopoulos, S; Esk, C; Hoshino, S; Brodsky, FM; (2010) The CHC22 human clathrin heavy chain isoform is involved in the cellular trafic of the glucose transporter GLUT4. M S-MEDECINE SCIENCES , 26 (1) pp. 33-36. 10.1051/medsci/201026133.

Vaughan, CK; Neckers, L; Piper, PW; (2010) Understanding of the Hsp90 molecular chaperone reaches new heights. NATURE STRUCTURAL & MOLECULAR BIOLOGY , 17 (12) pp. 1400-1404. 10.1038/nsmb1210-1400.

Virdee, S; Macmillan, D; Waksman, G; (2010) Semisynthetic Src SH2 Domains Demonstrate Altered Phosphopeptide Specificity Induced by Incorporation of Unnatural Lysine Derivatives. CHEM BIOL , 17 (3) 274 - 284. 10.1016/j.chembiol.2010.01.015.

W

Waksman, G; Fronzes, R; (2010) Molecular architecture of bacterial type IV secretion systems. TRENDS IN BIOCHEMICAL SCIENCES , 35 (12) pp. 691-698. 10.1016/j.tibs.2010.06.002.

Waksman, G; Fronzes, R; (2010) Molecular architecture of bacterial type IV secretion systems. Trends Biochem Sci , 35 (12) pp. 691-698. 10.1016/j.tibs.2010.06.002.

Wallden, K; Rivera-Calzada, A; Waksman, G; (2010) Type IV secretion systems: versatility and diversity in function. CELLULAR MICROBIOLOGY , 12 (9) pp. 1203-1212. 10.1111/j.1462-5822.2010.01499.x.

Wallden, K; Rivera-Calzeda, A; Waksman, G; (2010) Type IV secretion systems: diversity and versatility in function. Cell Microbiol.

Waudby, CA; Knowles, TPJ; Devlin, GL; Skepper, JN; Ecroyd, H; Carver, JA; Welland, ME; ... Meehan, S; + view all Waudby, CA; Knowles, TPJ; Devlin, GL; Skepper, JN; Ecroyd, H; Carver, JA; Welland, ME; Christodoulou, J; Dobson, CM; Meehan, S; - view fewer (2010) The Interaction of alpha B-Crystallin with Mature alpha-Synuclein Amyloid Fibrils Inhibits Their Elongation. BIOPHYS J , 98 (5) 843 - 851. 10.1016/j.bpj.2009.10.056.

Wilbur, JD; Hwang, PK; Brodsky, FM; Fletterick, RJ; (2010) Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain. Acta Crystallogr D Biol Crystallogr , 66 (Pt 3) pp. 314-318. 10.1107/S0907444909054535.

Wilbur, JD; Hwang, PK; Ybe, JA; Lane, M; Sellers, BD; Jacobson, MP; Fletterick, RJ; Wilbur, JD; Hwang, PK; Ybe, JA; Lane, M; Sellers, BD; Jacobson, MP; Fletterick, RJ; Brodsky, FM; - view fewer (2010) Conformation Switching of Clathrin Light Chain Regulates Clathrin Lattice Assembly. DEVELOPMENTAL CELL , 18 (5) pp. 841-848. 10.1016/j.devcel.2010.04.007.

Wu, H; Sun, L; Blombach, F; Brouns, SJJ; Snijders, APL; Lorenzen, K; van den Heuvel, RHH; ... van der Oost, J; + view all Wu, H; Sun, L; Blombach, F; Brouns, SJJ; Snijders, APL; Lorenzen, K; van den Heuvel, RHH; Heck, AJR; Fu, S; Li, XM; Zhang, XC; Rao, ZH; van der Oost, J; - view fewer (2010) Structure of the ribosome associating GTPase HflX. PROTEINS , 78 (3) 705 - 713. 10.1002/prot.22599.

Wyttenbach, T; Grabenauer, M; Thalassinos, K; Scrivens, JH; Bowers, MT; (2010) The Effect of Calcium Ions and Peptide Ligands on the Relative Stabilities of the Calmodulin Dumbbell and Compact Structures. J PHYS CHEM B , 114 (1) 437 - 447. 10.1021/jp906242m.

Y

Yeats, C; Redfern, O; ORENGO, C; (2010) A fast and automated solution for accurately resolving protein domain architectures. Bioinformatics , 26 (6) pp. 745-751. 10.1093/bioinformatics/btq034.

Yeats, C; Redfern, OC; Orengo, C; (2010) A fast and automated solution for accurately resolving protein domain architectures. BIOINFORMATICS , 26 (6) 745 - 751. 10.1093/bioinformatics/btq034.

Yeats, C; Redfern, OC; Orengo, C; (2010) A fast and automated solution for accurately resolving protein domain architectures. Bioinformatics , 26 (6) 745-51+-745-51+. 10.1093/bioinformatics/btq034%20%5Bdoi%5D.

Z

Zarrei, M; Wilkin, P; Ingrouille, M; Chase, MW; (2010) Gagea robusta (Liliaceae), a new species from Flora Iranica area. Kew Bulletin , 65 (2) pp. 327-336. 10.1007/s12225-010-9196-1.