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Number of items: 71.

A

Arkenau, HT; Kefford, R; Long, GV; (2011) Targeting BRAF for patients with melanoma. Br J Cancer , 104 (3) pp. 392-398. 10.1038/sj.bjc.6606030.

Arkenau, HT; Nordman, I; Dobbins, T; Ward, R; (2011) Reporting time-to-event endpoints and response rates in 4 decades of randomized controlled trials in advanced colorectal cancer. Cancer , 117 (4) pp. 832-840. 10.1002/cncr.25636.

B

Babu, B; Lee, M; Lee, L; Strobel, R; Brockway, O; Nickols, A; Sjoholm, R; (2011) Acetyl analogs of combretastatin A-4: Synthesis and biological studies. BIOORGAN MED CHEM , 19 (7) 2359 - 2367. 10.1016/j.bmc.2011.02.018.

Babu, B; Liu, Y; Plaunt, A; Riddering, C; Ogilvie, R; Westrate, L; Davis, R; (2011) Design, synthesis and DNA binding properties of orthogonally positioned diamino containing polyamide f-IPI. BIOCHEM BIOPH RES CO , 404 (3) 848 - 852. 10.1016/j.bbrc.2010.12.073.

Beltran, L; Chaussade, C; Vanhaesebroeck, B; Cutillas, PR; (2011) Calpain interacts with class IA phosphoinositide 3-kinases regulating their stability and signaling activity. Proc Natl Acad Sci U S A , 108 (39) pp. 16217-16222. 10.1073/pnas.1107692108.

Birkbak, NJ; Eklund, AC; Li, Q; McClelland, SE; Endesfelder, D; Tan, P; Tan, IB; (2011) Paradoxical relationship between chromosomal instability and survival outcome in cancer. Cancer Res , 71 (10) pp. 3447-3452. 10.1158/0008-5472.CAN-10-3667.

Brough, R; Frankum, JR; Sims, D; Mackay, A; Mendes-Pereira, AM; Bajrami, I; Costa-Cabral, S; (2011) Functional viability profiles of breast cancer. Cancer Discov , 1 (3) pp. 260-273. 10.1158/2159-8290.CD-11-0107.

Brown, NF; Marks, DJ; Smith, PJ; Bloom, SL; (2011) Splenomegaly. Br J Hosp Med (Lond) , 72 (11) M166-M169.

Brucoli, F; Hawkins, RM; James, CH; Wells, G; Jenkins, TC; Ellis, T; Hartley, JA; (2011) Novel C8-linked pyrrolobenzodiazepine (PBD)-heterocycle conjugates that recognize DNA sequences containing an inverted CCAAT box. BIOORG MED CHEM LETT , 21 (12) 3780 - 3783. 10.1016/j.bmcl.2011.04.054.

C

Calvert, H; Azzariti, A; (2011) The clinical development of inhibitors of poly(ADP-ribose) polymerase. ANNALS OF ONCOLOGY , 22 i53 - i59. 10.1093/annonc/mdq667.

Chavda, S; Liu, Y; Babu, B; Davis, R; Sielaff, A; Ruprich, J; Westrate, L; (2011) Hx, a Novel Fluorescent, Minor Groove and Sequence Specific Recognition Element: Design, Synthesis, and DNA Binding Properties of p-Anisylbenzimidazole-imidazole/pyrrole-Containing Polyamides. BIOCHEMISTRY-US , 50 (15) 3127 - 3136. 10.1021/bi102028a.

Coward, J; Kulbe, H; Chakravarty, P; Leader, D; Vassileva, V; Leinster, DA; Thompson, R; (2011) Interleukin-6 as a Therapeutic Target in Human Ovarian Cancer. CLINICAL CANCER RESEARCH , 17 (18) pp. 6083-6096. 10.1158/1078-0432.CCR-11-0945.

D

De Bono, JS; Logothetis, CJ; Molina, A; Fizazi, K; North, S; Chu, L; Chi, KN; (2011) Abiraterone and Increased Survival in Metastatic Prostate Cancer. NEW ENGLAND JOURNAL OF MEDICINE , 364 (21) pp. 1995-2005.

E

Endesfelder, D; McGranahan, N; Birkbak, NJ; Szallasi, Z; Kschischo, M; Graham, TA; Swanton, C; (2011) A breast cancer meta-analysis of two expression measures of chromosomal instability reveals a relationship with younger age at diagnosis and high risk histopathological variables. ONCOTARGET , 2 (7) pp. 529-537.

F

Feng, H; Hu, B; Liu, KW; Li, Y; Lu, X; Cheng, T; Yiin, JJ; (2011) Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans. J Clin Invest , 121 (12) pp. 4670-4684. 10.1172/JCI58559.

Fenton, TR; Gout, IT; (2011) Functions and regulation of the 70 kDa ribosomal S6 kinases. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY , 43 (1) pp. 47-59. 10.1016/j.bioce1.2010.09.018.

Forster, MD; Dedes, KJ; Sandhu, S; Frentzas, S; Kristeleit, R; Ashworth, A; Poole, CJ; (2011) Treatment with olaparib in a patient with PTEN-deficient endometrioid endometrial cancer. Nat Rev Clin Oncol , 8 (5) pp. 302-306. 10.1038/nrclinonc.2011.42.

Furstenberg, A; Walsh, SB; Howie, A; Jones, G; Unwin, RJ; (2011) Calcineurin-Inhibitor Induced Hypertension, Hyperkalaemia and Metabolic Acidosis Is Caused by Overactivity of the Sodium Chloride Cotransporter. In: AMERICAN JOURNAL OF TRANSPLANTATION. (pp. 406 - 406). WILEY-BLACKWELL

G

Gillmore, R; Stuart, S; Kirkwood, A; Hameeduddin, A; Woodward, N; Burroughs, AK; Meyer, T; (2011) EASL and mRECIST responses are independent prognostic factors for survival in hepatocellular cancer patients treated with transarterial embolisation. JOURNAL OF HEPATOLOGY , 55 (6) pp. 1309-1316.

Golubnitschaja, O; Swanton, C; Danesi, R; Costigliola, V; (2011) Promoting predictive, preventive and personalised medicine: European event of global importance. EPMA J , 2 (2) pp. 131-136. 10.1007/s13167-011-0088-8.

Grimmett, C; Bridgewater, J; Steptoe, A; Wardle, J; (2011) Lifestyle and quality of life in colorectal cancer survivors. QUAL LIFE RES , 20 (8) 1237 - 1245. 10.1007/s11136-011-9855-1.

Gunaratnam, M; de la Fuente, M; Hampel, SM; Todd, AK; Reszka, AP; Schätzlein, A; Neidle, S; (2011) Targeting pancreatic cancer with a G-quadruplex ligand. Bioorg Med Chem , 19 (23) pp. 7151-7157. 10.1016/j.bmc.2011.09.055.

H

Hartley, JA; (2011) The development of pyrrolobenzodiazepines as antitumour agents. EXPERT OPIN INV DRUG , 20 (6) 733 - 744. 10.1517/13543784.2011.573477.

Haylock-Jacobs, S; Comerford, I; Bunting, M; Kara, E; Townley, S; Klingler-Hoffmann, M; Vanhaesebroeck, B; (2011) PI3Kδ drives the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting effector T cell apoptosis and promoting Th17 differentiation. J Autoimmun , 36 (3-4) pp. 278-287. 10.1016/j.jaut.2011.02.006.

Hochdörfer, T; Kuhny, M; Zorn, CN; Hendriks, RW; Vanhaesebroeck, B; Bohnacker, T; Krystal, G; (2011) Activation of the PI3K pathway increases TLR-induced TNF-α and IL-6 but reduces IL-1β production in mast cells. Cell Signal , 23 (5) pp. 866-875. 10.1016/j.cellsig.2011.01.012.

Hoorn, EJ; Walsh, SB; McCormick, JA; Furstenberg, A; Yang, CL; Roeschel, T; Paliege, A; (2011) The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension. NAT MED , 17 (10) 1304 - U339. 10.1038/nm.2497.

J

Jiao, Y; Lawler, K; Patel, GS; Purushotham, A; Jones, AF; Grigoriadis, A; Tutt, A; (2011) DART: Denoising Algorithm based on Relevance network Topology improves molecular pathway activity inference. BMC BIOINFORMATICS , 12 (ARTN 403) 10.1186/1471-2105-12-403. Gold open access

Juergens, H; Daw, NC; Geoerger, B; Ferrari, S; Villarroel, M; Aerts, I; Whelan, J; (2011) Preliminary Efficacy of the Anti-Insulin-Like Growth Factor Type 1 Receptor Antibody Figitumumab in Patients With Refractory Ewing Sarcoma. JOURNAL OF CLINICAL ONCOLOGY , 29 (34) pp. 4534-4540. 10.1200/JCO.2010.33.0670.

K

Kato, H; Seto, K; Kobayashi, N; Yoshinaga, K; Meyer, T; Takei, M; (2011) CCK-2/gastrin receptor signaling pathway is significant for gemcitabine-induced gene expression of VEGF in pancreatic carcinoma cells. LIFE SCI , 89 (17-18) 603 - 608. 10.1016/j.lfs.2011.07.019.

Khan, MS; Tsigani, T; Rashid, M; Rabouhans, JS; Yu, D; Tu, VL; Caplin, M; (2011) Circulating Tumor Cells and EpCAM Expression in Neuroendocrine Tumors. CLIN CANCER RES , 17 (2) 337 - 345. 10.1158/1078-0432.CCR-10-1776.

Kudsiova, L; Ho, J; Fridrich, B; Harvey, R; Keppler, M; Ng, T; Hart, SL; (2011) Lipid chain geometry of C14 glycerol-based lipids: effect on lipoplex structure and transfection. MOL BIOSYST , 7 (2) 422 - 436. 10.1039/c0mb00149j.

Kulkarni, S; Sitaru, C; Jakus, Z; Anderson, KE; Damoulakis, G; Davidson, K; Hirose, M; (2011) PI3Kβ plays a critical role in neutrophil activation by immune complexes. Sci Signal , 4 (168) ra23-. 10.1126/scisignal.2001617.

L

Ledermann, JA; Raja, FA; (2011) Clinical trials and decision-making strategies for optimal treatment of relapsed ovarian cancer. EUROPEAN JOURNAL OF CANCER , 47 S104-S115.

Lee, AJ; Endesfelder, D; Rowan, AJ; Walther, A; Birkbak, NJ; Futreal, PA; Downward, J; (2011) Chromosomal instability confers intrinsic multidrug resistance. Cancer Res , 71 (5) pp. 1858-1870. 10.1158/0008-5472.CAN-10-3604.

Leoni, LM; Hartley, JA; (2011) Mechanism of Action: The Unique Pattern of Bendamustine-Induced Cytotoxicity. SEMIN HEMATOL , 48 (2) S12 - S23. 10.1053/j.seminhematol.2011.03.003.

Liccardi, G; Hartley, JA; Hochhauser, D; (2011) EGFR Nuclear Translocation Modulates DNA Repair following Cisplatin and Ionizing Radiation Treatment. CANCER RES , 71 (3) 1103 - 1114. 10.1158/0008-5472.CAN-10-2384. Gold open access

Liccardi, G.; (2011) Nuclear EGFR modulation of DNA repair. Doctoral thesis, UCL (University College London). Green open access
file

Lin, S; Kiakos, K; Lee, M; Hochhauser, D; Hartley, JA; (2011) Targeting the Mlul cell cycle box (MCB) sequence 5 '-ACGCGT-3 ' in the human Dbf4 promoter using the rationally designed polyamide formamido-imidazole-pyrrole-imidazole (f-IPI). CANCER RESEARCH , 71 10.1158/1538-7445.AM2011-665.

Liu, H; Wang, W; Chew, SK; Lee, SC; Li, J; Vassiliou, GS; Green, T; (2011) Stella-Cre mice are highly efficient Cre deleters. Genesis , 49 (8) pp. 689-695. 10.1002/dvg.20741.

Lolkema, MP; Arkenau, HT; Harrington, K; Roxburgh, P; Morrison, R; Roulstone, V; Twigger, K; (2011) A phase I study of the combination of intravenous reovirus type 3 Dearing and gemcitabine in patients with advanced cancer. Clin Cancer Res , 17 (3) pp. 581-588. 10.1158/1078-0432.CCR-10-2159.

Lowe, H.L.; (2011) Design, construction and evaluation of a humanised ADEPT system. Doctoral thesis, UCL (University College London).

M

Mahadevan, D; Plummer, R; Squires, MS; Rensvold, D; Kurtin, S; Pretzinger, C; Dragovich, T; (2011) A phase I pharmacokinetic and pharmacodynamic study of AT7519, a cyclin-dependent kinase inhibitor in patients with refractory solid tumors. ANN ONCOL , 22 (9) 2137 - 2143. 10.1093/annonc/mdq734.

Marsh, D; Suchak, K; Moutasim, KA; Vallath, S; Hopper, C; Jerjes, W; Upile, T; (2011) Stromal features are predictive of disease mortality in oral cancer patients. J PATHOL , 223 (4) 470 - 481. 10.1002/path.2830.

Maughan, TS; Adams, RA; Smith, CG; Meade, AM; Seymour, MT; Wilson, RH; Idziaszczyk, S; (2011) Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. Lancet , 377 (9783) pp. 2103-2114. 10.1016/S0140-6736(11)60613-2.

McCaughan, F; Pipinikas, CP; Janes, SM; George, PJ; Rabbitts, PH; Dear, PH; (2011) Genomic evidence of pre-invasive clonal expansion, dispersal and progression in bronchial dysplasia. J PATHOL , 224 (2) 153 - 159. 10.1002/path.2887.

O

Osawa, T; Davies, D; Hartley, JA; (2011) Mechanism of cell death resulting from DNA interstrand cross-linking in mammalian cells. CELL DEATH DIS , 2 , Article e187. 10.1038/cddis.2011.70. Gold open access

P

Pacey, S; Wilson, RH; Walton, M; Eatock, MM; Hardcastle, A; Zetterlund, A; Arkenau, HT; (2011) A phase I study of the heat shock protein 90 inhibitor alvespimycin (17-DMAG) given intravenously to patients with advanced solid tumors. Clin Cancer Res , 17 (6) pp. 1561-1570. 10.1158/1078-0432.CCR-10-1927.

Plummer, R; Wilson, RH; Calvert, H; Boddy, AV; Griffin, M; Sludden, J; Tilby, MJ; (2011) A Phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours. BRIT J CANCER , 104 (4) 593 - 598. 10.1038/bjc.2011.6.

Pors, K; Loadman, PM; Shnyder, SD; Sutherland, M; Sheldrake, HM; Guino, M; Kiakos, K; (2011) Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity. CHEM COMMUN , 47 (44) 12062 - 12064. 10.1039/c1cc15638a.

Puzanov, I; Lee, W; Chen, AP; Calcutt, MW; Hachey, DL; Vermeulen, WL; Spanswick, VJ; (2011) Phase I Pharmacokinetic and Pharmacodynamic Study of SJG-136, a Novel DNA Sequence Selective Minor Groove Cross-linking Agent, in Advanced Solid Tumors. CLIN CANCER RES , 17 (11) 3794 - 3802. 10.1158/1078-0432.CCR-10-2056.

R

Raja, FA; Griffin, CL; Qian, W; Hirte, H; Parmar, MK; Swart, AM; Ledermann, JA; (2011) Initial toxicity assessment of ICON6: a randomised trial of cediranib plus chemotherapy in platinum-sensitive relapsed ovarian cancer. BRIT J CANCER , 105 (7) 884 - 889. 10.1038/bjc.2011.334.

Reid, JM; Buhrow, SA; Kuffel, MJ; Jia, L; Spanswick, VJ; Hartley, JA; Thurston, DE; (2011) Pharmacokinetics, pharmacodynamics and metabolism of the dimeric pyrrolobenzodiazepine SJG-136 in rats. CANCER CHEMOTH PHARM , 68 (3) 777 - 786. 10.1007/s00280-010-1517-4.

Roylance, R; Endesfelder, D; Gorman, P; Burrell, RA; Sander, J; Tomlinson, I; Hanby, AM; (2011) Relationship of extreme chromosomal instability with long-term survival in a retrospective analysis of primary breast cancer. Cancer Epidemiol Biomarkers Prev , 20 (10) pp. 2183-2194. 10.1158/1055-9965.EPI-11-0343.

S

Saravanan, K; Barlow, HC; Barton, M; Calvert, AH; Golding, BT; Newell, DR; Northen, JS; (2011) Nucleoside Transport Inhibitors: Structure-Activity Relationships for Pyrimido[5,4-d]pyrimidine Derivatives That Potentiate Pemetrexed Cytotoxicity in the Presence of alpha(1)-Acid Glycoprotein. J MED CHEM , 54 (6) 1847 - 1859. 10.1021/jm101493z.

Short, SC; Giampieri, S; Worku, M; Alcaide-German, M; Sioftanos, G; Bourne, S; Lio, KI; (2011) Rad51 inhibition is an effective means of targeting DNA repair in glioma models and CD133+tumor-derived cells. NEURO-ONCOLOGY , 13 (5) pp. 487-499. 10.1093/neuonc/nor010.

Siddiqui, GK; Maclean, AB; Elmasry, K; Fong, AWT; Morris, RW; Rashid, M; Begent, RHJ; (2011) Immunohistochemical expression of VEGF predicts response to platinum based chemotherapy in patients with epithelial ovarian cancer. ANGIOGENESIS , 14 (2) 155 - 161. 10.1007/s10456-010-9199-4.

Sivabalasingham, S; Fersht, N; D'Souza, D; Rosenberg, I; Stacey, C; Davies, P; Guerro-Urbano, T; (2011) Preliminary Results from a Phase I/II Study of Intensity Modulated Radiotherapy in the Treatment of Meningiomas. CLIN ONCOL-UK , 23 (3) S53 - S53.

Smith, SW; Eardley, KS; Croft, AP; Nwosu, J; Howie, AJ; Cockwell, P; Isacke, CM; (2011) CD248(+) stromal cells are associated with progressive chronic kidney disease. KIDNEY INTERNATIONAL , 80 (2) pp. 200-208. 10.1038/ki.2011.103.

T

Taylor, RM; Fern, L; Whelan, J; Pearce, S; Grew, T; Millington, H; Ashton, J; (2011) "Your Place or Mine?'' Priorities for a Specialist Teenage and Young Adult (TYA) Cancer Unit: Disparity Between TYA and Professional Perceptions. JOURNAL OF ADOLESCENT AND YOUNG ADULT ONCOLOGY , 1 (3) pp. 145-151. 10.1089/jayao.2011.0037.

Taylor, RM; Grieve, A; Gibson, F; Dhawan, A; Franck, LS; (2011) Parental assessment of adolescent quality of life: can it replace self-assessment? QUALITY OF LIFE RESEARCH , 20 (10) pp. 1715-1720. 10.1007/s11136-011-9904-9.

Thirlwell, C; Schulz, LKE; Dibra, HK; Beck, S; (2011) Suffocating cancer: hypoxia-associated epimutations as targets for cancer therapy. CLINICAL EPIGENETICS , 3 (ARTN 9) 10.1186/1868-7083-3-9.

V

Vladimirou, E; Harry, E; Burroughs, N; McAinsh, AD; (2011) Springs, clutches and motors: driving forward kinetochore mechanism by modelling. Chromosome Res , 19 (3) pp. 409-421. 10.1007/s10577-011-9191-x.

van Zyl-Smit, RN; Binder, A; Meldau, R; Mishra, H; Semple, PL; Theron, G; Peter, J; (2011) Comparison of Quantitative Techniques including Xpert MTB/RIF to Evaluate Mycobacterial Burden. PLOS ONE , 6 (12) , Article e28815. 10.1371/journal.pone.0028815. Green open access
file

von Minckwitz, G; Schwedler, K; Schmidt, M; Barinoff, J; Mundhenke, C; Cufer, T; Maartense, E; (2011) Trastuzumab beyond progression: overall survival analysis of the GBG 26/BIG 3-05 phase III study in HER2-positive breast cancer. Eur J Cancer , 47 (15) pp. 2273-2281. 10.1016/j.ejca.2011.06.021.

W

Wang, AT; Sengerova, B; Cattell, E; Inagawa, T; Hartley, JM; Kiakos, K; Burgess-Brown, NA; (2011) Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair. GENE DEV , 25 (17) 1859 - 1870. 10.1101/gad.15699211.

Wang, XD; Lapi, E; Sullivan, A; Ratnayaka, I; Goldin, R; Hay, R; Lu, X; (2011) SUMO-modified nuclear cyclin D1 bypasses Ras-induced senescence. Cell Death Differ , 18 (2) pp. 304-314. 10.1038/cdd.2010.101.

Wen, PJ; Osborne, SL; Zanin, M; Low, PC; Wang, HT; Schoenwaelder, SM; Jackson, SP; (2011) Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells. Nat Commun , 2 491-. 10.1038/ncomms1500.

Westbury, CB; Sahlberg, KK; Borresen-Dale, AL; Isacke, CM; Yarnold, JR; (2011) Gene expression profiling of human dermal fibroblasts exposed to bleomycin sulphate does not differentiate between radiation sensitive and control patients. RADIAT ONCOL , 6 , Article 42. 10.1186/1748-717X-6-42. Gold open access

Whiteford, JR; Xian, X; Chaussade, C; Vanhaesebroeck, B; Nourshargh, S; Couchman, JR; (2011) Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148. Mol Biol Cell , 22 (19) pp. 3609-3624. 10.1091/mbc.E11-02-0099.

Y

Young, RJ; Tin, A; Brown, NJ; Staton, C; Lee, SM; Jital, M; Woll, P; (2011) SERUM BIOMARKERS IN LUNG CANCER PATIENTS FROM TWO CLINICAL TRIALS OF CHEMOTHERAPY WITH OR WITHOUT THALIDOMIDE. JOURNAL OF THORACIC ONCOLOGY , 6 (6) S1058-S1059.

Z

Zhang, EZ; Povazay, B; Laufer, J; Alex, A; Hofer, B; Pedley, B; Glittenberg, C; (2011) Multimodal photoacoustic and optical coherence tomography scanner using an all optical detection scheme for 3D morphological skin imaging. BIOMEDICAL OPTICS EXPRESS , 2 (8) pp. 2202-2215.

This list was generated on Sun Dec 4 03:35:57 2016 GMT.