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Number of items: 47.


Bagshawe, KD; Sharma, SK; (1996) Cyclosporine delays host immune response to antibody enzyme conjugate in ADEPT. In: (Proceedings) 2nd International Conference on New Trends in Clinical and Experimental Immunosuppression. (pp. pp. 3156-3158). APPLETON & LANGE

Bingham, JP; Hartley, JA; Souhami, RL; Grimaldi, KA; (1996) Strand-specific measurement of cisplatin-induced DNA damage and repair using quantitative PCR. NUCLEIC ACIDS RES , 24 (5) 987 - 989. Gold open access

Blakey, DC; Burke, PJ; Davies, DH; Dowell, RI; East, SJ; Eckersley, KP; Fitton, JE; (1996) ZD2767, an improved system for antibody-directed enzyme prodrug therapy that results in tumor regressions in colorectal tumor xenografts. CANCER RESEARCH , 56 (14) pp. 3287-3292.

Butler, J; Spanswick, VJ; Cummings, J; (1996) The autoxidation of the reduced forms of EO9. FREE RADICAL RES , 25 (2) 141 - 148.


Carter, WG; Sullivan, AC; Asamoah, KA; Sale, GJ; (1996) Purification and Characterization of an Insulin-Stimulated Insulin Receptor Serine Kinase †. Biochemistry , 35 (45) pp. 14340-14351. 10.1021/bi960732x.


Dahl, AM; Beverley, PCL; Stauss, HJ; (1996) A synthetic peptide derived from the tumor-associated protein mdm2 can stimulate autoreactive, high avidity cytotoxic T lymphocytes that recognize naturally processed protein. J IMMUNOL , 157 (1) 239 - 246.

Delgado, C; Pedley, RB; Herraez, A; Boden, R; Boden, JA; Keep, PA; Chester, KA; (1996) Enhanced tumour specificity of an anti-carcinoembrionic antigen Fab' fragment by poly(ethylene glycol) (PEG) modification. BRIT J CANCER , 73 (2) 175 - 182.


EnoAmooquaye, EA; Searle, F; Boden, JA; Sharma, SK; Burke, PJ; (1996) Altered biodistribution of an antibody-enzyme conjugate modified with polyethylene glycol. BRITISH JOURNAL OF CANCER , 73 (11) pp. 1323-1327. 10.1038/bjc.1996.253.


GhazalAswad, S; Calvert, AH; Newell, DR; (1996) A single sample assay for the estimation of the area under the free carboplatin plasma concentration versus time curve. CANCER CHEMOTH PHARM , 37 (5) 429 - 434.

GhazalAswad, S; Hogarth, L; Hall, AG; George, M; Sinha, DP; Lind, M; Calvert, AH; (1996) The relationship between tumour glutathione concentration, glutathione S-transferase isoenzyme expression and response to single agent carboplatin in epithelial ovarian cancer patients. BRIT J CANCER , 74 (3) 468 - 473.

Gombert, W; Borthwick, NJ; Wallace, DL; Hyde, H; Bofill, M; Pilling, D; Beverley, PCL; (1996) Fibroblasts prevent apoptosis of IL-2-deprived T cells without inducing proliferation: A selective effect on Bcl-x(L) expression. IMMUNOLOGY , 89 (3) 397 - 404.


Henstra, SA; Tolner, B; Duurkens, RHT; Konings, WN; Robillard, GT; (1996) Cloning, expression, and isolation of the mannitol transport protein from the thermophilic bacterium Bacillus stearothermophilus. J BACTERIOL , 178 (19) 5586 - 5591.

Highley, MS; Samandas, N; Ziras, N; Morgan, MM; Hill, ME; Stein, R; Barker, S; (1996) A phase II study of ifosfamide and bleomycin in advanced or recurrent cervical carcinoma. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER , 6 (4) pp. 323-327. 10.1046/j.1525-1438.1996.06040323.x.

Hochhauser, D; Schnieders, B; ErcikanAbali, E; Gorlick, R; MuiseHelmericks, R; Li, WW; Fan, JG; (1996) Effect of cyclin D1 overexpression on drug sensitivity in a human fibrosarcoma cell line. J NATL CANCER I , 88 (18) 1269 - 1275.


Köberle, B; Payne, J; Grimaldi, KA; Hartley, JA; Masters, JR; (1996) DNA repair in cisplatin-sensitive and resistant human cell lines measured in specific genes by quantitative polymerase chain reaction. Biochem Pharmacol , 52 (11) pp. 1729-1734.


Laohavinij, S; Wedge, SR; Lind, MJ; Bailey, N; Humphrey, A; Proctor, M; Chapman, F; (1996) A Phase I clinical study of the antipurine antifolate lometrexol (DDATHF) given with oral folic acid. INVEST NEW DRUG , 14 (3) 325 - 335.

Lee, M; Simpson, JE; Burns, AJ; Kupchinsky, S; Brooks, N; Hartley, JA; Kelland, LR; (1996) Novel platinum(II) derivatives of analogues of netropsin and distamycin: Synthesis, DNA binding and cytotoxic properties. MED CHEM RES , 6 (6) 365 - 371.

Lee, SM; Portmann, B; Margison, GP; (1996) Abnormal intracellular distribution of 06-alkylguanine-DNA-alkyltransferase in hepatitis B cirrhotic human liver: A potential cofactor in the development of hepatocellular carcinoma. Hepatology , 24 (5) pp. 987-990.

Lee, SM; Portmann, B; Margison, GP; (1996) Abnormal intracellular distribution of 06-alkylguanine-DNA-alkyltransferase in hepatitis-B cirrhotic human liver: a potential cofactor in the development of hepatocellular carcinoma. In: (pp. 24-).

Lee, SM; Radford, JA; Ryder, WDJ; Crowther, D; (1996) Prognostic factors for disease progression in advanced Hodgkin's disease. In: (Proceedings) VIth International Conference on Malignant Lymphoma, Lugano.. (pp. 52-). Annals of Oncology

Lee, SM; Reid, H; Elder, RH; Thatcher, N; Margison, GP; (1996) Inter- and intracellular heterogeneity of O6-alkylguanine-DNA alkyltransferase expression in human brain tumors: possible significance in nitrosourea therapy. Carcinogenesis , 17 (4) pp. 637-641.

Lind, MJ; GhazalAswad, S; Gumbrell, L; Fishwick, K; Craigs, D; Millward, MJ; Bailey, NP; (1996) Phase I study of pharmacologically based dosing of carboplatin with filgrastim support in women with epithelial ovarian cancer. J CLIN ONCOL , 14 (3) 800 - 805.

Loflin, PT; Altschuler, E; Hochhauser, D; Hickson, ID; Zwelling, LA; (1996) Phorbol ester-induced down-regulation of topoisomerase II alpha mRNA in a human erythroleukemia cell line - Evidence for a post-transcriptional mechanism. BIOCHEM PHARMACOL , 52 (7) 1065 - 1072.


Margison, GP; Rafferty, JA; Elder, RH; Kelly, J; Watson, AJ; Willington, MA; Lee, SM; (1996) Modulating nitrosourea response in tumors and normal tissue: application to fotemustine. Drugs of Today , 32 (Jan) pp. 51-59.

Mayalarp, SP; Hargreaves, RHJ; Butler, J; OHare, CC; Hartley, JA; (1996) Cross-linking and sequence specific alkylation of DNA by aziridinylquinones .1.. Quinone methides. J MED CHEM , 39 (2) 531 - 537.

Michael, NP; Chester, KA; Melton, RG; Robson, L; Nicholas, W; Boden, JA; Pedley, RB; (1996) In vitro and in vivo characterisation of a recombinant carboxypeptidase G(2)::anti-CEA scFv fusion protein. IMMUNOTECHNOLOGY , 2 (1) 47 - 57.

Mummaneni, V; Kaul, S; Igwemezie, LN; Newell, DR; Porter, D; Thomas, H; Calvert, AH; (1996) Bioequivalence assessment of etoposide phosphate and etoposide using pharmacodynamic and traditional pharmacokinetic parameters. J PHARMACOKINET BIOP , 24 (4) 313 - 325.


Pantaloni, C; Brabet, P; Bilanges, B; Dumuis, A; Houssami, S; Spengler, D; Bockaert, J; (1996) Alternative splicing in the N-terminal extracellular domain of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor modulates receptor selectivity and relative potencies of PACAP-27 and PACAP-38 in phospholipase C activation. J Biol Chem , 271 (36) pp. 22146-22151.

Pedley, RB; Boden, JA; Boden, R; Boxer, GM; Flynn, AA; Keep, PA; Begent, RHJ; (1996) Ablation of colorectal xenografts with combined radioimmunotherapy and tumor blood flow-modifying agents. CANCER RES , 56 (14) 3293 - 3300.

Porter, D; Boddy, A; Thomas, H; Lind, M; Newell, D; Calvert, AH; Robson, L; (1996) Etoposide phosphate infusion with therapeutic drug monitoring in combination with carboplatin dosed by area under the curve: A cancer research campaign phase I/II committee study. SEMIN ONCOL , 23 (6) 34 - 44.


RodriguezViciana, P; Warne, PH; Vanhaesebroeck, B; Waterfield, MD; Downward, J; (1996) Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation. EMBO JOURNAL , 15 (10) pp. 2442-2451.


Sandri, MI; Hochhauser, D; Ayton, P; Camplejohn, RC; Whitehouse, R; Turley, H; Gatter, K; (1996) Differential expression of the topoisomerase II alpha and beta genes in human breast cancers. BRIT J CANCER , 73 (12) 1518 - 1524.

Seidman, AD; Hochhauser, D; Gollub, M; Edelman, B; Yao, TJ; Hudis, CA; Francis, P; (1996) Ninety-six-hour paclitaxel infusion after progression during short taxane exposure: A phase II pharmacokinetic and pharmacodynamic study in metastatic breast cancer. J CLIN ONCOL , 14 (6) 1877 - 1884.

Sharma, SK; Bagshawe, KD; Melton, RG; Begent, RHJ; (1996) Effect of cyclosporine on immunogenicity of a bacterial enzyme carboxypeptidase G2 in ADEPT. In: (Proceedings) 2nd International Conference on New Trends in Clinical and Experimental Immunosuppression. (pp. pp. 3154-3155). APPLETON & LANGE

Shaw, JE; Kristeleit, RS; Hollis, S; Gokal, R; Boulton, AJ; (1996) Gustatory Sweating in Diabetes Mellitus. Diabetic Medicine , 13 (12) pp. 1033-1037.

Short, S; Chatterverdi, A; Leslie, M; (1996) The treatment of adrenal metastases. Clinical Oncology , 8 pp. 387-389.

Sigalas, I; Calvert, AH; Anderson, JJ; Neal, DE; Lunec, J; (1996) Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: Transforming ability and frequent detection in human cancer. NAT MED , 2 (8) 912 - 917.

Spanswick, VJ; Cummings, J; Smyth, JF; (1996) Enzymology of mitomycin C metabolic activation in tumour tissue - Characterization of a novel mitochondrial reductase. BIOCHEM PHARMACOL , 51 (12) 1623 - 1630.

Sunters, A; Grimaldi, KA; Souhami, RL; Hartley, JA; (1996) The use of alpha-DNA as an internal standard in the detection and quantitation of DNA damage in specific genes using Southern blotting. NUCLEIC ACIDS RES , 24 (12) 2456 - 2457. Gold open access


Thurston, DE; Bose, DS; Thompson, AS; Howard, PW; Leoni, A; Croker, SJ; Jenkins, TC; (1996) Synthesis of sequence-selective C8-linked pyrrolo[2,1-c][1,4]benzodiazepine DNA interstrand cross-linking agents. J ORG CHEM , 61 (23) 8141 - 8147.


Vanhaesebroeck, B; Kotani, K; Stein, RC; Svolinia, ; Downward, J; Waterfield, MD; (1996) PI 108, A novel human phosphoinositide 3-kinase. FASEB Journal , 10 (6)

Vanhaesebroeck, B; Stein, RC; Waterfield, MD; (1996) The study of phosphoinositide 3-kinase function. CANCER SURVEYS , 27 pp. 249-270.

Verhaar, MJ; Keep, PA; Hawkins, RE; Robson, L; Casey, JL; Pedley, B; Boden, JA; (1996) Technetium-99m radiolabeling using a phage-derived single-chain Fv with a C-terminal cysteine. Journal of Nuclear Medicine , 37 (5) pp. 868-872.


Waterfield, MD; MacDougall, L; Gout, I; Vanhaesebroeck, B; Domin, J; Pages, F; Panaretou, C; (1996) The PI 3 kinase family - Diversity in substrate specificity and activation mechanisms. FASEB JOURNAL , 10 (6) p. 1604.

Woll, PJ; Lee, SM; Lomax, L; Hodgetts, J; Stout, R; Burn, PA; Sims, T; (1996) Randomised phase II study of standard versus dose-intensive ICE chemotherapy with reinfusion of haemopoietic progenitors in whole blood in small cell lung cancer (SCLC). In: (Proceedings) Oral presentation. 1996 ASCO Annual Meeting, Philadelphia, Pennsylvania.. (pp. 333-). Proceedings of the American Society of Clinical Oncology

Wymann, MP; BulgarelliLeva, G; Zvelebil, MJ; Pirola, L; Vanhaesebroeck, B; Waterfield, MD; Panayotou, G; (1996) Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction. MOLECULAR AND CELLULAR BIOLOGY , 16 (4) pp. 1722-1733.


Zvelebil, MJ; MacDougall, L; Leevers, S; Volinia, S; Vanhaesebroeck, B; Gout, I; Panayotou, G; (1996) Structural and functional diversity of phosphoinositide 3-kinases. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES , 351 (1336) pp. 217-223. 10.1098/rstb.1996.0019.

This list was generated on Sun Mar 26 03:57:52 2017 BST.