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Number of items: 70.

B

BAILEY, N; CALVERT, H; (1995) ROLE OF TAXANES IN CANCER-THERAPY. BRIT J HOSP MED , 53 (1-2) 10 - 13.

BANERJEE, D; LENZ, HJ; SCHNIEDERS, B; MANNO, DJ; JU, JF; SPEARS, CP; HOCHHAUSER, D; ... BERTINO, JR; + view all (1995) TRANSFECTION OF WILD-TYPE BUT NOT MUTANT P53 INDUCES EARLY MONOCYTIC DIFFERENTIATION IN HL-60 CELLS AND INCREASES THEIR SENSITIVITY TO STRESS. CELL GROWTH DIFFER , 6 (11) 1405 - 1413.

BLAKEY, DC; DAVIES, DH; DOWELL, RI; EAST, SJ; BURKE, PJ; SHARMA, SK; SPRINGER, CJ; ... MELTON, RG; + view all (1995) ANTITUMOR EFFECTS OF AN ANTIBODY-CARBOXYPEPTIDASE G2 CONJUGATE IN COMBINATION WITH PHENOL MUSTARD PRODRUGS. BRITISH JOURNAL OF CANCER , 72 (5) pp. 1083-1088. 10.1038/bjc.1995.469.

BLEEHEN, NM; NEWLANDS, ES; LEE, SM; THATCHER, N; SELBY, P; CALVERT, AH; RUSTIN, GJS; ... STEVENS, MFG; + view all (1995) CANCER-RESEARCH CAMPAIGN PHASE-II TRIAL OF TEMOZOLOMIDE IN METASTATIC MELANOMA. J CLIN ONCOL , 13 (4) 910 - 913.

BROGGINI, M; COLEY, HM; MONGELLI, N; PESENTI, E; WYATT, MD; HARTLEY, JA; DINCALCI, M; (1995) DNA SEQUENCE-SPECIFIC ADENINE ALKYLATION BY THE NOVEL ANTITUMOR DRUG TALLIMUSTINE (FCE-24517), A BENZOYL NITROGEN-MUSTARD DERIVATIVE OF DISTAMYCIN. NUCLEIC ACIDS RES , 23 (1) 81 - 87. Gold open access

Bailey, N; Humphreys, A; Laohavinij, S; Lind, M; Robson, L; Calvert, A; (1995) Oral folic acid improves lometrexol toxicity profile: A phase I study. EUR J CANCER , 31A 931 - 931.

Banerjee, D; ErcikanAbali, E; Waltham, M; Schnieders, B; Hochhauser, D; Li, WW; Fan, JG; ... Bertino, JR; + view all (1995) Molecular mechanisms of resistance to antifolates, a review. ACTA BIOCHIMICA POLONICA , 42 (4) 457 - 464. Gold open access

Begent, RHJ; Chester, KA; Casey, J; Green, AJ; Napier, MP; Hopestone, L; Keep, PA; ... Johnson, CJ; + view all (1995) Antibodies from phage libraries - clinical imaging trial of a filamentous bacteriophage- derived single-chain FV anti-CEA expressed in Escherichia-coli. In: (pp. 16-).

Betticher, DC; Lee, SM; Morris, C; Clemons, M; Thatcher, N; (1995) Dacarbazine and interferon-alpha 2a in advanced malignant melanoma: high response rate and prolongation of response duration occur in different patient subpopulations. Melanoma Research , 5 (4) pp. 277-282.

Beyaert, R; Vanhaesebroeck, B; Declercq, W; Van Lint, J; Vandenabele, P; Agostinis, P; Vandenheede, JR; (1995) Casein kinase-1 phosphorylates the p75 tumor necrosis factor receptor and negatively regulates tumor necrosis factor signaling for apoptosis. J Biol Chem , 270 (40) pp. 23293-23299.

Bleehen, NM; Newlands, ES; Lee, SM; Thatcher, N; Selby, P; Calvert, AH; Rustin, GJ; ... Stevens, MF; + view all (1995) Brampton, M, Stevens MFG. Cancer Research Campaign phase-II trial of temozolomide in malignant melanoma. Journal of Clinical Oncology , 13 (4) pp. 910-913.

Bridgewater, J; Collins, M; (1995) Vaccine immunotherapy for cancer. Mol Cell Biol Hum Dis Ser , 5 pp. 140-156.

Bridgewater, JA; Gore, ME; (1995) Biological response modifiers in melanoma. Br Med Bull , 51 (3) pp. 656-677.

Bridgewater, JA; Springer, CJ; Knox, RJ; Minton, NP; Michael, NP; Collins, MK; (1995) Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954. Eur J Cancer , 31A (13-14) pp. 2362-2370.

C

CALVERT, AH; BODDY, A; BAILEY, NP; SIDDIQUI, N; HUMPHREYS, A; HUGHES, A; ROBSON, L; ... NEWELL, DR; + view all (1995) CARBOPLATIN IN COMBINATION WITH PACLITAXEL IN ADVANCED OVARIAN-CANCER - DOSE DETERMINATION AND PHARMACOKINETIC AND PHARMACODYNAMIC INTERACTIONS. SEMINARS IN ONCOLOGY , 22 (5) 91 - 98.

Cacchione, S; Cerone, MA; De Santis, P; Savino, M; (1995) Superstructural features of the upstream regulatory regions of two pea rbcS genes and nucleosomes positioning: theoretical prediction and experimental evaluation. Biophys Chem , 53 (3) pp. 267-281.

Casey, JL; Keep, PA; Chester, KA; Robson, L; Hawkins, RE; Begent, RHJ; (1995) Purification of bacterially expressed single-chain FV antibodies for clinial-applications using metal chelate chromatography. Journal of Immunological Methods , 179 (1) pp. 105-116.

Chester, KA; Begent, RHJ; Robson, L; Keep, PA; Pedley, RB; Boden, J; Boxer, G; ... and Hawkins, RE; + view all (1995) Filamentous phage antibodies: the power of selection for clinical use. In: Begent, RHJAH and A, , (eds.) New Antibody technology and the Emergence of Useful Cancer Therapy. London: Royal Society of Medicine Press

Chester, KA; Hawkins, RE; (1995) Clinical issues in antibody design. Trends in Biotechnology , 13 (8) pp. 294-300.

Clark, AS; Deans, B; Stevens, MF; Tisdale, MJ; Wheelhouse, RT; Denny, BJ; Hartley, JA; (1995) Antitumor imidazotetrazines. 32. Synthesis of novel imidazotetrazinones and related bicyclic heterocycles to probe the mode of action of the antitumor drug temozolomide. J Med Chem , 38 (9) pp. 1493-1504.

Cummings, J; Spanswick, VJ; Smyth, JF; (1995) Re-evaluation of the molecular pharmacology of mitomycin C. EUR J CANCER , 31A (12) 1928 - 1933.

D

DUNNE, J; HANBY, AM; POULSOM, R; JONES, TA; SHEER, D; CHIN, WG; DA, SM; ... OWEN, MJ; + view all (1995) MOLECULAR-CLONING AND TISSUE EXPRESSION OF FAT, THE HUMAN HOMOLOG OF THE DROSOPHILA FAT GENE THAT IS LOCATED ON CHROMOSOME 4Q34-Q35 AND ENCODES A PUTATIVE ADHESION MOLECULE. GENOMICS , 30 (2) 207 - 223.

Dalgleish, AG; Stein, RC; (1995) Lymphokines. In: Price, P and Sikora, K, (eds.) Treatment of cancer. (pp. 189-211). CRC Press

Decoster, E; Vanhaesebroeck, B; Vandenabeele, P; Grooten, J; Fiers, W; (1995) Generation and biological characterization of membrane-bound, uncleavable murine tumor necrosis factor. J Biol Chem , 270 (31) pp. 18473-18478.

Depraetere, S; Vanhaesebroeck, B; Fiers, W; Willems, J; Joniau, M; (1995) Polar agents with differentiation inducing capacity potentiate tumor necrosis factor-mediated cytotoxicity in human myeloid cell lines. J Leukoc Biol , 57 (1) pp. 141-151.

F

FORROW, SM; LEE, M; SOUHAMI, RL; HARTLEY, JA; (1995) THE EFFECT OF AT AND GC SEQUENCE-SPECIFIC MINOR GROOVE-BINDING AGENTS ON RESTRICTION-ENDONUCLEASE ACTIVITY. CHEM-BIOL INTERACT , 96 (2) 125 - 142.

FREEMANTLE, SJ; JACKMAN, AL; KELLAND, LR; CALVERT, AH; LUNEC, J; (1995) MOLECULAR CHARACTERIZATION OF 2 CELL-LINES SELECTED FOR RESISTANCE TO THE FOLATE-BASED THYMIDYLATE SYNTHASE INHIBITOR, ZD1694. BRIT J CANCER , 71 (5) 925 - 930.

G

GORE, ME; LEVY, V; RUSTIN, G; PERREN, T; CALVERT, AH; EARL, H; THOMPSON, JM; (1995) PACLITAXEL (TAXOL) IN RELAPSED AND REFRACTORY OVARIAN-CANCER - THE UK AND EIRE EXPERIENCE. BRIT J CANCER , 72 (4) 1016 - 1019.

GRIFFIN, RJ; CURTIN, NJ; NEWELL, DR; GOLDING, BT; DURKACZ, BW; CALVERT, AH; (1995) THE ROLE OF INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE AS RESISTANCE-MODIFYING AGENTS IN CANCER-THERAPY. BIOCHIMIE , 77 (6) 408 - 422.

GRIFFIN, RJ; PEMBERTON, LC; RHODES, D; BLEASDALE, C; BOWMAN, K; CALVERT, AH; CURTIN, NJ; ... GOLDING, BT; + view all (1995) NOVEL POTENT INHIBITORS OF THE DNA-REPAIR ENZYME POLY(ADP-RIBOSE)POLYMERASE (PARP). ANTI-CANCER DRUG DES , 10 (6) 507 - 514.

H

HARTLEY, JA; WEBBER, J; WYATT, MD; BORDENICK, N; LEE, M; (1995) NOVEL CYTOTOXIC DNA-SEQUENCE AND MINOR-GROOVE TARGETED PHOTOSENSITIZERS - CONJUGATES OF PYRENE AND NETROPSIN ANALOGS. BIOORGAN MED CHEM , 3 (6) 623 - 629.

Howie, AJ; Rowlands, DC; Reynolds, GM; Barnes, AD; (1995) Measurement of proliferation in renal biopsy specimens: evidence of subclinical tubular damage in the nephrotic syndrome. Nephrol Dial Transplant , 10 (12) pp. 2212-2218.

J

Jackman, AL; Calvert, AH; (1995) Folate-based thymidylate synthase inhibitors as anticancer drugs. ANN ONCOL , 6 (9) 871 - 881.

Jacobs, MHJ; vanderHeide, T; Tolner, B; Driessen, AJM; Konings, WN; (1995) Expression of the gltP gene of Escherichia coli in a glutamate transport-deficient mutant of Rhodobacter sphaeroides restores chemotaxis to glutamate. MOL MICROBIOL , 18 (4) 641 - 647.

Jameel, A; Stein, R; Rawson, N; Hedley, A; Stuttaford, J; Coombes, R; (1995) Comparative-study of intramuscular ketorolac tromethamine and morphine in patients experiencing cancer pain. Int J Oncol , 6 (6) pp. 1307-1311.

Johnson, PWM; Whelan, JS; Price, CGA; Lim, J; Matthews, J; Love, S; Norton, AJ; ... Lister, TA; + view all (1995) Patterns of survival in patients with recurrent follicular lymphoma: a 20 year study from a single centre. Journal of Clinical Oncology , 13 pp. 140-147.

L

LI, WW; FAN, JG; HOCHHAUSER, D; BANERJEE, D; ZIELINSKI, Z; ALMASAN, A; YIN, YX; ... BERTINO, JR; + view all (1995) LACK OF FUNCTIONAL RETINOBLASTOMA PROTEIN MEDIATES INCREASED RESISTANCE TO ANTIMETABOLITES IN HUMAN SARCOMA CELL-LINES. P NATL ACAD SCI USA , 92 (22) 10436 - 10440.

LIND, MJ; GUMBRELL, L; CANTWELL, BMJ; MILLWARD, MJ; SIMMONDS, D; PROCTOR, M; CHAPMAN, F; ... CALVERT, AH; + view all (1995) THE USE OF GRANULOCYTE-COLONY-STIMULATING FACTOR TO DELIVER 4 CYCLES OF IFOSFAMIDE AND EPIRUBICIN EVERY 14 DAYS IN WOMEN WITH ADVANCED OR METASTATIC BREAST-CANCER. BRIT J CANCER , 71 (3) 610 - 613.

Lee, SM; Betticher, DC; Thatcher, N; (1995) Melanoma: chemotherapy. British Medical Bulletin , 51 (3) pp. 609-630.

Lee, SM; Harper, P; Luthert, P; Hughes, RAC; (1995) Primary CNS lymphoma in association with IgM kappa-paraproteinaemia and peripheral polyneuropathy. European Neurology , 35 (4) pp. 237-239.

Lorrigan, P; Lee, SM; Betticher, D; Woodhead, M; Weir, D; Hanley, S; Hardy, C; (1995) Chemotherapy with vincristine/ifosphamide/carboplatin/etoposide in small cell lung cancer. Seminars in Oncology , 22 (3) pp. 32-41.

M

MARSHAM, PR; JACKMAN, AL; BARKER, AJ; BOYLE, FT; PEGG, SJ; WARDLEWORTH, JM; KIMBELL, R; ... HUGHES, LR; + view all (1995) QUINAZOLINE ANTIFOLATE THYMIDYLATE SYNTHASE INHIBITORS - REPLACEMENT OF GLUTAMIC-ACID IN THE C2-METHYL SERIES. J MED CHEM , 38 (6) 994 - 1004.

MILLWARD, MJ; NEWELL, DR; YUEN, K; MATTHEWS, JP; BALMANNO, K; CHARLTON, CJ; GUMBRELL, L; ... CALVERT, AH; + view all (1995) PHARMACOKINETICS AND PHARMACODYNAMICS OF PROLONGED ORAL ETOPOSIDE IN WOMEN WITH METASTATIC BREAST-CANCER. CANCER CHEMOTH PHARM , 37 (1-2) 161 - 167.

McGovern, UB; Jones, KT; Sharpe, GR; (1995) Intracellular calcium as a second messenger following growth stimulation of human keratinocytes. Br J Dermatol , 132 (6) pp. 892-896.

Millward, MJ; Newell, DR; Mummaneni, V; Igwemezie, LN; Balmanno, K; Charlton, CJ; Gumbrell, L; ... Calvert, AH; + view all (1995) Phase I and pharmacokinetic study of a water-soluble etoposide prodrug, etoposide phosphate (BMY-40481). EUR J CANCER , 31A (13-14) 2409 - 2411.

P

PEEKHAUS, N; TOLNER, B; POOLMAN, B; KRAMER, R; (1995) THE GLUTAMATE UPTAKE REGULATORY PROTEIN (GRP) OF ZYMAMONAS-MOBILIS AND ITS RELATION TO THE GLOBAL REGULATOR LRP OF ESCHERICHIA-COLI. J BACTERIOL , 177 (17) 5140 - 5147.

R

RAGHAVAN, D; VOKES, EE; CALVERT, AH; AISNER, J; ALBERTS, DS; GLANTZ, MJ; GIANNI, ; ... ROTH, BJ; + view all (1995) THE ACTIVITY OF PACLITAXEL IN GASTROINTESTINAL TUMORS - DISCUSSION. SEMIN ONCOL , 22 (5) 51 - 53.

ROGERS, GT; BURKE, PJ; SHARMA, SK; KOODIE, R; BODEN, JA; (1995) PLASMA-CLEARANCE OF AN ANTIBODY-ENZYME CONJUGATE IN ADEPT BY MONOCLONAL ANTI-ENZYME - ITS EFFECT ON PRODRUG ACTIVATION IN-VIVO. BRITISH JOURNAL OF CANCER , 72 (6) pp. 1357-1363. 10.1038/bjc.1995.515.

RUDD, GN; HARTLEY, JA; SOUHAMI, RL; (1995) PERSISTENCE OF CISPLATIN-INDUCED DNA INTERSTRAND CROSS-LINKING IN PERIPHERAL-BLOOD MONONUCLEAR-CELLS FROM ELDERLY AND YOUNG INDIVIDUALS. CANCER CHEMOTH PHARM , 35 (4) 323 - 326.

Rafi, I; Taylor, GA; Calvete, JA; Boddy, AV; Balmanno, K; Bailey, N; Lind, M; ... Newell, DR; + view all (1995) Clinical pharmacokinetic and pharmacodynamic studies with the nonclassical antifolate thymidylate synthase inhibitor 3,4-dihydro-2-amino-6-methyl-4-oxo-5-(4-pyridplthio)-quinazolone dihydrochloride (AG337) given by 24-hour continuous intravenous infusion. CLIN CANCER RES , 1 (11) 1275 - 1284.

Rohatiner, AZS; Johnson, PWM; Mahmoud, M; Arnott, SJ; Amess, JAL; Norton, AJ; Adams, K; ... Lister, TA; + view all (1995) Myelo-ablative therapy with ABMT for low grade non-Hodgkin's lymphoma. In:

S

SOO, KS; MICHIE, CA; BAKER, SR; WYLLIE, JH; BEVERLEY, PCL; (1995) SELECTIVE RECRUITMENT OF LYMPHOCYTE SUBSETS TO THE INFLAMED APPENDIX. CLIN EXP IMMUNOL , 100 (1) 133 - 138.

STEIN, RC; COOMBES, RC; GAZET, JC; FORD, HT; RAWSON, NSB; (1995) GESTRINONE IN MASTALGIA - A RANDOMIZED DOUBLE BIND PLACEBO-CONTROLLED TRIAL - REPLY. BREAST , 4 (1) p. 73. 10.1016/0960-9776(95)90055-1.

STOYANOV, B; VOLINIA, S; HANCK, T; RUBIO, I; LOUBTCHENKOV, M; MALEK, D; STOYANOVA, S; ... WETZKER, R; + view all (1995) CLONING AND CHARACTERIZATION OF A G-PROTEIN-ACTIVATED HUMAN PHOSPHOINOSITIDE-3 KINASE. SCIENCE , 269 (5224) 690 - 693.

Salter, J; MacLennan, K; Bridgewater, JA; Moore, J; Atkinson, H; Nicolson, M; Riches, P; (1995) The histological and immunohistochemical changes in the skin of patients with melanoma who develop changes in skin pigmentation following immunotherapy. Melanoma Res , 5 (4) pp. 267-271.

Shamash, J; Salam, AH; Wallace, DL; Beverley, PCL; Lister, TA; (1995) Induction of CD80 in low grade B cell lymphoma leads to enhanced mixed lymphocyte responses with allogeneic or autologous lymphocytes. BLOOD , 86 (10) 2131 - 2131.

Stein, RC; Coombes, RC; Howell, A; (1995) The basis of hormonal therapy of cancer. In: Peckham, M and Pinedo, HM and Veronesi, U, (eds.) Oxford textbook of oncology. (pp. 629-648). Oxford University Press

T

TOLNER, B; UBBINKKOK, T; POOLMAN, B; KONINGS, WN; (1995) CATION-SELECTIVITY OF THE L-GLUTAMATE TRANSPORTERS OF ESCHERICHIA-COLI, BACILLUS-STEAROTHERMOPHILUS AND BACILLUS-CALDOTENAX - DEPENDENCE ON THE ENVIRONMENT IN WHICH THE PROTEINS ARE EXPRESSED. MOL MICROBIOL , 18 (1) 123 - 133.

TOLNER, B; UBBINKKOK, T; POOLMAN, B; KONINGS, WN; (1995) CHARACTERIZATION OF THE PROTON GLUTAMATE SYMPORT PROTEIN OF BACILLUS-SUBTILIS AND ITS FUNCTIONAL EXPRESSION IN ESCHERICHIA-COLI. J BACTERIOL , 177 (10) 2863 - 2869.

Thatcher, N; Ranson, M; Lee, SM; Niven, R; Anderson, H; (1995) Chemotherapy in non-small cell lung cancer. Annals of Oncology , 6 (Suppl 1) pp. 83-94.

V

VERHAAR, MJ; CHESTER, KA; KEEP, PA; ROBSON, L; PEDLEY, RB; BODEN, JA; HAWKINS, RE; (1995) A SINGLE-CHAIN FV DERIVED FROM A FILAMENTOUS PHAGE LIBRARY HAS DISTINCT TUMOR TARGETING ADVANTAGES OVER ONE DERIVED FROM A HYBRIDOMA. INT J CANCER , 61 (4) 497 - 501.

VOLINIA, S; DHAND, R; VANHAESEBROECK, B; MACDOUGALL, L; STEIN, R; ZVELEBIL, MJ; DOMIN, J; ... WATERFIELD, MD; + view all (1995) HUMAN PHOSPHATIDYLINOSITOL 3-KINASE COMPLEX RELATED TO THE YEAST VPS34P-VPS15P PROTEIN SORTING SYSTEM. EMBO JOURNAL , 14 (14) pp. 3339-3348.

Vandenabeele, P; Declercq, W; Vanhaesebroeck, B; Grooten, J; Fiers, W; (1995) Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells. J Immunol , 154 (6) pp. 2904-2913.

von Schlippe, M; Whelan, JS; (1995) Primitive neuroectodermal tumour of the chest wall. Annals of Oncology , 6 (4) pp. 395-401.

W

WYATT, MD; LEE, M; GARBIRAS, BJ; SOUHAMI, RL; HARTLEY, JA; (1995) SEQUENCE SPECIFICITY OF ALKYLATION FOR A SERIES OF NITROGEN MUSTARD-CONTAINING ANALOGS OF DISTAMYCIN OF INCREASING BINDING-SITE SIZE - EVIDENCE FOR INCREASED CYTOTOXICITY WITH ENHANCED SEQUENCE SPECIFICITY. BIOCHEMISTRY-US , 34 (40) 13034 - 13041.

Wedge, SR; Laohavinij, S; Taylor, GA; Boddy, A; Calvert, AH; Newell, DR; (1995) Clinical pharmacokinetics of the antipurine antifolate (6R)-5,10-dideaza-5,6,7,8-tetrahydrofolic acid (lometrexol) administered with an oral folic acid supplement. CLIN CANCER RES , 1 (12) 1479 - 1486.

Whelan, JS; Souhami, RL; (1995) High dose therapy with Melphalan and Total Body Irradiation or Busulphan for Ewing's Sarcoma. In:

Wood, M; Haque, K; Povey, AC; Lee, SM; Cooper, DP; (1995) Monitoring of high dose DTIC therapy by measurement of 06-methylguanine and N7-methylguanine in peripheral leucocyte DNA. In: (pp. 32-).

Y

YOUNG, JL; DASER, A; BEVERLEY, PCL; (1995) IN-VITRO PROLIFERATIVE RESPONSES OF HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS TO NON-RECALL ANTIGENS. J IMMUNOL METHODS , 182 (2) 177 - 184.

Z

ZHU, X; TOMMASINO, M; VOUSDEN, K; SADOVNIKAVA, E; RAPPUOLI, R; CRAWFORD, L; KAST, M; ... STAUSS, HJ; + view all (1995) BOTH IMMUNIZATION WITH PROTEIN AND RECOMBINANT VACCINIA VIRUS CAN STIMULATE CTL SPECIFIC FOR THE E7 PROTEIN OF HUMAN-PAPILLOMA-VIRUS-16 IN H-2(D) MICE. SCAND J IMMUNOL , 42 (5) 557 - 563.

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