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Jump to: A | B | C | D | E | F | G | H | I | J | K | L | M | P | S | T | U | W
Number of items: 60.

A

Ambler, J; Baker, E; Bentley, D; Brown, L; Butler, K; Butler, P; Farr, D; ... Tweed, M; + view all (1999) Studies towards the identification of potent, selective and bioavailable thrombin inhibitors. Bioorganic & Medicinal Chemistry Letters , 9 (5) 737 - 742-737 - 742. 10.1016/S0960-894X(99)00061-X.

Ambler, J; Brown, L; Cockcroft, X-L; Grtter, M; Hayler, J; Janus, D; Jones, D; ... Wathey, B; + view all (1999) Optimisation of the P2 pharmacophore in a series of thrombin inhibitors: Ion-dipole interactions with lysine 60G. Bioorganic & Medicinal Chemistry Letters , 9 (9) 1317 - 1322-1317 - 1322. 10.1016/S0960-894X(99)00172-9.

B

Bailey, C; Baker, E; Hayler, J; Kane, P; (1999) Amidine protection for solution phase library synthesis. Tetrahedron Letters , 40 (26) 4847 - 4850-4847 - 4850. 10.1016/S0040-4039(99)00891-6.

Brash, PD; Foster, J; Vennart, W; Anthony, P; Tooke, JE; (1999) Magnetic resonance imaging techniques demonstrate soft tissue damage in the diabetic foot. DIABETIC MED , 16 (1) 55 - 61.

Brundish, D; Bull, A; Donovan, V; Fullerton, JD; Garman, SM; Hayler, JF; Janus, D; ... Talbot, MD; + view all (1999) Design and Synthesis of Thrombin Inhibitors: Analogues of MD-805 with Reduced Stereogenicity and Improved Potency. Journal of Medicinal Chemistry , 42 (22) pp. 4584-4603. 10.1021/jm9811209.

C

Chinswangwatanakul, V; Worthington, T; Lemoine, NR; Williamson, RCN; Kakkar, AK; (1999) Circulating vascular endothelial growth factor correlates with systemic thrombin generation in patients with pancreatic carcinoma. THROMBOSIS AND HAEMOSTASIS , 81 (5) p. 851.

Cole, C; Foster, AJ; Freeman, S; Jaffar, M; Murray, PE; Stratford, IJ; (1999) Review. The role of thymidine phosphorylase/PD-ECGF in cancer chemotherapy: a chemical perspective. Anti-cancer Drug Design , 14 (5) pp. 383-392.

Cole, C; Marks, DS; Jaffar, M; Stratford, IJ; Douglas, KT; Freeman, S; (1999) A similarity model for the human angiogenic factor, thymidine phosphorylase/platelet derived-endothelial cell growth factor. Anticancer Drug Des , 14 (5) pp. 411-420.

Crawley, CR; Hinchliffe, SJ; Reid, ED; Lomas, DA; (1999) Early supported discharge as an alternative to long stay hospital admission in exacerbations of chronic obstructive pulmonary disease. THORAX , 54 A44-A44.

D

Dafforn, TR; Mahadeva, R; Elliott, PR; Sivasothy, P; Lomas, DA; (1999) A kinetic mechanism for the polymerization of alpha1-antitrypsin. J Biol Chem , 274 (14) pp. 9548-9555. Gold open access

Davis, RL; Shrimpton, AE; Holohan, PD; Bradshaw, C; Feiglin, D; Collins, GH; Sonderegger, P; ... Lomas, DA; + view all (1999) Familial dementia caused by polymerization of mutant neuroserpin. Nature , 401 (6751) pp. 376-379. 10.1038/43894.

Davis, RL; Shrimpton, AE; Holohan, PD; Bradshaw, C; Feiglin, D; Collins, GH; Sonderegger, P; ... Lomas, DA; + view all (1999) Familial dementia caused by polymlerization of mutant neurosergin. NATURE , 401 (6751) pp. 376-379. 10.1038/43897.

E

Elliott, PR; Abrahams, JP; Lomas, DA; (1999) Crystal structure of wildtype alpha(1)-antitrypsin. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE , 159 (3) A192-A192.

F

Freeman, S; Jaffar, M; Stratford, I; (1999) Drug Targeting. 6881748.

G

Gaillard, MC; Mahadeva, R; Lomas, DA; (1999) Identification of DNA polymorphisms associated with the V type alpha1-antitrypsin gene. Biochim Biophys Acta , 1444 (2) pp. 166-170.

Goh, KL; Tooke, JE; Shore, AC; (1999) Vascular response to iontophoresis of drug carrier. J VASC RES , 36 (4) 335 - 336.

Gooding, KM; Tooke, JE; Shore, AC; (1999) The time course of the skin hyperaemic response during local heating. J VASC RES , 36 (4) 332 - 332.

Gooptu, B; Chang, WSW; Lomas, DA; (1999) Alpha(1)-antichymotrypsin deficiency: Conformational transitions in chronic airflow obstruction. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE , 159 (3) A798-A798.

Gooptu, B; Hazes, B; Chang, WSW; Dafforn, TR; Read, RJ; Carrell, RW; Lomas, DA; (1999) Protein structural transitions in chronic airflow obstruction: Insights from the characterisation and 2.5 angstrom crystal structure of a pathogenic form of alpha(1)-antichymotrypsin. THORAX , 54 A8-A8.

H

Hamid, S; Klaentschi, K; Shore, AC; Tooke, JE; (1999) A modified diffusion chamber to study the effect of hydrostatic pressure on fluid permeability. J VASC RES , 36 (4) 336 - 337.

Hattersley, AT; Tooke, JE; (1999) The fetal insulin hypothesis: an alternative explanation of the association of low birthweight with diabetes and vascular disease. LANCET , 353 (9166) 1789 - 1792.

Hayler, JF; (1999) NOVCISS A Combined Chemical Inventory & Safety Information System. Presented at: Eighth UK MDL Users Meeting, Kensington, London.

Hinchliffe, SJ; Reid, ED; Lomas, DA; (1999) Familial risk of airflow obstruction and emphysema. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE , 159 (3) A809-A809.

Huntington, JA; Pannu, NS; Hazes, B; Read, RJ; Lomas, DA; Carrell, RW; (1999) A 2.6 A structure of a serpin polymer and implications for conformational disease. J Mol Biol , 293 (3) pp. 449-455. 10.1006/jmbi.1999.3184.

I

Iqbal, S; Falzon, M; Mathie, RT; Williamson, RCN; Kakkar, AK; (1999) Thrombomodulin expression of primary breast cancer is a predicttor of axillary lymph node metastasis. THROMBOSIS AND HAEMOSTASIS pp. 833-834.

J

Jaffar, M; Everett, SA; Naylor, MA; Moore, SG; Ulhaq, S; Patel, KB; Stratford, MRL; ... Stratford, IJ; + view all (1999) Prodrugs for targeting hypoxic tissues: Regiospecific elimination of aspirin from reduced indolequinones. Bioorganic & Medicinal Chemistry Letters , 9 (1) pp. 113-118. 10.1016/S0960-894X(98)00695-7.

Jaffar, M; Stratford, IJ; (1999) Bioreductive drugs: selectivity towards hypoxic tissue. Expert Opinion on Therapeutic Patents , 9 (10) pp. 1371-1380. 10.1517/13543776.9.10.1371.

K

Kakkar, AK; Chinswangwatanakul, V; Lemoine, NR; Tebbutt, S; Williamson, RCN; (1999) Role of tissue factor expression on tumour cell invasion and growth of experimental pancreatic adenocarcinoma. BRITISH JOURNAL OF SURGERY , 86 (7) pp. 890-894. 10.1046/j.1365-2168.1999.01153.x.

Kakkar, AK; Williamson, RC; (1999) Antithrombotic therapy in cancer. BMJ , 318 (7198) pp. 1571-1572.

Kakkar, AK; Williamson, RCN; (1999) Antithrombotic therapy in cancer - Low molecular weight heparins may have a direct effect on tumours. BRITISH MEDICAL JOURNAL , 318 (7198) pp. 1571-1572.

Kakkar, AK; Williamson, RCN; (1999) Prevention of venous thromboembolism in cancer patients. SEMINARS IN THROMBOSIS AND HEMOSTASIS , 25 (2) pp. 239-243. 10.1055/s-2007-994925.

Kernick, DP; Tooke, JE; Shore, AC; (1999) The biological zero signal in laser Doppler fluximetry - origins and practical implications. PFLUG ARCH EUR J PHY , 437 (4) 624 - 631.

Kerrison, S; (1999) Official Health Statistics: An Unofficial Guide. [Book]. Arnold: London.

Kerrison, S; Clarke, A; Doehr, S; (1999) People and paper: survey of information sources and information needs of consultants, GPs and Nurses in N. Thames for evidence based practice. Journal of Interprofessional Care , 13 pp. 289-299.

Klaentschi, K; Shore, AC; Tooke, JE; Brown, JA; (1999) Pressure-permeability relationships in crosslinked basement membranes. MICROVASC RES , 58 (3) 329 - 332.

L

Lee, BC; Appleton, M; Shore, AC; Tooke, JE; Hattersley, AT; (1999) Impaired maximum microvascular hyperaemia in patients with MODY 3 (hepatocyte nuclear factor-1 alpha gene mutations). DIABETIC MED , 16 (9) 731 - 735.

Lee, BC; Shore, AC; Humphreys, JM; Hattersley, AT; Tooke, JE; (1999) Vascular function and ageing in subjects with a genetic predisposition to type 2 diabetes. DIABETOLOGIA , 42 A325 - A325.

Lewis, DM; Beaman, M; Shore, AC; Tooke, JE; (1999) Peripheral capillary filtration capacity is altered in asymptomatic proteinuria. KIDNEY INT , 55 (5) 2101 - 2101.

Lupu, F; Kakkar, AK; Lupu, C; Kakkar, VV; (1999) In situ detection of the activation of coagulation cascade in atherosclerotic and malignant tissues. THROMBOSIS AND HAEMOSTASIS pp. 522-523.

M

Mahadeva, R; Chang, WS; Dafforn, TR; Oakley, DJ; Foreman, RC; Calvin, J; Wight, DG; (1999) Heteropolymerization of S, I, and Z alpha1-antitrypsin and liver cirrhosis. J Clin Invest , 103 (7) pp. 999-1006. 10.1172/JCI4874.

Mahadeva, R; Dunn, AC; Westerbeek, RC; Sharples, L; Whitehouse, DB; Carroll, NR; Ross-Russell, RI; ... Lockwood, CM; + view all (1999) Anti-neutrophil cytoplasmic antibodies (ANCA) against bactericidal/permeability-increasing protein (BPI) and cystic fibrosis lung disease. CLINICAL AND EXPERIMENTAL IMMUNOLOGY , 117 (3) pp. 561-567.

Mahadeva, R; Elliott, PR; Dafforn, T; Oakley, DJ; Foreman, RC; Chang, WWS; Lomas, DA; (1999) Polymerisation and deficiency of F alpha(1)-antitrypsin (223Arg -> Cys) is independent of the 223Arg-Glu reactive loop salt bridge. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE , 159 (3) A810-A810.

Mawson, DM; Tooke, JE; Chaturvedi, N; Shore, AC; (1999) Assessment of microvascular function in white and highly pigmented skin. J VASC RES , 36 (4) 331 - 331.

McCloskey, SC; Hinchliffe, SJ; Reid, ED; Lomas, DA; (1999) Familial risk of airflow obstruction and emphysema. THORAX , 54 A54-A54.

Morita, S; Kakkar, AK; Scully, MF; (1999) Human pancreatic carcinoma cells can inhibit the anticoagulant activity of unfractionated but not low molecular weight heparin. THROMBOSIS AND HAEMOSTASIS p. 650.

Myers, LB; Brewin, CR; Winter, DA; (1999) Repressive coping and self-reports of parenting. BRIT J CLIN PSYCHOL , 38 73 - 82.

P

Phillips, RM; Naylor, MA; Jaffar, M; Doughty, SW; Everett, SA; Breen, AG; Choudry, GA; (1999) Bioreductive Activation of a Series of Indolequinones by Human DT-Diaphorase: Structure?Activity Relationships. Journal of Medicinal Chemistry , 42 (20) pp. 4071-4080. 10.1021/jm991063z.

S

Salih, A; Sirivatanauksorn, Y; Mathie, RT; Williamson, RCN; Kakkar, AK; (1999) Progesterone and thrombin increase release of vascular endothelial growth factor (VEGF) in human breast cancer cell line. THROMBOSIS AND HAEMOSTASIS p. 625.

Sirivatanauksorn, Y; Sirivatanauksorn, V; Bhattacharya, S; Davidson, BR; Dhillon, AP; Kakkar, AK; Williamson, RCN; (1999) Evolution of genetic abnormalities in hepatocellular carcinomas demonstrated by DNA fingerprinting. J PATHOL , 189 (3) 344 - 350.

Sirivatanauksorn, Y; Sirivatanauksorn, V; Bhattacharya, S; Davidson, BR; Dhillon, AP; Kakkar, AK; Williamson, RCN; (1999) Genomic heterogeneity in synchronous hepatocellular carcinomas. GUT , 45 (5) 761 - 765.

Sivasothy, P; Dafforn, TR; Gettins, PGW; Lomas, DA; (1999) Pathogenic alpha(1)-antitrypsin polymers are formed by reactive loop-beta-sheet A linkage. THORAX , 54 A78-A78.

Sivasothy, P; Dafforn, TR; Hiemstra, PS; Lomas, DA; (1999) The interaction of native, latent and cleaved plasma alpha-I-antitrypsin and human neutrophil defensin. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE , 159 (3) A481-A481.

Sivasothy, P; Daffron, TR; Hiemstra, PS; Lomas, DA; (1999) The interaction of M, S, Z, latent and cleaved plasma alpha-1-antitrypsin with human neutrophil defensin-1. THORAX , 54 A81-A81.

T

Taniguchi, T; Kakkar, AK; Ruf, W; Lemoine, NR; (1999) Tissue factor-factor VIIA pathway regulates gene expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase in human cancer cells. THROMBOSIS AND HAEMOSTASIS p. 15.

Taylor, DJ; Fisher, J; Jacob, J; Tooke, JE; (1999) The use of digital cameras in a mobile retinal screening environment. DIABETIC MED , 16 (8) 680 - 686.

Tooke, J; (1999) The association between insulin resistance and endotheliopathy. DIABETES OBES METAB , 1 S17 - S22.

Tooke, JE; Goh, KL; (1999) Vascular function in Type 2 diabetes mellitus and pre-diabetes: the case for intrinsic endotheliopathy. DIABETIC MED , 16 (9) 710 - 715.

Tooke, JE; Lee, BC; Humphreys, JM; Hattersley, AT; Shore, AC; (1999) Microvascular function and features of insulin resistance syndrome in healthy adults. DIABETOLOGIA , 42 A325 - A325.

U

Ulhaq, S; Chinje, EC; Naylor, MA; Jaffar, M; Stratford, IJ; Threadgill, MD; (1999) Heterocyclic analogues of l -citrulline as inhibitors of the isoforms of nitric oxide synthase (NOS) and identification of N ? -(4,5-dihydrothiazol-2-yl)ornithine as a potent inhibitor. Bioorganic & Medicinal Chemistry , 7 (9) pp. 1787-1796. 10.1016/S0968-0896(99)00136-4.

W

Worthington, TR; Williamson, RCN; Kakkar, AK; (1999) Overexpression of thrombomodulin inhibits invasion of human pancreatic adenocarcinoma cells. THROMBOSIS AND HAEMOSTASIS p. 55.

This list was generated on Sun Sep 17 04:43:19 2017 BST.