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Number of items: 69.

B

Bailey, JV; Webster, R; Hunter, R; Freemantle, N; Rait, G; Michie, S; Estcourt, C; ... Murray, E; + view all (2015) The Men's Safer Sex (MenSS) trial: protocol for a pilot randomised controlled trial of an interactive digital intervention to increase condom use in men. BMJ Open , 5 (2) , Article e007552. 10.1136/bmjopen-2014-007552. Green open access
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Barry, JA; Moran, E; Thomas, M; Hardiman, PJ; (2015) Prolactin and hostility in hospitalised patients and healthy women: A systematic review and meta-analysis. Journal of Obstetrics and Gynaecology , 35 (5) 10.3109/01443615.2014.970523. Green open access
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Bartlett, TE; Jones, A; Goode, EL; Fridley, BL; Cunningham, JM; Berns, EM; Wik, E; ... Widschwendter, M; + view all (2015) Intra-gene DNA methylation variability is a clinically independent prognostic marker in women's cancers. PLoS One , 10 (12) , Article e0143178. 10.1371/journal.pone.0143178. Green open access
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Bates, R; Blyuss, O; Alsaedi, A; Zaikin, A; (2015) Effect of noise in intelligent cellular decision making. PLOS ONE , 10 (5) , Article e0125079. 10.1371/journal.pone.0125079. Green open access
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Blyuss, O; Gentry-Maharaj, A; Fourkala, EO; Ryan, A; Zaikin, A; Menon, U; Jacobs, I; (2015) Serial Patterns of Ovarian Cancer Biomarkers in a Prediagnosis Longitudinal Dataset. Biomed Research International , 2015 , Article 681416. 10.1155/2015/681416. Green open access
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Blyuss, O; Koriashkina, L; Kiseleva, E; Molchanov, O; (2015) Optimal Placement of Irradiation Sources in the Planning of Radiotherapy: Mathematical Models and Methods of Solving. Computational and Mathematical Methods in Medicine , 2015 , Article 142987. 10.1155/2015/142987. Green open access
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Brima, N; Akintomide, H; Iguyovwe, V; Mann, S; (2015) A comparison of the expected and actual pain experienced by women during insertion of an intrauterine contraceptive device. Open Access Journal of Contraception , 2015 (6) 21 - 26. 10.2147/OAJC.S74624. Green open access
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Buckley, SM; Delhove, JM; Perocheau, DP; Karda, R; Rahim, AA; Howe, SJ; Ward, NJ; ... McKay, TR; + view all (2015) In vivo bioimaging with tissue-specific transcription factor activated luciferase reporters. Scientific Reports , 5 , Article 11842. 10.1038/srep11842. Green open access
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C

Caldwell, M; Moroz, T; Hapuarachchi, T; Bainbridge, A; Robertson, NJ; Cooper, CE; Tachtsidis, I; (2015) Modelling Blood Flow and Metabolism in the Preclinical Neonatal Brain during and Following Hypoxic-Ischaemia. PLoS One , 10 (10) , Article e0140171. 10.1371/journal.pone.0140171. Green open access
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Chadebecq, F; Vercauteren, T; Wimalasundera, R; Attilakos, G; David, AL; Deprest, J; Ourselin, S; (2015) Practical Dry Calibration With Medium Adaptation For Fluid-Immersed Endoscopy. Presented at: Hamlyn Symposium on Medical Robotics, London. (In press). Green open access
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Chandrasekaran, D; Menon, U; Evans, G; Crawford, R; Saridogan, E; Jacobs, C; Tischkowitz, M; ... Manchanda, R; + view all (2015) Risk reducing salpingectomy and delayed oophorectomy in high risk women: views of cancer geneticists, genetic counsellors and gynaecological oncologists in the UK. Familial Cancer , 14 (4) pp. 521-530. 10.1007/s10689-015-9823-y. Green open access
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Chandrasekaran, D; Menon, U; Evans, G; Crawford, R; Saridogan, E; Jacobs, C; Tischkowitz, M; ... Manchanda, R; + view all (2015) Risk reducing salpingectomy and delayed oophorectomy in high risk women: views of cancer geneticists, genetic counsellors and gynaecological oncologists in the UK. Familial Cancer , 14 (4) pp. 521-530. 10.1007/s10689-015-9823-y. Green open access
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D

Devall, AJ; Santos, JM; Fry, JP; Honour, JW; Brandão, ML; Lovick, TA; (2015) Elevation of brain allopregnanolone rather than 5-HT release by short term, low dose fluoxetine treatment prevents the estrous cycle-linked increase in stress sensitivity in female rats. European Neuropsychopharmacology , 25 (1) pp. 113-123. 10.1016/j.euroneuro.2014.11.017. Green open access
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Devrecker, A; Rosa, B; Desjardins, A; Alles, E; Garcia-Peraza Herrera, L; Maneas, E; Stoyanov, D; ... Vander Poorten, E; + view all (2015) Fluidic Actuation for Intra-operative In Situ Imaging. Presented at: 2015 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS), Hamburg. (In press). Green open access
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E

Eaton-Rosen, Z; Melbourne, A; Orasanu, E; Cardoso, MJ; Modat, M; Bainbridge, A; Kendall, GS; ... Ourselin, S; + view all (2015) Longitudinal measurement of the developing grey matter in preterm subjects using multi-modal MRI. Neuroimage , 111 580 - 589. 10.1016/j.neuroimage.2015.02.010. Green open access
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Ezzati, M; Bainbridge, A; Broad, KD; Kawano, G; Oliver-Taylor, A; Rocha-Ferreira, E; Alonso-Alconada, D; ... Robertson, NJ; + view all (2015) Immediate remote ischemic postconditioning after hypoxia ischemia in piglets protects cerebral white matter but not grey matter. Journal of Cerebral Blood Flow & Metabolism , 36 (8) pp. 1396-1411. 10.1177/0271678X15608862. Green open access
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F

Fernando, MA; Creighton, SM; Wood, D; (2015) The long-term management and outcomes of cloacal anomalies. Pediatr Nephrol , 30 (5) 759 - 765. 10.1007/s00467-014-2875-7. Green open access
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G

Gallagher, K; Aladangady, N; Marlow, N; (2015) The attitudes of neonatologists towards extremely preterm infants: a Q methodological study. Archives of Disease in Childhood 10.1136/archdischild-2014-308071. Green open access
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Gentry-Maharaj, A; Karpinskyj, C; Glazer, C; Burnell, M; Ryan, A; Fraser, L; Lanceley, A; ... Menon, U; + view all (2015) Use and perceived efficacy of complementary and alternative medicines after discontinuation of hormone therapy: a nested United Kingdom Collaborative Trial of Ovarian Cancer Screening cohort study. Menopause , 22 (4) 384 - 390. 10.1097/GME.0000000000000330. Green open access
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Girardet, A; Viart, V; Plaza, S; Daina, G; De Rycke, M; Des Georges, M; Fiorentino, F; ... Claustres, M; + view all (2015) The improvement of the best practice guidelines for preimplantation genetic diagnosis of cystic fibrosis: toward an international consensus. European Journal Of Human Genetics , 2016 (24) pp. 469-478. 10.1038/ejhg.2015.99. Green open access
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Gonzalez Malagon, SG; Melidoni, AN; Hernandez, D; Omar, BA; Houseman, L; Veeravalli, S; Scott, F; ... Shephard, EA; + view all (2015) The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing. Biochemical Pharmacology , 96 (3) pp. 267-277. 10.1016/j.bcp.2015.05.013. Green open access
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H

Harris, KA; Underwood, A; Kenna, DT; Brooks, A; Kavaliunaite, E; Kapatai, G; Tewolde, R; ... Dixon, G; + view all (2015) Whole-genome sequencing and epidemiological analysis do not provide evidence for cross-transmission of mycobacterium abscessus in a cohort of pediatric cystic fibrosis patients. Clinical Infectious Diseases , 60 (7) pp. 1007-1016. 10.1093/cid/ciu967. Green open access
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Hassell, KJ; Ezzati, M; Alonso-Alconada, D; Hausenloy, DJ; Robertson, NJ; (2015) New horizons for newborn brain protection: enhancing endogenous neuroprotection. Archive of Disease in Childhood Fetal Neonatal Edition , 100 (6) F541-F552. 10.1136/archdischild-2014-306284. Green open access
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Hillman, SL; Finer, S; Smart, MC; Mathews, C; Lowe, R; Rakyan, V; Hitman, GA; (2015) Novel DNA methylation profiles associated with key gene regulation and transcription pathways in blood and placenta of growth-restricted neonates. Epigenetics , 10 (1) pp. 50-61. 10.4161/15592294.2014.989741. Green open access
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J

James, CP; (2015) Cervical Antimicrobial Immunity in Pregnancy. Doctoral thesis , UCL (University College London).

Jenkinson, C; Elliott, V; Menon, U; Apostolidou, S; Fourkala, OE; Gentry-Maharaj, A; Pereira, SP; ... Costello, E; + view all (2015) Evaluation in pre-diagnosis samples discounts ICAM-1 and TIMP-1 as biomarkers for earlier diagnosis of pancreatic cancer. Journal of Proteomics , 113 pp. 400-402. 10.1016/j.jprot.2014.10.001. Green open access
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K

Knight, M; Brocklehurst, P; O’Brien, P; Quigley, MA; Kurinczuk, JJ; (2015) Planning for a cohort study to investigate the impact and management of influenza in pregnancy in a future pandemic. Health Services and Delivery Research , 3 (6) pp. 1-47. 10.3310/hsdr03060. Green open access
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Kuku, SY; (2015) Radiation-Induced Bowel Injury (RIBI): Exploring potential predictive and prognostic factors and strategies to improve the management of women treated with Pelvic Radiation for Cervical and Endometrial Cancers: Cancer Survivorship: Improving Quality of Life after Treatment for Gynaecological Cancers. Doctoral thesis , UCL (University College London). Green open access
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L

Lawrenson, K; Mhawech-Fauceglia, P; Worthington, J; Spindler, TJ; O'Brien, D; Lee, JM; Spain, G; ... Gayther, SA; + view all (2015) Identification of novel candidate biomarkers of epithelial ovarian cancer by profiling the Secretomes of three-dimensional genetic models of ovarian carcinogenesis. International Journal of Cancer , 137 (8) pp. 1806-1817. 10.1002/ijc.29197. Green open access
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Leung, TS; Kapur, K; Guilliam, A; Okell, J; Lim, B; MacDonald, LW; Meek, J; (2015) Screening neonatal jaundice based on the sclera color of the eye using digital photography. Biomedical Optics Express , 6 (11) pp. 4529-4538. 10.1364/BOE.6.004529. Green open access
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M

Manchanda, R; Legood, R; Burnell, M; McGuire, A; Raikou, M; Loggenberg, K; Wardle, J; ... Jacobs, I; + view all (2015) Cost-effectiveness of Population Screening for BRCA Mutations in Ashkenazi Jewish Women Compared With Family History-Based Testing. J Natl Cancer Inst , 107 (1) , Article dju380. 10.1093/jnci/dju380. Green open access
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Manchanda, R; Loggenberg, K; Sanderson, S; Burnell, M; Wardle, J; Gessler, S; Side, L; ... Jacobs, I; + view all (2015) Population testing for cancer predisposing BRCA1/BRCA2 mutations in the Ashkenazi-Jewish community: a randomized controlled trial. J Natl Cancer Inst , 107 (1) 379 -389. 10.1093/jnci/dju379. Green open access
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Maneas, E; Sato dos Santos, G; Deprest, J; Wimalasundera, R; David, AL; Vercauteren, T; Ourselin, S; (2015) Adaptive Filtering of Fibre-optic Fetoscopic Images for Fetal Surgery. Presented at: Hamlyn Symposium on Medical Robotics, London.

Marlow, N; (2015) Is survival and neurodevelopmental impairment at 2 years of age the gold standard outcome for neonatal studies? Arch Dis Child Fetal Neonatal Ed , 100 (1) F82 - F84. 10.1136/archdischild-2014-306191. Green open access
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Marlow, N; Morris, T; Brocklehurst, P; Carr, R; Cowan, F; Patel, N; Petrou, S; ... Doré, CJ; + view all (2015) A randomised trial of granulocyte-macrophage colony-stimulating factor for neonatal sepsis: childhood outcomes at 5 years. Arch Dis Child Fetal & Neonatal Edition , 100 (4) F320-F326. 10.1136/archdischild-2014-307410. Green open access
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Mattar, CN; Wong, AM; Hoefer, K; Alonso-Ferrero, ME; Buckley, SM; Howe, SJ; Cooper, JD; ... Rahim, AA; + view all (2015) Systemic gene delivery following intravenous administration of AAV9 to fetal and neonatal mice and late-gestation nonhuman primates. The FASEB Journal , 29 (9) 3876- 3888. 10.1096/fj.14-269092. Green open access
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Meisel, SF; Pashayan, N; Rahman, B; Side, L; Fraser, L; Gessler, S; Lanceley, A; (2015) Adjusting the frequency of mammography screening on the basis of genetic risk: Attitudes among women in the UK. Breast , 24 (3) 237 - 241. 10.1016/j.breast.2015.02.001. Green open access
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Menon, U; Ryan, A; Kalsi, J; Gentry-Maharaj, A; Dawnay, A; Habib, M; Apostolidou, S; ... Jacobs, I; + view all (2015) Risk Algorithm Using Serial Biomarker Measurements Doubles the Number of Screen-Detected Cancers Compared With a Single-Threshold Rule in the United Kingdom Collaborative Trial of Ovarian Cancer Screening. Journal of Clinical Oncology , 33 (18) pp. 2062-2071. 10.1200/JCO.2014.59.4945. Green open access
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Morgan, AS; (2015) Care of extremely premature babies in England, 1995 – Present. Doctoral thesis , UCL (University College London). Green open access
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Moro, F; Knez, J; Pateman, K; Derdelis, G; Foo, X; Jurkovic, D; (2015) Ultrasound-guided retrieval of lost intrauterine devices using very fine grasping forceps: a case series. Journal of Family Planning and Reproductive Health Care , 41 (3) pp. 205-209. 10.1136/jfprhc-2014-101088. Green open access
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N

Nicholls, JA; Potts, HW; Coleman, B; Patterson, DL; (2015) Legal and professional implications of shared care: a case study in oral anticoagulation stroke prevention therapy. BMC Health Serv Res , 15 , Article 93. 10.1186/s12913-015-0756-9. Green open access
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Nivsarkar, MS; Buckley, SM; Parker, AL; Perocheau, D; McKay, TR; Rahim, AA; Howe, SJ; (2015) Evidence for Contribution of CD4+CD25+ Regulatory T Cells in Maintaining Immune Tolerance to Human Factor IX following Perinatal Adenovirus Vector Delivery. Journal of Immunology Research , 2015 , Article 397879. 10.1155/2015/397879. Green open access
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Nouretdinov, I; Devetyarov, D; Vovk, V; Burford, B; Camuzeaux, S; Gentry-Maharaj, A; Tiss, A; ... Gammerman, A; + view all (2015) Multiprobabilistic prediction in early medical diagnoses. Annals of Mathematics and Artificial Intelligence , 74 (1) pp. 203-222. 10.1007/s10472-013-9367-5. Green open access
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O

O'Brien, DP; Sandanayake, NS; Jenkinson, C; Gentry-Maharaj, A; Apostolidou, S; Fourkala, EO; Camuzeaux, S; ... Timms, JF; + view all (2015) Serum CA19-9 is significantly upregulated up to 2 years before diagnosis with pancreatic cancer: implications for early disease detection. Clinical Cancer Research , 21 (3) pp. 622-631. 10.1158/1078-0432.CCR-14-0365. Green open access
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P

Paul, DS; Jones, A; Sellar, RS; Mayor, NP; Feber, A; Webster, AP; Afonso, N; ... Beck, S; + view all (2015) A donor-specific epigenetic classifier for acute graft-versus-host disease severity in hematopoietic stem cell transplantation. Genome Medicine , 7 (1) , Article 128. 10.1186/s13073-015-0246-z. Green open access
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Pickard, JM; Bøtker, HE; Crimi, G; Davidson, B; Davidson, SM; Dutka, D; Ferdinandy, P; ... Hausenloy, DJ; + view all (2015) Remote ischemic conditioning: from experimental observation to clinical application: report from the 8th Biennial Hatter Cardiovascular Institute Workshop. Basic Research in Cardiology , 110 (1) , Article 453. 10.1007/s00395-014-0453-6. Green open access
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Pratt, RJ; Deprest, J; Vercauteren, T; Ourselin, S; David, AL; (2015) Computer-assisted surgical planning and intraoperative guidance in fetal surgery: a systematic review. Prenatal Diagnosis , 35 (12) pp. 1159-1166. 10.1002/pd.4660. Green open access
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R

Rahman, B; Meisel, SF; Fraser, L; Side, L; Gessler, S; Wardle, J; Lanceley, A; (2015) Population-based genetic risk prediction and stratification for ovarian cancer: views from women at high risk. Familial Cancer , 14 (1) pp. 135-144. 10.1007/s10689-014-9769-5. Green open access
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Raine, R; a' Bháird, CN; Xanthopoulou, P; Wallace, I; Ardron, D; Harris, M; Barber, J; ... Livingston, G; + view all (2015) Use of a formal consensus development technique to produce recommendations for improving the effectiveness of adult mental health multidisciplinary team meetings. BMC Psychiatry , 15 , Article 143. 10.1186/s12888-015-0534-6. Green open access
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Ramus, SJ; Song, H; Dicks, E; Tyrer, JP; Rosenthal, AN; Intermaggio, MP; Fraser, L; ... Gayther, SA; + view all (2015) Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer. JNCI: Journal of The National Cancer Institute , 107 (11) 10.1093/jnci/djv214. Green open access
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Rocha-Ferreira, E; Hristova, M; (2015) Antimicrobial peptides and complement in neonatal hypoxia-ischemia induced brain damage. Front Immunol , 6 (56) 10.3389/fimmu.2015.00056. Green open access
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Rocha-Ferreira, E; Phillips, E; Francesch-Domenech, E; Thei, L; Peebles, DM; Raivich, G; Hristova, M; (2015) The role of different strain backgrounds in bacterial endotoxin-mediated sensitization to neonatal hypoxic-ischemic brain damage. Neuroscience , 311 pp. 292-307. 10.1016/j.neuroscience.2015.10.035. Green open access
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S

Sato Dos Santos, G; Maneas, E; Nikitichev, D; Barburas, A; David, AL; Deprest, J; Desjardins, A; ... Ourselin, S; + view all (2015) A Registration Approach to Endoscopic Laser Speckle Contrast Imaging for Intrauterine Visualisation of Placental Vessels. In: Frangi, AF and Hornegger, J and Navab, N and Wells, WM, (eds.) Medical Image Computing and Computer-Assisted Intervention – MICCAI 2015. (pp. pp. 455-462). Springer International Publishing Green open access
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Sharma, A; Burnell, M; Gentry-Maharaj, A; Campbell, S; Amso, NN; Seif, MW; Fletcher, G; ... Menon, U; + view all (2015) Quality Assurance and its impact on ovarian visualisation rates in the multicentre United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). Ultrasound in Obstetrics & Gynecology , 47 (2) pp. 228-235. 10.1002/uog.14929. Green open access
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Shaw, SWS; Blundell, MP; Pipino, C; Shangaris, P; Maghsoudlou, P; Ramachandra, DL; Georgiades, F; ... De Coppi, P; + view all (2015) Sheep CD34+Amniotic Fluid Cells Have Hematopoietic Potential and Engraft After Autologous In Utero Transplantation. Stem Cells , 33 (1) pp. 122-132. 10.1002/stem.1839. Green open access
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Smith, SG; Sestak, I; Forster, A; Partridge, A; Side, L; Wolf, MS; Horne, R; ... Cuzick, J; + view all (2015) Factors affecting uptake and adherence to breast cancer chemoprevention: a systematic review and meta-analysis. Annals of Oncology 10.1093/annonc/mdv590. Green open access
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Smith, SG; Sestak, I; Forster, AS; Partridge, A; Horne, R; Wardle, J; Cuzick, J; (2015) Factors affecting uptake and adherence to breast cancer chemoprevention: A systematic review and meta-analysis. In: (Proceedings) San Antonio Breast Cancer Symposium. Green open access
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Song, H; Dicks, E; Ramus, SJ; Tyrer, JP; Intermaggio, MP; Hayward, J; Edlund, CK; ... Pharoah, PD; + view all (2015) Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population. Journal of Clinical Oncology , 33 (26) pp. 2901-2907. 10.1200/JCO.2015.61.2408. Green open access
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Swanson, AM; David, AL; (2015) Animal models of fetal growth restriction: Considerations for translational medicine. Placenta , 36 (6) pp. 623-630. 10.1016/j.placenta.2015.03.003. Green open access
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T

Teschendorff, AE; Lee, SH; Jones, A; Fiegl, H; Kalwa, M; Wagner, W; Chindera, K; ... Widschwendter, M; + view all (2015) HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer. Genome Medicine , 7 (1) , Article 108. 10.1186/s13073-015-0233-4. Green open access
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Thomas, DS; Fourkala, EO; Apostolidou, S; Gunu, R; Ryan, A; Jacobs, I; Menon, U; ... Timms, JF; + view all (2015) Evaluation of serum CEA, CYFRA21-1 and CA125 for the early detection of colorectal cancer using longitudinal preclinical samples. British Journal of Cancer , 113 (2) pp. 268-274. 10.1038/bjc.2015.202. Green open access
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Tulay, P; Naja, RP; Cascales-Roman, O; Doshi, A; Serhal, P; SenGupta, SB; (2015) Investigation of microRNA expression and DNA repair gene transcripts in human oocytes and blastocysts. Journal of Assisted Reproduction and Genetics , 32 (12) pp. 1757-1764. 10.1007/s10815-015-0585-0. Green open access
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V

Verriotis, M; Fabrizi, L; Lee, A; Ledwidge, S; Meek, J; Fitzgerald, M; (2015) Cortical activity evoked by inoculation needle prick in infants up to one-year old. Pain , 156 (2) 222 - 230. 10.1097/01.j.pain.0000460302.56325.0c. Green open access
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W

Wang, G; Zuluaga, MA; Pratt, R; Aertsen, M; David, AL; Deprest, J; Vercauteren, T; (2015) Slic-Seg: Slice-by-slice Segmentation Propagation of the Placenta in Fetal MRI using One-plane Scribbles and Online Learning. In: Navab, N and Hornegger, J and Wells, WM and Frangi, AF, (eds.) Proceeding of Medical Image Computing and Computer-Assisted Intervention — MICCAI 2015. (pp. pp. 29-37). Springer International Publishing: Munich, Germany. Green open access
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Webster, R; Gerressu, M; Michie, S; Estcourt, C; Anderson, J; Ang, CS; Murray, E; ... Bailey, JV; + view all (2015) Defining the Content of an Online Sexual Health Intervention: The MenSS Website. JMIR Research Protocols , 4 (3) , Article e82. 10.2196/resprot.4316. Green open access
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Widschwendter, M; Burnell, M; Fraser, L; Rosenthal, AN; Philpott, S; Reisel, D; Dubeau, L; ... Dougall, WC; + view all (2015) Osteoprotegerin (OPG), the endogenous inhibitor of receptor activator of NF-κB ligand (RANKL), is dysregulated in BRCA mutation carriers. EBioMedicine , 2 (10) pp. 1331-1339. 10.1016/j.ebiom.2015.08.037. Green open access
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Williams, G; Fabrizi, L; Meek, J; Jackson, D; Tracey, I; Robertson, N; Slater, R; (2015) Functional magnetic resonance imaging can be used to explore tactile and nociceptive processing in the infant brain. Acta Paediatr , 104 (2) 158 - 166. 10.1111/apa.12848. Green open access
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X

Xia, W; Mari, JM; West, SJ; Ginsberg, Y; David, AL; Ourselin, S; Desjardins, AE; (2015) In-plane ultrasonic needle tracking using a fiber-optic hydrophone. Medical Physics , 42 (10) pp. 5983-5991. 10.1118/1.4931418. Green open access
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Xia, W; Nikitichev, DI; Mari, JM; West, SJ; Pratt, R; David, AL; Ourselin, S; ... Desjardins, AE; + view all (2015) Performance characteristics of an interventional multispectral photoacoustic imaging system for guiding minimally invasive procedures. Journal of Biomedical Optics , 20 (8) , Article 086005. 10.1117/1.JBO.20.8.086005. Green open access
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This list was generated on Sun May 26 08:05:00 2019 BST.