Anisimova, M;
Bielawski, J;
Dunn, K;
Yang, Z;
(2007)
Phylogenomic analysis of natural selection pressure in Streptococcus genomes.
BMC Evolutionary Biology
, 7
(August)
, Article 154. 10.1186/1471-2148-7-154.
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Abstract
In comparative analyses of bacterial pathogens, it has been common practice to discriminate between two types of genes: (i) those shared by pathogens and their non-pathogenic relatives (core genes), and (ii) those found exclusively in pathogens (pathogen-specific accessory genes). Rather than attempting to a priori delineate genes into sets more or less relevant to pathogenicity, we took a broad approach to the analysis of Streptococcus species by investigating the strength of natural selection in all clusters of homologous genes. The genus Streptococcus is comprised of a wide variety of both pathogenic and commensal lineages, and we relate our findings to the pre-existing knowledge of Streptococcus virulence factors.
| Type: | Article |
|---|---|
| Title: | Phylogenomic analysis of natural selection pressure in Streptococcus genomes |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/1471-2148-7-154 |
| Publisher version: | http://dx.doi.org/10.1186/1471-2148-7-154 |
| Language: | English |
| Additional information: | PMCID: PMC2031904 © 2007 Anisimova et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Biological Evolution, Gene Expression Regulation, Bacterial, Genome, Bacterial, Multigene Family, Phylogeny, Selection, Genetic, Streptococcus, Virulence |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment |
| URI: | https://discovery.ucl.ac.uk/id/eprint/99942 |
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