UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

IL-2(high) tissue-resident T cells in the human liver: Sentinels for hepatotropic infection

Pallett, LJ; Davies, J; Colbeck, EJ; Robertson, F; Hansi, N; Easom, NJW; Burton, AR; ... Maini, MK; + view all (2017) IL-2(high) tissue-resident T cells in the human liver: Sentinels for hepatotropic infection. Journal of Experimental Medicine , 214 (6) pp. 1567-1580. 10.1084/jem.20162115. Green open access

[thumbnail of Colbeck_IL-2_high tissue-resident T cells.pdf]
Preview
Text
Colbeck_IL-2_high tissue-resident T cells.pdf - Published Version

Download (2MB) | Preview

Abstract

The liver provides a tolerogenic immune niche exploited by several highly prevalent pathogens as well as by primary and metastatic tumors. We have sampled healthy and hepatitis B virus (HBV)-infected human livers to probe for a subset of T cells specialized to overcome local constraints and mediate immunity. We characterize a population of T-bet(lo)Eomes(lo)Blimp-1(hi)Hobit(lo) T cells found within the intrahepatic but not the circulating memory CD8 T cell pool expressing liver-homing/retention markers (CD69(+)CD103(+) CXCR6(+)CXCR3(+)). These tissue-resident memory T cells (TRM) are preferentially expanded in patients with partial immune control of HBV infection and can remain in the liver after the resolution of infection, including compartmentalized responses against epitopes within all major HBV proteins. Sequential IL-15 or antigen exposure followed by TGFβ induces liver-adapted TRM, including their signature high expression of exhaustion markers PD-1 and CD39. We suggest that these inhibitory molecules, together with paradoxically robust, rapid, cell-autonomous IL-2 and IFNγ production, equip liver CD8 TRM to survive while exerting local noncytolytic hepatic immunosurveillance.

Type: Article
Title: IL-2(high) tissue-resident T cells in the human liver: Sentinels for hepatotropic infection
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1084/jem.20162115
Publisher version: http://doi.org/10.1084/jem.20162115
Language: English
Additional information: This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/1557790
Downloads since deposit
137Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item