Teki, S;
Griffiths, TD;
(2016)
Brain Bases of Working Memory for Time Intervals in Rhythmic Sequences.
Frontiers in Neuroscience
, 10
, Article ARTN 239. 10.3389/fnins.2016.00239.
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Abstract
Perception of auditory time intervals is critical for accurate comprehension of natural sounds like speech and music. However, the neural substrates and mechanisms underlying the representation of time intervals in working memory are poorly understood. In this study, we investigate the brain bases of working memory for time intervals in rhythmic sequences using functional magnetic resonance imaging. We used a novel behavioral paradigm to investigate time-interval representation in working memory as a function of the temporal jitter and memory load of the sequences containing those time intervals. Human participants were presented with a sequence of intervals and required to reproduce the duration of a particular probed interval. We found that perceptual timing areas including the cerebellum and the striatum were more or less active as a function of increasing and decreasing jitter of the intervals held in working memory respectively whilst the activity of the inferior parietal cortex is modulated as a function of memory load. Additionally, we also analyzed structural correlations between gray and white matter density and behavior and found significant correlations in the cerebellum and the striatum, mirroring the functional results. Our data demonstrate neural substrates of working memory for time intervals and suggest that the cerebellum and the striatum represent core areas for representing temporal information in working memory.
| Type: | Article |
|---|---|
| Title: | Brain Bases of Working Memory for Time Intervals in Rhythmic Sequences |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fnins.2016.00239 |
| Publisher version: | http://dx.doi.org/10.3389/fnins.2016.00239 |
| Language: | English |
| Additional information: | © 2016 Teki and Griffiths. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, interval timing, time perception, working memory, rhythm, fMRI, SHORT-TERM-MEMORY, POSTERIOR PARIETAL CORTEX, MULTIPLE SYSTEM ATROPHY, BASAL GANGLIA, CEREBELLAR DEGENERATION, INDIVIDUAL-DIFFERENCES, AUDITORY RESPONSES, BETA OSCILLATIONS, NEURAL MECHANISMS, BEAT PERCEPTION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1508351 |
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